Stem Cell Research & Therapy

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Adipose-derived stromal cells modulating composite allotransplant survival is correlated with B cell regulation in a rodent hind-limb allotransplantation model
Stem Cell Research & Therapy - Tập 11 - Trang 1-12 - 2020
Chien-Chang Chen, Rong-Fu Chen, Jheng-Syuan Shao, Yun-Ting Li, Yu-Chi Wang, Gerald Brandacher, Jiin-Haur Chuang, Yur-Ren Kuo
Our previous studies demonstrated that adipose-derived mesenchymal stromal cells (ASCs) have immunomodulatory effects that prolong allograft survival in a rodent hind-limb allotransplant model. In this study, we investigated whether the effects of immunomodulation by ASCs on allograft survival are correlated with B cell regulation. B cells isolated from splenocytes were cocultured with ASCs harves...... hiện toàn bộ
BAM15 attenuates transportation-induced apoptosis in iPS-differentiated retinal tissue
Stem Cell Research & Therapy - Tập 10 - Trang 1-11 - 2019
Mingjun Tang, Ziming Luo, Yihui Wu, Jing Zhuang, Kaijing Li, Dongpeng Hu, Huifeng Rong, Bikun Xian, Jian Ge
BAM15 is a novel mitochondrial protonophore uncoupler capable of protecting mammals from acute renal ischemic-reperfusion injury and cold-induced microtubule damage. The purpose of our study was to investigate the effect of BAM15 on apoptosis during 5-day transportation of human-induced pluripotent stem (hiPS)-differentiated retinal tissue. Retinal tissues of 30 days and 60 days were transported w...... hiện toàn bộ
Tendon stem cell-derived exosomes regulate inflammation and promote the high-quality healing of injured tendon
Stem Cell Research & Therapy - Tập 11 - Trang 1-15 - 2020
Mingzhao Zhang, Hengchen Liu, Qingbo Cui, Peilin Han, Shulong Yang, Manyu Shi, Tingting Zhang, Zenan Zhang, Zhaozhu Li
Tendon stem cells (TSCs) have been reported to hold promises for tendon repair and regeneration. However, less is known about the effects of exosomes derived from TSCs. Therefore, we aimed to clarify the healing effects of TSC-derived exosomes (TSC-Exos) on tendon injury. The Achilles tendons of Sprague-Dawley male rats were used for primary culture of TSCs and tenocytes, and exosomes were isolate...... hiện toàn bộ
Oral ulcer treatment using human tonsil-derived mesenchymal stem cells encapsulated in trimethyl chitosan hydrogel: an animal model study
Stem Cell Research & Therapy -
Hyun Seok Ryu, Celine Abueva, Andrew Padalhin, So Young Park, Seung Hyeon Yoo, Hye Sun Seo, Phil‐Sang Chung, Seung Hoon Woo
Abstract Background Oral ulcers are a common side effect of chemotherapy and affect patients’ quality of life. While stem cell transplantation is a potential treatment for oral ulcers, its efficacy is limited as the stem cells tend to remain in the affected area for a short time. This study aims to ...... hiện toàn bộ
Bone marrow from periacetabular osteotomies as a novel source for human mesenchymal stromal cells
Stem Cell Research & Therapy - - 2023
Maximilian Handke, Anastasia Rakow, Debora Singer, Lea Miebach, Frank Schulze, Sander Bekeschus, Janosch Schoon, Georgi I. Wassilew
Bone marrow-derived mesenchymal stromal cells (BM-MSCs) are used in regenerative medicine and related research involving immunomodulatory, anti-inflammatory, anti-fibrotic and regenerative functions. Isolation of BM-MSCs from samples obtained during total hip arthroplasty (THA) is routinely possible. Advanced age and comorbidities of the majority of patients undergoing THA limit their applicabilit...... hiện toàn bộ
Autologous skin-derived neural precursor cell therapy reverses canine Alzheimer dementia-like syndrome in a proof of concept veterinary trial
