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The possible place of cathepsins and cystatins in the puzzle of Alzheimer disease
Springer Science and Business Media LLC - Tập 27 - Trang 225-247 - 1996
Lysosomal proteinases (cathepsins) and their endogenous inhibitors (cystatins) have been found to be closely associated with senile plaques, cerebrovascular amyloid deposits, and neurofibrillary tangles in Alzheimer disease (AD). Further, profound changes in the lysosomal system seem to be an early event in “at-risk” neurons of AD brains. There is an ongoing controversy as to whether lysosome-asso......
The effects of interleukin-1 receptor antagonist protein (IRAP) infusion following spinal cord transection in rats
Springer Science and Business Media LLC - Tập 27 - Trang 167-183 - 1996
A laminectomy was performed at the T5−T6 vertebral level in adult, male, Sprague-Dawley rats and the spinal cord transected with a scalpel. A group of sham animals was subjected to the same surgery without the transection step. A group of unhandled control rats was also included. A subgroup of transected animals received a subcutaneous osmotic minipump that dispensed IL-1 receptor antagonist prote......
Progesterone protects against lipid peroxidation following traumatic brain injury in rats
Springer Science and Business Media LLC - Tập 31 - Trang 1-11 - 1997
The gonadal hormone, progesterone, has been shown to have neuroprotective effects in injured nervous system, including the severity of postinjury cerebral edema. Progesterone’s attenuation of edema is accompanied by a sparing of neurons from secondary neuronal death and with improvements in cognitive outcome. In addition, we recently reported that postinjury blood-brain barrier (BBB) leakage, as m......
Evolutive levels of NGF in neurodegenerative disorders
Springer Science and Business Media LLC - Tập 24 Số 2-3 - Trang 231-234 - 1995
Age-related changes of RNA and lipid synthesis in vitro by retina and optic nerve of the rat
Springer Science and Business Media LLC - Tập 8 - Trang 131-148 - 1988
We examined the effects of age on RNA and lipid formation by whole retina and optic nerve in vitro. Male Wistar rats, aged 4, 12, and 24 mo, were used. From the results obtained the following conclusions may be drawn:
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Changes in synaptosomal pH and rates of oxygen radical formation induced by chlordecone
Springer Science and Business Media LLC - Tập 13 - Trang 95-106 - 1990
The resting pH of 7.14±0.02 within rat cortical synaptosomes is elevated in vitro by the insecticide chlordecone, in a dose-dependent manner. Chlordecone also reduces the rate of oxygen radical formation within synaptosomes. Both of these changes can also be demonstrated following in vivo treatment of rats with chlordecone (75 mg/kg body wt). Although chlordecone increases the permeability of the ......
Studies on the generation of an animal model for metachromatic leukodystrophy
Springer Science and Business Media LLC - Tập 27 - Trang 65-66 - 1996
N-acetylaspartylglutamate,N-acetylaspartate, andN-acetylated alpha-linked acidic dipeptidase in human brain and their alterations in Huntington and Alzheimer diseases
Springer Science and Business Media LLC - - 1997
Immunoblotting patterns of cytoskeletal dendritic protein expression in human neocortex
Springer Science and Business Media LLC - - 1997
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