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Interaction between gut microbiota and sex hormones and their relation to sexual dimorphism in metabolic diseases
Springer Science and Business Media LLC - Tập 14 - Trang 1-24 - 2023
Jose Antonio Santos-Marcos, Marina Mora-Ortiz, Manuel Tena-Sempere, Jose Lopez-Miranda, Antonio Camargo
Metabolic diseases, such as obesity, metabolic syndrome (MetS) and type 2 diabetes (T2D), are now a widespread pandemic in the developed world. These pathologies show sex differences in their development and prevalence, and sex steroids, mainly estrogen and testosterone, are thought to play a prominent role in this sexual dimorphism. The influence of sex hormones on these pathologies is not only r...... hiện toàn bộ
The science of sex and gender in human health: online courses to create a foundation for sex and gender accountability in biomedical research and treatment
Springer Science and Business Media LLC - - 2016
Jennifer L. Plank-Bazinet, Annie Sampson, Leah Miller, Emmanuel O. Fadiran, Deborah L. Kallgren, Rajeev Agarwal, Whitney Barfield, Claudette E. Brooks, Lisa Begg, Amy C. Mistretta, Pamela E. Scott, Janine Austin Clayton, Terri L. Cornelison
Interactive effects of asparagine and aspartate homeostasis with sex and age for the risk of type 2 diabetes risk
Springer Science and Business Media LLC - - 2020
Hao Luo, Xiaofei Feng, Xilin Yang, Ruiqin Hou, Zhong‐Ze Fang
Abstract Background Asparagine and aspartate homeostasis are linked with type 2 diabetes (T2D). This study aimed to explore whether asparagine and aspartate metabolism interacted with sex and age to increase the risk of T2D. Methods From 27 May 2015 to 3 August 2016, ...... hiện toàn bộ
Phân tích mạng lưới của các động mạch vành trước trái ở chuột bơi lội được đào tạo bằng kỹ thuật vi mô video tại chỗ Dịch bởi AI
Springer Science and Business Media LLC - Tập 12 - Trang 1-17 - 2021
Marianna Török, Petra Merkely, Anna Monori-Kiss, Eszter Mária Horváth, Réka Eszter Sziva, Borbála Péterffy, Attila Jósvai, Alex Ali Sayour, Attila Oláh, Tamás Radovits, Béla Merkely, Nándor Ács, György László Nádasy, Szabolcs Várbíró
Chúng tôi nhằm mục đích xác định sự khác biệt về giới tính trong các đặc điểm mạng lưới và nhận biết tác động của sự thay đổi hình học do tập bơi lâu dài trong mô hình chuột bị tăng huyết áp thất trái (LV) do tập thể dục. Ba mươi tám con chuột Wistar được chia thành bốn nhóm: nhóm ngồi yên đực, nhóm ngồi yên cái, nhóm tập thể dục đực và nhóm tập thể dục cái. Sau các buổi tập, hình thái và chức năn...... hiện toàn bộ
#giới tính #tăng huyết áp thất trái #bơi lội #động mạch vành #vi hình học video #tái cấu trúc mạch máu
Sex-based differences in growth-related IGF1 signaling in response to PAPP-A2 deficiency: comparative effects of rhGH, rhIGF1 and rhPAPP-A2 treatments
Springer Science and Business Media LLC -
María del Mar Fernández‐Arjona, Juan Antonio Micó Navarro, Antonio J. López-Gambero, Marialuisa de Ceglia, Miguel Rodríguez, Leticia Rubio, Fernando Rodrı́guez de Fonseca, Vicente Barrios, Julie A. Chowen, Jesús Argente, Patricia Rivera, Juan Suárez
Abstract Background Children with pregnancy-associated plasma protein-A2 (PAPP-A2) mutations resulting in low levels of bioactive insulin-like growth factor-1 (IGF1) and progressive postnatal growth retardation have improved growth velocity and height following recombinant...... hiện toàn bộ
In utero origin of sex-related differences in future cardiovascular disease
Springer Science and Business Media LLC - Tập 7 - Trang 1-7 - 2016
Sarah Schalekamp-Timmermans, Jerome Cornette, Albert Hofman, Willem A. Helbing, Vincent W. V. Jaddoe, Eric A. P. Steegers, Bero O. Verburg
There are sex differences in the risk of development of cardiovascular disease (CVD). According to the developmental origins of health and disease paradigm (DOHaD), CVD originates in fetal life. This study examines fetal sex differences in cardiovascular development in utero. In 1028 pregnant women, we assessed fetal circulation using pulsed wave Doppler examinations between 28 and 34 weeks gestat...... hiện toàn bộ
Genetic sex determination of mice by simplex PCR
Springer Science and Business Media LLC - Tập 8 - Trang 1-4 - 2017
Simon James Tunster
Investigating fetal development in mice necessitates the determination of fetal sex. However, whilst the sex of adult and juvenile mice can be readily distinguished from anogenital distance, the sex of fetal and neonatal mice cannot be identified visually. Instead, genetic sex must be determined by PCR amplification of X chromosome genes with divergent Y chromosome gametologs. Existing simplex PCR...... hiện toàn bộ
Nrf2 activation rescues stress-induced depression-like behaviour and inflammatory responses in male but not female rats
Springer Science and Business Media LLC - Tập 15 - Trang 1-19 - 2024
Ryan T. McCallum, Rachel-Karson Thériault, Joshua D. Manduca, Isaac S. B. Russell, Angel M. Culmer, Janan Shoja Doost, Tami A. Martino, Melissa L. Perreault
Major depressive disorder (MDD) is a recurring affective disorder that is two times more prevalent in females than males. Evidence supports immune system dysfunction as a major contributing factor to MDD, notably in a sexually dimorphic manner. Nuclear factor erythroid 2-related factor 2 (Nrf2), a regulator of antioxidant signalling during inflammation, is dysregulated in many chronic inflammatory...... hiện toàn bộ
The elimination half-life of crystalloid fluid is shorter in female than in male volunteers: a retrospective population kinetic analysis
Springer Science and Business Media LLC - - 2016
Robert G. Hahn
Sex differences in the transcriptome of extracellular vesicles secreted by fetal neural stem cells and effects of chronic alcohol exposure
Springer Science and Business Media LLC - Tập 14 - Trang 1-31 - 2023
Dae D. Chung, Amanda H. Mahnke, Marisa R. Pinson, Nihal A. Salem, Michael S. Lai, Natalie P. Collins, Andrew E. Hillhouse, Rajesh C. Miranda
Prenatal alcohol (ethanol) exposure (PAE) results in brain growth restriction, in part, by reprogramming self-renewal and maturation of fetal neural stem cells (NSCs) during neurogenesis. We recently showed that ethanol resulted in enrichment of both proteins and pro-maturation microRNAs in sub-200-nm-sized extracellular vesicles (EVs) secreted by fetal NSCs. Moreover, EVs secreted by ethanol-expo...... hiện toàn bộ
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