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E3 ubiquitin ligase RNF180 prevents excessive PCDH10 methylation to suppress the proliferation and metastasis of gastric cancer cells by promoting ubiquitination of DNMT1
Springer Science and Business Media LLC - Tập 15 - Trang 1-18 - 2023
Nannan Zhang, Xiaoliang Gao, Qiangqiang Yuan, Xin Fu, Pengliang Wang, Fenglin Cai, Hui Liu, Jing Zhang, Han Liang, Yongzhan Nie, Jingyu Deng
Downregulation of certain tumor-suppressor genes (TSGs) by aberrant methylation of CpG islands in the promoter region contributes a great deal to the oncogenesis and progression of several cancers, including gastric cancer (GC). Protocadherin 10 (PCDH10) is a newly identified TSG in various cancers and is downregulated in GC; however, the specific mechanisms of PCDH10 in GC remain elusive. Here, w...... hiện toàn bộ
Novel mutation points to a hot spot in CDKN1C causing Silver–Russell syndrome
Springer Science and Business Media LLC - - 2020
Gerhard Binder, Julian Ziegler, Roland Schweizer, Wisam Habhab, Tobias B. Haack, T. Heinrich, Thomas Eggermann
Abstract Background Pathogenic CDKN1C gain-of-function variants on the maternal allele were initially reported as a cause of IMAGe syndrome characterized by intrauterine growth retardation, metaphyseal dysplasia, primary adrenal insufficiency and genital anomalies. Recently, a maternally inherited ... hiện toàn bộ
BTB/POZ zinc finger protein ZBTB16 inhibits breast cancer proliferation and metastasis through upregulating ZBTB28 and antagonizing BCL6/ZBTB27
Springer Science and Business Media LLC - Tập 12 - Trang 1-15 - 2020
Jin He, Mingjun Wu, Lei Xiong, Yijia Gong, Renjie Yu, Weiyan Peng, Lili Li, Li Li, Shaorong Tian, Yan Wang, Qian Tao, Tingxiu Xiang
Breast cancer remains in urgent need of reliable diagnostic and prognostic markers. Zinc finger and BTB/POZ domain-containing family proteins (ZBTBs) are important transcription factors functioning as oncogenes or tumor suppressors. The role and regulation of ZBTB16 in breast cancer remain to be established. Reverse-transcription PCR and methylation-specific PCR were applied to detect expression a...... hiện toàn bộ
Comparison of pre-processing methodologies for Illumina 450k methylation array data in familial analyses
Springer Science and Business Media LLC - Tập 8 - Trang 1-14 - 2016
Emma Cazaly, Russell Thomson, James R. Marthick, Adele F. Holloway, Jac Charlesworth, Joanne L. Dickinson
Human methylome mapping in health and disease states has largely relied on Illumina Human Methylation 450k array (450k array) technology. Accompanying this has been the necessary evolution of analysis pipelines to facilitate data processing. The majority of these pipelines, however, cater for experimental designs where matched ‘controls’ or ‘normal’ samples are available. Experimental designs wher...... hiện toàn bộ
Erratum to: Imprinting disorders: a group of congenital disorders with overlapping patterns of molecular changes affecting imprinted loci
Springer Science and Business Media LLC - Tập 8 - Trang 1-3 - 2016
Thomas Eggermann, Guiomar Perez de Nanclares, Eamonn R. Maher, I. Karen Temple, Zeynep Tümer, David Monk, Deborah J. G. Mackay, Karen Grønskov, Andrea Riccio, Agnès Linglart, Irène Netchine
Evaluation of commercial kits for isolation and bisulfite conversion of circulating cell-free tumor DNA from blood
Springer Science and Business Media LLC - Tập 15 Số 1 - Trang 1-14 - 2023
Kresse, Stine H., Brandt-Winge, Sara, Pharo, Heidi, Flatin, Bjørnar T. B., Jeanmougin, Marine, Vedeld, Hege Marie, Lind, Guro E.
DNA methylation biomarkers in circulating cell-free DNA (cfDNA) have great clinical potential for cancer management. Most methods for DNA methylation analysis require bisulfite conversion, causing DNA degradation and loss. This is particularly challenging for cfDNA, which is naturally fragmented and normally present in low amounts. The aim of the present study was to identify an optimal combinatio...... hiện toàn bộ
Bisulfite profiling of the MGMT promoter and comparison with routine testing in glioblastoma diagnostics
Springer Science and Business Media LLC - Tập 14 - Trang 1-12 - 2022
Sascha Tierling, Wiebke M. Jürgens-Wemheuer, Alea Leismann, Julia Becker-Kettern, Michael Scherer, Arne Wrede, David Breuskin, Steffi Urbschat, Christoph Sippl, Joachim Oertel, Walter J. Schulz-Schaeffer, Jörn Walter
Promoter methylation of the DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT) is an acknowledged predictive epigenetic marker in glioblastoma multiforme and anaplastic astrocytoma. Patients with methylated CpGs in the MGMT promoter benefit from treatment with alkylating agents, such as temozolomide, and show an improved overall survival and progression-free interval. A precise determin...... hiện toàn bộ
Multifactorial analysis of the stochastic epigenetic variability in cord blood confirmed an impact of common behavioral and environmental factors but not of in vitro conception
Springer Science and Business Media LLC - Tập 10 - Trang 1-13 - 2018
D. Gentilini, E. Somigliana, L. Pagliardini, E. Rabellotti, P. Garagnani, L. Bernardinelli, E. Papaleo, M. Candiani, A. M. Di Blasio, P. Viganò
An increased incidence of imprint-associated disorders has been reported in babies born from assisted reproductive technology (ART). However, previous studies supporting an association between ART and an altered DNA methylation status of the conceived babies have been often conducted on a limited number of methylation sites and without correction for critical potential confounders. Moreover, all t...... hiện toàn bộ
LSD1 dual function in mediating epigenetic corruption of the vitamin D signaling in prostate cancer
Springer Science and Business Media LLC - Tập 9 - Trang 1-15 - 2017
Sebastiano Battaglia, Ellen Karasik, Bryan Gillard, Jennifer Williams, Trisha Winchester, Michael T. Moser, Dominic J Smiraglia, Barbara A. Foster
Lysine-specific demethylase 1A (LSD1) is a key regulator of the androgen (AR) and estrogen receptors (ER), and LSD1 levels correlate with tumor aggressiveness. Here, we demonstrate that LSD1 regulates vitamin D receptor (VDR) activity and is a mediator of 1,25(OH)2-D3 (vitamin D) action in prostate cancer (PCa). Athymic nude mice were xenografted with CWR22 cells and monitored weekly after testost...... hiện toàn bộ
IGF2/H19 hypomethylation is tissue, cell, and CpG site dependent and not correlated with body asymmetry in adolescents with Silver-Russell syndrome
Springer Science and Business Media LLC - - 2012
Kai Kannenberg, Karin Weber, Cathrin Binder, Christina Urban, Hans‐Joachim Kirschner, Gerhard Binder
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