Correlation between blood pressure changes and AMS, sleeping quality and exercise upon high-altitude exposure in young Chinese menSpringer Science and Business Media LLC - Tập 1 - Trang 1-9 - 2014
Yang Liu, Ji-Hang Zhang, Xu-Bin Gao, Xiao-Jing Wu, Jie Yu, Jian-Fei Chen, Shi-Zhu Bian, Xiao-Han Ding, Lan Huang
Excessive elevation of arterial blood pressure (BP) at high altitude can be detrimental to our health due to acute mountain sickness (AMS) or some AMS symptoms. This prospective and observational study aimed to elucidate blood pressure changes induced by exposure to high-altitude hypoxia and the relationships of these changes with AMS prevalence, AMS severity, sleep quality and exercise condition in healthy young men. A prospective observational study was performed in 931 male young adults exposed to high altitude at 3,700 m (Lhasa) from low altitude (LA, 500 m). Blood pressure measurement and AMS symptom questionnaires were performed at LA and on day 1, 3, 5, and 7 of exposure to high altitude. Lake Louise criteria were used to diagnose AMS. Likewise, the Athens Insomnia Scale (AIS) and the Epworth Sleepiness Scale (ESS) were filled out at LA and on day 1, 3, and 7 of exposure to high altitude. After acute exposure to 3,700 m, diastolic blood pressure (DBP) and mean arterial blood pressure (MABP) rose gradually and continually (P < 0.05). Analysis showed a relationship with AMS for only MABP (P < 0.05) but not for SBP and DBP (P > 0.05). Poor sleeping quality was generally associated with higher SBP or DBP at high altitude, although inconsistent results were obtained at different time (P < 0.05). SBP and Pulse BP increased noticeably after high-altitude exercise (P < 0.05). Our data demonstrate notable blood pressure changes under exposure to different high-altitude conditions: 1) BP increased over time. 2) Higher BP generally accompanied poor sleeping quality and higher incidence of AMS. 3) SBP and Pulse BP were higher after high-altitude exercise. Therefore, we should put more effort into monitoring BP after exposure to high altitude in order to guard against excessive increases in BP.
Mental health disorders in child and adolescent survivors of post-war landmine explosionsSpringer Science and Business Media LLC - Tập 2 - Trang 1-6 - 2015
Mohammad Ali Hemmati, Hamid Shokoohi, Mehdi Masoumi, Shahriar Khateri, Mohammadreza Soroush, Ehsan Modirian, Mahtab Poor Zamany Nejat Kermany, Maryam Hosseini, Batool Mousavi
To describe the mental health status of 78 child and adolescent survivors of post-war landmine explosions. Child and adolescent survivors of landmine explosions who were younger than 18 years old at the time of the study were identified and enrolled in this study. The mental health status of the participants was assessed by general health assessment and psychiatric examinations. Psychiatric assessment and diagnosis were undertaken using the Diagnostic and Statistical Manual for mental disorders (DSM-IV) criteria. A psychiatrist visited and interviewed each survivor and identified psychiatric disorders. Seventy-eight child and adolescent survivors with a mean age of 16.11 ± 2 years old were identified and agreed to participate in the study. The mean age of the victims at the time of injury was 8.2 ± 3.12 years old (range 2–15). Thirty-seven (47.4 %) of the adolescent survivors suffered from at least one psychiatric disorder. Twenty-nine survivors (37.1 %) were newly diagnosed and needed to start medication and psychiatric treatment. The most common findings were anxiety disorders (34.6 %), including posttraumatic stress disorder (PTSD) in 20 (25.6 %), and generalized anxiety disorder (GAD) in 7 (9 %) subjects. Mild-Moderate depression was found in 5 (6.4 %) subjects. No personality disorders were observed, and two patients suffered from mental retardation. The study results revealed a significant association between age of casualty, duration of injury and limb amputation, and types of psychological disorders. Child and adolescent survivors of landmine explosions had a high prevalence of psychiatric disorders.
Chinese expert consensus on echelons treatment of thoracic injury in modern warfareSpringer Science and Business Media LLC - - 2018
Zhao-Wen Zong, Zhi-Nong Wang, Si-Xu Chen, Hao Qin, Lian-Yang Zhang, Yue Shen, Lei Yang, Wen-Qiong Du, Can Chen, Xin Zhong, Lin Zhang, Jiang-Tao Huo, Li-Ping Kuai, Li-Xin Shu, Guo-Fu Du, Yu-Feng Zhao
The emergency treatment of thoracic injuries varies of general conditions and modern warfare. However, there are no unified battlefield treatment guidelines for thoracic injuries in the Chinese People’s Liberation Army (PLA). An expert consensus has been reached based on the epidemiology of thoracic injuries and the concept of battlefield treatment combined with the existing levels of military medical care in modern warfare. Since there are no differences in the specialized treatment for thoracic injuries between general conditions and modern warfare, first aid, emergency treatment, and early treatment of thoracic injuries are introduced separately in three levels in this consensus. At Level I facilities, tension pneumothorax and open pneumothorax are recommended for initial assessment during the first aid stage. Re-evaluation and further treatment for hemothorax, flail chest, and pericardial tamponade are recommended at Level II facilities. At Level III facilities, simple surgical operations such as emergency thoracotomy and debridement surgery for open pneumothorax are recommended. The grading standard for evidence evaluation and recommendation was used to reach this expert consensus.
