Cell-type-specific gene expression patterns in the knee cartilage in an osteoarthritis rat modelSpringer Science and Business Media LLC - Tập 18 - Trang 79-87 - 2017
Michal Korostynski, Natalia Malek, Marcin Piechota, Katarzyna Starowicz
Osteoarthritis (OA) is a chronic degenerative disease that leads to joint failure, pain, and disability. Gene regulation is implicated as a driver of the imbalance between the expression of catabolic and anabolic factors that eventually leads to the degeneration of osteoarthritic cartilage. In our model, knee-joint OA was induced in male Wistar rats by intra-articular sodium monoiodoacetate (MIA) ...... hiện toàn bộ
MPZL1 suppresses the cancer stem-like properties of lung cancer through β-catenin/TCF4 signalingSpringer Science and Business Media LLC - Tập 23 - Trang 1-10 - 2023
Qiao Ge, Chao Zhou, Chao Zang, Chao Li, Haining Hong, Kangwu Wang, Liwei Chen, Haonan Zhu, Ansheng Wang
This study was designed to explore the influence of myelin protein zero-like protein 1 (MPZL1) on the stem-like properties of cancer cells and the underlying mechanism in lung adenocarcinoma. Real-time quantitative polymerase chain reaction (RT-qPCR) was utilized to evaluate mRNA expression level. CCK8, wound healing, and transwell assays were applied to assess cell proliferation, migration, and i...... hiện toàn bộ
A high-throughput SNP array in the amphidiploid species Brassica napus shows diversity in resistance genesSpringer Science and Business Media LLC - Tập 14 - Trang 643-655 - 2014
Jessica Dalton-Morgan, Alice Hayward, Salman Alamery, Reece Tollenaere, Annaliese S. Mason, Emma Campbell, Dhwani Patel, Michał T. Lorenc, Bin Yi, Yan Long, Jinling Meng, Rosy Raman, Harsh Raman, Cindy Lawley, David Edwards, Jacqueline Batley
Single-nucleotide polymorphisms (SNPs)are molecular markers based on nucleotide variation and can be used for genotyping assays across populations and to track genomic inheritance. SNPs offer a comprehensive genotyping alternative to whole-genome sequencing for both agricultural and research purposes including molecular breeding and diagnostics, genome evolution and genetic diversity analyses, gen...... hiện toàn bộ
Spinach-based RNA mimicking GFP in plant cellsSpringer Science and Business Media LLC - Tập 22 - Trang 423-428 - 2022
Zhiming Yu, Yue Wang, Fengling Mei, Haiting Yan, Zhenhui Jin, Pengcheng Zhang, Xian Zhang, Mahmut Tör, Stephen Jackson, Nongnong Shi, Yiguo Hong
Spinach RNA-mimicking GFP (S-RMG) has been successfully used to monitor cellular RNAs including microRNAs in bacterium, yeast, and human cells. However, S-RMG has not been established in plants. In this study, we found that like bacterial, yeast, and human cellular tRNAs, plant tRNAs such as tRNALys can protect and/or stabilize the Spinach RNA aptamer interaction with the fluorophore DFHBI enablin...... hiện toàn bộ