Stem Cell Research & Therapy - - 2022
Michael Valenzuela, Thomas Duncan, Ajantha Abey, A Johnson, Christos Boulamatsis, Marshall A. Dalton, Erica Jacobson, Laurencie Brunel, Georgina Child, D Simpson, Michael E. Buckland, Aileen Lowe, Joyce Siette, Fred Westbrook, Paul McGreevy
Abstract Background Older companion dogs naturally develop a dementia-like syndrome with biological, clinical and therapeutic similarities to Alzheimer disease (AD). Given there has been no new safe, clinically effective and widely accessible treatment for AD for almost 20 years, an all-new cell the...... hiện toàn bộ
Cell therapy in end-stage liver disease: replace and remodel
Stem Cell Research & Therapy - Tập 14 - Trang 1-17 - 2023
Xin-Hao Hu, Lan Chen, Hao Wu, Yang-Bo Tang, Qiu-Min Zheng, Xu-Yong Wei, Qiang Wei, Qi Huang, Jian Chen, Xiao Xu
Liver disease is prevalent worldwide. When it reaches the end stage, mortality rises to 50% or more. Although liver transplantation has emerged as the most efficient treatment for end-stage liver disease, its application has been limited by the scarcity of donor livers. The lack of acceptable donor organs implies that patients are at high risk while waiting for suitable livers. In this scenario, c...... hiện toàn bộ
Human umbilical cord mesenchymal stromal cells attenuate pulmonary fibrosis via regulatory T cell through interaction with macrophage
Stem Cell Research & Therapy - Tập 12 - Trang 1-14 - 2021
Zan Tang, Junxiao Gao, Jie Wu, Guifang Zeng, Yan Liao, Zhenkun Song, Xiao Liang, Junyuan Hu, Yong Hu, Muyun Liu, Nan Li
Pulmonary fibrosis (PF) is a growing clinical problem with limited therapeutic options. Human umbilical cord mesenchymal stromal cell (hucMSC) therapy is being investigated in clinical trials for the treatment of PF patients. However, little is known about the underlying molecular and cellular mechanisms of hucMSC therapy on PF. In this study, the molecular and cellular behavior of hucMSC was inve...... hiện toàn bộ
Unrelated cord blood transplantation vs. HLA-matched sibling transplantation for adults with B-cell acute lymphoblastic leukemia in complete remission: superior OS for patients with long-term survival
Stem Cell Research & Therapy - Tập 13 - Trang 1-11 - 2022
Guangyu Sun, Baolin Tang, Kaidi Song, Yue Wu, Meijuan Tu, Xiang Wan, Wen Yao, Liangquan Geng, Ping Qiang, Xiaoyu Zhu
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an important curative therapy for adult acute lymphoblastic leukemia (ALL). For patients who lack a human leukocyte antigen (HLA)-matched sibling donor, unrelated cord blood (UCB) is an alternative graft option. Previous studies have focused mainly on all T- and B-cell ALL (B-ALL) patients, while data related specifically to adult B...... hiện toàn bộ
Galectin-9 is required for endometrial regenerative cells to induce long-term cardiac allograft survival in mice
Stem Cell Research & Therapy - Tập 11 - Trang 1-19 - 2020
Yiming Zhao, Xiang Li, Dingding Yu, Yonghao Hu, Wang Jin, Yafei Qin, Dejun Kong, Hongda Wang, Guangming Li, Alessandro Alessandrini, Hao Wang
Endometrial regenerative cells (ERCs), a novel type of mesenchymal-like stem cells, were identified as an attractive candidate for immunoregulation and induction of cardiac allograft tolerance. However, the underlying mechanisms of ERCs in immune regulation still remain largely unclear. The present study is designed to determine whether the expression of Galectin-9 (Gal-9), a soluble tandem-repeat...... hiện toàn bộ
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