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Early hippocampal synaptic plasticity and episodic like-memory deficits in a transgenic mouse model of Alzheimer disease - involvment of corticosterone
Springer Science and Business Media LLC - - 2013
Fabien Lanté, Magda Chafaï, Elisabeth Raymond, Ana Rita Salgueiro Peirera, Ingrid Bethus, Hélène Marie
Cellular stress signaling and the unfolded protein response in retinal degeneration: mechanisms and therapeutic implications
Springer Science and Business Media LLC - Tập 17 - Trang 1-19 - 2022
Todd McLaughlin, Andy Medina, Jacob Perkins, Maria Yera, Joshua J. Wang, Sarah X. Zhang
The retina, as part of the central nervous system (CNS) with limited capacity for self-reparation and regeneration in mammals, is under cumulative environmental stress due to high-energy demands and rapid protein turnover. These stressors disrupt the cellular protein and metabolic homeostasis, which, if not alleviated, can lead to dysfunction and cell death of retinal neurons. One primary cellular...... hiện toàn bộ
Therapeutic potential of autophagy-enhancing agents in Parkinson’s disease
Springer Science and Business Media LLC - Tập 12 - Trang 1-18 - 2017
Tim E. Moors, Jeroen J. M. Hoozemans, Angela Ingrassia, Tommaso Beccari, Lucilla Parnetti, Marie-Christine Chartier-Harlin, Wilma D. J. van de Berg
Converging evidence from genetic, pathological and experimental studies have increasingly suggested an important role for autophagy impairment in Parkinson’s Disease (PD). Genetic studies have identified mutations in genes encoding for components of the autophagy-lysosomal pathway (ALP), including glucosidase beta acid 1 (GBA1), that are associated with increased risk for developing PD. Observatio...... hiện toàn bộ
TRPA1 channels promote astrocytic Ca2+ hyperactivity and synaptic dysfunction mediated by oligomeric forms of amyloid-β peptide
Springer Science and Business Media LLC - Tập 12 - Trang 1-19 - 2017
Anthony Bosson, Adrien Paumier, Sylvie Boisseau, Muriel Jacquier-Sarlin, Alain Buisson, Mireille Albrieux
Excessive synaptic loss is thought to be one of the earliest events in Alzheimer’s disease (AD). However, the key mechanisms that maintain plasticity of synapses during adulthood or initiate synapse dysfunction in AD remain unknown. Recent studies suggest that astrocytes contribute to functional changes observed during synaptic plasticity and play a major role in synaptic dysfunction but astrocyte...... hiện toàn bộ
Renin angiotensin system and gender differences in dopaminergic degeneration
Springer Science and Business Media LLC - Tập 6 - Trang 1-13 - 2011
Ana I Rodriguez-Perez, Rita Valenzuela, Belen Joglar, Pablo Garrido-Gil, Maria J Guerra, Jose L Labandeira-Garcia
There are sex differences in dopaminergic degeneration. Men are approximately two times as likely as premenopausal women of the same age to develop Parkinson's disease (PD). It has been shown that the local renin angiotensin system (RAS) plays a prominent role in sex differences in the development of chronic renal and cardiovascular diseases, and there is a local RAS in the substantia nigra and do...... hiện toàn bộ
Identification of BACE2 as an avid ß-amyloid-degrading protease
Springer Science and Business Media LLC - Tập 7 Số 1 - 2012
Samer O. Abdul-Hay, Tomoko Sahara, Melinda McBride, Dongcheul Kang, Malcolm A. Leissring
Abstract Background Proteases that degrade the amyloid ß-protein (Aß) have emerged as key players in the etiology and potential treatment of Alzheimer’s disease (AD), but it is unlikely that all such proteases have been identified. To discover new Aß-degrading proteases (AßDPs), we conducted an u...... hiện toàn bộ
The 5th International Conference on Molecular Neurodegeneration: Overlapping Pathologies and Common Mechanisms
Springer Science and Business Media LLC - Tập 14 - Trang 1-73 - 2019
Peripheral immune system in aging and Alzheimer’s disease
Springer Science and Business Media LLC - Tập 13 - Trang 1-17 - 2018
Wei Cao, Hui Zheng
Alzheimer’s disease (AD) represents an urgent public health mandate. AD is no longer considered a neural-centric disease; rather, a plethora of recent studies strongly implicate a critical role played by neuroinflammation in the pathogeneses of AD and other neurodegenerative conditions. A close functional connection between the immune system and central nervous system is increasingly recognized. I...... hiện toàn bộ
The impact of human and mouse differences in NOS2 gene expression on the brain’s redox and immune environment
Springer Science and Business Media LLC - Tập 9 - Trang 1-15 - 2014
Michael D Hoos, Michael P Vitek, Lisa A Ridnour, Joan Wilson, Marilyn Jansen, Angela Everhart, David A Wink, Carol A Colton
Mouse models are used in the study of human disease. Despite well-known homologies, the difference in immune response between mice and humans impacts the application of data derived from mice to human disease outcomes. Nitric oxide synthase-2 (NOS2) is a key gene that displays species-specific outcomes via altered regulation of the gene promoter and via post-transcriptional mechanisms in humans th...... hiện toàn bộ
Immunotherapy targeting toll-like receptor 2 alleviates neurodegeneration in models of synucleinopathy by modulating α-synuclein transmission and neuroinflammation
Springer Science and Business Media LLC - Tập 13 - Trang 1-18 - 2018
Changyoun Kim, Brian Spencer, Edward Rockenstein, Hodaka Yamakado, Michael Mante, Anthony Adame, Jerel Adam Fields, Deborah Masliah, Michiyo Iba, He-Jin Lee, Robert A. Rissman, Seung-Jae Lee, Eliezer Masliah
Synucleinopathies of the aging population are an heterogeneous group of neurological disorders that includes Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) and are characterized by the progressive accumulation of α-synuclein in neuronal and glial cells. Toll-like receptor 2 (TLR2), a pattern recognition immune receptor, has been implicated in the pathogenesis of synucleinopathies bec...... hiện toàn bộ
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