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Oxidative stress in hypopituitary dwarf mice and in transgenic mice overexpressing human and bovine GH
Springer Science and Business Media LLC - Tập 22 - Trang 181-186 - 1999
Growth hormone (GH) stimulates metabolic activity. The purpose of this study was to examine whether it is involved in the aging process by increasing oxidative stress. Inorganic peroxides and lipid peroxides were measured in kidney and liver samples in dwarf mice that are deficient in GH, prolactin and thyrotropin and in transgenic mice that produce high levels of GH. In normal male mice, there wa......
Wild-derived mouse stocks: an underappreciated tool for aging research
Springer Science and Business Media LLC - Tập 30 - Trang 135-145 - 2008
Virtually all biomedical research makes use of a relatively small pool of laboratory-adapted, inbred, isogenic stocks of mice. Although the advantages of these models are many, there are a number of disadvantages as well. When studying a multifaceted process such as aging, the problems associated with using laboratory stocks are greatly inflated. On the other hand, wild-derived mouse stocks, loose......
Songbirds: A novel perspective on estrogens and the aging brain
Springer Science and Business Media LLC - Tập 27 - Trang 287-296 - 2006
Songbirds perform some remarkable feats of memory, including forming memories for songs and for complex spatial features of their environments. Research into the neural and hormonal control of these behaviors reveals discrete circuits that can retain considerable plasticity in adulthood. The songbird brain is also a prominent site of estrogen synthesis and a target of estrogen action. Estrogens co......
Twenty-seventh annual meeting — American Aging Association, twelfth annual meeting — American College of Clinical Gerontology
Springer Science and Business Media LLC - Tập 20 - Trang 235-256 - 1997
Circadian clock resetting in the mouse changes with age
Springer Science and Business Media LLC - Tập 31 - Trang 293-303 - 2009
The most widely recognised consequence of normal age-related changes in biological timing is the sleep disruption that appears in old age and diminishes the quality of life. These sleep disorders are part of the normal ageing process and consist primarily of increased amounts of wakefulness and reduced amounts of deep sleep. Changes in the amplitude and timing of the sleep-wake cycle appear to rep......
Obese-insulin resistance accelerates and aggravates cardiometabolic disorders and cardiac mitochondrial dysfunction in estrogen-deprived female rats
Springer Science and Business Media LLC - Tập 37 Số 2 - 2015
Predicting fat-free mass index and sarcopenia in assisted-living older adults
Springer Science and Business Media LLC - - 2014
Age-related alterations of plasma glutathione and oxidation of redox potentials in chimpanzee (Pan troglodytes) and rhesus monkey (Macaca mulatta)
Springer Science and Business Media LLC - Tập 36 - Trang 719-732 - 2014
Chimpanzee (Pan troglodytes) and rhesus macaque (Macaca mulatta) and humans (Homo sapiens) share physiological and genetic characteristics, but have remarkably different life spans, with chimpanzees living 50–60 % and the rhesus living 35–40 % of maximum human survival. Since oxidative processes are associated with aging and longevity, we might expect to see species differences in age-related oxid......
Brain lesions, hypertension and cognitive ageing in the 1921 and 1936 Aberdeen birth cohorts
Springer Science and Business Media LLC - - 2012
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