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Case report on two-cathinones abuse: MPHP and N-ethyl-4′methylnorpentedrone, with a fatal outcome
Springer Science and Business Media LLC - Tập 38 - Trang 243-254 - 2019
Lelievre Benedicte, Richeval Camille, Coulon Audrey, Iwanikow Deborah, Brofferio Morgan, Deguigne Marie, Boels David, Allorge Delphine, Ferec Severine, Drevin Guillaume, Jousset Nathalie, Gaulier Jean-Michel
The correlation between the rising consumption of new psychoactive drugs (NPS), including that of cathinones, and the occurrence of death has not been sufficiently backed up with published analytic data. In fact, the identification of cathinones in human biological samples remains difficult mainly due to the diversity of these substances and their high turnover. In this context, this manuscript ai...... hiện toàn bộ
Identification and quantification of 4′-methoxy-α-pyrrolidinobutiophenone (4-MeOPBP) in human plasma and urine using LC–TOF-MS in an autopsy case
Springer Science and Business Media LLC - - 2015
Kaori Shintani-Ishida, Mami Nakamura, Misa Tojo, Hiroshi Ikegaya
Development and validation of a sensitive LC–MS/MS method to analyze NBOMes in dried blood spots: evaluation of long-term stability
Springer Science and Business Media LLC - Tập 36 - Trang 113-121 - 2017
Kelly Francisco da Cunha, Marcos Nogueira Eberlin, Jose Luiz Costa
We evaluated the use of dried blood spots (DBS) to determine seven NBOMes by liquid chromatography–tandem mass spectrometry (LC–MS/MS), and also evaluated the stability of these compounds in this dried matrix. An LC–MS/MS method was developed and fully validated to quantify seven NBOMes (25C-, 25H-, 25I-, 25B-, 25G-, 25D- and 25E-NBOMe) in DBS samples. The extraction procedure was optimized using ...... hiện toàn bộ
Toxicokinetic studies of the four new psychoactive substances 4-chloroethcathinone, N-ethylnorpentylone, N-ethylhexedrone, and 4-fluoro-alpha-pyrrolidinohexiophenone
Springer Science and Business Media LLC - - 2020
Lea Wagmann, Sascha K. Manier, Niels Eckstein, Hans H. Maurer, Markus R. Meyer
Difficulties interpreting concentrations in fatal cases: example of 2,5-dimethoxy-4-chloroamphetamine
Springer Science and Business Media LLC - Tập 40 - Trang 383-392 - 2022
Benedicte Lelievre, Vincent Dupont, Celine Buchaillet, Nathalie Jousset, Marie Deguigne, Vincent Cirimele
Death related to the use of drugs is evident when drugs are detected in biological matrices within toxic levels, but sometimes it can be less obvious. Intoxications after 2,5-dimethoxy-4-chloroamphetamine (DOC) use are occurring but up to date, only one fatality has been reported. Here we present the case of a young woman admitted to hospital as she presented vomiting, convulsions and cardiorespir...... hiện toàn bộ
Reporting the novel synthetic cathinone 5-PPDI through its analytical characterization by mass spectrometry and nuclear magnetic resonance
Springer Science and Business Media LLC - Tập 36 - Trang 447-457 - 2018
David Fabregat-Safont, Xoán Carbón, Cristina Gil, Mireia Ventura, Juan V. Sancho, Félix Hernández, Maria Ibáñez
In this work, the identification and characterization of the novel synthetic cathinone 5-PPDI found in a suspect drug sample were performed. The suspect sample was analyzed by gas chromatography–mass spectrometry (GC–MS), Fourier-transformed infrared (FTIR) spectroscopy, ultra-high performance liquid chromatography–high-resolution mass spectrometry (HRMS) and nuclear magnetic resonance (NMR) spect...... hiện toàn bộ
Anti-mitragynine monoclonal antibody-based ELISA for determination of alkaloids in the kratom cocktail
Springer Science and Business Media LLC - Tập 35 - Trang 167-172 - 2016
Supattra Limsuwanchote, Waraporn Putalun, Niwat Keawpradub, Hiroyuki Tanaka, Satoshi Morimoto, Juraithip Wungsintaweekul
Kratom cocktail or the fatal 4 × 100 formula is defined as a mixture of boiled kratom leaves, cola drink, and cough syrup. In the present study, we focused on application of the indirect competitive enzyme-linked immunosorbent assay (ic-ELISA) using the anti-mitragynine (MG) monoclonal antibody (anti-MG mAb) to the kratom cocktail. The ic-ELISA is a rapid method for quantification of the major kra...... hiện toàn bộ
Characterisation of AMB-FUBINACA metabolism and CB1-mediated activity of its acid metabolite
Springer Science and Business Media LLC - Tập 41 - Trang 114-125 - 2022
Hunter D. J. Webb, David B. Finlay, Shuli Chen, Andrea J. Vernall, Eric Sparkes, Samuel D. Banister, Rhonda J. Rosengren, Michelle Glass
AMB-FUBINACA is a synthetic cannabinoid receptor agonist (SCRA) which is primarily metabolised by hepatic enzymes producing AMB-FUBINACA carboxylic acid. The metabolising enzymes associated with this biotransformation remain unknown. This study aimed to determine if AMB-FUBINACA metabolism could be reduced in the presence of carboxylesterase (CES) inhibitors and recreational drugs commonly consume...... hiện toàn bộ
Murders with VX: Aum Shinrikyo in Japan and the assassination of Kim Jong-Nam in Malaysia
Springer Science and Business Media LLC - Tập 36 - Trang 542-544 - 2018
Tomomasa Nakagawa, Anthony T. Tu
Fatal intoxication with 1,1-difluoroethane (DFE) due to inhalation of a spray cleaner: analysis by GC–MS
Springer Science and Business Media LLC - Tập 37 - Trang 245-249 - 2018
Suguru Torimitsu, Yusuke Fujii, Kanju Saka, Hiroko Abe, Yohsuke Makino, Fumiko Chiba, Hirotaro Iwase
Animal studies suggested that halogenated hydrocarbons such as 1,1-difluoroethane (DFE) sensitized myocardial tissues to catecholamines and might cause fatal arrhythmia. In this paper, we report a case of a fatality that was associated with DFE abuse, and quantified DFE concentrations in postmortem specimens using gas chromatography–mass spectrometry (GC–MS). Femoral vein blood, cardiac blood, and...... hiện toàn bộ
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