The ‘R’ principles in laboratory animal experiments - 2020
Kook Hyun Lee, Jun Young Lee, Byoung-Kab Kang
AbstractSince the Three Rs of replacement, reduction and refinement was proposed
by Russel and Birch in 1959, researchers have a moral duty to minimize harm to
animals. Even though animal experiments are performed by the Three Rs concept,
animal researches which do not comply with international rules and standards are
not accepted as well. As animal welfare has been important global issues, the
me... hiện toàn bộ
Perilla oil improves blood flow through inhibition of platelet aggregation and thrombus formation Tập 30 Số 1 - Trang 21 - 2014
Ja-Young Jang, Tae-Su Kim, Jingmei Cai, Ji‐Hyun Kim, Young‐Eun Kim, Kyungha Shin, Kwang-Sei Kim, Sung-Pyo Lee, Myung‐Hwa Kang, Ehn‐Kyoung Choi, Man Hee Rhee, Yun-Bae Kim
Synaptic loss and amyloid beta alterations in the rodent hippocampus induced by streptozotocin injection into the cisterna magna - 2020
Yujin Ahn, Ji Hun Seo, Junghyung Park, Jinyoung Won, Hyeon-Gu Yeo, Keon‐Woo Kim, Chang‐Yeop Jeon, Jae‐Won Huh, Sang-Rae Lee, Dong‐Seok Lee, Youngjeon Lee
AbstractTo date, researchers have developed various animal models of Alzheimer’s
disease (AD) to investigate its mechanisms and to identify potential therapeutic
treatments. A widely recognized model that mimics the pathology of human
sporadic AD involves intracerebroventricular (ICV) injection with streptozotocin
(STZ). However, ICV injections are an invasive approach, which creates
limitations i... hiện toàn bộ
Age-dependent differences in myelin basic protein expression in the hippocampus of young, adult and aged gerbils - 2017
Ji Hyeon Ahn, Tae-Kyeong Lee, Joon Ha Park, Jeong Hwi Cho, In Hye Kim, Jae Chul Lee, Seongkweon Hong, Yong Hwan Jeon, Il Jun Kang, Young Joo Lee, Moo‐Ho Won, Choong‐Hyun Lee
Ventilator-induced lung-injury in mouse models: Is there a trap?
Jon Pétur Joelsson, Sævar Ingþórsson, Jennifer Kricker, Þórarinn Guðjónsson, Sigurbergur Kárason
AbstractVentilator-induced lung injury (VILI) is a serious acute injury to the
lung tissue that can develop during mechanical ventilation of patients. Due to
the mechanical strain of ventilation, damage can occur in the bronchiolar and
alveolar epithelium resulting in a cascade of events that may be fatal to the
patients. Patients requiring mechanical ventilation are often critically ill,
which li... hiện toàn bộ
Comparison of response to LPS-induced sepsis in three DBA/2 stocks derived from different sources Tập 37 Số 1 - 2021
Ji Won Park, Su Jin Lee, Ji Eun Kim, Mi Ju Kang, Su Ji Bae, Yun Ju Choi, Jeong Eun Gong, Kil Soo Kim, Young‐Suk Jung, Joon‐Yong Cho, Yeon Shik Choi, Dae Youn Hwang, Hyun Keun Song
AbstractSepsis, one of the most fatal diseases in the world, is known to
culminate in multiple organ failure due to an uncontrolled inflammatory
response. Hence, the use of animal models in sepsis research is very important
to study complex immune responses. The current study was undertaken to compare
commercial stocks with KFDA stocks of DBA/2 mice as an animal model for sepsis
study. To compare ... hiện toàn bộ