A Technical Assessment of the Utility of Reverse Phase Protein Arrays for the Study of the Functional Proteome in Non-microdissected Human Breast Cancers - 2010
Bryan T. Hennessy, Yiling Lu, Ana M. González-Angulo, Mark Carey, Simen Myhre, Ju Zhang, Michael A. Davies, Wenbin Liu, Kevin R. Coombes, Funda Meric‐Bernstam, Isabelle Bedrosian, Mollianne J. McGahren, Roshan Agarwal, Fan Zhang, Jens Overgaard, Jan Alsner, Richard M. Neve, Wen Lin Kuo, Joe W. Gray, Anne Lise Børresen-Dale, Gordon B. Mills
Abstract Introduction The lack of large panels of validated antibodies, tissue
handling variability, and intratumoral heterogeneity potentially hamper
comprehensive study of the functional proteome in non-microdissected solid
tumors. The purpose of this study was to address these concerns and to
demonstrate clinical utility for the functional analysis of proteins in
non-microdissected breast tumor... hiện toàn bộ
Deep undepleted human serum proteome profiling toward biomarker discovery for Alzheimer’s disease - 2019
Kaushik Dey, Hong Wang, Mingming Niu, Bing Bai, Xusheng Wang, Yuxin Li, Ji-Hoon Cho, Haiyan Tan, Ashutosh Mishra, Anthony A. High, Ping‐Chung Chen, Zhiping Wu, Thomas G. Beach, Junmin Peng
Proteomic profiling of lung adenocarcinoma indicates heightened DNA repair, antioxidant mechanisms and identifies LASP1 as a potential negative predictor of survival Tập 13 Số 1 - 2016
Johannes F. Fahrmann, Dmitry Grapov, Brett S. Phinney, Carol Stroble, Brian C. DeFelice, William N. Rom, David R. Gandara, Yanhong Zhang, Oliver Fiehn, Harvey I. Pass, Suzanne Miyamoto
Laser capture microdissection coupled mass spectrometry (LCM-MS) for spatially resolved analysis of formalin-fixed and stained human lung tissues Tập 17 Số 1 - 2020
Jeremy Herrera, Venkatesh Mallikarjun, Silvia Rosini, María Ángeles Montero, Craig Lawless, Stacey Warwood, ronan.ocualain not provided, David Knight, Martin A. Schwartz, Joe Swift
Abstract Background Haematoxylin and eosin (H&E)—which respectively stain nuclei
blue and other cellular and stromal material pink—are routinely used for
clinical diagnosis based on the identification of morphological features. A
richer characterization can be achieved by laser capture microdissection coupled
to mass spectrometry (LCM-MS), giving an unbiased assay of the proteins that
make up the ... hiện toàn bộ