Springer Science and Business Media LLC

Công bố khoa học tiêu biểu

* Dữ liệu chỉ mang tính chất tham khảo

Sắp xếp:  
Cyclic AMP is a key regulator of M1 to M2a phenotypic conversion of microglia in the presence of Th2 cytokines
Springer Science and Business Media LLC - Tập 13 - Trang 1-14 - 2016
Mousumi Ghosh, Yong Xu, Damien D. Pearse
Microglia and macrophages play a central role in neuroinflammation. Pro-inflammatory cytokines trigger their conversion to a classically activated (M1) phenotype, sustaining inflammation and producing a cytotoxic environment. Conversely, anti-inflammatory cytokines polarize the cells towards an alternatively activated (M2), tissue reparative phenotype. Elucidation of the signal transduction pathwa...... hiện toàn bộ
Choroid plexus-selective inactivation of adenosine A2A receptors protects against T cell infiltration and experimental autoimmune encephalomyelitis
Springer Science and Business Media LLC - Tập 19 - Trang 1-15 - 2022
Wu Zheng, Yijia Feng, Zhenhai Zeng, Mengqian Ye, Mengru Wang, Xin Liu, Ping Tang, Huiping Shang, Xiaoting Sun, Xiangxiang Lin, Muran Wang, Zhengzheng Li, Yiyun Weng, Wei Guo, Sergii Vakal, Jiang-fan Chen
Multiple sclerosis (MS) is one of the most common autoimmune disorders characterized by the infiltration of immune cells into the brain and demyelination. The unwanted immunosuppressive side effect of therapeutically successful natalizumab led us to focus on the choroid plexus (CP), a key site for the first wave of immune cell infiltration in experimental autoimmune encephalomyelitis (EAE), for th...... hiện toàn bộ
Lipoxin A4 inhibits microglial activation and reduces neuroinflammation and neuropathic pain after spinal cord hemisection
Springer Science and Business Media LLC - Tập 13 - Trang 1-11 - 2016
Alessandra Cadete Martini, Temugin Berta, Stefânia Forner, Gang Chen, Allisson Freire Bento, Ru-Rong Ji, Giles Alexander Rae
Spinal cord injury (SCI) is a severe neurological disorder with many disabling consequences, including persistent neuropathic pain, which develops in about 40 % of SCI patients and is induced and sustained by excessive and uncontrolled spinal neuroinflammation. Here, we have evaluated the effects of lipoxin A4 (LXA4), a member of a unique class of endogenous lipid mediators with both anti-inflamma...... hiện toàn bộ
Neuregulin-1 inhibits neuroinflammatory responses in a rat model of organophosphate-nerve agent-induced delayed neuronal injury
Springer Science and Business Media LLC - Tập 12 - Trang 1-13 - 2015
Yonggang Li, Pamela J Lein, Gregory D Ford, Cuimei Liu, Kyndra C Stovall, Todd E White, Donald A Bruun, Teclemichael Tewolde, Alicia S Gates, Timothy J Distel, Monique C Surles-Zeigler, Byron D Ford
Neuregulin-1 (NRG-1) has been shown to act as a neuroprotectant in animal models of nerve agent intoxication and other acute brain injuries. We recently demonstrated that NRG-1 blocked delayed neuronal death in rats intoxicated with the organophosphate (OP) neurotoxin diisopropylflurophosphate (DFP). It has been proposed that inflammatory mediators are involved in the pathogenesis of OP neurotoxin...... hiện toàn bộ
Grape seed-derived procyanidins alleviate gout pain via NLRP3 inflammasome suppression
Springer Science and Business Media LLC - - 2017
Hai-Jiao Liu, Xiu-Xiu Pan, Bingqian Liu, Xuan Gui, Liang Hu, Chun-Yi Jiang, Yuan Han, Yixin Fan, Yawen Tang, Wentao Li
Correction to: BET protein inhibition regulates cytokine production and promotes neuroprotection after spinal cord injury
Springer Science and Business Media LLC - Tập 19 - Trang 1-2 - 2022
Judith Sánchez-Ventura, Jesús Amo-Aparicio, Xavier Navarro, Clara Penas
Activation of TRPV1 by capsaicin induces functional Kinin B1 receptor in rat spinal cord microglia
Springer Science and Business Media LLC - Tập 9 - Trang 1-17 - 2012
Sébastien Talbot, Jenny Pena Dias, Karim Lahjouji, Maurício Reis Bogo, Maria Martha Campos, Pierrette Gaudreau, Réjean Couture
The kinin B1 receptor (B1R) is upregulated by pro-inflammatory cytokines and oxydative stress, which are enhanced by transient receptor potential vanilloid subtype 1 (TRPV1) activation. To examine the link between TRPV1 and B1R in inflammatory pain, this study aimed to determine the ability of TRPV1 to regulate microglial B1R expression in the spinal cord dorsal horn, and the underlying mechanism....... hiện toàn bộ
RGS10 deficiency ameliorates the severity of disease in experimental autoimmune encephalomyelitis
Springer Science and Business Media LLC - Tập 13 - Trang 1-12 - 2016
Jae-Kyung Lee, George T. Kannarkat, Jaegwon Chung, Hyun Joon Lee, Kareem L. Graham, Malú G. Tansey
Regulator of G-protein signaling (RGS) family proteins, which are GTPase accelerating proteins (GAPs) that negatively regulate G-protein-coupled receptors (GPCRs), are known to be important modulators of immune cell activation and function. Various single-nucleotide polymorphisms in RGS proteins highly correlate with increased risk for multiple sclerosis (MS), an autoimmune, neurodegenerative diso...... hiện toàn bộ
Mossy cell hypertrophy and synaptic changes in the hilus following mild diffuse traumatic brain injury in pigs
Springer Science and Business Media LLC - Tập 17 - Trang 1-18 - 2020
Michael R. Grovola, Nicholas Paleologos, Kathryn L. Wofford, James P. Harris, Kevin D. Browne, Victoria Johnson, John E. Duda, John A. Wolf, D. Kacy Cullen
Each year in the USA, over 2.4 million people experience mild traumatic brain injury (TBI), which can induce long-term neurological deficits. The dentate gyrus of the hippocampus is notably susceptible to damage following TBI, as hilar mossy cell changes in particular may contribute to post-TBI dysfunction. Moreover, microglial activation after TBI may play a role in hippocampal circuit and/or syn...... hiện toàn bộ
Systemic inflammation in early neonatal mice induces transient and lasting neurodegenerative effects
Springer Science and Business Media LLC - Tập 12 - Trang 1-18 - 2015
Filipa L Cardoso, Jasmin Herz, Adelaide Fernandes, João Rocha, Bruno Sepodes, Maria A Brito, Dorian B McGavern, Dora Brites
The inflammatory mediator lipopolysaccharide (LPS) has been shown to induce acute gliosis in neonatal mice. However, the progressive effects on the murine neurodevelopmental program over the week that follows systemic inflammation are not known. Thus, we investigated the effects of repeated LPS administration in the first postnatal week in mice, a condition mimicking sepsis in late preterm infants...... hiện toàn bộ
Tổng số: 2,724   
  • 1
  • 2
  • 3
  • 4
  • 5
  • 6
  • 10