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Regulation of cell function by rho family GTPases
Springer Science and Business Media LLC - Tập 21 - Trang 139-148 - 2000
Rho GTPases act as molecular switches to control many basic cellular activities that are also critical to the specialized functions of phagocytic leukocytes. Our laboratory has studied the regulation of Rho GTPase function, how these GTPases interact with specific effectors to modulate cell function, and how these events are coordinated in the stimulated cell. Areas of major interest include NADPH...... hiện toàn bộ
Interleukin-10 production and T cell-suppressive capacity in B cell subsets from atherosclerotic apoE −/− mice
Springer Science and Business Media LLC - Tập 65 - Trang 995-1008 - 2017
The evidence regarding the role of regulatory B cells (Breg) in atherosclerosis are scarce, and there are contradictory data about their atheroprotective properties. Due to the demonstrated protective function of Breg in different inflammatory diseases mainly through interleukin-10 (IL-10) production, the knowledge of their participation in atherosclerosis immunopathology would be very valuable. T...... hiện toàn bộ
Statins and autoimmunity
Springer Science and Business Media LLC - Tập 56 - Trang 348-357 - 2013
Statins have immunomodulatory effects. Hence, they could be advantageous for different reasons. First, statins can serve as adjunct therapy in autoimmune diseases. Second, they may play a role in the prevention of accelerated atherosclerosis in the same population. In this review, we discuss the mechanisms of immune regulation by statins and review the literature for their benefit in many autoimmu...... hiện toàn bộ
Dual role of the adaptor protein SLP-65
Springer Science and Business Media LLC - Tập 34 - Trang 143-155 - 2006
B cell development is characterized by a coordinated progression through defined stages that are controlled at several checkpoints. Signals from the pre-B cell receptor (pre-BCR) are essential for regulated transition from the pre-B cell stage. The adaptor protein SLP-65 plays a key role in this signaling pathway. Recent findings indicate an additional function of SLP-64 as a tumor suppressor that...... hiện toàn bộ
Increased synthesis and intestinal expression of IL-39 in patients with inflammatory bowel disease
Springer Science and Business Media LLC - - Trang 1-9 - 2023
IL-39 (Interleukin-39) is a heterodimeric cytokine composed of IL-23p19 and EBI3 (Epstein-Barr virus-induced gene 3) subunits. Despite the evidence that correlates the role of IL-39 in regulating inflammation, its expression in the intestinal microenvironment of IBD (inflammatory bowel disease) patients is still unknown. Thus, this work was focused on characterizing relative mRNA (messenger RNA) I...... hiện toàn bộ
Efficiency and safety of eltrombopag for multi-line failed Chinese patients with immune thrombocytopenia: cases with decreased megakaryocyte response well from single-center experience
Springer Science and Business Media LLC - - 2022
Pulmonary defense and the human cathelicidin hCAP-18/LL-37
Springer Science and Business Media LLC - Tập 31 - Trang 75-89 - 2005
Antimicrobial peptides form an important component of the innate immune system. The cathelicidin family, a key member of the antimicrobial peptide defenses, has been highly conserved throughout evolution. Though widespread in mammals, there is currently only one identified human example, hCAP-18/LL-37. The cathelicidins have been found to have multiple functions, in addition to their known antimic...... hiện toàn bộ
The autoimmune lymphoproliferative syndrome: an experiment of nature involving lymphocyte apoptosis
Springer Science and Business Media LLC - Tập 40 - Trang 87-92 - 2007
Autoimmune lymphproliferative syndrome (ALPS) is a human disorder that has been characterized in the past two decades at both a functional and a genetic level. The underlying basis for this disorder is a defect in lymphocyte apoptosis that alters immune homeostasis resulting in an expansion of a normally rare circulating lymphocyte, the alpha beta double negative T cell. The abnormality in Fas med...... hiện toàn bộ
Qa-1, a nonclassical class I histocompatibility molecule with roles in innate and adaptive immunity
Springer Science and Business Media LLC - Tập 29 - Trang 81-92 - 2004
Qa-1, a nonclassical class I histocompatibility molecule expressed in mice, predominantly assembles with a single nonameric peptide, Qdm, derived from the signal sequence of certain class Ia molecules. The Qa-1/Qdm complex is the primary ligand for CD94/NKG2A inhibitory receptors expressed on a major fraction of natural killer (NK) cells. cells become susceptible to killing by NK cells under condi...... hiện toàn bộ
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