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Severe community-acquired pneumonia in general medical wards: outcomes and impact of initial antibiotic selection
Springer Science and Business Media LLC - Tập 19 - Trang 1-10 - 2019
Most international guidelines recommend empirical therapy for community-acquired pneumonia (CAP) to be based on site of care. Some patients with severe CAP are managed in general wards because of limited intensive care unit (ICU) bed or because of unrecognition of the pneumonia severity. Appropriate initial antibiotic treatment for severe CAP outside ICU has not yet been established. This study ai...... hiện toàn bộ
Clinical features of anti-synthetase syndrome associated interstitial lung disease: a retrospective cohort in China
Springer Science and Business Media LLC - Tập 21 - Trang 1-9 - 2021
Anti-synthetase syndrome (ASSD) is a chronic autoimmune condition characterized by antibodies directed against an aminoacycl transfer RNA synthetase (ARS) along with a group of clinical features including the classical clinical triad: inflammatory myopathy, arthritis, and interstitial lung disease (ILD). ASSD is highly heterogenous due to different organ involvement, and ILD is the main cause of m...... hiện toàn bộ
Long-term dyspnea, regional ventilation distribution and peripheral lung function in COVID-19 survivors: a 1 year follow up study
Springer Science and Business Media LLC - Tập 22 - Trang 1-10 - 2022
Dyspnea is common after COVID-19 pneumonia and can be characterized by a defective CO2 diffusion (DLCO) despite normal pulmonary function tests (PFT). Nevertheless, DLCO impairment tends to normalize at 1 year, with no dyspnea regression. The altered regional distribution of ventilation and a dysfunction of the peripheral lung may characterize dyspnea at 1 year after COVID-19 pneumonia. We aimed a...... hiện toàn bộ
Effect of obesity on constant workrate exercise in hyperinflated men with COPD
Springer Science and Business Media LLC - Tập 10 - Trang 1-9 - 2010
Chronic obstructive pulmonary disease (COPD) and a high body mass index (BMI) can both affect pulmonary volumes as well as exercise tolerance, but their combined effect on these outcomes is not well known. The aim of this study was to investigate the effects of increased BMI during constant workrate cycle ergometry in patients with COPD. Men with COPD and hyperinflation were divided according to W...... hiện toàn bộ
Feasibility study for early supported discharge in adults with respiratory infection in the UK
Springer Science and Business Media LLC - Tập 14 - Trang 1-8 - 2014
Many patients with pneumonia and lower respiratory tract infection that could be treated as outpatients according to their clinical severity score, are in fact admitted to hospital. We investigated whether, with medical and social input, these patients could be discharged early and treated at home.
Objectives: (1) To assess the feasibility of providing an early supported discharge scheme for pati...... hiện toàn bộ
Prediction of risk and clinical outcome of cuproptosis in lung squamous carcinoma
Springer Science and Business Media LLC - Tập 23 - Trang 1-17 - 2023
Lung squamous cell carcinoma (LUSC) is an important subtype of non-small cell lung cancer. Its special clinicopathological features and molecular background determine the limitations of its treatment. A recent study published on Science defined a newly regulatory cell death (RCD) form – cuproptosis. Which manifested as an excessive intracellular copper accumulation, mitochondrial respiration-depen...... hiện toàn bộ
Restoring the epigenetic landscape of lung microbiome: potential therapeutic approach for chronic respiratory diseases
Springer Science and Business Media LLC - Tập 24 - Trang 1-9 - 2024
Chronic respiratory diseases, such as chronic obstructive pulmonary disease (COPD) and bronchiectasis, present significant threats to global health. Recent studies have revealed the crucial role of the lung microbiome in the development of these diseases. Pathogens have evolved complex strategies to evade the immune response, with the manipulation of host cellular epigenetic mechanisms playing a p...... hiện toàn bộ
Internet access and use by COPD patients in the National Emphysema/COPD Association Survey
Springer Science and Business Media LLC - Tập 14 - Trang 1-11 - 2014
Technology offers opportunities to improve healthcare, but little is known about Internet use by COPD patients. We tested two hypotheses: Internet access is associated with socio-demographic disparities and frequency of use is related to perceived needs. We analyzed data from a 2007–2008 national convenience sample survey of COPD patients to determine the relationship between Internet access and f...... hiện toàn bộ
No effect of epoprostenol on right ventricular diameter in patients with acute pulmonary embolism: a randomized controlled trial
Springer Science and Business Media LLC - Tập 10 - Trang 1-9 - 2010
Right ventricular dilatation in the setting of acute pulmonary embolism is associated with an adverse prognosis. Treatment with a pulmonary vasodilator has never been studied systematically. We evaluated the effect of epoprostenol on right ventricular diameter and function in patients with acute pulmonary embolism and right ventricular dilatation. In a randomized, single-blind study, 14 patients w...... hiện toàn bộ
Mutation status analysis of 58 patients with advanced ALK fusion gene positive non small cell lung cancer
Springer Science and Business Media LLC - Tập 23 - Trang 1-8 - 2023
To analyze the characteristics and prognostic values of Anaplastic Lymphoma Kinase (ALK) fusion gene partner, gene subtype and abundance in tumor tissues of advanced Non Small Cell Lung Cancer (NSCLC) patients with positive ALK fusion gene and to explore the best treatment mode of ALK-Tyrosine Kinase Inhibitors(TKIs). Cases of advanced NSCLC patients with ALK positive confirmed by both Next Genera...... hiện toàn bộ
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