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Modulation of PMN receptors for chemotactic peptides
Springer Science and Business Media LLC - Tập 2 - Trang 139-144 - 2014
Mark P. Fletcher, John I. Gallin
Expression of IL-5 receptors on B cells: Role in mucosal B cell responses
Springer Science and Business Media LLC - - 1991
Gregory R. Harriman, Kirsi C. Allison, Warren Strober
IL-5 plays an important role in mucosal B cell responses. An in vitro model of IgA B cell differentiation, CH12LX, has been used to demonstrate that IL-5R are expressed on both IgM+ and IgA+ B cells and that IL-5 will enhance secretion of both IgM and IgA by CH12LX B cells, depending on the surface isotype of individual cells. Further, the enhanced secretion of Ig in response to IL-5 is associated...... hiện toàn bộ
Human T cell immunodeficiency
Springer Science and Business Media LLC - Tập 35 - Trang 117-125 - 2006
Eyal Grunebaum, Nigel Sharfe, Chaim M. Roifman
Severe combined immunodeficiency (SCID) is a heterogeneous group of diseases that are invariably fatal in infancy unless treated by hematopoietic stem cell replacement. For many years we have worked to better manage patients affected by SCID through rapid and accurate diagnosis followed by treatment aimed at achieving long-lasting immune reconstitution. By extensive immunological, biochemical, and...... hiện toàn bộ
Assembly of MHC Class I Molecules within the Endoplasmic Reticulum
Springer Science and Business Media LLC -
Yinan Zhang, David B. Williams
Melatonin: a potential therapeutic approach for the management of primary Sjögren’s syndrome
Springer Science and Business Media LLC - - 2023
Yi Liu, Ya-Qin Tan, Gang Zhou
Division of labor during primary humoral immunity
Springer Science and Business Media LLC - Tập 55 - Trang 277-286 - 2012
Cristina L. Swanson, Roberta Pelanda, Raul M. Torres
B lymphocytes are often considered a homogenous population. However, B cells in both mouse and humans are comprised of distinct subpopulations that differ in development, phenotype, function, and microenvironmental niches. Much of our understanding about how these different B-cells populations mount antibody responses has been derived from experimental findings in mouse models and based on the use...... hiện toàn bộ
Immune regulation by novel costimulatory molecules
Springer Science and Business Media LLC - Tập 28 - Trang 39-48 - 2003
Chen Dong, Roza I. Nurieva, Durbaka V. R. Prasad
CD4 helper T (Th)-cells and the cytokines that they produce play essential regulatory roles in immune and autoimmune responses. Th activation and differentiation is regulated by costimulatory receptors. CD28 and CTLA-4 are important in maintaining the threshold of T-cell activation. ICOS and PD-1 are novel costimulatory receptors expressed on activated T-cells. B7-H3 recognizes a putative costimul...... hiện toàn bộ
Role of γδ T cells in immunity to infectious diseases and the regulation of hematolymphoid cell development
Springer Science and Business Media LLC - Tập 17 - Trang 13-22 - 1998
Simon R. Carding
My research interests are twofold. The first is to define the biochemical and molecular mechanisms that regulate hematopoietic cell development. In particular, the role that the cytokine interleukin-2 (IL2) plays in regulating the development and selection of lymphocyte progenitor cells, and in myelopoiesis are primary areas of research. The second is to understand the role that γδ T cells play in...... hiện toàn bộ
Regulation of G-protein-coupled signaling pathways in allergic inflammation
Springer Science and Business Media LLC - Tập 43 - Trang 62-76 - 2008
Kirk M. Druey
Allergic diseases such as asthma are elicited by maladaptive activation of immune cells such as mast cells and lymphocytes by otherwise innocuous allergens. The numerous mediators secreted by such cells promote both acute inflammation and, in many instances, chronic tissue remodeling. Most of these compounds exert their effects on end-organ targets such as epithelial and endothelial cells and airw...... hiện toàn bộ
Molecular and cellular mechanisms of donor cell-induced tolerance
Springer Science and Business Media LLC - Tập 26 - Trang 119-129 - 2002
James F. George, Leonik Ahumada, Ailing Lu
The induction of immunologic tolerance to solid organ allografts is a subject of intense investigation because of the morbidity and mortality associated with standard immunosuppressive therapy. One method that is currently in clinical and preclinical testing involves the transient ablation of recipient T cells using polyclonal antithymocyte sera or monoclonal anti-CD4/CD8 antibody treatment, follo...... hiện toàn bộ
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