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Early hippocampal synaptic plasticity and episodic like-memory deficits in a transgenic mouse model of Alzheimer disease - involvment of corticosterone
Springer Science and Business Media LLC - - 2013
Cellular stress signaling and the unfolded protein response in retinal degeneration: mechanisms and therapeutic implications
Springer Science and Business Media LLC - Tập 17 - Trang 1-19 - 2022
The retina, as part of the central nervous system (CNS) with limited capacity
for self-reparation and regeneration in mammals, is under cumulative
environmental stress due to high-energy demands and rapid protein turnover.
These stressors disrupt the cellular protein and metabolic homeostasis, which,
if not alleviated, can lead to dysfunction and cell death of retinal neurons.
One primary cellular...
Therapeutic potential of autophagy-enhancing agents in Parkinson’s disease
Springer Science and Business Media LLC - Tập 12 - Trang 1-18 - 2017
Converging evidence from genetic, pathological and experimental studies have
increasingly suggested an important role for autophagy impairment in Parkinson’s
Disease (PD). Genetic studies have identified mutations in genes encoding for
components of the autophagy-lysosomal pathway (ALP), including glucosidase beta
acid 1 (GBA1), that are associated with increased risk for developing PD.
Observatio...
TRPA1 channels promote astrocytic Ca2+ hyperactivity and synaptic dysfunction mediated by oligomeric forms of amyloid-β peptide
Springer Science and Business Media LLC - Tập 12 - Trang 1-19 - 2017
Excessive synaptic loss is thought to be one of the earliest events in
Alzheimer’s disease (AD). However, the key mechanisms that maintain plasticity
of synapses during adulthood or initiate synapse dysfunction in AD remain
unknown. Recent studies suggest that astrocytes contribute to functional changes
observed during synaptic plasticity and play a major role in synaptic
dysfunction but astrocyte...
Renin angiotensin system and gender differences in dopaminergic degeneration
Springer Science and Business Media LLC - Tập 6 - Trang 1-13 - 2011
There are sex differences in dopaminergic degeneration. Men are approximately
two times as likely as premenopausal women of the same age to develop
Parkinson's disease (PD). It has been shown that the local renin angiotensin
system (RAS) plays a prominent role in sex differences in the development of
chronic renal and cardiovascular diseases, and there is a local RAS in the
substantia nigra and do...
Identification of BACE2 as an avid ß-amyloid-degrading protease
Springer Science and Business Media LLC - Tập 7 Số 1 - 2012
Abstract Background Proteases that degrade the amyloid ß-protein (Aß) have
emerged as key players in the etiology and potential treatment of Alzheimer’s
disease (AD), but it is unlikely that all such proteases have been identified.
To discover new Aß-degrading proteases (AßDPs), we conducted an unbiased,
genome-scale, functional cDNA screen designed to identify proteases capable of
lowering net Aß...
The 5th International Conference on Molecular Neurodegeneration: Overlapping Pathologies and Common Mechanisms
Springer Science and Business Media LLC - Tập 14 - Trang 1-73 - 2019
Peripheral immune system in aging and Alzheimer’s disease
Springer Science and Business Media LLC - Tập 13 - Trang 1-17 - 2018
Alzheimer’s disease (AD) represents an urgent public health mandate. AD is no
longer considered a neural-centric disease; rather, a plethora of recent studies
strongly implicate a critical role played by neuroinflammation in the
pathogeneses of AD and other neurodegenerative conditions. A close functional
connection between the immune system and central nervous system is increasingly
recognized. I...
The impact of human and mouse differences in NOS2 gene expression on the brain’s redox and immune environment
Springer Science and Business Media LLC - Tập 9 - Trang 1-15 - 2014
Mouse models are used in the study of human disease. Despite well-known
homologies, the difference in immune response between mice and humans impacts
the application of data derived from mice to human disease outcomes. Nitric
oxide synthase-2 (NOS2) is a key gene that displays species-specific outcomes
via altered regulation of the gene promoter and via post-transcriptional
mechanisms in humans th...
Immunotherapy targeting toll-like receptor 2 alleviates neurodegeneration in models of synucleinopathy by modulating α-synuclein transmission and neuroinflammation
Springer Science and Business Media LLC - Tập 13 - Trang 1-18 - 2018
Synucleinopathies of the aging population are an heterogeneous group of
neurological disorders that includes Parkinson’s disease (PD) and dementia with
Lewy bodies (DLB) and are characterized by the progressive accumulation of
α-synuclein in neuronal and glial cells. Toll-like receptor 2 (TLR2), a pattern
recognition immune receptor, has been implicated in the pathogenesis of
synucleinopathies bec...
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