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Genetic Causes of Kidney Stones and Kidney Failure
Springer Science and Business Media LLC - Tập 10 - Trang 2-18 - 2011
Genetics plays an important role in establishing susceptibility to nephrolithiasis, although diet and other environmental factors make major contributions. In a small number of patients, the genetic causes of stones are more clearly established. Four of these hereditary diseases include primary hyperoxaluria, Dent disease, cystinuria, and adenine phosphoribosyltransferase deficiency, which results......
Role of Osteoblasts in Regulation of Energy Metabolism
Springer Science and Business Media LLC - Tập 11 - Trang 2-10 - 2012
Diseases of compromised glucose metabolism, such as type II diabetes, have been for years correlated with defects in bone mass or strength. However, a reverse regulation of energy homeostasis by the skeleton was not suspected until very recently. A series of genetic studies have demonstrated that the skeleton regulates glucose metabolism and energy expenditure in an endocrine manner. The bone-deri......
Forward: A Fresh Look at Measuring and Altering Bone Quality
Springer Science and Business Media LLC - Tập 14 - Trang 131-132 - 2016
This special issue of Clinical Reviews in Bone and Mineral Metabolism presents a series of review articles on how bone quality is measured and how it is altered by intervention. These articles highlight the great progress that has been made over the past three decades to define and study bone quality. The stage is now set to harness these concepts of bone quality for development of new approaches ......
A Review on Bone Mineral Density Loss in Total Knee Replacements Leading to Increased Fracture Risk
Springer Science and Business Media LLC - - 2017
Neurological complications of Paget's disease
Springer Science and Business Media LLC - Tập 1 - Trang 135-143 - 2002
The neurologic complications of Paget's disease are infrequent but can be severe and are often treatable. Paget's disease should be considered as a posible cause of neurologic symptoms, including those with previously undiagnosed disease. Routine neurological assessments should be performed at regular intervals in patients with known Paget's disease of the spine or cranium. The outcome of treatmen......
Affective Disorders, Bone Metabolism, and Osteoporosis
Springer Science and Business Media LLC - Tập 6 Số 3-4 - Trang 101-113 - 2008
Vitamin D in Fracture Prevention and Muscle Function and Fall Prevention
Springer Science and Business Media LLC - Tập 7 - Trang 107-112 - 2009
This chapter reviews the potential of vitamin D for the prevention of falls and fractures. Evidence from randomized-controlled trials will be reviewed for both endpoints, as well as epidemiologic data that links higher 25-hydroxyvitamin D (25(OH)D) status to better bone and muscle health. The chapter addresses the evidence of fracture and fall prevention by dose of vitamin D, by type of dwelling a......
Cathepsin L trong Quá trình Tái cấu trúc Xương Bình Thường và Bệnh Lý Dịch bởi AI
Springer Science and Business Media LLC - Tập 9 - Trang 107-121 - 2011
Cathepsin L là một endopeptidase cysteine lysosome phổ biến, chủ yếu tham gia vào quá trình chuyển hóa protein nội bào. Tuy nhiên, hiện nay đã được xác định rõ rằng enzym này cũng có thể liên quan đến việc điều tiết các quá trình sinh học quan trọng khác, bao gồm cả quá trình tiêu xương. Do đó, sự thay đổi mức độ biểu hiện của Cathepsin L có thể dẫn đến những rối loạn trong sự cân bằng xương và, c......
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