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Withania somnifera as a potential candidate to ameliorate high fat diet-induced anxiety and neuroinflammation
Springer Science and Business Media LLC - Tập 14 Số 1 - 2017
Taranjeet Kaur, Gurcharan Kaur
Vitamin B12 is neuroprotective in experimental pneumococcal meningitis through modulation of hippocampal DNA methylation
Springer Science and Business Media LLC - Tập 17 Số 1 - 2020
Karina Barbosa de Queiroz, Vanessa Cavalcante-Silva, Flávia L. Lopes, Gifone A. Rocha, Vânia D’Almeida, Roney Santos Coimbra
Abstract Background Bacterial meningitis (BM) causes apoptotic damage to the hippocampus and homocysteine (Hcy) accumulation to neurotoxic levels in the cerebrospinal fluid of children. The Hcy pathway controls bioavailability of methyl, and its homeostasis can be modulated by vitamin B12<...... hiện toàn bộ
Novel role for SLPI in MOG-induced EAE revealed by spinal cord expression analysis
Springer Science and Business Media LLC - Tập 5 - Trang 1-20 - 2008
Andre M Mueller, Xiomara Pedré, Thomas Stempfl, Ingo Kleiter, Sebastien Couillard-Despres, Ludwig Aigner, Gerhard Giegerich, Andreas Steinbrecher
Experimental autoimmune encephalomyelitis (EAE) induced by myelin oligodendrocyte protein (MOG) in female Dark Agouti (DA) rats is a chronic demyelinating animal model of multiple sclerosis (MS). To identify new candidate molecules involved in the evolution or repair of EAE-lesions we used Affymetrix oligonucleotide microarrays to compare the spinal cord transcriptome at the peak of EAE, during re...... hiện toàn bộ
Evidence of innate immune dysfunction in first-episode psychosis patients with accompanying mood disorder
Springer Science and Business Media LLC - Tập 19 - Trang 1-15 - 2022
Heather K. Hughes, Houa Yang, Tyler A. Lesh, Cameron S. Carter, Paul Ashwood
Inflammation and increases in inflammatory cytokines are common findings in psychiatric disorders such as schizophrenia (SCZ), bipolar disorder (BD), and major depressive disorder (MDD). Meta-analyses of studies that measured circulating cytokines have provided evidence of innate inflammation across all three disorders, with some overlap of inflammatory cytokines such as IL-6 and TNF-α. However, d...... hiện toàn bộ
Chronic airway-induced allergy in mice modifies gene expression in the brain toward insulin resistance and inflammatory responses
Springer Science and Business Media LLC - Tập 10 - Trang 1-11 - 2013
Heela Sarlus, Xiuzhe Wang, Angel Cedazo-Minguez, Marianne Schultzberg, Mircea Oprica
Chronic systemic inflammation affects brain functionality and may negatively influence the progression of neurodegenerative disorders. Allergy is a chronic inflammatory disease affecting more than 20% of the Western population. Little is known regarding the influence of allergy on brain functions. The aim of the present study was to obtain a global overview of the genes that drive the effects of p...... hiện toàn bộ
Cyclic AMP is a key regulator of M1 to M2a phenotypic conversion of microglia in the presence of Th2 cytokines
Springer Science and Business Media LLC - Tập 13 - Trang 1-14 - 2016
Mousumi Ghosh, Yong Xu, Damien D. Pearse
Microglia and macrophages play a central role in neuroinflammation. Pro-inflammatory cytokines trigger their conversion to a classically activated (M1) phenotype, sustaining inflammation and producing a cytotoxic environment. Conversely, anti-inflammatory cytokines polarize the cells towards an alternatively activated (M2), tissue reparative phenotype. Elucidation of the signal transduction pathwa...... hiện toàn bộ
Choroid plexus-selective inactivation of adenosine A2A receptors protects against T cell infiltration and experimental autoimmune encephalomyelitis
Springer Science and Business Media LLC - Tập 19 - Trang 1-15 - 2022
Wu Zheng, Yijia Feng, Zhenhai Zeng, Mengqian Ye, Mengru Wang, Xin Liu, Ping Tang, Huiping Shang, Xiaoting Sun, Xiangxiang Lin, Muran Wang, Zhengzheng Li, Yiyun Weng, Wei Guo, Sergii Vakal, Jiang-fan Chen
Multiple sclerosis (MS) is one of the most common autoimmune disorders characterized by the infiltration of immune cells into the brain and demyelination. The unwanted immunosuppressive side effect of therapeutically successful natalizumab led us to focus on the choroid plexus (CP), a key site for the first wave of immune cell infiltration in experimental autoimmune encephalomyelitis (EAE), for th...... hiện toàn bộ
Lipoxin A4 inhibits microglial activation and reduces neuroinflammation and neuropathic pain after spinal cord hemisection
Springer Science and Business Media LLC - Tập 13 - Trang 1-11 - 2016
Alessandra Cadete Martini, Temugin Berta, Stefânia Forner, Gang Chen, Allisson Freire Bento, Ru-Rong Ji, Giles Alexander Rae
Spinal cord injury (SCI) is a severe neurological disorder with many disabling consequences, including persistent neuropathic pain, which develops in about 40 % of SCI patients and is induced and sustained by excessive and uncontrolled spinal neuroinflammation. Here, we have evaluated the effects of lipoxin A4 (LXA4), a member of a unique class of endogenous lipid mediators with both anti-inflamma...... hiện toàn bộ
Leukocyte infiltration in experimental stroke
Springer Science and Business Media LLC - - 2013
Nina Vindegaard Grønberg, Flemming Fryd Johansen, Uffe Kristiansen, Henrik Hasseldam
Abstract Stroke is one of the leading causes of death worldwide. At present, the only available treatment is thrombolysis, which should be initiated no later than 4.5 hours after onset of symptoms. Several studies have shown that an attenuation of the inflammatory response in relation to stroke could widen the therapeutic window. However, the immune syste...... hiện toàn bộ
Neuregulin-1 inhibits neuroinflammatory responses in a rat model of organophosphate-nerve agent-induced delayed neuronal injury
Springer Science and Business Media LLC - Tập 12 - Trang 1-13 - 2015
Yonggang Li, Pamela J Lein, Gregory D Ford, Cuimei Liu, Kyndra C Stovall, Todd E White, Donald A Bruun, Teclemichael Tewolde, Alicia S Gates, Timothy J Distel, Monique C Surles-Zeigler, Byron D Ford
Neuregulin-1 (NRG-1) has been shown to act as a neuroprotectant in animal models of nerve agent intoxication and other acute brain injuries. We recently demonstrated that NRG-1 blocked delayed neuronal death in rats intoxicated with the organophosphate (OP) neurotoxin diisopropylflurophosphate (DFP). It has been proposed that inflammatory mediators are involved in the pathogenesis of OP neurotoxin...... hiện toàn bộ
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