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Macrophage heterogeneity in lymphoid tissues
Springer Science and Business Media LLC - Tập 35 - Trang 541-552 - 2013
Joke M. M. den Haan, Luisa Martinez-Pomares
Macrophages in lymphoid organs exhibit a wide variety of phenotypes and functions. These cells excel in the removal of apoptotic cells that arise during the generation of immune cells and are thereby essential for the prevention of auto-immune responses. In addition to this macrophages in the secondary lymphoid organs form an important barrier for spreading of infections by phagocytosis of pathoge... hiện toàn bộ
Immunopathogenesis of idiopathic nephrotic syndrome with relapse
Springer Science and Business Media LLC - Tập 36 - Trang 421-429 - 2014
Djillali Sahali, Kelhia Sendeyo, Melanie Mangier, Vincent Audard, Shao Yu Zhang, Philippe Lang, Mario Ollero, Andre Pawlak
Idiopathic change nephrotic syndrome (INS), the most frequent glomerular disease in children and young adults, is characterized by heavy proteinuria and a relapsing remitting course. Although the mechanisms underlying the pathophysiology of proteinuria remain unclear, clinical and experimental observations suggest that lymphocyte and podocyte disturbances are two sides of the disease. The current ... hiện toàn bộ
Dietary and metabolic modulators of hepatic immunity
Springer Science and Business Media LLC - Tập 40 - Trang 175-188 - 2017
Antonella Carambia, Johannes Herkel
The liver is the central metabolic organ of the organism and is thus constantly exposed to gut-derived dietary and microbial antigens. The liver maintains homoeostatic tolerance to these mostly harmless antigens. However, the liver also functions as a barrier organ to harmful pathogens and is thus permissive to liver inflammation. The regulation of the delicate balance between liver tolerance and ... hiện toàn bộ
Listeria monocytogenes: a model pathogen to study antigen-specific memory CD8 T cell responses
Springer Science and Business Media LLC - Tập 37 - Trang 301-310 - 2015
Shaniya H. Khan, Vladimir P. Badovinac
Memory CD8 T cells play a critical role in providing protection to immune hosts by orchestrating rapid elimination of pathogen-infected cells after re-infection. Systemic bacterial infection with Listeria monocytogenes has been a favored approach for researchers to characterize pathogen-specific CD8 T cell responses, and in-depth understanding of L. monocytogenes biology has provided invaluable ex... hiện toàn bộ
Picket-fences in the plasma membrane: functions in immune cells and phagocytosis
Springer Science and Business Media LLC - Tập 40 - Trang 605-615 - 2018
Sivakami M. Mylvaganam, Sergio Grinstein, Spencer A. Freeman
Recent studies of molecular mobility in the plasma membrane have revealed that diffusion is restricted by cytoskeletal networks or fences. Transmembrane protein “pickets” that reversibly associate with the membrane-associated skeleton and with the pericellular coat impede the movement of unattached bystander molecules. While membrane picket-fences were originally described as barriers to free diff... hiện toàn bộ
Immunosenescence is both functional/adaptive and dysfunctional/maladaptive
Springer Science and Business Media LLC - Tập 42 - Trang 521-536 - 2020
T. Fulop, A. Larbi, K. Hirokawa, A. A. Cohen, J. M. Witkowski
Alterations in the immune system with aging are considered to underlie many age-related diseases. However, many elderly individuals remain healthy until even a very advanced age. There is also an increase in numbers of centenarians and their apparent fitness. We should therefore change our unilaterally detrimental consideration of age-related immune changes. Recent data taking into consideration t... hiện toàn bộ
AHR signaling in the development and function of intestinal immune cells and beyond
Springer Science and Business Media LLC - Tập 40 Số 4 - Trang 371-377 - 2018
Luisa Cervantes-Barragán, Marco Colonna
Role of glia and extracellular matrix in controlling neuroplasticity in the central nervous system
Springer Science and Business Media LLC - Tập 45 - Trang 377-387 - 2023
Egor Dzyubenko, Dirk M. Hermann
Neuronal plasticity is critical for the maintenance and modulation of brain activity. Emerging evidence indicates that glial cells actively shape neuroplasticity, allowing for highly flexible regulation of synaptic transmission, neuronal excitability, and network synchronization. Astrocytes regulate synaptogenesis, stabilize synaptic connectivity, and preserve the balance between excitation and in... hiện toàn bộ
The decidua—the maternal bed embracing the embryo—maintains the pregnancy
Springer Science and Business Media LLC - Tập 38 - Trang 635-649 - 2016
Mayumi Mori, Agnes Bogdan, Timea Balassa, Timea Csabai, Júlia Szekeres-Bartho
The decidua has been known as maternal uterine tissue, which plays essential roles in protecting the embryo from being attacked by maternal immune cells and provides nutritional support for the developing embryo prior to placenta formation. However, there are questions that still remain to be answered: (1) How does the decidua supply nutrition and provide a physical scaffold for the growing embryo... hiện toàn bộ
Intravital imaging of anti-tumor immune response and the tumor microenvironment
Springer Science and Business Media LLC - Tập 32 - Trang 305-317 - 2010
Tomasz Zal, Grzegorz Chodaczek
Tumor growth, invasiveness, and metastasis are dynamic processes involving cancer interactions with the extracellular matrix, the vasculature, and various types of non-cancerous host cells that form the tumor stroma. An often-present stromal component is the immune cells, such as tumor-associated myeloid and lymphocytic infiltrates, yet endogenous anti-tumor immune responses are typically ineffect... hiện toàn bộ
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