Springer Science and Business Media LLC
Công bố khoa học tiêu biểu
* Dữ liệu chỉ mang tính chất tham khảo
Sắp xếp:
Coordinated regulation of Myc trans-activation targets by Polycomb and the Trithorax group protein Ash1
Springer Science and Business Media LLC - Tập 8 - Trang 1-16 - 2007
The Myc oncoprotein is a transcriptional regulator whose function is essential for normal development. Myc is capable of binding to 10% of the mammalian genome, and it is unclear how a developing embryo controls the DNA binding of its abundant Myc proteins in order to avoid Myc's potential for inducing tumorigenesis. To identify chromatin binding proteins with a potential role in controlling Myc a...... hiện toàn bộ
Early growth response protein 1 regulates promoter activity of α-plasma membrane calcium ATPase 2, a major calcium pump in the brain and auditory system
Springer Science and Business Media LLC - Tập 18 Số 1 - Trang 1-14 - 2017
Along with sodium/calcium (Ca2+) exchangers, plasma membrane Ca2+ ATPases (ATP2Bs) are main regulators of intracellular Ca2+ levels. There are four ATP2B paralogs encoded by four different genes. Atp2b2 encodes the protein pump with the fastest activation, ATP2B2. In mice, the Atp2b2 transcript has several alternate transcriptional start site variants: α, β, µ and δ. These variants are expressed i...... hiện toàn bộ
Exploration of carbohydrate binding behavior and anti-proliferative activities of Arisaema tortuosum lectin
Springer Science and Business Media LLC - Tập 20 - Trang 1-15 - 2019
Lectins have come a long way from being identified as proteins that agglutinate cells to promising therapeutic agents in modern medicine. Through their specific binding property, they have proven to be anti-cancer, anti-insect, anti-viral agents without affecting the non-target cells. The Arisaema tortuosum lectin (ATL) is a known anti-insect and anti-cancer candidate, also has interesting physica...... hiện toàn bộ
MAR-mediated integration of plasmid vectors for in vivo gene transfer and regulation
Springer Science and Business Media LLC - Tập 14 - Trang 1-12 - 2013
The in vivo transfer of naked plasmid DNA into organs such as muscles is commonly used to assess the expression of prophylactic or therapeutic genes in animal disease models. In this study, we devised vectors allowing a tight regulation of transgene expression in mice from such non-viral vectors using a doxycycline-controlled network of activator and repressor proteins. Using these vectors, we dem...... hiện toàn bộ
A protein knockdown strategy to study the function of β-catenin in tumorigenesis
Springer Science and Business Media LLC - Tập 4 - Trang 1-11 - 2003
The Wnt signaling pathway plays critical roles in cell proliferation and cell fate determination at many stages of development. A critical downstream target of Wnt signaling is the cytosolic β-catenin, which is stabilized upon Wnt activation and promotes transcription of a variety of target genes including c-myc and cyclin D. Aberrant Wnt signaling, which results from mutations of either β-catenin...... hiện toàn bộ
Stringent and reproducible tetracycline-regulated transgene expression by site-specific insertion at chromosomal loci with pre-characterised induction characteristics
Springer Science and Business Media LLC - - 2007
The ability to regulate transgene expression has many applications, mostly concerning the analysis of gene function. Desirable induction characteristics, such as low un-induced expression, high induced expression and limited cellular heterogeneity, can be seriously impaired by chromosomal position effects at the site of transgene integration. Many clones may therefore need to be screened before on...... hiện toàn bộ
Evaluation of suitable reference genes for gene expression studies in bronchoalveolar lavage cells from horses with inflammatory airway diseaseAbstract
Background
The stability of reference genes has a tremendous effect on the results of relative quantification of genes expression by quantitative polymerase chain reaction. Equine Inflammatory Airway Disease (IAD) is a common condition often treated with corticosteroids. The diagnosis of... ... hiện toàn bộ
Springer Science and Business Media LLC - Tập 12 Số 1 - 2011
Pre-amplification in the context of high-throughput qPCR gene expression experiment
Springer Science and Business Media LLC - Tập 16 - Trang 1-10 - 2015
With the introduction of the first high-throughput qPCR instrument on the market it became possible to perform thousands of reactions in a single run compared to the previous hundreds. In the high-throughput reaction, only limited volumes of highly concentrated cDNA or DNA samples can be added. This necessity can be solved by pre-amplification, which became a part of the high-throughput experiment...... hiện toàn bộ
Targeting of highly conserved Dengue virus sequences with anti-Dengue virus trans-splicing group I intronsAbstract
Background
Dengue viruses (DENV) are one of the most important viral diseases in the world with approximately 100 million infections and 200,000 deaths each year. The current lack of an approved tetravalent vaccine and ineffective insecticide control measures warrant a search for alterna... ... hiện toàn bộ
Springer Science and Business Media LLC - - 2010
Mutational analysis of highly conserved aspartate residues essential to the catalytic core of the piggyBac transposase
Springer Science and Business Media LLC - Tập 9 - Trang 1-20 - 2008
The piggyBac mobile element is quickly gaining popularity as a tool for the transgenesis of many eukaryotic organisms. By studying the transposase which catalyzes the movement of piggyBac, we may be able to modify this vector system to make it a more effective transgenesis tool. In a previous publication, Sarkar A, Sim C, Hong YS, Hogan JR, Fraser MJ, Robertson HM, and Collins FH have proposed the...... hiện toàn bộ
Tổng số: 598
- 1
- 2
- 3
- 4
- 5
- 6
- 10