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Chronoimmunology: from preclinical assessments to clinical applications
Springer Science and Business Media LLC - Tập 44 - Trang 149-151 - 2022
Th17 cells in autoimmune demyelinating disease
Springer Science and Business Media LLC - Tập 32 - Trang 71-77 - 2010
Recently published studies in multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE) have demonstrated an association between the development of demyelinating plaques and the accumulation of Th17 cells in the central nervous system and periphery. However, a causal relationship has been difficult to establish. In fact, in reports published thus far, interleukin (IL)-17A deficie...... hiện toàn bộ
Functions of the aryl hydrocarbon receptor in the skin
Springer Science and Business Media LLC - Tập 35 - Trang 677-691 - 2013
Among other functions, the skin serves as the barrier against the environment and provides vital protection from physical or chemical harm and from infection. Skin cells express the aryl hydrocarbon receptor (AHR), a ligand-activated transcription factor and sensor of environmental chemicals; at the same time, AHR ligands are abundant in skin from exogenous or endogenous sources. For example, sola...... hiện toàn bộ
The origin of DCs and capacity for immunologic tolerance in central and peripheral tissues
Springer Science and Business Media LLC - Tập 39 Số 2 - Trang 137-152 - 2017
The autoinflammatory diseases: a fashion with blurred boundaries!
Springer Science and Business Media LLC - Tập 37 - Trang 359-362 - 2015
Monogenic autoinflammatory diseases are defined as a group of conditions with a clinical and biological inflammatory syndrome but little or no evidence of autoimmunity. Over 17 years have passed since the discovery of the first autoinflammatory gene, MEFV, responsible for familial Mediterranean fever. Substantive progress has been made since then, highlighting the key role of the inflammasome in t...... hiện toàn bộ
The multiple faces of leukocyte interstitial migration
Springer Science and Business Media LLC - Tập 36 - Trang 227-251 - 2014
Spatiotemporal control of leukocyte dynamics within tissues is critical for successful innate and adaptive immune responses. Homeostatic trafficking and coordinated infiltration into and within sites of inflammation and infection rely on signaling in response to extracellular cues that in turn controls a variety of intracellular protein networks regulating leukocyte motility, migration, chemotaxis...... hiện toàn bộ
Monocyte heterogeneity in cardiovascular disease
Springer Science and Business Media LLC - Tập 35 - Trang 553-562 - 2013
Only a few decades ago, students of the pathophysiology of cardiovascular disease paid little heed to the involvement of inflammation and immunity. Multiple lines of evidence now point to the participation of innate and adaptive immunity and inflammatory signaling in a variety of cardiovascular conditions. Hence, interest has burgeoned in this intersection. This review will focus on the contributi...... hiện toàn bộ
Treatment of type 2 diabetes by targeting interleukin-1: a meta-analysis of 2921 patients
Springer Science and Business Media LLC - Tập 41 - Trang 413-425 - 2019
With obesity and type 2 diabetes prevalence steadily increasing and no effective means in sight to support the population in obtaining and maintaining stable weight loss, there is an imminent need for pharmacological therapy to treat and prevent type 2 diabetes. Current anti-diabetic treatment is symptomatic, and very few drugs have both a strong preclinical rationale and clinical proof-of-princip...... hiện toàn bộ
Impacts of the apoptosis inhibitor of macrophage (AIM) on obesity-associated inflammatory diseases
Springer Science and Business Media LLC - Tập 36 - Trang 3-12 - 2013
Obesity is associated with various metabolic and cardiovascular diseases caused by chronic, low-grade inflammation that is initially observed in obese adipose tissue. In addition, many etiological studies in humans have shown a strong correlation between obesity and inflammatory autoimmune diseases. In this review, we focus on the involvement of apoptosis inhibitor of macrophage (AIM), a macrophag...... hiện toàn bộ
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