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NMR Study of Complexation of Aromatic Ligands with Heptadeoxynucleotide 5"-d(GCGAAGC) Forming Stable Hairpin Structure in Aqueous Solution
Springer Science and Business Media LLC - Tập 36 - Trang 708-717 - 2002
A. N. Veselkov, R. J. Eaton, A. V. Semanin, V. I. Pakhomov, L. N. Djimant, L. Karawaew, D. B. Davies
Complex formation of hairpin-producing heptadeoxynucleotide 5"-d(GCGAAGC) with aromatic molecules: acridine dye proflavine and anthracycline antibiotic daunomycin was studied by one-dimensional 1H NMR and two-dimensional correlation 1H–1H (2D-TOCSY, 2D-NOESY), 1H–31P (2D-HMBC) NMR spectroscopy (500 and 600 MHz) in aqueous solution. Concentration and temperature dependences for the chemical shifts ...... hiện toàn bộ
Main regulatory element (MRE) of the Danio rerio α/β-globin gene domain exerts enhancer activity toward the promoters of the embryonic-larval and adult globin genes
Springer Science and Business Media LLC - - 2016
Anastasia P. Kovina, Н. В. Петрова, Sergey V. Razin, O. V. Yarovaia
Ebola hemorrhagic fever: Properties of the pathogen and development of vaccines and chemotherapeutic agents
Springer Science and Business Media LLC - Tập 49 - Trang 480-493 - 2015
O. I. Kiselev, A. V. Vasin, M. P. Shevyryova, E. G. Deeva, K. V. Sivak, V. V. Egorov, V. B. Tsvetkov, A. Yu. Egorov, E. A. Romanovskaya-Romanko, L. A. Stepanova, A. B. Komissarov, L. M. Tsybalova, G. M. Ignatjev
Ebola hemorrhagic fever (EHF) epidemic currently ongoing in West Africa is not the first among numerous epidemics in the continent. Yet it seems to be the worst EHF epidemic outbreak caused by Ebola virus Zaire since 1976 as regards its extremely large scale and rapid spread in the population. Experiments to study the agent have continued for more than 20 years. The EHF virus has a relatively simp...... hiện toàn bộ
The ATPase subunit 6 gene of Leptomonas seymouri (Trypanosomatidae) is transcribed and edited as a polycistronic mRNA
Springer Science and Business Media LLC - Tập 39 - Trang 53-57 - 2005
E. A. Bessolitsina, A. V. Fedyakov, E. M. Merzlyak, A. A. Kolesnikov
The maturation of mRNA was studied for the Leptomonas seymouri mitochondrial A6 gene coding for ATPase subunit 6. RT-PCR showed that the cytochrome b and A6 genes are transcribed to produce a polycistronic RNA. The RT-PCR products, containing the cDNAs of these genes, were cloned and sequenced. Comparison of the sequence for 12 clones revealed four types of transcripts representing partly or compl...... hiện toàn bộ
Calculations of DNA Condensation Caused by Ligand Adsorption
Springer Science and Business Media LLC - - 2001
V. B. Teif, D. Yu. Lando
A method for calculating the curves of DNA transition from linear to condensed state upon binding of condensing ligands has been developed. The character of the transition and ligand concentration necessary for condensation have been shown to be governed by the length of DNA molecule, energy and stoichiometry parameters of the DNA–ligand complex (equilibrium constant between linear and condensed f...... hiện toàn bộ
Chromatin structure and transcription regulation in Saccharomyces cerevisiae
Springer Science and Business Media LLC - Tập 44 - Trang 856-869 - 2010
S. A. Osipov, O. V. Preobrazhenskaya, V. L. Karpov
The nucleosome organization of eukaryotic chromatin determines the DNA accessibility for regulatory factors during transcription. Nucleosome positioning at promoters is an important factor that affects gene expression. Recent studies showed that yeast promoters can be divided into two groups differing in chromatin organization. It became clear that genes with similar chromatin structures in the pr...... hiện toàn bộ
Regulation of m6A RNA Methylation and Its Effect on Myogenic Differentiation in Murine Myoblasts
Springer Science and Business Media LLC - Tập 53 - Trang 384-392 - 2019
J. N. Chen, Y. Chen, Y. Y. Wei, M. A. Raza, Q. Zou, X. Y. Xi, L. Zhu, G. Q. Tang, Y. Z. Jiang, X. W. Li
N6-methyladenosine (m6A) has been identified as a conserved epitranscriptomic modification of eukaryotic mRNAs, and plays important biological roles in the regulation of cellular metabolic processes. However, its role in myogenic differentiation is unclear. Here, we altered the m6A RNA methylation level by overexpression of METTL3, and explored the effect of m6A RNA methylation on myogenic differe...... hiện toàn bộ
Molecular Structure of the Lactobacillus plantarum Sucrose Utilization Locus: Comparison with Pediococcus pentosaceus
Springer Science and Business Media LLC - Tập 35 - Trang 15-22 - 2001
D. G. Naumoff, V. A. Livshits
Structure of the sucrose utilization locus in a Lactobacillus plantarum type strain was studied using PCR and Southern hybridization. Restriction map analysis revealed its high similarity to the sequenced sucrose utilization locus of Pediococcus pentosaceus pSRQ1. The L. plantarum locus proved to contain oppositely oriented scrA and the scrBRagl operon, but not agaS. The L. plantarum sucrase gene ...... hiện toàn bộ
Conformational States of the Water-Soluble Fragment of Cytochrome b5. I. pH-Induced Denaturation
Springer Science and Business Media LLC - Tập 36 - Trang 718-725 - 2002
L. V. Basova, N. B. Ilyina, K. S. Vassilenko, E. I. Tiktopulo, V. E. Bychkova
Cytochrome b 5 is a membrane protein that comprises two fragments: one is water-soluble and heme-containing, and the other is hydrophobic and membrane-embedded. The function of electron transfer is performed by the former whose crystal structure is known; however, its conformational states when in the membrane field and interacting with other proteins are still to be studied. Previously, we propos...... hiện toàn bộ
Ribonuclease binase induces death in T-cell acute lymphoblastic leukemia cells by apoptosis
Springer Science and Business Media LLC - Tập 50 - Trang 302-306 - 2016
K. M. Burnysheva, I. Yu. Petrushanko, P. V. Spirin, V. S. Prassolov, A. A. Makarov, V. A. Mitkevich
Bacterial ribonuclease binase is a potential anticancer agent. In the present study, we have determined the toxic effect of binase towards cell lines of T-cell acute lymphoblastic leukemia Jurkat and CEMss. We have shown that binase induces apoptosis in these cells. At the same time, binase does not cause toxic effects in leukocytes of healthy donors, which suggests that binase activity towards le...... hiện toàn bộ
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