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Withania somnifera as a potential candidate to ameliorate high fat diet-induced anxiety and neuroinflammation
Springer Science and Business Media LLC - Tập 14 Số 1 - 2017
Vitamin B12 is neuroprotective in experimental pneumococcal meningitis through modulation of hippocampal DNA methylation
Springer Science and Business Media LLC - Tập 17 Số 1 - 2020
Abstract Background Bacterial meningitis (BM) causes apoptotic damage to the
hippocampus and homocysteine (Hcy) accumulation to neurotoxic levels in the
cerebrospinal fluid of children. The Hcy pathway controls bioavailability of
methyl, and its homeostasis can be modulated by vitamin B12, a cofactor of the
methionine synthase enzyme. Herein, the neuroprotective potential and the
underlying mode o...
Novel role for SLPI in MOG-induced EAE revealed by spinal cord expression analysis
Springer Science and Business Media LLC - Tập 5 - Trang 1-20 - 2008
Experimental autoimmune encephalomyelitis (EAE) induced by myelin
oligodendrocyte protein (MOG) in female Dark Agouti (DA) rats is a chronic
demyelinating animal model of multiple sclerosis (MS). To identify new candidate
molecules involved in the evolution or repair of EAE-lesions we used Affymetrix
oligonucleotide microarrays to compare the spinal cord transcriptome at the peak
of EAE, during re...
Evidence of innate immune dysfunction in first-episode psychosis patients with accompanying mood disorder
Springer Science and Business Media LLC - Tập 19 - Trang 1-15 - 2022
Inflammation and increases in inflammatory cytokines are common findings in
psychiatric disorders such as schizophrenia (SCZ), bipolar disorder (BD), and
major depressive disorder (MDD). Meta-analyses of studies that measured
circulating cytokines have provided evidence of innate inflammation across all
three disorders, with some overlap of inflammatory cytokines such as IL-6 and
TNF-α. However, d...
Chronic airway-induced allergy in mice modifies gene expression in the brain toward insulin resistance and inflammatory responses
Springer Science and Business Media LLC - Tập 10 - Trang 1-11 - 2013
Chronic systemic inflammation affects brain functionality and may negatively
influence the progression of neurodegenerative disorders. Allergy is a chronic
inflammatory disease affecting more than 20% of the Western population. Little
is known regarding the influence of allergy on brain functions. The aim of the
present study was to obtain a global overview of the genes that drive the
effects of p...
Cyclic AMP is a key regulator of M1 to M2a phenotypic conversion of microglia in the presence of Th2 cytokines
Springer Science and Business Media LLC - Tập 13 - Trang 1-14 - 2016
Microglia and macrophages play a central role in neuroinflammation.
Pro-inflammatory cytokines trigger their conversion to a classically activated
(M1) phenotype, sustaining inflammation and producing a cytotoxic environment.
Conversely, anti-inflammatory cytokines polarize the cells towards an
alternatively activated (M2), tissue reparative phenotype. Elucidation of the
signal transduction pathwa...
FTY720 (fingolimod) modulates the severity of viral-induced encephalomyelitis and demyelination
Springer Science and Business Media LLC - Tập 11 - Trang 1-12 - 2014
FTY720 (fingolimod) is the first oral drug approved by the Food and Drug
Administration for treatment of patients with the relapsing-remitting form of
the human demyelinating disease multiple sclerosis. Evidence suggests that the
therapeutic benefit of FTY720 occurs by preventing the egress of lymphocytes
from lymph nodes thereby inhibiting the infiltration of disease-causing
lymphocytes into the ...
Choroid plexus-selective inactivation of adenosine A2A receptors protects against T cell infiltration and experimental autoimmune encephalomyelitis
Springer Science and Business Media LLC - Tập 19 - Trang 1-15 - 2022
Multiple sclerosis (MS) is one of the most common autoimmune disorders
characterized by the infiltration of immune cells into the brain and
demyelination. The unwanted immunosuppressive side effect of therapeutically
successful natalizumab led us to focus on the choroid plexus (CP), a key site
for the first wave of immune cell infiltration in experimental autoimmune
encephalomyelitis (EAE), for th...
Lipoxin A4 inhibits microglial activation and reduces neuroinflammation and neuropathic pain after spinal cord hemisection
Springer Science and Business Media LLC - Tập 13 - Trang 1-11 - 2016
Spinal cord injury (SCI) is a severe neurological disorder with many disabling
consequences, including persistent neuropathic pain, which develops in about
40 % of SCI patients and is induced and sustained by excessive and uncontrolled
spinal neuroinflammation. Here, we have evaluated the effects of lipoxin A4
(LXA4), a member of a unique class of endogenous lipid mediators with both
anti-inflamma...
Leukocyte infiltration in experimental stroke
Springer Science and Business Media LLC - - 2013
Abstract Stroke is one of the leading causes of death worldwide. At present, the
only available treatment is thrombolysis, which should be initiated no later
than 4.5 hours after onset of symptoms. Several studies have shown that an
attenuation of the inflammatory response in relation to stroke could widen the
therapeutic window. However, the immune system has important functions following
infarct...
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