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Role of neurotrophins and neurotrophin receptors in the in vitro invasion and heparanase production of human prostate cancer cells
Springer Science and Business Media LLC - Tập 17 - Trang 307-314 - 1999
E. Timothy Walch, Dario Marchetti
The role of the neurotrophins (NTs) and their corresponding receptors (NTRs) TrkA, TrkB, TrkC, and p75NTR in neoplasia has received relatively little attention. However, because malignant cell migration within the prostate occurs predominantly by direct extension around prostatic nerves, the presence and possible upregulation of NTs from autocrine/paracrine sources and NTR expression within prosta... hiện toàn bộ
Interaction between lung cancer cells and astrocytes via specific inflammatory cytokines in the microenvironment of brain metastasis
Springer Science and Business Media LLC - Tập 28 - Trang 13-25 - 2010
Toshihiro Seike, Kyota Fujita, Yukiko Yamakawa, Mizuho A. Kido, Soichi Takiguchi, Norihiro Teramoto, Haruo Iguchi, Mami Noda
The incidence of brain metastasis is increasing, however, little is known about molecular mechanism responsible for lung cancer-derived brain metastasis and their development in the brain. In the present study, brain pathology was examined in an experimental model system of brain metastasis as well as in human brain with lung cancer metastasis. In an experimental model, after 3–6 weeks of intracar... hiện toàn bộ
Molecular alterations as target for therapy in metastatic osteosarcoma: a review of literature
Springer Science and Business Media LLC - Tập 28 - Trang 493-503 - 2011
J. PosthumaDeBoer, M. A. Witlox, G. J. L. Kaspers, B. J. van Royen
Treating metastatic osteosarcoma (OS) remains a challenge in oncology. Current treatment strategies target the primary tumour rather than metastases and have a limited efficacy in the treatment of metastatic disease. Metastatic cells have specific features that render them less sensitive to therapy and targeting these features might enhance the efficacy of current treatment. A detailed study of th... hiện toàn bộ
Revealing the concealed: A tribute to Donald L. Morton, MD
Springer Science and Business Media LLC -
S. David Nathanson, Ian Wood
Diagnostic and prognostic significance of flow cytometry immunophenotyping in patients with leptomeningeal carcinomatosis
Springer Science and Business Media LLC - Tập 32 - Trang 383-391 - 2015
D. Subirá, M. Simó, J. Illán, C. Serrano, S. Castañón, R. Gonzalo, J. J. Granizo, M. Martínez-García, M. Navarro, J. Pardo, J. Bruna
Some patients with epithelial-cell cancers develop leptomeningeal carcinomatosis (LC), a severe complication difficult to diagnose and with an adverse prognosis. This study explores the contribution of flow cytometry immunophenotyping (FCI) to the diagnosis and prognosis of LC. Cerebrospinal fluid (CSF) samples from patients diagnosed with LC were studied using FCI. Expression of the epithelial-ce... hiện toàn bộ
Dietary 4-HPR suppresses the development of bone metastasis in vivo in a mouse model of prostate cancer progression
Springer Science and Business Media LLC - Tập 18 - Trang 429-438 - 2000
Mohammad R. Shaker, Guang Yang, Terry L. Timme, Sang H. Park, Dov Kadmon, Chengzhen Ren, Xiaorong Ji, Hon-Man Lee, Inder Sehgal, Mario Anzano, Michael B. Sporn, Timothy C. Thompson
The effects of the synthetic retinoid N-(4-hydroxyphenyl) retinamide (4-HPR) on prostate cancer metastasis in vivo were evaluated in the mouse prostate reconstitution (MPR) model. MPRs were produced by infection of either heterozygous (+/−) or nullizygous (−/−) p53-mutant fetal prostatic epithelial cells with the recombinant retrovirus Zipras/myc 9. Previous studies have documented that loss of p5... hiện toàn bộ
Is survival really better after repeated lung metastasectomy?
Springer Science and Business Media LLC - Tập 38 Số 1 - Trang 73-75 - 2021
Francesca Fiorentino, Tom Treasure
Use of RNA interference to inhibit integrin (α6β4)-mediated invasion and migration of breast carcinoma cells
Springer Science and Business Media LLC - Tập 20 - Trang 569-576 - 2003
Elizabeth A. Lipscomb, Aisling S. Dugan, Isaac Rabinovitz, Arthur M. Mercurio
The application of small interfering RNA (siRNA) oligonucleotides to silence gene expression has profound implications for the intervention of human diseases including cancer. Using this technique, we explored the possibility that the α6β4 integrin, a laminin adhesion receptor with a recognized role in the invasive phenotype of many carcinomas, represents a potential therapeutic target to inhibit ... hiện toàn bộ
Mass spectrometry-based proteomic capture of proteins bound to the MACC1 promoter in colon cancer
Springer Science and Business Media LLC - - 2020
Ya‐Hui Huang, Yong‐Bing Xiang, Zheng Xie, Yuxiang Cai, Qiongzhi Yang, Huichao Huang, Zhuchu Chen, Zhefeng Xiao, Qiaojun He
Chemically modified tetracyclines inhibit human melanoma cell invasion and metastasis
Springer Science and Business Media LLC - - 1998
Richard E. B. Seftor, Elisabeth A. Seftor, Joseph E. De Larco, David E. Kleiner, Jill Leferson, William G. Stetler-Stevenson, Thomas F. McNamara, Lorne M. Golub, Mary J. C. Hendrix
Recent work has shown that chemically modified tetracyclines (CMTs) are potent inhibitors of matrix metal-loproteinase (MMP) activity, both in vitro and in vivo, which is distinct from their antimicrobial activities (Golub et al. Crit Rev Oral Biol Med, 2, 297-321, 1991; Ryan et al. Curr Opin Rheumatol, 8, 238-47, 1996). The process of tumor cell invasion requires MMP-mediated degradation of extra... hiện toàn bộ
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