Immune checkpoint modulators in cancer immunotherapy: recent advances and emerging conceptsSpringer Science and Business Media LLC - Tập 15 - Trang 1-53 - 2022
Yuchen Wang, Hao Zhang, Chao Liu, Zeyu Wang, Wantao Wu, Nan Zhang, Longbo Zhang, Jason Hu, Peng Luo, Jian Zhang, Zaoqu Liu, Yun Peng, Zhixiong Liu, Lanhua Tang, Quan Cheng
The discovery of immune checkpoint inhibitors (ICIs) has now been universally acknowledged as a significant breakthrough in tumor therapy after the targeted treatment of checkpoint molecules: anti-programmed cell death protein 1/programmed cell death ligand 1 (PD-1/PD-L1) and anti-cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) on several cancer types achieved satisfying results. However, the...... hiện toàn bộ
Driver mutations (JAK2V617F, MPLW515L/K or CALR), pentraxin-3 and C-reactive protein in essential thrombocythemia and polycythemia veraSpringer Science and Business Media LLC - - 2017
Federico Lussana, Alessandra Carobbio, Silvia Salmoiraghi, Paola Guglielmelli, Alessandro M. Vannucchi, Barbara Bottazzi, Roberto Leone, Alberto Mantovani, Tiziano Barbui, Alessandro Rambaldi
The management of metastatic GIST: current standard and investigational therapeuticsSpringer Science and Business Media LLC - Tập 14 - Trang 1-12 - 2021
Ciara M. Kelly, Laura Gutierrez Sainz, Ping Chi
Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the gastrointestinal tract. The majority of GISTs harbor gain of function mutations in either KIT or PDGFRα. Determination of the GIST molecular subtype upon diagnosis is important because this information informs therapeutic decisions in both the adjuvant and metastatic setting. The management of GIST was revolutionized...... hiện toàn bộ
Targeting macrophages in hematological malignancies: recent advances and future directionsSpringer Science and Business Media LLC - Tập 15 - Trang 1-29 - 2022
Wei Li, Fang Wang, Rongqun Guo, Zhilei Bian, Yongping Song
Emerging evidence indicates that the detection and clearance of cancer cells via phagocytosis induced by innate immune checkpoints play significant roles in tumor-mediated immune escape. The most well-described innate immune checkpoints are the “don’t eat me” signals, including the CD47/signal regulatory protein α axis (SIRPα), PD-1/PD-L1 axis, CD24/SIGLEC-10 axis, and MHC-I/LILRB1 axis. Molecules...... hiện toàn bộ