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BTB/POZ zinc finger protein ZBTB16 inhibits breast cancer proliferation and metastasis through upregulating ZBTB28 and antagonizing BCL6/ZBTB27
Springer Science and Business Media LLC - Tập 12 - Trang 1-15 - 2020
Jin He, Mingjun Wu, Lei Xiong, Yijia Gong, Renjie Yu, Weiyan Peng, Lili Li, Li Li, Shaorong Tian, Yan Wang, Qian Tao, Tingxiu Xiang
Breast cancer remains in urgent need of reliable diagnostic and prognostic markers. Zinc finger and BTB/POZ domain-containing family proteins (ZBTBs) are important transcription factors functioning as oncogenes or tumor suppressors. The role and regulation of ZBTB16 in breast cancer remain to be established. Reverse-transcription PCR and methylation-specific PCR were applied to detect expression a...... hiện toàn bộ
Evaluation of commercial kits for isolation and bisulfite conversion of circulating cell-free tumor DNA from blood
Springer Science and Business Media LLC - Tập 15 Số 1 - Trang 1-14 - 2023
Kresse, Stine H., Brandt-Winge, Sara, Pharo, Heidi, Flatin, Bjørnar T. B., Jeanmougin, Marine, Vedeld, Hege Marie, Lind, Guro E.
DNA methylation biomarkers in circulating cell-free DNA (cfDNA) have great clinical potential for cancer management. Most methods for DNA methylation analysis require bisulfite conversion, causing DNA degradation and loss. This is particularly challenging for cfDNA, which is naturally fragmented and normally present in low amounts. The aim of the present study was to identify an optimal combinatio...... hiện toàn bộ
Multifactorial analysis of the stochastic epigenetic variability in cord blood confirmed an impact of common behavioral and environmental factors but not of in vitro conception
Springer Science and Business Media LLC - Tập 10 - Trang 1-13 - 2018
D. Gentilini, E. Somigliana, L. Pagliardini, E. Rabellotti, P. Garagnani, L. Bernardinelli, E. Papaleo, M. Candiani, A. M. Di Blasio, P. Viganò
An increased incidence of imprint-associated disorders has been reported in babies born from assisted reproductive technology (ART). However, previous studies supporting an association between ART and an altered DNA methylation status of the conceived babies have been often conducted on a limited number of methylation sites and without correction for critical potential confounders. Moreover, all t...... hiện toàn bộ
Altered H3K4me3 profile at the TFAM promoter causes mitochondrial alterations in preadipocytes from first-degree relatives of type 2 diabetics
Springer Science and Business Media LLC - Tập 15 - Trang 1-24 - 2023
Michele Longo, Federica Zatterale, Rosa Spinelli, Jamal Naderi, Luca Parrillo, Pasqualina Florese, Cecilia Nigro, Alessia Leone, Augusta Moccia, Antonella Desiderio, Gregory A. Raciti, Claudia Miele, Ulf Smith, Francesco Beguinot
First-degree relatives of type 2 diabetics (FDR) exhibit a high risk of developing type 2 diabetes (T2D) and feature subcutaneous adipocyte hypertrophy, independent of obesity. In FDR, adipose cell abnormalities contribute to early insulin-resistance and are determined by adipocyte precursor cells (APCs) early senescence and impaired recruitment into the adipogenic pathway. Epigenetic mechanisms s...... hiện toàn bộ
Impact of BMI and waist circumference on epigenome-wide DNA methylation and identification of epigenetic biomarkers in blood: an EWAS in multi-ethnic Asian individuals
Springer Science and Business Media LLC - - 2021
Yuqing Chen, Irfahan Kassam, Suk Hiang Lau, Jaspal S. Kooner, Rory Wilson, Annette Peters, Juliane Winkelmann, John C. Chambers, Vincent Chow, Chiea Chuen Khor, Rob M van Dam, Yik-Ying Teo, Marie Loh, Xueling Sim
Abstract Background The prevalence of obesity and its related chronic diseases have been increasing especially in Asian countries. Obesity-related genetic variants have been identified, but these explain little of the variation in BMI. Recent studies reported associations between DNA methylation and...... hiện toàn bộ
