Wild-derived mouse stocks: an underappreciated tool for aging research

Springer Science and Business Media LLC - Tập 30 - Trang 135-145 - 2008
James M. Harper1,2
1Department of Pathology and Geriatrics Center, University of Michigan School of Medicine, Ann Arbor, USA
2Ann Arbor, USA

Tóm tắt

Virtually all biomedical research makes use of a relatively small pool of laboratory-adapted, inbred, isogenic stocks of mice. Although the advantages of these models are many, there are a number of disadvantages as well. When studying a multifaceted process such as aging, the problems associated with using laboratory stocks are greatly inflated. On the other hand, wild-derived mouse stocks, loosely defined here as either wild-caught individuals or the recent progeny of wild-caught individuals, have much to offer to biogerontology research. Hence, the aims of this review are threefold: (1) to (re)acquaint readers with the pros and cons of using a typical inbred laboratory mouse model for aging research; (2) to reintroduce the notion of using wild-derived mouse stocks in aging research as championed by Austad, Miller and others for more than a decade, and (3) to provide an overview of recent advances in biogerontology using wild-derived mouse stocks.

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