Stem Cell Research & Therapy
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Controlling stem cell fate using cold atmospheric plasma
Stem Cell Research & Therapy - Tập 11 - Trang 1-10 - 2020
The stem cell is the foundation of regenerative medicine and tissue engineering.
Regulating specific stem cell fate, such as cell attachment, proliferation,
differentiation, and even death, undergoes continuous development. Cold
atmospheric plasma (CAP), the core technology of plasma medicine, is attracting
tremendous attention due to its ability and versatility to manipulate various
types of cell...
Peripheral infusion of human umbilical cord mesenchymal stem cells rescues acute liver failure lethality in monkeys
Stem Cell Research & Therapy - Tập 10 - Trang 1-13 - 2019
Acute liver failure (ALF) is a complicated clinical syndrome associated with
high mortality, with liver transplantation as the only treatment option.
Treatment of mesenchymal stem cells has shown a potential therapeutic option for
acute liver failure. However, the lack of random clinical trials and large
non-human primate studies makes it necessary to assess the efficacy and safety
in the clinic. ...
Low level laser therapy promotes bone regeneration by coupling angiogenesis and osteogenesis
Stem Cell Research & Therapy - Tập 12 - Trang 1-18 - 2021
Bone tissue engineering is a new concept bringing hope for the repair of large
bone defects, which remains a major clinical challenge. The formation of
vascularized bone is key for bone tissue engineering. Growth of specialized
blood vessels termed type H is associated with bone formation. In vivo and in
vitro studies have shown that low level laser therapy (LLLT) promotes
angiogenesis, fracture h...
Neural tissue engineering using embryonic and induced pluripotent stem cells
Stem Cell Research & Therapy - Tập 2 - Trang 1-9 - 2011
With the recent start of the first clinical trial evaluating a human embryonic
stem cell-derived therapy for the treatment of acute spinal cord injury, it is
important to review the current literature examining the use of embryonic stem
cells for neural tissue engineering applications with a focus on diseases and
disorders that affect the central nervous system. Embryonic stem cells exhibit
plurip...
Histone demethylase JMJD6 regulates cellular migration and proliferation in adipose-derived mesenchymal stem cells
Stem Cell Research & Therapy - Tập 9 - Trang 1-13 - 2018
Adipose-derived mesenchymal stem cells (ADSCs) have been extensively explored as
a promising therapeutic agent due to their differentiation, proliferation and
migration abilities. The epigenetic mechanisms that regulate the fate of
mesenchymal stem cells (MSCs) have been described in detail. However, the
epigenetic modulation of ADSCs proliferation and migration is poorly understood.
The present s...
Immortalization of human adipose-derived stromal cells: production of cell lines with high growth rate, mesenchymal marker expression and capability to secrete high levels of angiogenic factors
Stem Cell Research & Therapy - Tập 5 - Trang 1-15 - 2014
Human adipose-derived stromal cells (hASCs), due to their relative feasibility
of isolation and ability to secrete large amounts of angiogenic factors, are
being evaluated for regenerative medicine. However, their limited culture life
span may represent an obstacle for both preclinical investigation and
therapeutic use. To overcome this problem, hASCs immortalization was performed
in order to obta...
Potential application of mesenchymal stem cells and their exosomes in lung injury: an emerging therapeutic option for COVID-19 patients
Stem Cell Research & Therapy - Tập 11 - Trang 1-33 - 2020
The COVID-19 pandemic has negatively impacted the global public health and the
international economy; therefore, there is an urgent need for an effective
therapy to treat COVID-19 patients. Mesenchymal stem cells (MSCs) have been
proposed as an emerging therapeutic option for the SARS-CoV-2 infection.
Recently, numerous clinical trials have been registered to examine the safety
and efficacy of dif...
Synergistic effect of chitosan-alginate composite hydrogel enriched with ascorbic acid and alpha-tocopherol under hypoxic conditions on the behavior of mesenchymal stem cells for wound healing
Stem Cell Research & Therapy - Tập 14 - Trang 1-20 - 2023
In regenerative medicine, especially skin tissue engineering, the focus is on
enhancing the quality of wound healing. Also, several constructs with different
regeneration potentials have been used for skin tissue engineering. In this
study, the regenerative properties of chitosan-alginate composite hydrogels in
skin wound healing under normoxic and hypoxic conditions were investigated in
vitro. Th...
Influence of platelet storage time on human platelet lysates and platelet lysate-expanded mesenchymal stromal cells for bone tissue engineering
Stem Cell Research & Therapy - Tập 11 - Trang 1-18 - 2020
Human platelet lysate (HPL) is emerging as the preferred xeno-free supplement
for the expansion of mesenchymal stromal cells (MSCs) for bone tissue
engineering (BTE) applications. Due to a growing demand, the need for
standardization and scaling-up of HPL has been highlighted. However, the optimal
storage time of the source material, i.e., outdated platelet concentrates (PCs),
remains to be determ...
Label extension, single-arm, phase III study shows efficacy and safety of stempeucel® in patients with critical limb ischemia due to atherosclerotic peripheral arterial disease
Stem Cell Research & Therapy - Tập 14 - Trang 1-13 - 2023
Peripheral arterial disease (PAD) of lower extremities comprises a clinical
spectrum that extends from asymptomatic patients to critical limb ischemia (CLI)
patients. 10% to 40% of the patients are at the risk of primary amputation. This
study was planned in “no-option” patients of CLI due to atherosclerotic PAD to
assess the efficacy and safety of pooled, allogeneic, adult human bone
marrow-deriv...
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