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SOCS3 gene silencing does not occur through methylation and mutations in gastric cancer
Springer Science and Business Media LLC - Tập 35 - Trang 1114-1125 - 2022
Gastric cancer (GC) is ranked the third leading cause of cancer-related deaths worldwide. Mutations and epigenetic alterations in several essential genes, including p53, KRAS, PIK3CA, FAT4 and ARID1A, are often reported. Furthermore, loss of SOCS3 expression was reported in GC, suggesting its tumor suppressor role. To assess the mutational and methylation status of SOCS3, we performed gene panel e...... hiện toàn bộ
Establishment and characterization of NCC-ASPS2-C1: a novel patient-derived cell line of alveolar soft part sarcoma
Springer Science and Business Media LLC -
The mechanism of the contribution of ICAM-1 to epithelial–mesenchymal transition (EMT) in bladder cancer
Springer Science and Business Media LLC - - 2024
Bladder cancer is one of the most prevalent cancers worldwide. Moreover, if not optimally treated, bladder cancer is a significant burden on healthcare systems due to multiple recurrences which often require more aggressive therapies. Therefore, targeted anti-cancer therapies, developed based on an in-depth understanding of specific proteins and molecular mechanisms, are promising in cancer treatm...... hiện toàn bộ
Circ0001320 inhibits lung cancer cell growth and invasion by regulating TNFAIP1 and TPM1 expression through sponging miR-558
Springer Science and Business Media LLC - Tập 34 - Trang 468-477 - 2020
Lung cancer is the most affected malignant tumor in the world, and its specific pathogenesis is still unclear. It has been confirmed that circ0001320 is down-regulated in lung cancer, but its mechanism has not been reported. Further study found that circ0001320 was down-regulated in lung cancer cells, localized in the cytoplasm, and had multiple miR-558 binding sites. Dual-luciferase reporter gene...... hiện toàn bộ
Human endometrial cytodifferentiation by histone deacetylase inhibitors
Springer Science and Business Media LLC - Tập 19 Số 1 - Trang 38-42 - 2006
mTOR inhibitor everolimus reduces invasiveness of melanoma cells
Springer Science and Business Media LLC - Tập 33 - Trang 88-97 - 2019
The mammalian target of rapamycin (mTOR) plays a key role in several cellular processes: proliferation, survival, invasion, and angiogenesis, and therefore, controls cell behavior both in health and in disease. Dysregulation of the mTOR signaling is involved in some of the cancer hallmarks, and thus the mTOR pathway is an important target for the development of a new anticancer therapy. The object...... hiện toàn bộ
History of leukemia-lymphoma cell lines
Springer Science and Business Media LLC - Tập 23 - Trang 75-82 - 2010
We outline the near 50-year history of leukemia-lymphoma (LL) cell lines — a key model system in biomedicine. Due to the detailed documentation of their oncogenomic and transcriptional alterations via recent advances in molecular medicine, LL cell lines may be fitted to parent tumors with a degree of precision unattainable in other cancers. We have surveyed the corpus of published LL cell lines an...... hiện toàn bộ
Establishment of an immortalized human erythroid cell line sustaining differentiation potential without inducible gene expression system
Springer Science and Business Media LLC - Tập 35 - Trang 408-417 - 2021
Ex vivo manufactured red blood cells (RBC) generated from immortalized erythroid cell lines which can continuously grow are expected to become a significant alternative in future transfusion therapies. The ectopic expression of human papilloma virus (HPV) E6/E7 gene has successfully been employed to establish these cell lines. To induce differentiation and maturation of the immortalized cell lines...... hiện toàn bộ
Bone morphogenetic protein 2 may be a good predictor of success in oocyte fertilization during assisted reproductive technology
Springer Science and Business Media LLC - Tập 23 - Trang 83-88 - 2010
The aim of this study was to determine whether the bone-morphogenetic proreins-2 (BMP-2) or-7 (BMP-7) levels in follicular fluid (FF) are associated with success in oocyte fertilization during assisted reproductive technology (ART) treatment. Twenty-four cycles in 24 patients who underwent oocyte retrieval in Sugiyama clinic were included in this retrospective study. The patients were divided into...... hiện toàn bộ
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