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Oxidative stress in hypopituitary dwarf mice and in transgenic mice overexpressing human and bovine GH
Springer Science and Business Media LLC - Tập 22 - Trang 181-186 - 1999
Growth hormone (GH) stimulates metabolic activity. The purpose of this study was to examine whether it is involved in the aging process by increasing oxidative stress. Inorganic peroxides and lipid peroxides were measured in kidney and liver samples in dwarf mice that are deficient in GH, prolactin and thyrotropin and in transgenic mice that produce high levels of GH. In normal male mice, there wa......
Age-related histological and zinc content changes in adult nonhyperplastic prostate glands
Springer Science and Business Media LLC - Tập 36 - Trang 167-181 - 2013
To clarify age-related histological and Zn content changes in nonhyperplastic adult prostate glands, a quantitative morphometric and energy-dispersive X-ray fluorescence analyses were performed. The prostates were obtained from autopsies of 63 subjects aged 21–70 years who died mainly from trauma. It was found that histologically normal prostate tissue undergoes substantial changes throughout agin......
Dietary fat modifies mitochondrial and plasma membrane apoptotic signaling in skeletal muscle of calorie-restricted mice
Springer Science and Business Media LLC - Tập 35 - Trang 2027-2044 - 2012
Calorie restriction decreases skeletal muscle apoptosis, and this phenomenon has been mechanistically linked to its protective action against sarcopenia of aging. Alterations in lipid composition of membranes have been related with the beneficial effects of calorie restriction. However, no study has been designed to date to elucidate if different dietary fat sources with calorie restriction modify......
Wild-derived mouse stocks: an underappreciated tool for aging research
Springer Science and Business Media LLC - Tập 30 - Trang 135-145 - 2008
Virtually all biomedical research makes use of a relatively small pool of laboratory-adapted, inbred, isogenic stocks of mice. Although the advantages of these models are many, there are a number of disadvantages as well. When studying a multifaceted process such as aging, the problems associated with using laboratory stocks are greatly inflated. On the other hand, wild-derived mouse stocks, loose......
Entropy production in human life span: A thermodynamical measure for aging
Springer Science and Business Media LLC - Tập 17 - Trang 29-31 - 1994
From the human entropy production per surface area obtained in a previous study, entropy productions per human individual of various ages are calculated. It is shown that the entropy production increases from birth to about 16 years of age for males and to about 14 years of age for females, and then gradually decreases afterwards. This two-stage principle characteristic of entropy production (the ......
Homer-1a immediate early gene expression correlates with better cognitive performance in aging
Springer Science and Business Media LLC - Tập 35 - Trang 1799-1808 - 2012
The molecular mechanisms underlying cognitive decline during healthy aging remain largely unknown. Utilizing aged wild-type C57BL/6 mice as a model for normal aging, we tested the hypothesis that cognitive performance, memory, and learning as assessed in established behavioral testing paradigms are correlated with the differential expression of isoforms of the Homer family of synaptic scaffolding ......
Songbirds: A novel perspective on estrogens and the aging brain
Springer Science and Business Media LLC - Tập 27 - Trang 287-296 - 2006
Songbirds perform some remarkable feats of memory, including forming memories for songs and for complex spatial features of their environments. Research into the neural and hormonal control of these behaviors reveals discrete circuits that can retain considerable plasticity in adulthood. The songbird brain is also a prominent site of estrogen synthesis and a target of estrogen action. Estrogens co......
Twenty-seventh annual meeting — American Aging Association, twelfth annual meeting — American College of Clinical Gerontology
Springer Science and Business Media LLC - Tập 20 - Trang 235-256 - 1997
Circadian clock resetting in the mouse changes with age
Springer Science and Business Media LLC - Tập 31 - Trang 293-303 - 2009
The most widely recognised consequence of normal age-related changes in biological timing is the sleep disruption that appears in old age and diminishes the quality of life. These sleep disorders are part of the normal ageing process and consist primarily of increased amounts of wakefulness and reduced amounts of deep sleep. Changes in the amplitude and timing of the sleep-wake cycle appear to rep......
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