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Antineuronal Antibodies Against Neurotransmitter Receptors and Synaptic Proteins in Schizophrenia: Current Knowledge and Clinical Implications
Springer Science and Business Media LLC - - 2015
A Naturalistic Study of Galantamine for Alzheimer’s Disease
Springer Science and Business Media LLC - Tập 20 - Trang 935-943 - 2012
Objective: To collect descriptive data on the treatment of Alzheimer’s disease with galantamine under naturalistic conditions.
Study design: This was a prospective, open-label, observational study.
Patients: Subjects (n = 345) with mild to moderately severe dementia of the Alzheimer’s type were recruited from 48 hospitals in Australia.
...... hiện toàn bộ
Levetiracetam Compared with Valproic Acid for the Prevention of Postoperative Seizures After Supratentorial Tumor Surgery: A Retrospective Chart Review
Springer Science and Business Media LLC - Tập 27 - Trang 753-759 - 2013
Antiepileptic drugs are commonly given for perioperative prophylaxis after brain tumor surgery, and there has been growing interest in levetiracetam, a second-generation antiepileptic drug. This retrospective study compared the seizure outcomes, side effects and durability of levetiracetam with valproic acid after a craniotomy for supratentorial brain tumors. Between 2009 and 2012, 282 consecutive...... hiện toàn bộ
Spotlight on Eszopiclone in Insomnia
Springer Science and Business Media LLC - Tập 22 - Trang 975-978 - 2012
Eszopiclone (Lunesta®), the S-enantiomer of racemic zopiclone, is a nonbenzodiazepine hypnotic agent that is approved in the US as an oral, once-nightly therapy for insomnia in adults; eszopiclone is also currently under review by the European Medicines Agency. Eszopiclone is rapidly absorbed after oral administration without any next-day clinical residual effects being detected. Large, well desig...... hiện toàn bộ
Targeting BKCa Channels in Migraine: Rationale and Perspectives
Springer Science and Business Media LLC - Tập 34 - Trang 325-335 - 2020
Large (big)-conductance calcium-activated potassium (BKCa) channels are expressed in migraine-related structures such as the cranial arteries, trigeminal ganglion and trigeminal spinal nucleus, and they play a substantial role in vascular tonus and neuronal excitability. Using synthetic BKCa channels openers was associated with headache as a frequent adverse effect in healthy volunteers. Additiona...... hiện toàn bộ
Early Non-Response to Antipsychotic Treatment in Schizophrenia: A Systematic Review and Meta-Analysis of Evidence-Based Management Options
Springer Science and Business Media LLC - Tập 37 - Trang 499-512 - 2023
Early non-response is a well-established prognostic marker but evidence-based and consistent recommendations to manage it are limited. The aim of this systematic review and meta-analysis was to generate evidence-based strategies for the management of schizophrenia patients with early non-response to 2 weeks of antipsychotic treatment. We conducted a systematic review and meta-analysis of randomize...... hiện toàn bộ
Leveraging Molecular and Immune-Based Therapies in Leptomeningeal Metastases
Springer Science and Business Media LLC - Tập 37 - Trang 45-67 - 2022
Leptomeningeal metastases represent an aggressive stage of cancer with few durable treatment options. Improved understanding of cancer biology, neoplastic reliance on oncogenic driver mutations, and complex immune system interactions have resulted in an explosion in cancer-directed therapy in the last two decades to include small molecule inhibitors and immune checkpoint inhibitors. Most of these ...... hiện toàn bộ
Pharmacotherapy for Neuropsychiatric Symptoms in Frontotemporal Dementia
Springer Science and Business Media LLC - Tập 35 - Trang 1081-1096 - 2021
Despite significant progress in the understanding of the frontotemporal dementias (FTDs), there remains no disease-modifying treatment for these conditions, and limited effective symptomatic treatment. Behavioural variant frontotemporal dementia (bvFTD) is the most common FTD syndrome, and is characterized by severe impairments in behaviour, personality and cognition. Neuropsychiatric symptoms are...... hiện toàn bộ
Role of Dopamine Receptor Agonists in the Treatment of Restless Legs Syndrome
Springer Science and Business Media LLC - - 2004
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