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Human T cell immunodeficiency
Springer Science and Business Media LLC - Tập 35 - Trang 117-125 - 2006
Eyal Grunebaum, Nigel Sharfe, Chaim M. Roifman
Severe combined immunodeficiency (SCID) is a heterogeneous group of diseases that are invariably fatal in infancy unless treated by hematopoietic stem cell replacement. For many years we have worked to better manage patients affected by SCID through rapid and accurate diagnosis followed by treatment aimed at achieving long-lasting immune reconstitution. By extensive immunological, biochemical, and...... hiện toàn bộ
Division of labor during primary humoral immunity
Springer Science and Business Media LLC - Tập 55 - Trang 277-286 - 2012
Cristina L. Swanson, Roberta Pelanda, Raul M. Torres
B lymphocytes are often considered a homogenous population. However, B cells in both mouse and humans are comprised of distinct subpopulations that differ in development, phenotype, function, and microenvironmental niches. Much of our understanding about how these different B-cells populations mount antibody responses has been derived from experimental findings in mouse models and based on the use...... hiện toàn bộ
Molecular and cellular mechanisms of donor cell-induced tolerance
Springer Science and Business Media LLC - Tập 26 - Trang 119-129 - 2002
James F. George, Leonik Ahumada, Ailing Lu
The induction of immunologic tolerance to solid organ allografts is a subject of intense investigation because of the morbidity and mortality associated with standard immunosuppressive therapy. One method that is currently in clinical and preclinical testing involves the transient ablation of recipient T cells using polyclonal antithymocyte sera or monoclonal anti-CD4/CD8 antibody treatment, follo...... hiện toàn bộ
Humoral immune durability of IgG for anti-SARS-CoV-2 in the normal pregnant women in Wuhan, China
Springer Science and Business Media LLC - Tập 69 - Trang 395-397 - 2021
Hongwen Ma, Jing Peng, Ruobing Li, Xuan Zheng, Shiyao Wu, Heng Yin, Min Li, Liu Qin, Fei Tang, Yun Zhao
Mechanisms of autoimmunity
Springer Science and Business Media LLC - Tập 27 - Trang 203-217 - 2003
Robert Eisenberg
Autoimmunity results from the failure of self-tolerance of the adaptive immune system. The reactivity of antibodies and T cells against endogenous antigens frequently causes organ damage, and consequent autoimmune disease. Systemic lupus erythematosus (SLE) is an extreme example of such a breakdown of tolerance. Our studies with spontaneous genetic mouse models of SLE and an experimentally induced...... hiện toàn bộ
A brief personal history of cancer immunotherapy at Stanford: if these walls could talk…
Springer Science and Business Media LLC - Tập 58 - Trang 277-281 - 2014
Ron Levy
This is a journey that began in medical school at Stanford in 1963 and that is still underway, now as faculty member here for the past 40 years. History is by its nature selective, and I chose highlights that reflect on the remarkable progress we have made using the immune system to treat cancer. We will never be satisfied until we eliminate suffering and early mortality from cancer, but the progr...... hiện toàn bộ
Genetic engineering of T cells for adoptive immunotherapy
Springer Science and Business Media LLC - Tập 42 - Trang 166-181 - 2008
Angel Varela-Rohena, Carmine Carpenito, Elena E. Perez, Max Richardson, Richard V. Parry, Michael Milone, John Scholler, Xueli Hao, Angela Mexas, Richard G. Carroll, Carl H. June, James L. Riley
To be effective for the treatment of cancer and infectious diseases, T cell adoptive immunotherapy requires large numbers of cells with abundant proliferative reserves and intact effector functions. We are achieving these goals using a gene therapy strategy wherein the desired characteristics are introduced into a starting cell population, primarily by high efficiency lentiviral vector-mediated tr...... hiện toàn bộ
Immunity and protection, the unfolding of a tale
Springer Science and Business Media LLC - Tập 38 - Trang 305-318 - 2007
Maurizio Zanetti
Immunological memory is at the core of protective mechanisms against microbial pathogens and possibly of defenses against tumors. Here, a new perspective is offered on the qualitative and quantitative aspects of the T cell response as it relates to protection. Two main points are proposed. First, the conditions of the initial immune response (priming) are critically important in the induction of T...... hiện toàn bộ
CXCL12 in control of neuroinflammation
Springer Science and Business Media LLC - Tập 52 - Trang 53-63 - 2012
Miljana Momcilović, Marija Mostarica-Stojković, Djordje Miljković
Inflammation within the central nervous system (CNS) is strictly controlled and if possible prevented. Such a tight control is necessary due to high sensitivity of nervous tissue to mechanical and biochemical consequences of inflammation. Still, neuroinflammation is a typical feature of a chronic, inflammatory, demyelinating disease multiple sclerosis (MS) and its animal model experimental autoimm...... hiện toàn bộ
Hepatitis C virus evasion of adaptive immune responses: a model for viral persistence
Springer Science and Business Media LLC - Tập 47 - Trang 216-227 - 2010
Kelly P. Burke, Andrea L. Cox
Hepatitis C virus (HCV) infects over 170 million people worldwide and is a leading cause of cirrhosis and hepatocellular carcinoma. Approximately 80% of those acutely infected clear the infection, whereas the remaining 20% progress to chronic infection. Hepatitis C thus provides a model in which successful and unsuccessful responses can be compared to better understand the human response to viral ...... hiện toàn bộ
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