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Comparative analysis of growth characteristics of Sprague Dawley rats obtained from different sources
Springer Science and Business Media LLC - Tập 31 - Trang 166-173 - 2015
Genetic background in animal models is an intrinsic research variable in biomedical research. Although inbred strains offer genetic uniformity, the outbred stocks, known for genetic variability are often used to develop animal models of human disease. The genetic variability is considered to be even higher when outbred stocks are obtained from different sources. In order to examine the degree of v......
Quinolone susceptibility and genetic characterization of Salmonella enterica subsp. enterica isolated from pet turtles
Springer Science and Business Media LLC - Tập 33 - Trang 49-56 - 2017
Turtle-borne Salmonella enterica owns significance as a leading cause in human salmonellosis. The current study aimed to determine the quinolone susceptibility and the genetic characteristics of 21 strains of S. enterica subsp. enterica isolated from pet turtles. Susceptibility of four antimicrobials including nalidixic acid, ciprofloxacin, ofloxacin, and levofloxacin was examined in disk diffusio......
Toxicity of antioxidative extract collected from Styela clava tunics in ICR mice
Springer Science and Business Media LLC - Tập 31 - Trang 125-133 - 2015
Some polymers and bioactive compounds derived from Styela clava tunic (SCT) have been reported as traditional medicine for the treatment of inflammation, oxidative stress and surgical wounds although there is little scientific evidence of their liver and kidney toxicity. To investigate the toxicity of ethanol extracts of SCT (EtSCT) in the liver and kidney of ICR mice, alterations in related marke......
Effects of coenzyme Q10 on the antioxidant system in SD rats exposed to lipopolysaccharide-induced toxicity
Springer Science and Business Media LLC - Tập 33 - Trang 24-31 - 2017
The study was performed to see the effects of coenzyme Q10 (CoQ10) on blood biochemical components and hepatic antioxidant system in rats exposed to lipopolysaccharide (LPS)-induced toxicity. A total of 24 rats were allocated to four groups: control (CON), 100 mg/kg BW of LPS (LPS), 100 mg of CoQ10/kg BW with LPS (LCQI) and 300 mg of CoQ10/kg BW with LPS (LCQII). The LPS and LCQI groups showed a s......
Biochemical, morphological and molecular assessments of n butanol fraction of Phoenix dactylifera L. following exposure to inorganic mercury on the liver of Wistar ratsAbstract
Background
Mercury chloride (HgCl2 ) damages tissues it comes in contact with in sufficient concentration. This study evaluated the protective effects of n- butanol fraction of Phoenix dactylifera (BFPD) on mercury-tri... ...
Springer Science and Business Media LLC - Tập 40 Số 1
[18F]FET PET is a useful tool for treatment evaluation and prognosis prediction of anti-angiogenic drug in an orthotopic glioblastoma mouse model
Springer Science and Business Media LLC - Tập 34 - Trang 248-256 - 2018
O-2-18F-fluoroethyl-l-tyrosine ([18F]FET) has been widely used for glioblastomas (GBM) in clinical practice, although evaluation of its applicability in non-clinical research is still lacking. The objective of this study was to examine the value of [18F]FET for treatment evaluation and prognosis prediction of anti-angiogenic drug in an orthotopic mouse model of GBM. Human U87MG cells were implante......
High fat diet accelerates and exacerbates microgliosis and neuronal damage/death in the somatosensory cortex after transient forebrain ischemia in gerbils
Springer Science and Business Media LLC - Tập 36 - Trang 1-10 - 2020
Obesity has been known as an independent risk factor for stroke. Effects of high-fat diet (HFD)-induced obesity on neuronal damage in the somatosensory cortex of animal models of cerebral ischemia have not been studied yet. In this study, HFD-induced obesity was used to study the impact of obesity on neuronal damage/loss and microgliosis in the somatosensory cortex of a gerbil model of 5-min trans......
Working with laboratory rodents in Spain: a survey on welfare and wellbeing
Springer Science and Business Media LLC - Tập 37 - Trang 1-10 - 2021
Replacement, reduction and refinement, the 3R principles, provide a framework to minimize the use and suffering of animals in science. In this context, we aimed to determine the actual perception that individuals working with laboratory rodents in biomedical research have on animal welfare and on their interaction with the animals, as well as how they perceive its impact on their social relations.......
Dendropanax morbifera Léveille extract ameliorates d-galactose-induced memory deficits by decreasing inflammatory responses in the hippocampus
Springer Science and Business Media LLC - Tập 33 - Trang 283-290 - 2017
In the present study, we examined the effects of Dendropanax morbifera Léveille leaf extract (DML) on dgalactose-induced morphological changes in microglia and cytokines, including pro-inflammatory cytokines (interleukin [IL]-1β, IL-6, and tumor necrosis factor [TNF]-α) and anti-inflammatory cytokines (IL-4 and IL-10) in the hippocampus. Administration of DML to d-galactose-treated mice significan......
Synaptic loss and amyloid beta alterations in the rodent hippocampus induced by streptozotocin injection into the cisterna magnaAbstract To date, researchers have developed various animal models of Alzheimer’s disease (AD) to investigate its mechanisms and to identify potential therapeutic treatments. A widely recognized model that mimics the pathology of human sporadic AD involves intracerebroventricular (ICV) injection with streptozotocin (STZ). However, ICV injections are an invasive appr... ...
Springer Science and Business Media LLC - - 2020
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