Stem Cell Research & Therapy
Công bố khoa học tiêu biểu
* Dữ liệu chỉ mang tính chất tham khảo
Sắp xếp:
Neural tissue engineering using embryonic and induced pluripotent stem cells
Stem Cell Research & Therapy - Tập 2 - Trang 1-9 - 2011
With the recent start of the first clinical trial evaluating a human embryonic stem cell-derived therapy for the treatment of acute spinal cord injury, it is important to review the current literature examining the use of embryonic stem cells for neural tissue engineering applications with a focus on diseases and disorders that affect the central nervous system. Embryonic stem cells exhibit plurip......
Influence of platelet storage time on human platelet lysates and platelet lysate-expanded mesenchymal stromal cells for bone tissue engineering
Stem Cell Research & Therapy - Tập 11 - Trang 1-18 - 2020
Human platelet lysate (HPL) is emerging as the preferred xeno-free supplement for the expansion of mesenchymal stromal cells (MSCs) for bone tissue engineering (BTE) applications. Due to a growing demand, the need for standardization and scaling-up of HPL has been highlighted. However, the optimal storage time of the source material, i.e., outdated platelet concentrates (PCs), remains to be determ......
Bile acid: a potential inducer of colon cancer stem cells
Stem Cell Research & Therapy - Tập 7 - Trang 1-10 - 2016
Although the unconjugated secondary bile acids, specifically deoxycholic acid (DCA) and lithocholic acid (LCA), are considered to be risk factors for colorectal cancer, the precise mechanism(s) by which they regulate carcinogenesis is poorly understood. We hypothesize that the cytotoxic bile acids may promote stemness in colonic epithelial cells leading to generation of cancer stem cells (CSCs) th......
A gene signature is critical for intrahepatic cholangiocarcinoma stem cell self-renewal and chemotherapeutic response
Stem Cell Research & Therapy - Tập 13 - Trang 1-18 - 2022
Improved understanding of the stemness regulation mechanism in intrahepatic cholangiocarcinoma (ICC) could identify targets and guidance for adjuvant transarterial chemoembolization (TACE). TCGA database was excavated to identify the ICC stemness-associated genes. The pro-stemness effect of target genes was further analyzed by sphere formation assay, qRT-PCR, western blot, flow cytometric analysis......
Strategies to improve the immunosuppressive properties of human mesenchymal stem cells
Stem Cell Research & Therapy - Tập 6 - Trang 1-10 - 2015
Mesenchymal stem cells (MSCs) are of particular interest for the treatment of immune-related diseases because of their immunosuppressive capacities. However, few clinical trials of MSCs have yielded satisfactory results. A number of clinical trials using MSCs are currently in progress worldwide. Unfortunately, protocols and methods, including optimized culture conditions for the harvest of MSCs, h......
Long noncoding RNA CCDC144NL-AS1 knockdown induces naïve-like state conversion of human pluripotent stem cells
Stem Cell Research & Therapy - - 2019
Determining the optimal stage for cryopreservation of human embryonic stem cell-derived retinal pigment epithelial cells
Stem Cell Research & Therapy - Tập 13 - Trang 1-16 - 2022
Human embryonic stem cell-derived retinal pigment epithelial cells (hESC-derived RPE) are a promising source for cell-replacement therapy to treat retinal degenerative diseases, but research on RPE cryopreservation is limited. This study aimed to determine the best phase for RPE cryopreservation to preserve the post-thaw function and uncover the mechanism underlying RPE freezing tolerance. hESC-de......
Autologous adipose-derived regenerative cell therapy modulates development of hypertrophic scarring in a red Duroc porcine model
Stem Cell Research & Therapy - Tập 8 - Trang 1-11 - 2017
Effective prevention and treatment of hypertrophic scars (HTSs), a common consequence of deep-partial thickness injury, remain a significant clinical challenge. Previous studies from our group have shown that autologous adipose-derived regenerative cells (ADRCs) represent a promising approach to improve wound healing and, thereby, impact HTS development. The purpose of this study was to assess the......
Evaluation of ex vivo produced endothelial progenitor cells for autologous transplantation in primates
Stem Cell Research & Therapy - Tập 9 - Trang 1-11 - 2018
Autologous transplantation of endothelial progenitor cells (EPCs) is a promising therapeutic approach in the treatment of various vascular diseases. We previously reported a two-step culture system for scalable generation of human EPCs derived from cord blood CD34+ cells ex vivo. Here, we now apply this culture system to expand and differentiate human and nonhuman primate EPCs from mobilized perip......
Infrapatellar fat pad-derived mesenchymal stem cell-based spheroids enhance their therapeutic efficacy to reverse synovitis and fat pad fibrosis
Stem Cell Research & Therapy - Tập 12 - Trang 1-19 - 2021
To investigate the in vitro and in vivo anti-inflammatory/anti-fibrotic capacity of IFP-MSC manufactured as 3D spheroids. Our hypothesis is that IFP-MSC do not require prior cell priming to acquire a robust immunomodulatory phenotype in vitro in order to efficiently reverse synovitis and IFP fibrosis, and secondarily delay articular cartilage damage in vivo. Human IFP-MSC immunophenotype, tripoten......
Tổng số: 2,774
- 1
- 2
- 3
- 4
- 5
- 6
- 10