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Extension of mouse lifespan by overexpression of catalase
Springer Science and Business Media LLC - Tập 28 - Trang 209-218 - 2006
The free radical theory of aging was originally proposed 50 years ago, and is arguably the most popular mechanism explaining the aging process. According to this theory, aging results from the progressive decline in organ function due to the damage generated by reactive oxygen species (ROS). These chemical species are a normal part of metabolism, and a group of enzymes exists to protect cells agai...... hiện toàn bộ
Age-associated changes in the electrophoretic pattern of the high molecular weight non-histone proteins from mouse liver, hepatoma and spleen chromatin
Springer Science and Business Media LLC - Tập 3 - Trang 74-77 - 1980
The water-soluble fractions of non-histone chromatin (NHC) proteins were isolated from 0.35M NaCl extracts of liver and spleen chromatin of young and old CBA mice and hepatomas of old mice. SDS-disc electrophoretic patterns of proteins with higher molecular weight were compared. Tissue specificity and age changes of the patterns have been found; however, in spleen chromatin the differences of NHC ...... hiện toàn bộ
Adiponectin protects rat hippocampal neurons against excitotoxicity
Springer Science and Business Media LLC - Tập 33 - Trang 155-165 - 2010
Adiponectin exerts multiple regulatory functions in the body and in the hypothalamus primarily through activation of its two receptors, adiponectin receptor1 and adiponectin receptor 2. Recent studies have shown that adiponectin receptors are widely expressed in other areas of the brain including the hippocampus. However, the functions of adiponectin in brain regions other than the hypothalamus ar...... hiện toàn bộ
Inflammatory markers and incident frailty in men and women: the English Longitudinal Study of Ageing
Springer Science and Business Media LLC - Tập 35 - Trang 2493-2501 - 2013
Cross-sectional studies show that higher blood concentrations of inflammatory markers tend to be more common in frail older people, but longitudinal evidence that these inflammatory markers are risk factors for frailty is sparse and inconsistent. We investigated the prospective relation between baseline concentrations of the inflammatory markers C-reactive protein (CRP) and fibrinogen and risk of ...... hiện toàn bộ
Association of handgrip strength with chronic diseases and multimorbidity
Springer Science and Business Media LLC - Tập 35 - Trang 929-941 - 2012
The prevalence of chronic diseases has risen along with increased longevity. Co-occurrence of two or more chronic diseases in an individual (multimorbidity) is prevalent and poses a huge burden to individuals and the society. However, determinants of multimorbidity are largely unknown. Handgrip strength is a general indicator of muscle strength and linked with premature mortality. However, its rol...... hiện toàn bộ
A botanical containing freeze dried açai pulp promotes healthy aging and reduces oxidative damage in sod1 knockdown flies
Springer Science and Business Media LLC - Tập 35 Số 4 - Trang 1117-1132 - 2013
SDAT: Prevention may be possible
Springer Science and Business Media LLC - Tập 11 - Trang 168-168 - 1988
Ultraviolet-A triggers photoaging in model nematode Caenorhabditis elegans in a DAF-16 dependent pathway
Springer Science and Business Media LLC - Tập 38 - Trang 1-13 - 2016
Ultraviolet radiations (UV) are the primary causative agent for skin aging (photoaging) and cancer, especially UV-A. The mode of action and the molecular mechanism behind the damages caused by UV-A is not well studied, in vivo. The current study was employed to investigate the impact of UV-A exposure using the model organism, Caenorhabditis elegans. Analysis of lifespan, healthspan, and other cogn...... hiện toàn bộ
Contributions of mild parkinsonian signs to gait performance in the elderly
Springer Science and Business Media LLC - Tập 36 Số 4 - 2014
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