Autologous adipose-derived regenerative cell therapy modulates development of hypertrophic scarring in a red Duroc porcine modelStem Cell Research & Therapy - Tập 8 - Trang 1-11 - 2017
Philippe Foubert, Diana Zafra, Mike Liu, Rohit Rajoria, Damian Gutierrez, Mayer Tenenhaus, John K. Fraser
Effective prevention and treatment of hypertrophic scars (HTSs), a common consequence of deep-partial thickness injury, remain a significant clinical challenge. Previous studies from our group have shown that autologous adipose-derived regenerative cells (ADRCs) represent a promising approach to improve wound healing and, thereby, impact HTS development. The purpose of this study was to assess the...... hiện toàn bộ
Evaluation of ex vivo produced endothelial progenitor cells for autologous transplantation in primatesStem Cell Research & Therapy - Tập 9 - Trang 1-11 - 2018
Meng Qin, Xin Guan, Yu Zhang, Bin Shen, Fang Liu, Qingyu Zhang, Yupo Ma, Yongping Jiang
Autologous transplantation of endothelial progenitor cells (EPCs) is a promising therapeutic approach in the treatment of various vascular diseases. We previously reported a two-step culture system for scalable generation of human EPCs derived from cord blood CD34+ cells ex vivo. Here, we now apply this culture system to expand and differentiate human and nonhuman primate EPCs from mobilized perip...... hiện toàn bộ
Inhibition of TGFβ improves hematopoietic stem cell niche and ameliorates cancer-related anemiaStem Cell Research & Therapy - Tập 12 - Trang 1-17 - 2021
Boyan Wang, Yi Wang, Hainan Chen, Senyu Yao, Xiaofan Lai, Yuan Qiu, Jianye Cai, Yinong Huang, Xiaoyue Wei, Yuanjun Guan, Tao Wang, Jiancheng Wang, Andy Peng Xiang
Cancer cachexia is a wasting syndrome that is quite common in terminal-stage cancer patients. Cancer-related anemia is one of the main features of cancer cachexia and mostly results in a poor prognosis. The disadvantages of the current therapies are obvious, but few new treatments have been developed because the pathological mechanism remains unclear. C57BL/6 mice were subcutaneously injected with...... hiện toàn bộ
The functions and clinical application potential of exosomes derived from adipose mesenchymal stem cells: a comprehensive reviewStem Cell Research & Therapy - Tập 10 - Trang 1-12 - 2019
Pengyu Hong, Hao Yang, Yue Wu, Kun Li, Zhangui Tang
Exosomes are extracellular membranous nanovesicles that mediate local and systemic intercellular communication by transporting proteins or nucleic acids (DNA and RNA) into target cells, thus altering the behaviors of recipient cells. Recent studies have revealed that these vesicles play a critical role in many biological functions, such as cell proliferation, immune regulation, nerve regeneration,...... hiện toàn bộ
The preclinical and clinical progress of cell sheet engineering in regenerative medicineStem Cell Research & Therapy - Tập 14 - Trang 1-23 - 2023
Danping Hu, Xinyu Li, Jie Li, Pei Tong, Zhe Li, Ge Lin, Yi Sun, Juan Wang
Cell therapy is an accessible method for curing damaged organs or tissues. Yet, this approach is limited by the delivery efficiency of cell suspension injection. Over recent years, biological scaffolds have emerged as carriers of delivering therapeutic cells to the target sites. Although they can be regarded as revolutionary research output and promote the development of tissue engineering, the de...... hiện toàn bộ