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Automatized Patient-Specific Methodology for Numerical Determination of Biomechanical Corneal Response
Springer Science and Business Media LLC - Tập 44 - Trang 1753-1772 - 2015
This work presents a novel methodology for building a three-dimensional patient-specific eyeball model suitable for performing a fully automatic finite element (FE) analysis of the corneal biomechanics. The reconstruction algorithm fits and smooths the patient’s corneal surfaces obtained in clinic with corneal topographers and creates an FE mesh for the simulation. The patient’s corneal elevation ......
Shear stress-mediated changes in the expression of leukocyte adhesion receptors on human umbilical vein endothelial cellsin vitro
Springer Science and Business Media LLC - Tập 23 - Trang 247-256 - 1995
Extensive monocyte recruitment is an early phenomenon associated with the development of atherosclerotic lesions, suggesting an active role for the involvement of adhesion receptors expressed by endothelial cells. In this study we describe the contribution of hemodynamic shear forces in regulating the expression of a few of the monocyte adhesion receptors, including intercellular adhesion molecule......
Acoustic Estimation of Neck Fluid Volume
Springer Science and Business Media LLC - Tập 42 - Trang 2132-2142 - 2014
Recently we showed that fluid accumulation in the neck can narrow the upper airway (UA) and increase its collapsibility, which may exacerbate obstructive sleep apnea (OSA). However, the available methods for measuring neck fluid volume (NFV) are inconvenient and expensive. Narrowing of the UA due to fluid accumulation could change acoustic characteristics of respiratory sounds. In this study, we d......
Electrical Localization of Neural Activity in the Dorsal Horn of the Spinal Cord: A Modeling Study
Springer Science and Business Media LLC - Tập 32 - Trang 1694-1709 - 2004
Intraspinal microstimulation is a means of eliciting coordinated motor responses for restoration of function. However, detailed maps of the neuroanatomy of the human spinal cord are lacking, and it is not clear where electrodes should be implanted. We developed an electrical approach to localize active neurons in the spinal cord using potentials recorded from the surface of the spinal cord. We eva......
A Finite Element Model for Ultrafast Laser–Lamellar Keratoplasty
Springer Science and Business Media LLC - Tập 34 - Trang 169-183 - 2006
A biomechanical model of the human cornea is employed in a finite element formulation for simulating the effects of Ultrafast Laser–Lamellar Keratoplasty. Several computer simulations were conducted to study curvature changes of the central corneal zone under various physiological and surgical factors. These factors included the combined effect of corneal flap and residual stromal bed thickness on......
Fetal Transcatheter Trileaflet Heart Valve Hemodynamics: Implications of Scaling on Valve Mechanics and Turbulence
Springer Science and Business Media LLC - Tập 48 - Trang 1683-1693 - 2020
The scarcity of data available on the best approach for pulmonary fetal valve replacement or implantation necessitate an investigation on whether practices using adult transcatheter valves could be translated to fetal applications. The objective of this study is to evaluate the hemodynamic characteristics and the turbulent properties of a fetal sized trileaflet transcatheter pulmonary valve in com......
Sailing the Seven Seas: A Multinational Comparison of ChatGPT’s Performance on Medical Licensing Examinations
Springer Science and Business Media LLC - - Trang 1-4 - 2023
The use of AI-powered technology, particularly OpenAI’s ChatGPT, holds significant potential to reshape healthcare and medical education. Despite existing studies on the performance of ChatGPT in medical licensing examinations across different nations, a comprehensive, multinational analysis using rigorous methodology is currently lacking. Our study sought to address this gap by evaluating the per......
The Feasibility of Enhancing Susceptibility of Glioblastoma Cells to IRE Using a Calcium Adjuvant
Springer Science and Business Media LLC - Tập 45 - Trang 2535-2547 - 2017
Irreversible electroporation (IRE) is a cellular ablation method used to treat a variety of cancers. IRE works by exposing tissues to pulsed electric fields which cause cell membrane disruption. Cells exposed to lower energies become temporarily permeable while greater energy exposure results in cell death. For IRE to be used safely in the brain, methods are needed to extend the area of ablation w......
Non-destructive Characterization of Skeletal Muscle Extracellular Matrix Morphology by Combining Optical Coherence Tomography (OCT) Imaging with Tissue Clearing
Springer Science and Business Media LLC - Tập 51 - Trang 2323-2336 - 2023
Histology is an essential step to visualize and analyze the microstructure of any biological tissue; however, histological processing is often irreversible, and histological samples are unable to be imaged or tested further. In this work, a novel non-destructive protocol is proposed for morphological analysis of skeletal muscles, combining Optical Coherence Tomography (OCT) imaging with Tissue Cle......
Evaluation of a Drift Flux Model for Simulating Submicrometer Aerosol Dynamics in Human Upper Tracheobronchial Airways
Springer Science and Business Media LLC - Tập 36 - Trang 1714-1734 - 2008
In this study, a hybrid drift flux velocity correction (DF-VC) model that accounts for both submicrometer particle diffusion and inertia was extended to transient conditions and was tested against existing experimental deposition data measured in a replica cast of the human tracheobronchial (TB) region for laminar and turbulent flow. To evaluate the effectiveness of the DF-VC model, deposition res......
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