The adipocyte is an important source of factors that act as circulating
regulators of bone metabolism. These include estrogens, and the adipokines,
leptin, resistin, adiponectin, and probably others. Leptin acts directly on bone
cells, and in some experimental models these effects are modified by its actions
on the central nervous system, which impact on appetite, body weight, and
insulin sensitiv... hiện toàn bộ