Abstract Several susceptibility genes differentially impact on the lifetime risk
for breast cancer. Technological advances over the past years have enabled the
detection of genetic risk factors through high-throughput screening of large
breast cancer case–control series. High- to intermediate penetrance alleles have
now been identified in more than 20 genes involved in DNA damage signalling and
re... hiện toàn bộ
Ingrid P. Vogelaar, Rachel S. van der Post, Tanya M. Bisseling, J. Han van Krieken, Marjolijn J. L. Ligtenberg, Nicoline Hoogerbrugge
Abstract Worldwide, gastric cancer is one of the most common forms of cancer,
with a high morbidity and mortality. Several environmental factors predispose to
the development of gastric cancer, such as Helicobacter pylori infection, diet
and smoking. Familial clustering of gastric cancer is seen in 10% of cases, and
approximately 3% of gastric cancer cases arise in the setting of hereditary
diffus... hiện toàn bộ
AbstractAlthoughCDKN2Ais well-known as a susceptibility gene for melanoma and
pancreatic cancer, germline variants have also been anecdotally associated with
a broader range of neoplasms including neural system tumors, head and neck
squamous cell carcinomas, breast carcinomas, as well as sarcomas. TheCDKN2Agene
encodes for two distinct tumor suppressor proteins, p16INK4Aand p14ARF, however,
the in... hiện toàn bộ
Carmen Radecki Breitkopf, Pamela S. Sinicrope, Kari G. Rabe, Tabetha A. Brockman, Christi A. Patten, Robert R. McWilliams, Shawna L. Ehlers, Gloria M. Petersen