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Synthetic biology, patenting, health and global justice
Springer Science and Business Media LLC - Tập 7 - Trang 87-98 - 2012
Henk van den Belt
The legal and moral issues that synthetic biology (SB) and its medical applications are likely to raise with regard to intellectual property (IP) and patenting are best approached through the lens of a theoretical framework highlighting the “co-construction” or “co-evolution” of patent law and technology. The current situation is characterized by a major contest between the so-called IP frame and ... hiện toàn bộ
Do-it-yourself biology: challenges and promises for an open science and technology movement
Springer Science and Business Media LLC - Tập 7 - Trang 115-126 - 2013
Thomas Landrain, Morgan Meyer, Ariel Martin Perez, Remi Sussan
The do-it-yourself biology (DIYbio) community is emerging as a movement that fosters open access to resources permitting modern molecular biology, and synthetic biology among others. It promises in particular to be a source of cheaper and simpler solutions for environmental monitoring, personal diagnostic and the use of biomaterials. The successful growth of a global community of DIYbio practition... hiện toàn bộ
Hướng tới việc lắp ráp một divisome tối thiểu Dịch bởi AI
Springer Science and Business Media LLC - Tập 8 - Trang 237-247 - 2014
Zohreh Nourian, Andrew Scott, Christophe Danelon
Việc xây dựng một tế bào tối thiểu không thể giảm thiểu, có đầy đủ các thuộc tính thiết yếu của một hệ thống sống là một trong những thách thức lớn nhất mà sinh học tổng hợp phải đối mặt. Một nhiệm vụ phổ biến mà mọi hệ thống sống đều thực hiện là phân chia vỏ tế bào. Do đó, việc lắp ráp một công cụ phân tử cơ bản, mặc dù đầy đủ, hỗ trợ cho việc phân chia ngăn, là một bước quan trọng hướng tới việ... hiện toàn bộ
Weighting schemes in metabolic graphs for identifying biochemical routes
Springer Science and Business Media LLC - Tập 8 - Trang 47-57 - 2013
S. Ghosh, P. Baloni, S. Vishveshwara, N. Chandra
Metabolism forms an integral part of all cells and its study is important to understand the functioning of the system, to understand alterations that occur in disease state and hence for subsequent applications in drug discovery. Reconstruction of genome-scale metabolic graphs from genomics and other molecular or biochemical data is now feasible. Few methods have also been reported for inferring b... hiện toàn bộ
A synthetic biology approach allows inducible retrotransposition in whole plants
Springer Science and Business Media LLC - Tập 4 - Trang 133-138 - 2010
Gudrun Böhmdorfer, Andrea Tramontano, Kerstin Luxa, Andreas Bachmair
Retrotransposons are mobile genetic elements that transpose by reverse transcription of element RNA, followed by insertion of the cDNA into new positions of the host genome. Although they are major constituents of eukaryotic genomes, many facets of their biology remain to be understood. Transposition is generally rare, suggesting that it is subject to tight regulation. However, only the first regu... hiện toàn bộ
Modeling metabolic adjustment in Mycobacterium tuberculosis upon treatment with isoniazid
Springer Science and Business Media LLC - Tập 4 - Trang 299-309 - 2011
Ashwini G. Bhat, Rohit Vashisht, Nagasuma Chandra
Complex biological systems exhibit a property of robustness at all levels of organization. Through different mechanisms, the system tries to sustain stress such as due to starvation or drug exposure. To explore whether reconfiguration of the metabolic networks is used as a means to achieve robustness, we have studied possible metabolic adjustments in Mtb upon exposure to isoniazid (INH), a front-l... hiện toàn bộ
Programming languages for synthetic biology
Springer Science and Business Media LLC - Tập 4 Số 4 - Trang 265-269 - 2010
P Umesh, F. Naveen, Chanchala Uma Maheswara Rao, Achuthsankar S. Nair
Are we doing synthetic biology?
Springer Science and Business Media LLC - - 2012
Manuel Porcar, Juli Peretó
Synthetic Biology is a singular, revolutionary scenario with a vast range of practical applications but, is SB research really based on engineering principles? Is it contributing to the artificial synthesis of life or using approaches “sophisticated” enough to fall outside the scope of biotechnology or metabolic engineering? We have reviewed the state of the art on synthetic biology and we conclud... hiện toàn bộ
Processing DNA molecules as text
Springer Science and Business Media LLC - Tập 4 - Trang 227-236 - 2010
Uri Shabi, Shai Kaplan, Gregory Linshiz, Tuval BenYehezkel, Hen Buaron, Yair Mazor, Ehud Shapiro
Polymerase Chain Reaction (PCR) is the DNA-equivalent of Gutenberg’s movable type printing, both allowing large-scale replication of a piece of text. De novo DNA synthesis is the DNA-equivalent of mechanical typesetting, both ease the setting of text for replication. What is the DNA-equivalent of the word processor? Biology labs engage daily in DNA processing—the creation of variations and combina... hiện toàn bộ
Computational design of digital and memory biological devices
Springer Science and Business Media LLC - Tập 1 - Trang 183-195 - 2008
Guillermo Rodrigo, Alfonso Jaramillo
The use of combinatorial optimization techniques with computational design allows the development of automated methods to design biological systems. Automatic design integrates design principles in an unsupervised algorithm to sample a larger region of the biological network space, at the topology and parameter levels. The design of novel synthetic transcriptional networks with targeted behaviors ... hiện toàn bộ
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