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Transcriptome sequencing in pediatric acute lymphoblastic leukemia identifies fusion genes associated with distinct DNA methylation profiles
Springer Science and Business Media LLC - Tập 10 - Trang 1-14 - 2017
Structural chromosomal rearrangements that lead to expressed fusion genes are a
hallmark of acute lymphoblastic leukemia (ALL). In this study, we performed
transcriptome sequencing of 134 primary ALL patient samples to comprehensively
detect fusion transcripts. We combined fusion gene detection with genome-wide
DNA methylation analysis, gene expression profiling, and targeted sequencing to
determi...
Skeletal Plasmacytoma: Progression of disease and impact of local treatment; an analysis of SEER database
Springer Science and Business Media LLC - - 2009
Previous reports suggest an as yet unidentifiable subset of patients with
plasmacytoma will progress to myeloma. The current study sought to establish the
risk of developing myeloma and determine the prognostic factors affecting the
progression of disease. Patients with plasmacytoma diagnosed between 1973 and
2005 were identified in the SEER database(1164 patients). Patient demographics
and clinic...
Tumor organoids: applications in cancer modeling and potentials in precision medicine
Springer Science and Business Media LLC - - 2022
Cancer is a top-ranked life-threatening disease with intratumor heterogeneity.
Tumor heterogeneity is associated with metastasis, relapse, and therapy
resistance. These factors contribute to treatment failure and an unfavorable
prognosis. Personalized tumor models faithfully capturing the tumor
heterogeneity of individual patients are urgently needed for precision medicine.
Advances in stem cell c...
Correction to: Oroxylin A promotes PTEN-mediated negative regulation of MDM2 transcription via SIRT3-mediated deacetylation to stabilize p53 and inhibit glycolysis in wt-p53 cancer cells
Springer Science and Business Media LLC - Tập 12 - Trang 1-2 - 2019
The original article [1] contains several errors.
Splicing factor 3b subunit 1 (Sf3b1) haploinsufficient mice display features of low risk Myelodysplastic syndromes with ring sideroblasts
Springer Science and Business Media LLC - Tập 7 - Trang 1-10 - 2014
The presence of somatic mutations in splicing factor 3b subunit 1 (SF3B1) in
patients with Myelodysplastic syndromes with ring sideroblasts (MDS-RS)
highlights the importance of the RNA-splicing machinery in MDS. We previously
reported the presence of bone marrow (BM) RS in Sf3b1 heterozygous (Sf3b1+/−)
mice which are rarely found in mouse models of MDS. Sf3b1+/− mice were
originally engineered to...
Drugging KRAS: current perspectives and state-of-art review
Springer Science and Business Media LLC - Tập 15 - Trang 1-22 - 2022
After decades of efforts, we have recently made progress into targeting KRAS
mutations in several malignancies. Known as the ‘holy grail’ of targeted cancer
therapies, KRAS is the most frequently mutated oncogene in human malignancies.
Under normal conditions, KRAS shuttles between the GDP-bound ‘off’ state and the
GTP-bound ‘on’ state. Mutant KRAS is constitutively activated and leads to
persiste...
Targeting nucleotide metabolism: a promising approach to enhance cancer immunotherapy
Springer Science and Business Media LLC -
AbstractTargeting nucleotide metabolism can not only inhibit tumor initiation
and progression but also exert serious side effects. With in-depth studies of
nucleotide metabolism, our understanding of nucleotide metabolism in tumors has
revealed their non-proliferative effects on immune escape, indicating the
potential effectiveness of nucleotide antimetabolites for enhancing
immunotherapy. A growi...
Recent advances in targeted strategies for triple-negative breast cancer
Springer Science and Business Media LLC -
AbstractTriple-negative breast cancer (TNBC), a highly aggressive subtype of
breast cancer, negatively expresses estrogen receptor, progesterone receptor,
and the human epidermal growth factor receptor 2 (HER2). Although chemotherapy
is the main form of treatment for patients with TNBC, the effectiveness of
chemotherapy for TNBC is still limited. The search for more effective therapies
is urgent. ...
Thrombospondin-2 promotes prostate cancer bone metastasis by the up-regulation of matrix metalloproteinase-2 through down-regulating miR-376c expression
Springer Science and Business Media LLC - Tập 10 - Trang 1-17 - 2017
Thrombospondin-2 (TSP-2) is a secreted matricellular glycoprotein that is found
to mediate cell-to-extracellular matrix attachment and participates in many
physiological and pathological processes. The expression profile of TSP-2 on
tumors is controversial, and it up-regulates in some cancers, whereas it
down-regulates in others, suggesting that the functional role of TSP-2 on tumors
is still unce...
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