Ethyl glucuronide in hair of non-excessive alcohol consumers: correlations and gender influence

Springer Science and Business Media LLC - Tập 34 - Trang 186-190 - 2015
Cleo L. Crunelle1, Delphine Cappelle1, Eva Flamand2, Jeroen Cox2, Adrian Covaci1, Mireille De Doncker3, Alexander L. N. van Nuijs1, Peter Michielsen4, Michel Yegles5, Hugo Neels1,3
1Toxicological Center, University of Antwerp, Antwerp, Belgium
2Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium
3Toxicology and TDM Laboratory, ZNA Stuivenberg, Antwerp, Belgium
4Department of Gastroenterology and Hepatology, University Hospital Antwerp, Antwerp, Belgium
5Laboratoire National de Santé, Service de Toxicologie, Dudelange, Luxembourg

Tóm tắt

Hair ethyl glucuronide (hEtG) is a marker used for previous alcohol consumption. Correlations have been reported between the amount of alcohol consumed and hEtG concentration, but little has been published regarding relatively low levels of alcohol consumption and associated hEtG concentrations close to the limit of quantification (LOQ). Here, we investigate hEtG concentrations in non-excessive (<60 g/day) alcohol consumers and address the role of gender differences in hEtG concentration within this population. Daily alcohol consumption over a period of 3 months prior to hair collection was assessed using the Timeline Followback interview in 130 non-excessive (<60 g/day) alcohol consumers. Participants showed large variation in consumption, ranging from 10 g (~1 unit) to 3300 g (~330 units), during the prior 3 months. Eight individuals abstained from alcohol and served as a control group. HEtG was measured using gas chromatography–mass spectrometry in hair segments 0–3 cm in length, and varied from

Tài liệu tham khảo

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