AcknowledgementSpringer Science and Business Media LLC - Tập 19 - Trang 985-987 - 2012
The Gut Microbiota in Parkinson Disease: Interactions with Drugs and Potential for Therapeutic ApplicationsSpringer Science and Business Media LLC - - 2024
Elisa Menozzi, Anthony H. V. Schapira
The concept of a ‘microbiota-gut-brain axis’ has recently emerged as an important player in the pathophysiology of Parkinson disease (PD), not least because of the reciprocal interaction between gut bacteria and medications. The gut microbiota can influence levodopa kinetics, and conversely, drugs administered for PD can influence gut microbiota composition. Through a two-step enzymatic pathway, g...... hiện toàn bộ
AcknowledgementSpringer Science and Business Media LLC - Tập 17 - Trang 1067-1070 - 2012
Peginterferon Beta-1a: A Review of Its Use in Patients with Relapsing-Remitting Multiple SclerosisSpringer Science and Business Media LLC - Tập 29 - Trang 171-179 - 2015
Sheridan M. Hoy
Peginterferon beta-1a (Plegridy™), an interferon beta-1a conjugated to a methoxy polyethylene glycol (PEG) molecule, is available in the EU and the USA for the treatment of adults with relapsing-remitting multiple sclerosis (RRMS). In a 96-week multinational, phase III study in this patient population (ADVANCE), subcutaneous peginterferon beta-1a 125 µg every 2 weeks significantly reduced the adju...... hiện toàn bộ
Do Antidepressants Have Any Meaningful Potential for AbuseSpringer Science and Business Media LLC - Tập 4 - Trang 253-255 - 2012
Samuel G. Siris
A small number of cases in the literature over the past 30 years suggest the possibility of abuse of antidepressant medications. However, this number is minuscule compared with the vast population of individuals who have received antidepressant treatment. Consequently, any possible benefit of routinely warning patients of the possibility that antidepressants might be abusable substances would be m...... hiện toàn bộ
Restless Legs SyndromeSpringer Science and Business Media LLC - Tập 22 - Trang 497-518 - 2012
Pankaj Satija, William G. Ondo
Restless legs syndrome (RLS) is clinically defined by the presence of (i) an urge to move the legs with or without an actual paraesthesia; (ii) a worsening of symptoms with inactivity; (iii) improvement with activity; and (iv) a worsening of symptoms in the evening and at night. Patients may use a variety of semantic phrases to describe their symptoms but all must have an urge to move. Most people...... hiện toàn bộ
COMT Inhibitors in the Management of Parkinson’s DiseaseSpringer Science and Business Media LLC - Tập 36 - Trang 261-282 - 2022
Margherita Fabbri, Joaquim J. Ferreira, Olivier Rascol
Levodopa treatment remains the gold standard for Parkinson’s disease, but shortcomings related to the pharmacological profile, notably, oral administration and the consequent occurrence of motor complications, have led to the development of several add-on levodopa treatments or to research to improve the method of delivery. Motor fluctuations, and to a lesser extent non-motor fluctuations, concern...... hiện toàn bộ