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Extracellular ATP and the P2X7receptor in astrocyte-mediated motor neuron death: implications for amyotrophic lateral sclerosis
Springer Science and Business Media LLC - Tập 7 - Trang 1-9 - 2010
During pathology of the nervous system, increased extracellular ATP acts both as a cytotoxic factor and pro-inflammatory mediator through P2X7 receptors. In animal models of amyotrophic lateral sclerosis (ALS), astrocytes expressing superoxide dismutase 1 (SOD1G93A) mutations display a neuroinflammatory phenotype and contribute to disease progression and motor neuron death. Here we studied the rol...... hiện toàn bộ
Leucine-rich repeat kinase-2 (LRRK2) modulates paraquat-induced inflammatory sickness and stress phenotype
Springer Science and Business Media LLC - Tập 16 - Trang 1-13 - 2019
Leucine-rich repeat kinase 2 (LRRK2) is a common gene implicated in Parkinson’s disease (PD) and is also thought to be fundamentally involved in numerous immune functions. Thus, we assessed the role of LRRK2 in the context of the effects of the environmental toxicant, paraquat, that has been implicated in PD and is known to affect inflammatory processes. Male LRRK2 knockout (KO) and transgenic mic...... hiện toàn bộ
Inflammation early in life is a vulnerability factor for emotional behavior at adolescence and for lipopolysaccharide-induced spatial memory and neurogenesis alteration at adulthood
Springer Science and Business Media LLC - Tập 11 - Trang 1-13 - 2014
The postnatal period is a critical time window during which inflammatory events have significant and enduring effects on the brain, and as a consequence, induce alterations of emotional behavior and/or cognition later in life. However, the long-term effect of neonatal inflammation on behavior during adolescence, a sensitive period for the development of neurodevelopmental psychiatric disorders, ha...... hiện toàn bộ
Differential effects of Th1, monocyte/macrophage and Th2 cytokine mixtures on early gene expression for molecules associated with metabolism, signaling and regulation in central nervous system mixed glial cell cultures
Springer Science and Business Media LLC - Tập 6 - Trang 1-27 - 2009
Cytokines secreted by immune cells and activated glia play central roles in both the pathogenesis of and protection from damage to the central nervous system (CNS) in multiple sclerosis (MS). We have used gene array analysis to identify the initial direct effects of cytokines on CNS glia by comparing changes in early gene expression in CNS glial cultures treated for 6 hours with cytokines typical ...... hiện toàn bộ
Central administration of insulin-like growth factor-I decreases depressive-like behavior and brain cytokine expression in mice
Springer Science and Business Media LLC - Tập 8 - Trang 1-14 - 2011
Exogenous administration of insulin-like growth factor (IGF)-I has anti-depressant properties in rodent models of depression. However, nothing is known about the anti-depressant properties of IGF-I during inflammation, nor have mechanisms by which IGF-I alters behavior following activation of the innate immune system been clarified. We hypothesized that central IGF-I would diminish depressive-like...... hiện toàn bộ
5, 8, 11, 14-eicosatetraynoic acid suppresses CCL2/MCP-1 expression in IFN-γ-stimulated astrocytes by increasing MAPK phosphatase-1 mRNA stabilityAbstract
Background
The peroxisome proliferator-activated receptor (PPAR)-α activator, 5,8,11,14-eicosatetraynoic acid (ETYA), is an arachidonic acid analog. It is reported to inhibit up-regulation of pro-inflammatory genes; however, its underlying mechanism of action is largely unknown. In the p... ... hiện toàn bộ
Springer Science and Business Media LLC - - 2012
LPS preconditioning redirects TLR signaling following stroke: TRIF-IRF3 plays a seminal role in mediating tolerance to ischemic injury
Springer Science and Business Media LLC - Tập 8 - Trang 1-12 - 2011
Toll-like receptor 4 (TLR4) is activated in response to cerebral ischemia leading to substantial brain damage. In contrast, mild activation of TLR4 by preconditioning with low dose exposure to lipopolysaccharide (LPS) prior to cerebral ischemia dramatically improves outcome by reprogramming the signaling response to injury. This suggests that TLR4 signaling can be altered to induce an endogenously...... hiện toàn bộ
Đặc trưng của một dòng tế bào viêm thần kinh người trưởng thành bất tử mới và sự kích hoạt của nó bởi amyloid-beta Dịch bởi AI
Springer Science and Business Media LLC - Tập 13 - Trang 1-15 - 2016
Bệnh Alzheimer có liên quan đến sự kích hoạt tế bào viêm thần kinh do amyloid-beta (Aβ) gây ra. Phản ứng viêm này thúc đẩy tổn thương tế bào thần kinh, và các liệu pháp đang được tìm kiếm để hạn chế sự kích hoạt tế bào viêm. Các nỗ lực sàng lọc nhằm phát triển các chất ức chế dược lý mới yêu cầu một hệ thống tế bào in vitro vững chắc. Các mô hình hiện tại thiếu phản ứng đáng kể với Aβ và việc sử d...... hiện toàn bộ
#bệnh Alzheimer #amyloid-beta #tế bào viêm thần kinh #kích hoạt tế bào #cannabinoids
Nitrosative damage during retrovirus infection-induced neuropathic pain
Springer Science and Business Media LLC - Tập 15 - Trang 1-16 - 2018
Peripheral neuropathy is currently the most common neurological complication in HIV-infected individuals, occurring in 35–50% of patients undergoing combination anti-retroviral therapy. Data have shown that distal symmetric polyneuropathy develops in mice by 6 weeks following infection with the LP-BM5 retrovirus mixture. Previous work from our laboratory has demonstrated that glial cells modulate ...... hiện toàn bộ
Inhibition of the NLRP3 inflammasome provides neuroprotection in rats following amygdala kindling-induced status epilepticus
Springer Science and Business Media LLC - Tập 11 Số 1 - 2014
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