Gene-specific DNA methylation profiles and LINE-1 hypomethylation are associated with myocardial infarction risk
Springer Science and Business Media LLC - Tập 7 - Trang 1-12 - 2015
Simonetta Guarrera, Giovanni Fiorito, N. Charlotte Onland-Moret, Alessia Russo, Claudia Agnoli, Alessandra Allione, Cornelia Di Gaetano, Amalia Mattiello, Fulvio Ricceri, Paolo Chiodini, Silvia Polidoro, Graziella Frasca, Monique W. M. Verschuren, Jolanda M. A. Boer, Licia Iacoviello, Yvonne T. van der Schouw, Rosario Tumino, Paolo Vineis, Vittorio Krogh, Salvatore Panico, Carlotta Sacerdote, Giuseppe Matullo
DNA methylation profiles are responsive to environmental stimuli and metabolic shifts. This makes DNA methylation a potential biomarker of environmental-related and lifestyle-driven diseases of adulthood. Therefore, we investigated if white blood cells’ (WBCs) DNA methylation profiles are associated with myocardial infarction (MI) occurrence. Whole-genome DNA methylation was investigated by microa...... hiện toàn bộ
Expression of integrin β-7 is epigenetically enhanced in multiple myeloma subgroups with high-risk cytogenetics
Springer Science and Business Media LLC - Tập 15 - Trang 1-14 - 2023
Samrat Roy Choudhury, Stephanie D. Byrum, Duah Alkam, Cody Ashby, Fenghuang Zhan, Alan J. Tackett, Frits Van Rhee
Oncogenic overexpression of integrin-β7 (ITGB7) in cases of high-risk multiple myeloma (MM) was reported to promote enhanced interactions between neoplastic plasma-B cells and stromal cells to develop cell-adhesion mediated drug resistance. Expression profiles of adhesion related genes were analyzed in a cohort of MM patients containing major IgH translocations or hyperdiploidies (HY), diagnosed a...... hiện toàn bộ
Methylation of ZNF331 is an independent prognostic marker of colorectal cancer and promotes colorectal cancer growth
Springer Science and Business Media LLC - Tập 9 - Trang 1-12 - 2017
Yuzhu Wang, Tao He, James G. Herman, Enqiang Linghu, Yunsheng Yang, François Fuks, Fuyou Zhou, Linjie Song, Mingzhou Guo
ZNF331 was reported to be a transcriptional repressor. Methylation of the promoter region of ZNF331 has been found frequently in human esophageal and gastric cancers. The function and methylation status of ZNF331 remain to be elucidated in human colorectal cancer (CRC). Six colorectal cancer cell lines, 146 cases of primary colorectal cancer samples, and 10 cases of noncancerous colorectal mucosa ...... hiện toàn bộ
Unlocking the potential of targeting histone-modifying enzymes for treating IBD and CRC
Springer Science and Business Media LLC - Tập 15 - Trang 1-13 - 2023
Bing Liang, Yanhong Wang, Jiazhen Xu, Yingchun Shao, Dongming Xing
Dysregulation of histone modifications has been implicated in the pathogenesis of both inflammatory bowel disease (IBD) and colorectal cancer (CRC). These diseases are characterized by chronic inflammation, and alterations in histone modifications have been linked to their development and progression. Furthermore, the gut microbiota plays a crucial role in regulating immune responses and maintaini...... hiện toàn bộ
Epimutations in both the TESK2 and MMACHC promoters in the Epi-cblC inherited disorder of intracellular metabolism of vitamin B12
Springer Science and Business Media LLC - Tập 14 Số 1 - 2022
Abderrahim Oussalah, Youssef Siblini, Sébastien Hergalant, Céline Chéry, Pierre Rouyer, Catia Cavicchi, Renzo Guerrini, Pierre‐Emmanuel Morange, David‐Alexandre Trégouët, Mihaela Pupavac, David K. Watkins, Tomi Pastinen, Wendy K. Chung, Can Fıçıcıoğlu, François Feillet, D. Sean Froese, Matthias Baumgartner, Jean‐François Benoist, Jacek Majewski, Amelia Morrone, David S. Rosenblatt, Jean Louis Guéant
AbstractBackgroundepi-cblCis a recently discovered inherited disorder of intracellular vitamin B12metabolism associating hematological, neurological, and cardiometabolic outcomes. It is produced by an epimutation at the promoter common toCCDC163Pand... hiện toàn bộ
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