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Transcriptome sequencing in pediatric acute lymphoblastic leukemia identifies fusion genes associated with distinct DNA methylation profiles
Springer Science and Business Media LLC - Tập 10 - Trang 1-14 - 2017
Yanara Marincevic-Zuniga, Johan Dahlberg, Sara Nilsson, Amanda Raine, Sara Nystedt, Carl Mårten Lindqvist, Eva C. Berglund, Jonas Abrahamsson, Lucia Cavelier, Erik Forestier, Mats Heyman, Gudmar Lönnerholm, Jessica Nordlund, Ann-Christine Syvänen
Structural chromosomal rearrangements that lead to expressed fusion genes are a hallmark of acute lymphoblastic leukemia (ALL). In this study, we performed transcriptome sequencing of 134 primary ALL patient samples to comprehensively detect fusion transcripts. We combined fusion gene detection with genome-wide DNA methylation analysis, gene expression profiling, and targeted sequencing to determi...... hiện toàn bộ
Skeletal Plasmacytoma: Progression of disease and impact of local treatment; an analysis of SEER database
Springer Science and Business Media LLC - - 2009
Muhammad Umar Jawad, Sean P Scully
Previous reports suggest an as yet unidentifiable subset of patients with plasmacytoma will progress to myeloma. The current study sought to establish the risk of developing myeloma and determine the prognostic factors affecting the progression of disease. Patients with plasmacytoma diagnosed between 1973 and 2005 were identified in the SEER database(1164 patients). Patient demographics and clinic...... hiện toàn bộ
Tumor organoids: applications in cancer modeling and potentials in precision medicine
Springer Science and Business Media LLC - - 2022
Hanxiao Xu, Dechao Jiao, Aiguo Liu, Kongming Wu
Cancer is a top-ranked life-threatening disease with intratumor heterogeneity. Tumor heterogeneity is associated with metastasis, relapse, and therapy resistance. These factors contribute to treatment failure and an unfavorable prognosis. Personalized tumor models faithfully capturing the tumor heterogeneity of individual patients are urgently needed for precision medicine. Advances in stem cell c...... hiện toàn bộ
Correction to: Oroxylin A promotes PTEN-mediated negative regulation of MDM2 transcription via SIRT3-mediated deacetylation to stabilize p53 and inhibit glycolysis in wt-p53 cancer cells
Springer Science and Business Media LLC - Tập 12 - Trang 1-2 - 2019
Kai Zhao, Yuxin Zhou, Chen Qiao, Ting Ni, Zhiyu Li, Xiaotang Wang, Qinglong Guo, Na Lu, Libin Wei
The original article [1] contains several errors.
Splicing factor 3b subunit 1 (Sf3b1) haploinsufficient mice display features of low risk Myelodysplastic syndromes with ring sideroblasts
Springer Science and Business Media LLC - Tập 7 - Trang 1-10 - 2014
Valeria Visconte, Ali Tabarroki, Li Zhang, Yvonne Parker, Edy Hasrouni, Reda Mahfouz, Kyoichi Isono, Haruhiko Koseki, Mikkael A Sekeres, Yogen Saunthararajah, John Barnard, Daniel Lindner, Heesun J Rogers, Ramon V Tiu
The presence of somatic mutations in splicing factor 3b subunit 1 (SF3B1) in patients with Myelodysplastic syndromes with ring sideroblasts (MDS-RS) highlights the importance of the RNA-splicing machinery in MDS. We previously reported the presence of bone marrow (BM) RS in Sf3b1 heterozygous (Sf3b1+/−) mice which are rarely found in mouse models of MDS. Sf3b1+/− mice were originally engineered to...... hiện toàn bộ
MicroRNA-mediated regulation of KRAS in cancer
Springer Science and Business Media LLC - - 2014
Minlee Kim, Frank J. Slack
Drugging KRAS: current perspectives and state-of-art review
Springer Science and Business Media LLC - Tập 15 - Trang 1-22 - 2022
Kaushal Parikh, Giuseppe Banna, Stephen V. Liu, Alex Friedlaender, Aakash Desai, Vivek Subbiah, Alfredo Addeo
After decades of efforts, we have recently made progress into targeting KRAS mutations in several malignancies. Known as the ‘holy grail’ of targeted cancer therapies, KRAS is the most frequently mutated oncogene in human malignancies. Under normal conditions, KRAS shuttles between the GDP-bound ‘off’ state and the GTP-bound ‘on’ state. Mutant KRAS is constitutively activated and leads to persiste...... hiện toàn bộ
Targeting nucleotide metabolism: a promising approach to enhance cancer immunotherapy
Springer Science and Business Media LLC -
Hui Wu, Yue Gong, Peng Ji, Yifan Xie, Yi‐Zhou Jiang, Guang-yu Liu
AbstractTargeting nucleotide metabolism can not only inhibit tumor initiation and progression but also exert serious side effects. With in-depth studies of nucleotide metabolism, our understanding of nucleotide metabolism in tumors has revealed their non-proliferative effects on immune escape, indicating the potential effectiveness of nucleotide antimetabolites for...... hiện toàn bộ
Recent advances in targeted strategies for triple-negative breast cancer
Springer Science and Business Media LLC -
Shuangli Zhu, Yuze Wu, Bin Song, Ming Yi, Yichao Yan, Qi Mei, Kongming Wu
AbstractTriple-negative breast cancer (TNBC), a highly aggressive subtype of breast cancer, negatively expresses estrogen receptor, progesterone receptor, and the human epidermal growth factor receptor 2 (HER2). Although chemotherapy is the main form of treatment for patients with TNBC, the effectiveness of chemotherapy for TNBC is still limited. The search for mor...... hiện toàn bộ
Thrombospondin-2 promotes prostate cancer bone metastasis by the up-regulation of matrix metalloproteinase-2 through down-regulating miR-376c expression
Springer Science and Business Media LLC - Tập 10 - Trang 1-17 - 2017
Po-Chun Chen, Chih-Hsin Tang, Liang-Wei Lin, Chun-Hao Tsai, Cheng-Ying Chu, Tien-Huang Lin, Yuan-Li Huang
Thrombospondin-2 (TSP-2) is a secreted matricellular glycoprotein that is found to mediate cell-to-extracellular matrix attachment and participates in many physiological and pathological processes. The expression profile of TSP-2 on tumors is controversial, and it up-regulates in some cancers, whereas it down-regulates in others, suggesting that the functional role of TSP-2 on tumors is still unce...... hiện toàn bộ
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