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Mitochondrial genetic apparatus functioning in mice spleen cells under radiation-induced apoptosis
Springer Science and Business Media LLC - Tập 44 - Trang 915-922 - 2010
N. E. Gubina, E. V. Evdokimovsky, T. E. Ushakova
The important role of mitochondria in the process of programmed cell death is widely accepted now. There is a set of nuclear-encoded mitochondrial proteins involved in this process. Apart from this, a mitochondrion contains its own genetic apparatus comprising mtDNA and replication, transcription, and translation systems. However, a mechanism of mitochondria genetic information realization under a...... hiện toàn bộ
Ribosomal Antibiotics
Springer Science and Business Media LLC - Tập 35 - Trang 509-520 - 2001
A. S. Mankin
In spite of decades of research, our understanding of the principles of antibiotic binding to the ribosome and the mechanisms of drug action remains only fragmentary. Recent progress in biochemical and genetic studies of some “old” and new antibiotics and the availability of high-resolution structures of the ribosome subunits allows mapping the antibiotic-binding sites at atomic resolution. In thi...... hiện toàn bộ
Detecting shared pathways linked to rheumatoid arthritis with other autoimmune diseases in a in silico analysis
Springer Science and Business Media LLC - Tập 50 Số 3 - Trang 462-469 - 2016
Weiying Zheng, Lin Hua
Preparing of single-stranded DNA in single-stage PCR with low-melt excess primer for hybridization on biochips
Springer Science and Business Media LLC - Tập 45 - Trang 237-240 - 2011
D. O. Fesenko, A. E. Kornienko, A. V. Chudinov, T. V. Nasedkina
A method for fluorescently labeled single-stranded DNA (ssDNA) production during single-stage polymerase chain reaction (PCR) for subsequent hybridization on a biochip was described. This approach, whose efficiency was confirmed in the case of DARC gene, is considered as an alternative to two-stage nested PCR, consisting of two separate reactions: symmetric and asymmetric. Implementation of PCR in...... hiện toàn bộ
Experimental Molecular Design of Combined Vaccines
Springer Science and Business Media LLC - Tập 37 - Trang 464-467 - 2003
L. R. Lebedev, E. P. Goncharova, A. A. Sizov, L. E. Bulychev, A. M. Odegov, A. B. Ryzhikov
A method was elaborated to construct combined artificial immunogens simulating virus particles. The gist was exposing protein antigenic determinants of one virus on the particle surface and delivering plasmids with genes for antigenic proteins of another virus to specialized immune cells. Such immunogens were constructed and shown to induce biosynthesis of specific antibodies against HIV-1 and the...... hiện toàn bộ
Novel strategies to clone identical and distinct DNA sequences for several complex genomes
Springer Science and Business Media LLC - Tập 34 - Trang 521-534 - 2000
E. R. Zabarovsky
In this minireview I briefly describe the new methods suggested for cloning sequences identical by descent, homo-or hemizygously deleted, amplified or polymorphic, and compare them with the most efficient techniques developed earlier. The new methods include cloning of identical sequences (CIS), cloning of polymorphic sequences (COP), and cloning of deleted sequences (CODE). Although these methods...... hiện toàn bộ
Oncolytic Properties of a Mumps Virus Vaccine Strain in Human Melanoma Cell Lines
Springer Science and Business Media LLC - Tập 52 - Trang 570-576 - 2018
Y. I. Ammour, O. O. Ryabaya, A. V. Milovanova, A. V. Sidorov, I. E. Shohin, V. V. Zverev, T. V. Nasedkina
The oncolytic potential of the attenuated mumps virus (MV) vaccine strain Leningrad-3 (L-3) was evaluated in a panel of four human metastatic melanoma cell lines. The lines were shown to be susceptible and permissive to MV infection. Efficient MV replication led to death of melanoma cells, but the effect differed among the cell lines. Possible mechanisms mediating the selectivity of MV L-3 towards...... hiện toàn bộ
Proteomic Profile of the Bacterium Sinorhizobium meliloti Depends on Its Life Form and Host Plant Species
Springer Science and Business Media LLC - Tập 52 - Trang 779-785 - 2018
K. S. Antonets, O. P. Onishchuk, O. N. Kurchak, K. V. Volkov, A. N. Lykholay, E. A. Andreeva, E. E. Andronov, A. G. Pinaev, N. A. Provorov, A. A. Nizhnikov
Abstract—The importance of root nodule bacteria in biotechnology is determined by their distinctive feature: symbiotic nitrogen fixation resulting in the production of organic nitrogen-containing compounds. While interacting with host legume plants, the cells of these bacteria undergo global changes at all levels of expression of genetic information leading to the formation in root nodules of so-c...... hiện toàn bộ
SIVA1 Regulates the Stability of Single-Stranded DNA-Binding Protein 3 Isoforms
Springer Science and Business Media LLC - Tập 52 - Trang 707-714 - 2018
Z. Yin, K. Zhang, X. Peng, Z. Jiang, W. Yuan, Y. Wang, Y. Li, X. Ye, Y. Dong, Y. Wan, B. Ni, P. Zhu, X. Fan, X. Wu, X. Mo
The assembly of LIM-homeodomain (LIM-HD) transcriptional complex plays important roles in early neuronal development. The stability of LIM-HD is controlled by single-strand binding protein 3 (SSBP3) via a cascade mechanism protecting it from proteasomal degradation. The expression level of SSBP3 has to be precisely regulated. Although a decrease of SSBP3 level is associated with several diseases, ...... hiện toàn bộ
Comparison of Aberrant Methylation of CpG Islands in the p16/CDKN2A and p14/ARF Promoters in Non-Small Cell Lung Cancer and Acute Lymphoblastic Leukemia
Springer Science and Business Media LLC - - 2004
V. V. Zemlyakova, В. В. Стрельников, I. B. Zborovskaya, O. V. Balukova, О. А. Майорова, Е. В. Васильев, D. V. Zaletaev, М. В. Немцова
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