TRPA1 channels promote astrocytic Ca2+ hyperactivity and synaptic dysfunction mediated by oligomeric forms of amyloid-β peptideSpringer Science and Business Media LLC - Tập 12 - Trang 1-19 - 2017
Anthony Bosson, Adrien Paumier, Sylvie Boisseau, Muriel Jacquier-Sarlin, Alain Buisson, Mireille Albrieux
Excessive synaptic loss is thought to be one of the earliest events in Alzheimer’s disease (AD). However, the key mechanisms that maintain plasticity of synapses during adulthood or initiate synapse dysfunction in AD remain unknown. Recent studies suggest that astrocytes contribute to functional changes observed during synaptic plasticity and play a major role in synaptic dysfunction but astrocyte...... hiện toàn bộ
Increased 90-kDa ribosomal S6 kinase (Rsk) activity is protective against mutant huntingtin toxicitySpringer Science and Business Media LLC - - 2011
Xavier Xifró, Marta Anglada-Huguet, Laura Rué, Ana Saavedra, Esther Pérez‐Navarro, Jordi Alberch
Abstract
Background
The 90-kDa ribosomal S6 kinase (Rsk) family is involved in cell survival. Rsk activation is regulated by sequential phosphorylations controlled by extracellular signal-regulated kinase (ERK) 1/2 and 3-phosphoinositide-dependent protein kinase 1 (PDK1). Altered ERK1/2 and PDK1 ...... hiện toàn bộ
A panel of CSF proteins separates genetic frontotemporal dementia from presymptomatic mutation carriers: a GENFI studySpringer Science and Business Media LLC - Tập 16 - Trang 1-14 - 2021
Sofia Bergström, Linn Öijerstedt, Julia Remnestål, Jennie Olofsson, Abbe Ullgren, Harro Seelaar, John C. van Swieten, Matthis Synofzik, Raquel Sanchez-Valle, Fermin Moreno, Elizabeth Finger, Mario Masellis, Carmela Tartaglia, Rik Vandenberghe, Robert Laforce, Daniela Galimberti, Barbara Borroni, Chris R. Butler, Alexander Gerhard, Simon Ducharme, Jonathan D. Rohrer, Anna Månberg, Caroline Graff, Peter Nilsson
A detailed understanding of the pathological processes involved in genetic frontotemporal dementia is critical in order to provide the patients with an optimal future treatment. Protein levels in CSF have the potential to reflect different pathophysiological processes in the brain. We aimed to identify and evaluate panels of CSF proteins with potential to separate symptomatic individuals from indi...... hiện toàn bộ
Hyperpolarization-activated cyclic nucleotide gated channels: a potential molecular link between epileptic seizures and Aβ generation in Alzheimer’s diseaseSpringer Science and Business Media LLC - Tập 7 - Trang 1-15 - 2012
Yuhki Saito, Tsuyoshi Inoue, Gang Zhu, Naoki Kimura, Motohiro Okada, Masaki Nishimura, Nobuyuki Kimura, Shigeo Murayama, Sunao Kaneko, Ryuichi Shigemoto, Keiji Imoto, Toshiharu Suzuki
One of the best-characterized causative factors of Alzheimer’s disease (AD) is the generation of amyloid-β peptide (Aβ). AD subjects are at high risk of epileptic seizures accompanied by aberrant neuronal excitability, which in itself enhances Aβ generation. However, the molecular linkage between epileptic seizures and Aβ generation in AD remains unclear. X11 and X11-like (X11L) gene knockout mice...... hiện toàn bộ
Evaluation of Dimebon in cellular model of Huntington's diseaseSpringer Science and Business Media LLC - Tập 3 Số 1 - 2008
Jun Wu, Qin Li, Ilya Bezprozvanny
Abstract
Background
Dimebon is an antihistamine compound with a long history of clinical use in Russia. Recently, Dimebon has been proposed to be useful for treating neurodegenerative disorders. It has demonstrated efficacy in phase II Alzheimer's disease (AD) and Huntington's disease (HD) clinic...... hiện toàn bộ
The generation and function of soluble apoE receptors in the CNSSpringer Science and Business Media LLC - Tập 1 - Trang 1-13 - 2006
G William Rebeck, Mary Jo LaDu, Steven Estus, Guojun Bu, Edwin J Weeber
More than a decade has passed since apolipoprotein E4 (APOE-ε4) was identified as a primary risk factor for Alzheimer 's disease (AD), yet researchers are even now struggling to understand how the apolipoprotein system integrates into the puzzle of AD etiology. The specific pathological actions of apoE4, methods of modulating apolipoprotein E4-associated risk, and possible roles of apoE in normal ...... hiện toàn bộ
Conformation dependent monoclonal antibodies distinguish different replicating strains or conformers of prefibrillar Aβ oligomersSpringer Science and Business Media LLC - Tập 5 - Trang 1-10 - 2010
Rakez Kayed, Isabel Canto, Leonid Breydo, Suhail Rasool, Tamas Lukacsovich, Jessica Wu, Ricardo Albay, Anna Pensalfini, Stephen Yeung, Elizabeth Head, J Lawrence Marsh, Charles Glabe
Age-related neurodegenerative diseases share a number of important pathological features, such as accumulation of misfolded proteins as amyloid oligomers and fibrils. Recent evidence suggests that soluble amyloid oligomers and not the insoluble amyloid fibrils may represent the primary pathological species of protein aggregates. We have produced several monoclonal antibodies that specifically reco...... hiện toàn bộ