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Cheminformatics models based on machine learning approaches for design of USP1/UAF1 abrogators as anticancer agents
Springer Science and Business Media LLC - Tập 9 - Trang 33-43 - 2015
Divya Wahi, Salma Jamal, Sukriti Goyal, Aditi Singh, Ritu Jain, Preeti Rana, Abhinav Grover
Cancer cells have upregulated DNA repair mechanisms, enabling them survive DNA damage induced during repeated rapid cell divisions and targeted chemotherapeutic treatments. Cancer cell proliferation and survival targeting via inhibition of DNA repair pathways is currently a very promiscuous anti-tumor approach. The deubiquitinating enzyme, USP1 is known to promote DNA repair via complexing with UA...... hiện toàn bộ
In silico study of peptide inhibitors against BACE 1
Springer Science and Business Media LLC - - 2015
Navya Raj, Agnes Helen, N. Manoj, G. Harish, Vinoy Thomas, Shailja Singh, Seema Sehrawat, Shaguna Seth, Achuthsankar S. Nair, Abhinav Grover, Pawan K. Dhar
Design of a novel nucleoside analog as potent inhibitor of the NAD+ dependent deacetylase, SIRT2
Springer Science and Business Media LLC - Tập 4 - Trang 257-263 - 2011
Padavattan Sivaraman, Suresh Mattegunta, Gottumukkala V. Subbaraju, Chava Satyanarayana, Balasundaram Padmanabhan
Sirtuins (class III histone deacetylase) are evolutionarily conserved NAD+-dependent enzymes that catalyze the deacetylation of acetyl-lysine residues of histones and other target proteins. Because of their associations in various pathophysiological conditions, the identification of small molecule modulators has been of significant interest. In the present study, virtual screening was carried out ...... hiện toàn bộ
Bivariate microarray analysis: statistical interpretation of two-channel functional genomics data
Springer Science and Business Media LLC - Tập 2 Số 3-4 - Trang 95-104 - 2008
Albert Hsiao, Shankar Subramaniam
Recent advances and opportunities in synthetic logic gates engineering in living cells
Springer Science and Business Media LLC - Tập 8 - Trang 271-282 - 2014
Vijai Singh
Recently, a number of synthetic biologic gates including AND, OR, NOR, NOT, XOR and NAND have been engineered and characterized in a wide range of hosts. The hope in the emerging synthetic biology community is to construct an inventory of well-characterized parts and install distinct gene and circuit behaviours that are externally controllable. Though the field is still growing and major successes...... hiện toàn bộ
Evolution of tryptophan biosynthetic pathway in microbial genomes: a comparative genetic study
Springer Science and Business Media LLC - - 2014
V. K. Priya, Susmita Sarkar, Somdatta Sinha
Experiments inside a box lead to out-of-the-box ideas on cellular organization
Springer Science and Business Media LLC - Tập 8 - Trang 223-226 - 2014
Liedewij Laan
Microtubules are biopolymers that assemble from tubulin dimers into hollow tubes and play an important role in cellular organization. Their fascinating properties and variety of functions, like for example chromosome segregation, sperm propagation and polarity establishment, have made them a popular subject of study. In this perspective I focus on the contribution of minimal in vitro systems to o...... hiện toàn bộ
PROTDES: CHARMM toolbox for computational protein design
Springer Science and Business Media LLC - Tập 2 - Trang 105-113 - 2009
María Suárez, Pablo Tortosa, Alfonso Jaramillo
We present an open-source software able to automatically mutate any residue positions and find the best aminoacids in an arbitrary protein structure without requiring pairwise approximations. Our software, PROTDES, is based on CHARMM and it searches automatically for mutations optimizing a protein folding free energy. PROTDES allows the integration of molecular dynamics within the protein design. ...... hiện toàn bộ
Simulation of developmental changes in action potentials with ventricular cell models
Springer Science and Business Media LLC - Tập 1 Số 1 - Trang 11-23 - 2007
Hitomi Itoh, Yoshiro Naito, Masaru Tomita
Hướng tới việc lắp ráp một divisome tối thiểu Dịch bởi AI
Springer Science and Business Media LLC - Tập 8 - Trang 237-247 - 2014
Zohreh Nourian, Andrew Scott, Christophe Danelon
Việc xây dựng một tế bào tối thiểu không thể giảm thiểu, có đầy đủ các thuộc tính thiết yếu của một hệ thống sống là một trong những thách thức lớn nhất mà sinh học tổng hợp phải đối mặt. Một nhiệm vụ phổ biến mà mọi hệ thống sống đều thực hiện là phân chia vỏ tế bào. Do đó, việc lắp ráp một công cụ phân tử cơ bản, mặc dù đầy đủ, hỗ trợ cho việc phân chia ngăn, là một bước quan trọng hướng tới việ...... hiện toàn bộ
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