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Interaction between gut microbiota and sex hormones and their relation to sexual dimorphism in metabolic diseases
Springer Science and Business Media LLC - Tập 14 - Trang 1-24 - 2023
Jose Antonio Santos-Marcos, Marina Mora-Ortiz, Manuel Tena-Sempere, Jose Lopez-Miranda, Antonio Camargo
Metabolic diseases, such as obesity, metabolic syndrome (MetS) and type 2 diabetes (T2D), are now a widespread pandemic in the developed world. These pathologies show sex differences in their development and prevalence, and sex steroids, mainly estrogen and testosterone, are thought to play a prominent role in this sexual dimorphism. The influence of sex hormones on these pathologies is not only r...... hiện toàn bộ
Phân tích mạng lưới của các động mạch vành trước trái ở chuột bơi lội được đào tạo bằng kỹ thuật vi mô video tại chỗ Dịch bởi AI
Springer Science and Business Media LLC - Tập 12 - Trang 1-17 - 2021
Marianna Török, Petra Merkely, Anna Monori-Kiss, Eszter Mária Horváth, Réka Eszter Sziva, Borbála Péterffy, Attila Jósvai, Alex Ali Sayour, Attila Oláh, Tamás Radovits, Béla Merkely, Nándor Ács, György László Nádasy, Szabolcs Várbíró
Chúng tôi nhằm mục đích xác định sự khác biệt về giới tính trong các đặc điểm mạng lưới và nhận biết tác động của sự thay đổi hình học do tập bơi lâu dài trong mô hình chuột bị tăng huyết áp thất trái (LV) do tập thể dục. Ba mươi tám con chuột Wistar được chia thành bốn nhóm: nhóm ngồi yên đực, nhóm ngồi yên cái, nhóm tập thể dục đực và nhóm tập thể dục cái. Sau các buổi tập, hình thái và chức năn...... hiện toàn bộ
#giới tính #tăng huyết áp thất trái #bơi lội #động mạch vành #vi hình học video #tái cấu trúc mạch máu
Sex-based differences in growth-related IGF1 signaling in response to PAPP-A2 deficiency: comparative effects of rhGH, rhIGF1 and rhPAPP-A2 treatments
Springer Science and Business Media LLC -
María del Mar Fernández‐Arjona, Juan Antonio Micó Navarro, Antonio J. López-Gambero, Marialuisa de Ceglia, Miguel Rodríguez, Leticia Rubio, Fernando Rodrı́guez de Fonseca, Vicente Barrios, Julie A. Chowen, Jesús Argente, Patricia Rivera, Juan Suárez
Abstract Background Children with pregnancy-associated plasma protein-A2 (PAPP-A2) mutations resulting in low levels of bioactive insulin-like growth factor-1 (IGF1) and progressive postnatal growth retardation have improved growth velocity and height following recombinant...... hiện toàn bộ
Sex differences in the transcriptome of extracellular vesicles secreted by fetal neural stem cells and effects of chronic alcohol exposure
Springer Science and Business Media LLC - Tập 14 - Trang 1-31 - 2023
Dae D. Chung, Amanda H. Mahnke, Marisa R. Pinson, Nihal A. Salem, Michael S. Lai, Natalie P. Collins, Andrew E. Hillhouse, Rajesh C. Miranda
Prenatal alcohol (ethanol) exposure (PAE) results in brain growth restriction, in part, by reprogramming self-renewal and maturation of fetal neural stem cells (NSCs) during neurogenesis. We recently showed that ethanol resulted in enrichment of both proteins and pro-maturation microRNAs in sub-200-nm-sized extracellular vesicles (EVs) secreted by fetal NSCs. Moreover, EVs secreted by ethanol-expo...... hiện toàn bộ
Sex differences in stress and immune responses during confinement in Antarctica
Springer Science and Business Media LLC - Tập 10 - Trang 1-17 - 2019
C. Strewe, D. Moser, J.-I. Buchheim, H.-C. Gunga, A. Stahn, B. E. Crucian, B. Fiedel, H. Bauer, P. Gössmann-Lang, D. Thieme, E. Kohlberg, A. Choukèr, M. Feuerecker
Antarctica challenges human explorers by its extreme environment. The effects of these unique conditions on the human physiology need to be understood to best mitigate health problems in Antarctic expedition crews. Moreover, Antarctica is an adequate Earth-bound analogue for long-term space missions. To date, its effects on human physiology have been studied mainly in male cohorts though more fema...... hiện toàn bộ
Role for ovarian hormones in purinoceptor-dependent natriuresis
Springer Science and Business Media LLC - Tập 11 - Trang 1-10 - 2020
Eman Y. Gohar, Malgorzata Kasztan, Shali Zhang, Edward W. Inscho, David M. Pollock
Premenopausal women have a lower risk of hypertension compared to age-matched men and postmenopausal women. P2Y2 and P2Y4 purinoceptor can be considered potential contributors to hypertension due to their emerging roles in regulating renal tubular Na+ transport. Activation of these receptors inhibits epithelial Na+ channel activity (ENaC) via a phospholipase C (PLC)-dependent pathway resulting in ...... hiện toàn bộ
Sex differences and the role of IL-10 in ischemic stroke recovery
Springer Science and Business Media LLC - Tập 6 Số 1 - Trang 1-5 - 2015
Conway, Sarah E., Roy-O’Reilly, Meaghan, Friedler, Brett, Staff, Ilene, Fortunato, Gilbert, McCullough, Louise D.
Females experience poorer recovery after ischemic stroke compared to males, even after controlling for age and stroke severity. IL-10 is an anti-inflammatory cytokine produced by T regulatory cells and Th2 CD4+ helper T cells. In ischemic stroke, an excessive IL-10 response contributes to post-stroke immunosuppression, which worsens outcomes. However, it is unknown if sex differences exist in IL-1...... hiện toàn bộ
Nociceptin/orphanin FQ modulates energy homeostasis through inhibition of neurotransmission at VMN SF-1/ARC POMC synapses in a sex- and diet-dependent manner
Springer Science and Business Media LLC - - 2019
Jennifer Hernández, Carolina Fabelo, Lynnea Perez, Clare Moore, Rachel C Chang, Edward J. Wagner
Sexually dimorphic effect of aging on skeletal muscle protein synthesis
Springer Science and Business Media LLC - Tập 3 - Trang 1-11 - 2012
Gordon I Smith, Dominic N Reeds, Angela M Hall, Kari T Chambers, Brian N Finck, Bettina Mittendorfer
Although there appear to be no differences in muscle protein turnover in young and middle aged men and women, we have reported significant differences in the rate of muscle protein synthesis between older adult men and women. This suggests that aging may affect muscle protein turnover differently in men and women. We measured the skeletal muscle protein fractional synthesis rate (FSR) by using sta...... hiện toàn bộ
SP-A2 contributes to miRNA-mediated sex differences in response to oxidative stress: pro-inflammatory, anti-apoptotic, and anti-oxidant pathways are involved
Springer Science and Business Media LLC - Tập 8 - Trang 1-15 - 2017
George T. Noutsios, Nithyananda Thorenoor, Xuesheng Zhang, David S. Phelps, Todd M. Umstead, Faryal Durrani, Joanna Floros
Human innate host defense molecules, surfactant protein A1 (SP-A1), and SP-A2 differentially affect the function and proteome of the alveolar macrophage (AM). We hypothesized that SP-A genes differentially regulate the AM miRNome. Humanized transgenic mice expressing SP-A1 and SP-A2 were subjected to O3-induced oxidative stress (OxS) or filtered air (FA), AMs were isolated, and miRNA levels were m...... hiện toàn bộ
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