Stem Cell Research & Therapy
SCIE-ISI SCOPUS (2010-2025)
1757-6512
Cơ quản chủ quản: BioMed Central Ltd. , BMC
Lĩnh vực:
Biochemistry, Genetics and Molecular Biology (miscellaneous)Medicine (miscellaneous)Molecular MedicineCell Biology
Phân tích ảnh hưởng
Các bài báo tiêu biểu
Mechanisms of mesenchymal stem/stromal cell function
Tập 7 Số 1 - 2016
AbstractThe past decade has seen an explosion of research directed toward better
understanding of the mechanisms of mesenchymal stem/stromal cell (MSC) function
during rescue and repair of injured organs and tissues. In addition to
delineating cell–cell signaling and molecular controls for MSC differentiation,
the field has made particular progress in defining several other mechanisms
through whic...
Mesenchymal stem cells generate a CD4+CD25+Foxp3+ regulatory T cell population during the differentiation process of Th1 and Th17 cells
Tập 4 Số 3 - 2013
Comparative analysis of human mesenchymal stem cells from bone marrow and adipose tissue under xeno-free conditions for cell therapy
Tập 6 Số 1 - 2015
Hypoxia mediated isolation and expansion enhances the chondrogenic capacity of bone marrow mesenchymal stromal cells
Tập 3 - Trang 1-13 - 2012
The capacity of bone marrow mesenchymal stromal cells (BMSCs) to be induced into
chondrocytes has drawn much attention for cell-based cartilage repair. BMSCs
represent a small proportion of cells of the bone marrow stromal compartment
and, thus, culture expansion is a necessity for therapeutic use. However, there
is no consensus on how BMSCs should be isolated nor expanded to maximize their
chondr...
Treatment of severe COVID-19 with human umbilical cord mesenchymal stem cells
- 2020
Abstract Background COVID-19 is a highly infectious respiratory disease. No
therapeutics have yet been proven effective for treating severe COVID-19.
Objectives To determine whether human umbilical cord mesenchymal stem cell
infusion may be effective and safe for the treatment of severe COVID-19. Methods
Patients with severe COVID-19 were randomly divided into 2 groups: the standard
treatment grou...
Exosomes derived from umbilical cord mesenchymal stem cells reduce microglia-mediated neuroinflammation in perinatal brain injury
- 2019
AbstractBackgroundPreterm newborns are at high risk of developing
neurodevelopmental deficits caused by neuroinflammation leading to perinatal
brain injury. Human Wharton’s jelly mesenchymal stem cells (hWJ-MSC) derived
from the umbilical cord have been suggested to reduce neuroinflammation, in part
through the release of extracellular vesicle-like exosomes. Here, we studied
whether exosomes deriv...
Enhancement of therapeutic potential of mesenchymal stem cell-derived extracellular vesicles
- 2019
Abstract After the initial investigations into applications of mesenchymal stem
cells (MSCs) for cell therapy, there was increased interest in their secreted
soluble factors. Following studies of MSCs and their secreted factors,
extracellular vesicles (EVs) released from MSCs have emerged as a new mode of
intercellular crosstalk. MSC-derived EVs have been identified as essential
signaling mediator...
MSC-secreted TGF-β regulates lipopolysaccharide-stimulated macrophage M2-like polarization via the Akt/FoxO1 pathway
Tập 10 Số 1 - 2019
Abstract Background An uncontrolled inflammatory response is a critical
pathophysiological feature of sepsis. Mesenchymal stem cells (MSCs) induce
macrophage phenotype polarization and reduce inflammation in sepsis.
MSC-secreted transforming growth factor beta (TGF-β) participated in the immune
modulatory function of MSCs. However, the underlying mechanism of MSC-secreted
TGF-β was not fully eluci...