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Microglial inclusions and neurofilament light chain release follow neuronal α-synuclein lesions in long-term brain slice cultures
Springer Science and Business Media LLC - Tập 16 - Trang 1-17 - 2021
Melanie Barth, Mehtap Bacioglu, Niklas Schwarz, Renata Novotny, Janine Brandes, Marc Welzer, Sonia Mazzitelli, Lisa M. Häsler, Manuel Schweighauser, Thomas V. Wuttke, Deborah Kronenberg-Versteeg, Karina Fog, Malene Ambjørn, Ania Alik, Ronald Melki, Philipp J. Kahle, Derya R. Shimshek, Henner Koch, Mathias Jucker, Gaye Tanriöver
Proteopathic brain lesions are a hallmark of many age-related neurodegenerative diseases including synucleinopathies and develop at least a decade before the onset of clinical symptoms. Thus, understanding of the initiation and propagation of such lesions is key for developing therapeutics to delay or halt disease progression. Alpha-synuclein (αS) inclusions were induced in long-term murine and hu...... hiện toàn bộ
ZNStress: a high-throughput drug screening protocol for identification of compounds modulating neuronal stress in the transgenic mutant sod1G93R zebrafish model of amyotrophic lateral sclerosis
Springer Science and Business Media LLC - - 2016
Alexander McGown, Dame Pamela J. Shaw, Tennore Ramesh
Amyotrophic lateral sclerosis (ALS) is a lethal neurodegenerative disease with death on average within 2–3 years of symptom onset. Mutations in superoxide dismutase 1 (SOD1) have been identified to cause ALS. Riluzole, the only neuroprotective drug for ALS provides life extension of only 3 months on average. Thishighlights the need for compound screening in disease models to identify new neuroprot...... hiện toàn bộ
Correction: Unravelling cell type-specific responses to Parkinson’s Disease at single cell resolution
Springer Science and Business Media LLC - - 2024
Araks Martirosyan, Rizwan Ansari, Francisco Pestana, Katja Hebestreit, Hayk Gasparyan, Razmik Aleksanyan, Silvia Hnatova, Suresh Poovathingal, Catherine Marneffe, Dietmar R. Thal, Andrew Kottick, Victor J. Hanson-Smith, Sebastian Guelfi, William Plumbly, T. Grant Belgard, Emmanouil Metzakopian, Matthew G. Holt
Cảnh quan biểu hiện và sự đồng điều chỉnh của các gen lão hóa đặc hiệu theo mô và loại tế bào ở người Dịch bởi AI
Springer Science and Business Media LLC - - 2022
Peng Xu, Minghui Wang, Won-min Song, Qian Wang, Guo-Cheng Yuan, Peter H. Sudmant, Habil Zare, Zhidong Tu, Miranda E. Orr, Bin Zhang
Lão hóa tế bào là một phản ứng căng thẳng phức tạp ảnh hưởng đến chức năng tế bào và sức khỏe của cơ thể. Nhiều yếu tố phát triển và môi trường, chẳng hạn như tín hiệu nội tại của tế bào, bức xạ, căng thẳng oxy hóa, gen ung thư và sự tích tụ protein, kích hoạt các gen và con đường có thể dẫn đến lão hóa. Đã có những nỗ lực to lớn để xác định và đặc trưng hóa các gen lão hóa (SnGs) trong các hệ thố...... hiện toàn bộ
#lão hóa tế bào #gen lão hóa #phân tích mạng lưới gen #RNA-seq #mô người #tính đặc hiệu theo loại tế bào
A validated antibody panel for the characterization of tau post-translational modifications
Springer Science and Business Media LLC - Tập 12 - Trang 1-19 - 2017
Ebru Ercan, Sameh Eid, Christian Weber, Alexandra Kowalski, Maria Bichmann, Annika Behrendt, Frank Matthes, Sybille Krauss, Peter Reinhardt, Simone Fulle, Dagmar E. Ehrnhoefer
Tau is a microtubule-binding protein, which is subject to various post-translational modifications (PTMs) including phosphorylation, methylation, acetylation, glycosylation, nitration, sumoylation and truncation. Aberrant PTMs such as hyperphosphorylation result in tau aggregation and the formation of neurofibrillary tangles, which are a hallmark of Alzheimer’s disease (AD). In order to study the ...... hiện toàn bộ
Pathological phosphorylation of tau and TDP-43 by TTBK1 and TTBK2 drives neurodegeneration
Springer Science and Business Media LLC - - 2018
Laura M. Taylor, Pamela J. McMillan, Nicole F. Liachko, Timothy J. Strovas, Bernardino Ghetti, Thomas D. Bird, C. Dirk Keene, Brian C. Kraemer
An exo-cell assay for examining real-time γ-secretase activity and inhibition
Springer Science and Business Media LLC - Tập 4 - Trang 1-9 - 2009
Christopher C Shelton, Yuan Tian, Mark G Frattini, Yue-Ming Li
γ-Secretase is an aspartyl protease that cleaves multiple substrates that are involved in broad biological processes ranging from stem cell development to neurodegeneration. The investigation of γ-secretase has been limited by currently available assays that require genetic or biochemical manipulation in the form of substrate transfection or membrane preparation. Here we report an exo-cell assay t...... hiện toàn bộ
The 5th International Conference on Molecular Neurodegeneration: Overlapping Pathologies and Common Mechanisms
Springer Science and Business Media LLC - Tập 14 - Trang 1-73 - 2019
Immunotherapy targeting toll-like receptor 2 alleviates neurodegeneration in models of synucleinopathy by modulating α-synuclein transmission and neuroinflammation
Springer Science and Business Media LLC - Tập 13 - Trang 1-18 - 2018
Changyoun Kim, Brian Spencer, Edward Rockenstein, Hodaka Yamakado, Michael Mante, Anthony Adame, Jerel Adam Fields, Deborah Masliah, Michiyo Iba, He-Jin Lee, Robert A. Rissman, Seung-Jae Lee, Eliezer Masliah
Synucleinopathies of the aging population are an heterogeneous group of neurological disorders that includes Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) and are characterized by the progressive accumulation of α-synuclein in neuronal and glial cells. Toll-like receptor 2 (TLR2), a pattern recognition immune receptor, has been implicated in the pathogenesis of synucleinopathies bec...... hiện toàn bộ
A C9ORF72 BAC mouse model recapitulates key epigenetic perturbations of ALS/FTD
Springer Science and Business Media LLC - Tập 12 - Trang 1-11 - 2017
Rustam Esanov, Gabriela Toro Cabrera, Nadja S. Andrade, Tania F. Gendron, Robert H. Brown, Michael Benatar, Claes Wahlestedt, Christian Mueller, Zane Zeier
Amyotrophic Lateral Sclerosis (ALS) is a fatal and progressive neurodegenerative disorder with identified genetic causes representing a significant minority of all cases. A GGGGCC hexanucleotide repeat expansion (HRE) mutation within the C9ORF72 gene has recently been identified as the most frequent known cause of ALS. The expansion leads to partial heterochromatinization of the locus, yet mutant ...... hiện toàn bộ
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