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Mục tiêu của nghiên cứu này là (1) đánh giá Chất lượng Cuộc sống Chủ quan (SQOL) của bệnh nhân mắc Hội chứng Mệt mỏi Mãn tính (CFS) bằng cách sử dụng một khái niệm chung và so sánh các phát hiện với những nhóm mắc rối loạn tâm thần và những người khỏe mạnh, và (2) điều tra xem liệu có và, nếu có, thì mức độ nào các biến xã hội-dân số và lâm sàng dự đoán SQOL ở bệnh nhân CFS. Bảy mươi ba bệnh nhân được chẩn đoán mắc CFS đã được chọn ngẫu nhiên và phỏng vấn từ hai phòng khám chuyên khoa. CFS được chẩn đoán theo Tiêu chuẩn Oxford. SQOL được đánh giá bằng Công cụ Đánh giá Chất lượng Cuộc sống Ngắn của Manchester (MANSA) và Chất lượng Cuộc sống Liên quan đến Sức khỏe (HRQOL) bằng Nghiên cứu Kết quả Y tế Dạng Ngắn 36 (MOS) SF-36. Một loạt các bảng câu hỏi về tâm trạng và triệu chứng, bao gồm Bảng câu hỏi Kiểm tra triệu chứng (SCL-90-R), đã được sử dụng để đánh giá các khía cạnh khác nhau của triệu chứng như các biến số dự đoán tiềm năng. Các phân tích hồi quy đa biến đã được thực hiện để xác định các yếu tố dự đoán SQOL. Tổng thể, SQOL của bệnh nhân CFS ở mức thấp và ít thuận lợi hơn so với các nhóm mắc rối loạn tâm thần và những người khỏe mạnh. Mức độ hài lòng đặc biệt thấp về cuộc sống nói chung, các hoạt động thư giãn và tình hình tài chính. Mặc dù SQOL chỉ có mối tương quan vừa phải với HRQOL, điểm số SCL-90-R, đặc biệt là điểm số thang đo Trầm cảm SCL-90-R, là yếu tố dự đoán tốt nhất của SQOL, giải thích 35% sự biến thiên. HRQOL và SQOL chung có vẻ tách biệt mặc dù có một số chồng lấp. Các phát hiện nhấn mạnh rằng SQOL bị ảnh hưởng đáng kể ở bệnh nhân CFS. Các triệu chứng trầm cảm là "yếu tố dự đoán" mạnh mẽ nhất về mặt thống kê của SQOL, mặc dù chiều hướng của mối quan hệ không được thiết lập. Những dữ liệu này cho thấy việc điều trị trầm cảm liên quan đến CFS, không phân biệt nguyên nhân, có thể giúp cải thiện SQOL ở bệnh nhân CFS.

To examine the responsiveness of Functional Assessment of Cancer Therapy-Prostate (FACT-P) and Short Form-12 Health Survey version 2 (SF-12 v2) in prostate cancer patients because there is a lack of evidence to support their responsiveness in this patient population. One hundred sixty-eight subjects with prostate cancer were surveyed at baseline and at 6 months using the SF-12 v2 and FACT-P version 4. Internal responsiveness was assessed using paired t test and generalized estimating equation. External responsiveness was evaluated using receiver operating characteristic curve analysis. The internal responsiveness of the FACT-P and SF-12 v2 to detect positive change was satisfactory. The FACT-P and SF-12 v2 could not detect negative change. The FACT-P and the SF-12 v2 performed the best in distinguishing between improved general health and worsened general health. The FACT-P performed better in distinguishing between unchanged general health and worsened general health. The SF-12 v2 performed better in distinguishing between unchanged general health and improved general health. Positive change detected by these measures should be interpreted with caution as they might be too responsive to detect “noise,” which is not clinically significant. The ability of the FACT-P and the SF-12 v2 to detect negative change was disappointing. The internal and external responsiveness of the social well-being of the FACT-P cannot be supported, suggesting that it is not suitable to longitudinally monitor the social component of HRQOL in prostate cancer patients. The study suggested that generic and disease-specific measures should be used together to complement each other.

Using the SF-12 to measure physical and mental functioning, the authors examine the intra-individual changes in health-related quality of life (HRQOL) 6 months post-discharge for depressed older adults. In addition, they examine three sets of predictors that might influence these changes. The sample of depressed older adults was recruited from an inpatient geropsychiatry unit. Although their physical and mental health scores on the SF-12 were lower than comparable norms, the sample showed an average increase in their mental functioning but a decrease in the physical functioning over the 6 months. Negative life-events were significant predictors of people who reported no change in their mental health functioning and decreases in their physical health functioning. Interestingly, those who experienced positive life events were more likely to report declines and younger participants were more likely to report no change in their physical functioning. The findings indicate that the effects of depression on HRQOL can have enduring effects on a sample of previously hospitalized older adults. The significance of life event changes might signify the importance of taking into account non-traditional areas of medical interventions. Further, the findings indicate the usefulness of the SF-12 quantifying HRQOL outcomes.

This systematic review was performed to identify all relevant health-related quality of life (HRQoL) issues associated with COVID-19. A systematic literature search was undertaken in April 2020. In four teams of three reviewers each, all abstracts were independently reviewed for inclusion by two reviewers. Using a pre-defined checklist of 93 criteria for each publication, data extraction was performed independently by two reviewers and subsequently compared and discussed. If necessary, a third reviewer resolved any discrepancies. The search was updated in February 2021 to retrieve new publications on HRQoL issues including issues related to the long-term consequences of COVID-19. The search in April 2020 identified 3342 potentially relevant publications, and 339 publications were selected for full-text review and data extraction. We identified 75 distinct symptoms and other HRQoL issues categorized into 12 thematic areas; from general symptoms such as fever, myalgia, and fatigue, to neurological and psychological issues. The updated search revealed three extra issues experienced during active disease and long-term problems with fatigue, psychological issues and impaired cognitive function. This first comprehensive systematic review provides a detailed overview of the wide range of HRQoL issues experienced by patients with COVID-19 throughout the course of the disease. It demonstrates the devastating impact of the disease and provides critically important information for clinicians, to enable them to better recognize the disease and to provide knowledge important for treatment and follow-up. The results provided the foundation for the international development of a COVID-19 specific patient-reported HRQoL questionnaire.

