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Modulation of PMN receptors for chemotactic peptides
Springer Science and Business Media LLC - Tập 2 - Trang 139-144 - 2014
Expression of IL-5 receptors on B cells: Role in mucosal B cell responses
Springer Science and Business Media LLC - - 1991
IL-5 plays an important role in mucosal B cell responses. An in vitro model of
IgA B cell differentiation, CH12LX, has been used to demonstrate that IL-5R are
expressed on both IgM+ and IgA+ B cells and that IL-5 will enhance secretion of
both IgM and IgA by CH12LX B cells, depending on the surface isotype of
individual cells. Further, the enhanced secretion of Ig in response to IL-5 is
associated...
Human T cell immunodeficiency
Springer Science and Business Media LLC - Tập 35 - Trang 117-125 - 2006
Severe combined immunodeficiency (SCID) is a heterogeneous group of diseases
that are invariably fatal in infancy unless treated by hematopoietic stem cell
replacement. For many years we have worked to better manage patients affected by
SCID through rapid and accurate diagnosis followed by treatment aimed at
achieving long-lasting immune reconstitution. By extensive immunological,
biochemical, and...
Assembly of MHC Class I Molecules within the Endoplasmic Reticulum
Springer Science and Business Media LLC -
Melatonin: a potential therapeutic approach for the management of primary Sjögren’s syndrome
Springer Science and Business Media LLC - - 2023
Division of labor during primary humoral immunity
Springer Science and Business Media LLC - Tập 55 - Trang 277-286 - 2012
B lymphocytes are often considered a homogenous population. However, B cells in
both mouse and humans are comprised of distinct subpopulations that differ in
development, phenotype, function, and microenvironmental niches. Much of our
understanding about how these different B-cells populations mount antibody
responses has been derived from experimental findings in mouse models and based
on the use...
Immune regulation by novel costimulatory molecules
Springer Science and Business Media LLC - Tập 28 - Trang 39-48 - 2003
CD4 helper T (Th)-cells and the cytokines that they produce play essential
regulatory roles in immune and autoimmune responses. Th activation and
differentiation is regulated by costimulatory receptors. CD28 and CTLA-4 are
important in maintaining the threshold of T-cell activation. ICOS and PD-1 are
novel costimulatory receptors expressed on activated T-cells. B7-H3 recognizes a
putative costimul...
Role of γδ T cells in immunity to infectious diseases and the regulation of hematolymphoid cell development
Springer Science and Business Media LLC - Tập 17 - Trang 13-22 - 1998
My research interests are twofold. The first is to define the biochemical and
molecular mechanisms that regulate hematopoietic cell development. In
particular, the role that the cytokine interleukin-2 (IL2) plays in regulating
the development and selection of lymphocyte progenitor cells, and in
myelopoiesis are primary areas of research. The second is to understand the role
that γδ T cells play in...
Regulation of G-protein-coupled signaling pathways in allergic inflammation
Springer Science and Business Media LLC - Tập 43 - Trang 62-76 - 2008
Allergic diseases such as asthma are elicited by maladaptive activation of
immune cells such as mast cells and lymphocytes by otherwise innocuous
allergens. The numerous mediators secreted by such cells promote both acute
inflammation and, in many instances, chronic tissue remodeling. Most of these
compounds exert their effects on end-organ targets such as epithelial and
endothelial cells and airw...
Molecular and cellular mechanisms of donor cell-induced tolerance
Springer Science and Business Media LLC - Tập 26 - Trang 119-129 - 2002
The induction of immunologic tolerance to solid organ allografts is a subject of
intense investigation because of the morbidity and mortality associated with
standard immunosuppressive therapy. One method that is currently in clinical and
preclinical testing involves the transient ablation of recipient T cells using
polyclonal antithymocyte sera or monoclonal anti-CD4/CD8 antibody treatment,
follo...
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