Immunity and protection, the unfolding of a tale

Springer Science and Business Media LLC - Tập 38 - Trang 305-318 - 2007
Maurizio Zanetti1
1The Laboratory of Immunology, Department of Medicine and Moores Cancer Center, University of California, San Diego, La Jolla, USA

Tóm tắt

Immunological memory is at the core of protective mechanisms against microbial pathogens and possibly of defenses against tumors. Here, a new perspective is offered on the qualitative and quantitative aspects of the T cell response as it relates to protection. Two main points are proposed. First, the conditions of the initial immune response (priming) are critically important in the induction of T cell memory and protection. Second, at the present time, protection against microbial pathogens appears to correlate with the function of central memory T cells. A series of considerations and suggestions are being made for new ways to optimize the induction of protective T cell responses by vaccination both in the immunologically naive and experienced individual; emphasis is placed on: dose of antigen, the availability of T cell help, avoidance of overt inflammatory conditions and efforts to decelerate cellular senescence in responding T cells.

Tài liệu tham khảo

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