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NBS-ARC domain sequence variations in RX1 homologues of cultivated and wild potato species
Springer Science and Business Media LLC - Tập 46 - Trang 107-109 - 2012
K. V. Boris, N. N. Ryzhova, E. Z. Kochieva
The NBS-ARC domain sequences of Rx1 homologues were characterized in ten accessions of cultivated and wild potato species differing in their susceptibility to potato virus X. The NBS-ARC domain sequences studied contained a number of indels and nucleotide substitutions, some of them resulting in amino acid substitutions in the conserved motifs of the domain. There were no direct associations betwe...... hiện toàn bộ
Association of SLC18A1, TPH1, and RELN gene polymorphisms with risk of paranoid schizophrenia
Springer Science and Business Media LLC - Tập 48 - Trang 546-555 - 2014
D. Yu. Galaktionova, A. E. Gareeva, E. K. Khusnutdinova, T. V. Nasedkina
A biochip was developed to examine the polymorphisms of genes associated with schizophrenia risk, including DISC1, RELN, ZNF804A, PLXNA2, COMT, SLC18A1, CACNA1C, ANK2, TPH1, PLAA, and SNAP-25. Allele and genotype frequencies of the genes were determined in 198 schizophrenics and 192 healthy subjects from Bashkortostan (ethnic Russians and Tatars). The frequencies of allele A (p = 0.007) and genoty...... hiện toàn bộ
Phân Tích Các Đột Biến Dị Thường Của Gen Bệnh Huntington Trong Các Dân Tộc Ở Khu Vực Volga–Ural Dịch bởi AI
Springer Science and Business Media LLC - Tập 37 - Trang 818-826 - 2003
I. A. Kutuev, R. I. Fatkhlislamova, I. M. Khidiyatova, E. K. Khusnutdinova
Mười một quần thể của khu vực Volga–Ural đã được phân tích liên quan đến ba đột biến nội gen của gen bệnh Huntington (IT15), bao gồm đột biến cực kỳ đa hình (CAG)n và đột biến đa hình ở mức độ vừa (CCG)n của exon 1, và đột biến trung tính del2642 của exon 58. Đối với (CAG)n, đã quan sát 101 kiểu gen, với số lượng kiểu gen thay đổi từ 15 ở người Bashkir Đông Nam đến 34 ở người Mari. Độ đa dạng alen...... hiện toàn bộ
#bệnh Huntington #đa hình gen #quần thể dân tộc #khu vực Volga–Ural #alen.
Genomic organization of a tumor growth inhibitor geneING1
Springer Science and Business Media LLC - Tập 34 - Trang 232-236 - 2000
A. V. Baranova, D. V. Ivanov, N. V. Makeeva, M. Corcoran, E. A. Nikitin, T. A. Borodina, A. B. Poltaraus, O. Glinshchikova, A. B. Soudarikov, D. Oscier, N. K. Yankovsky
ING1, a supposed tumor suppressor gene, codes for a p33 protein involved in cell proliferation control and regulation of apoptosis. A GenBank search revealed two groups of expressed sequence tags corresponding toING1 mRNA forms. The 3′ exon 2 is the same in both forms whereas the 5′ exons 1a and 1b differ.ING1-containing cosmids were found in the LA13NC05 library. EachING1...... hiện toàn bộ
Replication of the Baculovirus Genome
Springer Science and Business Media LLC - Tập 37 - Trang 250-259 - 2003
V. S. Mikhailov
The review describes the current state of studying the baculovirus DNA replication. The structural organization of replication initiation sites and replication intermediates are considered. Attention is focused on virus replication factors, including DNA polymerase, helicase, IE-1, LEF-1, LEF-2, and LEF-3.
Comparative Study of the M.BstF5I-1 and M.BstF5I-3 DNA Methyltransferases from the Bacillus stearothermophilus F5 Restriction–Modification System
Springer Science and Business Media LLC - Tập 36 - Trang 110-116 - 2002
N. A. Netesova, L. N. Golikova, L. G. Ovetchkina, A. A. Evdokimov, E. G. Malygin, N. S. Gololobova, D. A. Gonchar, S. Kh. Degtyarev
The BstF5I restriction–modification system from Bacillus stearothermophilus F5, unlike all known restriction–modification systems, contains three genes encoding DNA methyltransferases. In addition to revealing two DNA methylases responsible for modification of adenine in different DNA strands, it has been first shown that one bacterial cell has two DNA methylases, M.BstF5I-1 and M.BstF5I-3, with s...... hiện toàn bộ
Phylogeny and evolution of the ribulose 1,5-bisphosphate carboxylase/oxygenase genes in prokaryotes
Springer Science and Business Media LLC - - 2009
T. P. Tourova, Elizaveta M. Spiridonova
Combinatorial libraries of phage antibodies: Application for analysis of gene segments encoding variable domains of autoantibodies to tumor necrosis factor
Springer Science and Business Media LLC - Tập 45 - Trang 82-92 - 2011
M. A. Vikhrova, V. V. Morozova, Ya. A. Khlusevich, N. V. Tikunova
Twenty unique phage antibodies to human tumor necrosis factor alpha were selected from a naive combinatorial library of human single chain variable fragments. Analysis of gene segments encoding selected antibodies showed that the repertoire of variable domains of heavy and light chains included variable domains of both naive autoantibodies and antibodies produced through somatic hypermutation.
The Effect of Ca2+ Ions on DNA Compaction in the Complex with HMGB1 Nonhistone Chromosomal Protein
Springer Science and Business Media LLC - Tập 38 - Trang 590-600 - 2004
A. M. Polyanichko, E. V. Chikhirzhina, V. V. Andrushchenko, E. I. Kostyleva, H. Wieser, V. I. Vorob'ev
The analysis of absorption and circular dichroism spectra in UV and IR regions showed that Ca2+ ions interact with the phosphate groups of DNA and the HMGB1 protein. Not only the negatively charged C-terminal part of the protein molecule, but also its DNA-binding domains participate in the interaction with metal ions. The latter leads to a change in the mode of protein–DNA interaction. The presenc...... hiện toàn bộ
Substrate-binding properties of the family 54 module of Clostridium thermocellum Lic16A laminarinase
Springer Science and Business Media LLC - Tập 44 - Trang 591-595 - 2010
I. A. Dvortsov, N. A. Lunina, V. V. Zverlov, G. A. Velikodvorskaya
Endo-β-1.3–1.4-glucanase Lic16A of the moderate thermophilic anaerobe Clostridium thermocellum has a complex multimodular structure. In addition to the catalytic module, Lic16A contains eight auxiliary modules, five of which are substrate-binding modules. The new family 54 substrate-binding module CBM54 (25.2 kDa), which is at the N terminus of the enzyme, has a cleavage site in its N-terminal par...... hiện toàn bộ
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