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Macrophage heterogeneity in lymphoid tissues
Springer Science and Business Media LLC - Tập 35 - Trang 541-552 - 2013
Joke M. M. den Haan, Luisa Martinez-Pomares
Macrophages in lymphoid organs exhibit a wide variety of phenotypes and functions. These cells excel in the removal of apoptotic cells that arise during the generation of immune cells and are thereby essential for the prevention of auto-immune responses. In addition to this macrophages in the secondary lymphoid organs form an important barrier for spreading of infections by phagocytosis of pathoge...... hiện toàn bộ
Immunopathogenesis of idiopathic nephrotic syndrome with relapse
Springer Science and Business Media LLC - Tập 36 - Trang 421-429 - 2014
Djillali Sahali, Kelhia Sendeyo, Melanie Mangier, Vincent Audard, Shao Yu Zhang, Philippe Lang, Mario Ollero, Andre Pawlak
Idiopathic change nephrotic syndrome (INS), the most frequent glomerular disease in children and young adults, is characterized by heavy proteinuria and a relapsing remitting course. Although the mechanisms underlying the pathophysiology of proteinuria remain unclear, clinical and experimental observations suggest that lymphocyte and podocyte disturbances are two sides of the disease. The current ...... hiện toàn bộ
Dietary and metabolic modulators of hepatic immunity
Springer Science and Business Media LLC - Tập 40 - Trang 175-188 - 2017
Antonella Carambia, Johannes Herkel
The liver is the central metabolic organ of the organism and is thus constantly exposed to gut-derived dietary and microbial antigens. The liver maintains homoeostatic tolerance to these mostly harmless antigens. However, the liver also functions as a barrier organ to harmful pathogens and is thus permissive to liver inflammation. The regulation of the delicate balance between liver tolerance and ...... hiện toàn bộ
Listeria monocytogenes: a model pathogen to study antigen-specific memory CD8 T cell responses
Springer Science and Business Media LLC - Tập 37 - Trang 301-310 - 2015
Shaniya H. Khan, Vladimir P. Badovinac
Memory CD8 T cells play a critical role in providing protection to immune hosts by orchestrating rapid elimination of pathogen-infected cells after re-infection. Systemic bacterial infection with Listeria monocytogenes has been a favored approach for researchers to characterize pathogen-specific CD8 T cell responses, and in-depth understanding of L. monocytogenes biology has provided invaluable ex...... hiện toàn bộ
AHR signaling in the development and function of intestinal immune cells and beyond
Springer Science and Business Media LLC - Tập 40 Số 4 - Trang 371-377 - 2018
Luisa Cervantes-Barragán, Marco Colonna
Role of glia and extracellular matrix in controlling neuroplasticity in the central nervous system
Springer Science and Business Media LLC - Tập 45 - Trang 377-387 - 2023
Egor Dzyubenko, Dirk M. Hermann
Neuronal plasticity is critical for the maintenance and modulation of brain activity. Emerging evidence indicates that glial cells actively shape neuroplasticity, allowing for highly flexible regulation of synaptic transmission, neuronal excitability, and network synchronization. Astrocytes regulate synaptogenesis, stabilize synaptic connectivity, and preserve the balance between excitation and in...... hiện toàn bộ
Correction to: The pathogenicity of Th17 cells in autoimmune diseases
Springer Science and Business Media LLC - Tập 41 Số 3 - Trang 299-299 - 2019
Keiko Yasuda, Yusuke Takeuchi, Keiji Hirota
Biology of interleukin-22
Springer Science and Business Media LLC - Tập 32 - Trang 17-31 - 2010
Kerstin Wolk, Ellen Witte, Katrin Witte, Katarzyna Warszawska, Robert Sabat
Interleukin (IL)-22 is a member of the IL-10 family of cytokines and represents an important effector molecule of activated Th22, Th1, and Th17 cells, as well as Tc-cell subsets, γδ T cells, natural killer (NK), and NKT cells. IL-22 mediates its effects via a heterodimeric transmembrane receptor complex consisting of IL-22R1 and IL-10R2 and subsequent Janus kinase–signal transducers and activators...... hiện toàn bộ
Complement in the pathogenesis of Alzheimer’s disease
Springer Science and Business Media LLC - Tập 40 - Trang 113-124 - 2017
B. Paul Morgan
The emergence of complement as an important player in normal brain development and pathological remodelling has come as a major surprise to most scientists working in neuroscience and almost all those working in complement. That a system, evolved to protect the host against infection, should have these unanticipated roles has forced a rethink about what complement might be doing in the brain in he...... hiện toàn bộ
Sexual dimorphism in HIV-1 infection
Springer Science and Business Media LLC - Tập 41 - Trang 195-202 - 2018
Anne Rechtien, Marcus Altfeld
Sex-specific differences affecting various aspects of HIV-1 infection have been reported, including differences in susceptibility to infection, course of HIV-1 disease, and establishment of viral reservoirs. Once infected, initial plasma levels of HIV-1 viremia in women are lower compared to men while the rates of progression to AIDS are similar. Factors contributing to these sex differences are p...... hiện toàn bộ
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