Glutathione protects PC12 cells from ascorbate- and dopamine-induced apoptosisSpringer Science and Business Media LLC - Tập 123 - Trang 263-268 - 1998
F. Si, Gregory M. Ross, Seon H. Shin
The role of reduced glutathione (GSH) on ascorbate- and dopamine-induced
apoptosis in PC12 cells was investigated. Ascorbate is a potent reducing agent
and is thus expected to protect against dopamine-induced apoptosis. However, we
found that both ascorbate and dopamine killed PC12 cells and ascorbate enhanced
dopamine-induced toxicity. The EC50 of cell toxicity induced by ascorbate,
dopamine and... hiện toàn bộ
Region specific regulation of glutamic acid decarboxylase mRNA expression by dopamine neurons in rat brainSpringer Science and Business Media LLC - Tập 77 - Trang 611-620 - 1989
N. Lindefors, S. Brene, M. Herrera-Marschitz, H. Persson
In situ hybridization histochemistry and RNA blots were used to study the
expression of glutamic acid decarboxylase (GAD) mRNA in rats with or without a
unilateral lesion of midbrain dopamine neurons. Two populations of GAD mRNA
positive neurons were found in the intact caudate-putamen, substantia nigra and
fronto-parietal cortex. In caudate-putamen, only one out of ten of the GAD mRNA
positive ne... hiện toàn bộ
The influence of goals on movement kinematics during imitationSpringer Science and Business Media LLC - Tập 204 - Trang 353-360 - 2009
Kelly S. Wild, Ellen Poliakoff, Emma Gowen, Andrew Jerrison
This study took a quantitative approach to investigate movement kinematics
during the imitation of goal-directed and non-goal directed movements. Motion
tracking equipment was used to record the hand movements of 15 healthy
participants during an imitation task involving aiming movements that varied in
speed. We predicted that movement kinematics would be most similar to the
observed movements in ... hiện toàn bộ
Task goal and grip force dynamicsSpringer Science and Business Media LLC - Tập 156 - Trang 451-457 - 2004
Kimberlee Jordan, Karl M. Newell
This study examined the effect of task goal on the structure of isometric force
variability during precision grasping. In general, variability of isometric
force production decreases when participants are asked to maintain a particular
force output and are provided with visual feedback, although the irregularity of
force output tends to increase under these conditions. In the current study we
comp... hiện toàn bộ
Differential effects of stimulation of the cat's red nucleus on lumbar alpha motoneurones and their Renshaw cellsSpringer Science and Business Media LLC - Tập 62 - Trang 161-174 - 1986
H. -D. Henatsch, J. Meyer-Lohmann, U. Windhorst, J. Schmidt
1. The red nucleus region was stereotaxically stimulated with short trains of
high-frequency alternating current pulses in anaesthetized cats. The effects
were studied, in contralateral lumbar segments, on the responses of
microrecorded individual Renshaw cells (RCs) to antidromic or orthodromic test
shocks of ventral root or muscle nerve fibres. Monosynaptic reflexes (MRs) of
their motoneurone po... hiện toàn bộ