Objective: Several methods currently used for determining meaningful or important change in health-related quality of life (HRQoL) measures are anchored by global transition items. It can be empirically demonstrated that patients’ responses to these gold standards for change do not adequately incorporate the prior condition, yet these transition items play an influential role in patient–clinician communications and cannot be disregarded. This follow-up study queried patients to better understand how they ascertained their transition assessments. Data source: Prior to their qualitative interviews, the 41 participants in this study had completed 1 year of enrollment in a clinical study with bi-monthly HRQoL telephone interviews that included the SF-36 and a disease-specific HRQoL instrument (asthma, COPD, or heart disease), as well as global transition assessments for each instruments domains. Study design: We used face-to-face cognitive interview and the think aloud approaches to obtain qualitative clues for understanding patient reports of HRQoL changes over time. Interview transcripts were coded using the four components of the Rapkin–Schwarz Appraisal Model: frame of reference; sampling strategy; standards of comparison; and combinatory algorithm. Principal findings: Patients’ explanations for determining global transition item responses often focused on current mobility and fatigue patterns, physicians’ statements about their conditions, comparisons of their current states with the prior health conditions, and strong personal convictions that reflected a resistance to voicing any emotional changes. Patients also expressed primary health concerns, like back pain, that were not related to the chronic conditions (asthma, COPD or heart disease) under investigation. >Conclusions: HRQoL studies and patient–clinician communications that incorporate global transition assessments to anchor the interpretations of HRQoL changes should also consider additional relevant questions to understand the process patients uses to appraise and report changes in HRQoL.

This study explores changes in emotional component of subjective well-being (SWB) of patients after their first myocardial infarction (MI) and two kinds of mechanisms: attribution of positive (PA) and negative (NA) affect and a mediation effect of coping. Affect and coping strategies (problem-, emotion-, and avoidance-focused) were assessed in 121 male patients (age 52.26 ± 7.08 years) a few days after the first MI and then 1 and 6 months later. The indicator of emotional SWB was affect balance, calculated as the ratio of PA to NA. Mediation was tested using the PROCESS macro. The affect balance changed over time, from a predominance of negativity a few days post-MI to more positive 1 and 6 months later (F 2, 119 = 21.87, p < 0.001). The results of parallel multiple mediation showed a mediating effect of emotion-focused coping on the changes in affect balance over time. Separate analyses for PA and NA showed the same results for NA. Problem-focused coping mediated PA changes in the early post-hospitalization period. Myocardial infarction may activate PA alongside the NA, but the predominance of PA over NA in both early and late post-hospitalization period was minimal. Affect balance appeared to be largely dependent on NA and its changes. Coping strategies partly mediated the changes in well-being, providing a basis for practical interventions.

Radical prostatectomy is a commonly performed procedure with perioperative complication rates of 30 % using standardized reporting methodology. We aim to determine whether perioperative complications and functional outcomes impact quality of life 1 year after surgical treatment. Quality of life, functional and oncological outcomes were assessed in patients who underwent open retropubic radical prostatectomy at a single academic institution between 2003 and 2009, preoperatively and 1 year after surgery using the EORTC QLQ-C30, the IIEF-5 and an institutional questionnaire. Perioperative complications were recorded using the Clavien–Dindo classification. Patients without complications were compared to patients with any, low- or high-grade complications. The global health score domain of the EORTC QLQ-C30 is reported for various oncological and functional outcomes and contrasted to stratified categories of complications and functional outcomes. A full dataset was available for 29.5 % (n = 856) of all patients. The overall complication rate was 27.5 % (235/856). A total of 307 complications were recorded of whom 88.9 % (273/307) were low grade. In this study, population global health perception did not decline after surgery (70.5 ± 21.2 vs. 74.4 ± 19.7; p < 0.0001). Complications showed only statistical but no clinical meaningful influence on global health perception as well as on functional and symptom scales. Patients who met combined outcome criteria experienced the best postoperative global health score (86.0 ± 13.1 and 86.0 ± 14.2). Perioperative complications and functional outcomes have a measurable impact on quality of life 1 year following surgery. While perioperative complications have a statistical effect, functional outcomes showed a clinically more profound effect on postoperative global health perception.

Addressing quality of life (QOL) issues in the spinal cord injured (SCI) population is imperative as the majority survive their initial injury and longevity now approaches that of the general population. The purpose of this mixed method, descriptive, longitudinal feasibility study was to describe and compare QOL in 10 adult SCI individuals and their family caregivers (FCs) during the initial 6 months following rehabilitation. Instruments used were the SF-36 and two horizontal visual analog scales, one for pain and one for QOL. Participants completed the instruments and a face-to-face in-depth interview at 1-, 3-, and 6-months following inpatient rehabilitation. SCI individuals reported low physical function, role physical (RP), and role emotional (RE) scores on the SF-36, while reporting high general health (GH), mental health and social functioning on the SF-36. FCs reported lower RP, GH and vitality scores, while reporting higher physical functioning and RE scores. On the visual analog scales, persons with SCI reported lower QOL while FCs reported more pain at 3 and 6 months. This study suggests that more work is needed to identify interventions which could enhance QOL during the transition from rehabilitation to home for SCI individuals and their FCs.