Động lực biểu hiện của các bản sao định kỳ trong quá trình tiến triển chu kỳ tế bào ung thư và mối tương quan của chúng với độ nhạy thuốc chống ung thư Dịch bởi AI Springer Science and Business Media LLC -
Chunxiao Li, Jinsong Wang, Wenna Wang, Dongkui Xu, Yantong Zhou, Fang-Zhou Sun, Yiqun Li, Fengzhu Guo, Jia-Lu Ma, Xueyan Zhang, Meng-Jiao Chang, Binghe Xu, Fei Ma, Haili Qian
Tóm tắt
Tiền đề
Chu kỳ tế bào là trung tâm của các hoạt động tế bào và được điều phối bởi các cơ chế điều hòa phức tạp, trong đó điều hòa phiên mã là một trong những thành phần quan trọng nhất. Sự cắt ghép thay thế làm mở rộng mạng lưới điều hòa một cách đáng kể bằng cách tạo ra các isoform phiên mã của các gen để kiểm soát tinh vi chu kỳ tế bào. Tuy nhiên, các kiểu biểu hiện của isoform phiên mã trong chu kỳ tế bào vẫn chưa được rõ ràng. Các liệu pháp nhắm đến các điểm kiểm soát chu kỳ tế bào thường được sử dụng như các liệu pháp chống ung thư, nhưng không có liệu pháp nào được thiết kế hoặc đánh giá ở cấp độ phiên mã cắt ghép thay thế. Tính hữu ích của những phiên bản này như các dấu hiệu của độ nhạy thuốc liên quan đến chu kỳ tế bào vẫn chưa được biết đến, và các nghiên cứu về các kiểu biểu hiện của các phiên bản liên quan đến thuốc nhắm mục tiêu chu kỳ tế bào cũng rất hiếm.
Acute kidney injury in severely injured patients admitted to the intensive care unitSpringer Science and Business Media LLC - - 2020
Alberto García, Ramiro Manzano-Núñez, Juan Gabriel Bayona, María Paula Naranjo, Dary Neicce Villa, Manuel Moreno, Sebastian Ossa, Juan M. Martínez, Nathalia Martinez, Juan Carlos Puyana
Abstract
Background
Our objective was to identify possible associations between clinical and laboratory variables and the risk of developing acute kidney injury (AKI) in severely injured patients admitted to the intensive care unit (ICU) for whom creatine kinase (CK) levels were available.
Methods
For this retrospective observational study, we analyzed adult trauma patients admitted to the ICU from 2011 to 2015 at Fundación Valle del Lili (FVL) University Hospital. Our primary outcome was the incidence of AKI. Multivariate regression analysis was used to assess risk factors for this outcome.
Results
A total of 315 patients were included. The trauma mechanisms were blunt (n = 130), penetrating (n = 66) and blast (n = 44) trauma. The median (interquartile range, IQR) of injury severity score (ISS) was 21 (16–29). AKI developed in 75 patients (23.8%). Multivariate regression analysis revealed that the thoracic abbreviated injury scale (AIS) value (median (IQR) in the AKI group: 3 (0–4)), Acute Physiology and Chronic Health Evaluation (APACHE II) score (median (IQR) in the AKI group: 18 (10–27)), CK greater than 5000 U/L, lactic acid concentration at admission, and dobutamine administration were independently associated with AKI.
Conclusion
We found that age, APACHE II score, thoracic trauma, lactic acidosis, and dobutamine administration were independently associated with AKI. Trauma surgeons need to be aware of the increased odds of AKI if one of these factors is identified during the evaluation and treatment of injured patients.
Physician-level variation in the diagnosis of myocardial infarction and the use of angiography among Veterans with elevated troponinSpringer Science and Business Media LLC - Tập 3 - Trang 1-5 - 2016
David E. Winchester, Nayan Agarwal, Lucas Burke, Steven Bradley, Tatiana Schember, Carsten Schmalfuss
Cardiac troponin assays have improved the ability to detect myocardial damage. However, ascertaining whether troponin elevation is due to myocardial infarction (MI) or secondary to another process can be challenging. Our aim is to evaluate provider-level variation in the diagnosis of MI and the use of invasive coronary angiography (ICA) among patients with undifferentiated elevations in cardiac troponin. We analyzed data from all patients with elevated troponin levels in a single Veterans Affairs (VA) Medical Center between 2006 and 2007. One of several cardiologists prospectively evaluated each patient’s presentation and course of care. We compared the frequency of MI diagnosis and ICA use between physicians using univariate odds ratios (OR). Among 761 patients, 34.0 % were diagnosed with MI and 25.9 % underwent ICA. The unadjusted rates of MI (23.9 to 56.7 %, P = 0.02) and ICA (17.3 to 73.3 %, P < 0.001) differed between physicians. Comparing the patient cohorts for each physician, baseline characteristics were similar except for chest pain. In multivariate regression, factors associated with the use of cardiac ICA included an abnormal electrocardiograph (ECG) (OR = 1.89, P = 0.014), level of troponin (OR = 1.71, P = 0.004), chest pain (OR = 8.60, P < 0.001), and care by non-VA physicians (OR = 4.45, P = 0.006). One physician had a lower ICA use (OR = 0.56, P = 0.017). In multivariate regression of MI, no physician-level variation was observed. Among patients with elevated troponin, the likelihood of being diagnosed with MI and undergoing ICA is dependent on their clinical presentation. After adjustment, physician-level variation in care was observed for the use of ICA, but not for the diagnosis of MI.
A double-edged sword: CRISPR-Cas9 is emerging as a revolutionary technique for genome editingSpringer Science and Business Media LLC - Tập 2 - Trang 1-2 - 2015
Chun-xiao Li, Hai-li Qian
In May 2015, Professor Xiao Yang authored a review on the development of CRISPR-Cas9 techniques in the journal of Military Medical Research. This review provided a valuable overview of this major scientific advance. It has been four years since the first publication of the CRISPR-Cas9 breakthrough (Science. 2012; 337: 816–21). The use of this technique has expanded into various scientific areas and is being developed into a systematic technical platform that may contribute to many bioengineering fields involving DNA sequence editing.
