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Oxidative stress in hypopituitary dwarf mice and in transgenic mice overexpressing human and bovine GH
Springer Science and Business Media LLC - Tập 22 - Trang 181-186 - 1999
Growth hormone (GH) stimulates metabolic activity. The purpose of this study was to examine whether it is involved in the aging process by increasing oxidative stress. Inorganic peroxides and lipid peroxides were measured in kidney and liver samples in dwarf mice that are deficient in GH, prolactin and thyrotropin and in transgenic mice that produce high levels of GH. In normal male mice, there wa......
Wild-derived mouse stocks: an underappreciated tool for aging research
Springer Science and Business Media LLC - Tập 30 - Trang 135-145 - 2008
Virtually all biomedical research makes use of a relatively small pool of laboratory-adapted, inbred, isogenic stocks of mice. Although the advantages of these models are many, there are a number of disadvantages as well. When studying a multifaceted process such as aging, the problems associated with using laboratory stocks are greatly inflated. On the other hand, wild-derived mouse stocks, loose......
Twenty-seventh annual meeting — American Aging Association, twelfth annual meeting — American College of Clinical Gerontology
Springer Science and Business Media LLC - Tập 20 - Trang 235-256 - 1997
Circadian clock resetting in the mouse changes with age
Springer Science and Business Media LLC - Tập 31 - Trang 293-303 - 2009
The most widely recognised consequence of normal age-related changes in biological timing is the sleep disruption that appears in old age and diminishes the quality of life. These sleep disorders are part of the normal ageing process and consist primarily of increased amounts of wakefulness and reduced amounts of deep sleep. Changes in the amplitude and timing of the sleep-wake cycle appear to rep......
Obese-insulin resistance accelerates and aggravates cardiometabolic disorders and cardiac mitochondrial dysfunction in estrogen-deprived female rats
Springer Science and Business Media LLC - Tập 37 Số 2 - 2015
Predicting fat-free mass index and sarcopenia in assisted-living older adults
Springer Science and Business Media LLC - - 2014
Brain lesions, hypertension and cognitive ageing in the 1921 and 1936 Aberdeen birth cohorts
Springer Science and Business Media LLC - - 2012
Alzheimer’s disease: A hypothesis on pathogenesis
Springer Science and Business Media LLC - Tập 23 - Trang 147-161 - 2000
Alzheimer’s disease (AD) is the major cause of dementia. It is a systemic disorder whose major manifestations are in the brain. AD cases can be categorized into two groups on the basis of the age of onset-before or after about age 60. The majority of cases, 90–95 percent, are in the late onset category. Early onset cases are largely, if not all, familial (FAD). These are caused by mutations in the......
Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways
Springer Science and Business Media LLC - Tập 35 - Trang 235-249 - 2011
In genome-wide association studies (GWAS) of complex traits, single SNP analysis is still the most applied approach. However, the identified SNPs have small effects and provide limited biological insight. A more appropriate approach to interpret GWAS data of complex traits is to analyze the combined effect of a SNP set grouped per pathway or gene region. We used this approach to study the joint ef......
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