Immunopathogenesis of idiopathic nephrotic syndrome with relapse

Springer Science and Business Media LLC - Tập 36 - Trang 421-429 - 2014
Djillali Sahali1,2,3, Kelhia Sendeyo2, Melanie Mangier2, Vincent Audard1,2, Shao Yu Zhang2, Philippe Lang1,2, Mario Ollero2, Andre Pawlak2
1Service de Néphrologie et Transplantation, AP-HP, CHU Henri Mondor, Creteil, France
2INSERM U955, UFR Paris-Est Creteil, Creteil, France
3Inserm U955, Hôpital Henri Mondor, Créteil, France

Tóm tắt

Idiopathic change nephrotic syndrome (INS), the most frequent glomerular disease in children and young adults, is characterized by heavy proteinuria and a relapsing remitting course. Although the mechanisms underlying the pathophysiology of proteinuria remain unclear, clinical and experimental observations suggest that lymphocyte and podocyte disturbances are two sides of the disease. The current hypothesis suggests that immune cells release a putative factor, which alters podocyte function resulting in nephrotic proteinuria. Besides T-cell abnormalities, recent evidence of B-cell depletion efficacy in sustained remissions added a new challenge in understanding the immunological mechanisms of INS. In this review, we discuss recent insights related to podocyte disorders occurring in INS and their relevance in human diseases.

Tài liệu tham khảo

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