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A fractionation method to identify qauntitative changes in protein expression mediated by IGF-1 on the proteome of murine C2C12 myoblasts
Springer Science and Business Media LLC - Tập 7 Số 1 - Trang 28 - 2009
Protein and phosphoprotein levels in glioma and adenocarcinoma cell lines grown in normoxia and hypoxia in monolayer and three-dimensional cultures
Springer Science and Business Media LLC - Tập 10 - Trang 1-13 - 2012
Three dimensional (3D) growths of cancer cells in vitro are more reflective of in situ cancer cell growth than growth in monolayer (2D). The present study is designed to determine changes in protein and phosphoprotein that reflect adaptation of tumor cells to 3D as compared to 2D. Since relative hypoxia is a common feature of most solid tumors, the present study also aims to look at the impact of ...... hiện toàn bộ
Increase in local protein concentration by field-inversion gel electrophoresis
Springer Science and Business Media LLC - Tập 5 - Trang 1-14 - 2007
Proteins that migrate through cross-linked polyacrylamide gels (PAGs) under the influence of a constant electric field experience negative factors, such as diffusion and non-specific trapping in the gel matrix. These negative factors reduce protein concentrations within a defined gel volume with increasing migration distance and, therefore, decrease protein separation efficiency. Enhancement of pr...... hiện toàn bộ
Comparative analysis of proteome maps of silkworm hemolymph during different developmental stages
Springer Science and Business Media LLC - Tập 8 - Trang 1-10 - 2010
The silkworm Bombyx mori is a lepidopteran insect with four developmental stages: egg, larva (caterpillar), pupa, and adult. The hemolymph of the silkworm is in an open system that circulates among all organs, and functions in nutrient and hormone transport, injury, and immunity. To understand the intricate developmental mechanisms of metamorphosis, silkworm hemolymph from different developmental ...... hiện toàn bộ
A comparison of imputation procedures and statistical tests for the analysis of two-dimensional electrophoresis data
Springer Science and Business Media LLC - Tập 8 - Trang 1-12 - 2010
Numerous gel-based softwares exist to detect protein changes potentially associated with disease. The data, however, are abundant with technical and structural complexities, making statistical analysis a difficult task. A particularly important topic is how the various softwares handle missing data. To date, no one has extensively studied the impact that interpolating missing data has on subsequen...... hiện toàn bộ
Dynamic changes of urinary proteins in a focal segmental glomerulosclerosis rat model
Springer Science and Business Media LLC - Tập 12 - Trang 1-9 - 2014
In contrast to blood, which has mechanisms to maintain a homeostatic internal environment, urine is more likely to reflect changes in the body. As urine accumulates all types of changes, identifying the precise cause of changes in the urine proteome is challenging and crucial in biomarker discovery. To reduce the effects of both genetic and environmental factors on the urinary proteome, this study...... hiện toàn bộ
Glycoproteomic analysis of two mouse mammary cell lines during transforming growth factor (TGF)-β induced epithelial to mesenchymal transition
Springer Science and Business Media LLC - Tập 7 - Trang 1-17 - 2009
TGF-β acts as an antiproliferative factor in normal epithelial cells and at early stages of oncogenesis. However, later in tumor development TGF-β can become tumor promoting through mechanisms including the induction of epithelial-to-mesenchymal transition (EMT), a process that is thought to contribute to tumor progression, invasion and metastasis. To identify EMT-related breast cancer therapeutic...... hiện toàn bộ
Effects of human and porcine bile on the proteome of Helicobacter hepaticus
Springer Science and Business Media LLC - Tập 10 - Trang 1-16 - 2012
Helicobacter hepaticus colonizes the intestine and liver of mice causing hepatobiliary disorders such as hepatitis and hepatocellular carcinoma, and has also been associated with inflammatory bowel disease in children. In its habitat, H. hepaticus must encounter bile which has potent antibacterial properties. To elucidate virulence and host-specific adaptation mechanisms of H. hepaticus modulated...... hiện toàn bộ
A risk score model based on TGF-β pathway-related genes predicts survival, tumor microenvironment and immunotherapy for liver hepatocellular carcinomaAbstract
Background
Transforming growth factor-beta (TGF-β) signal is an important pathway involved in all stages of liver hepatocellular carcinoma (LIHC) initiation and progression. Therefore, targeting TGF- β pathway may be a potential therapeutic strategy for LIHC. Prediction of patients’ tumor c... ... hiện toàn bộ
Springer Science and Business Media LLC - Tập 20 Số 1 - 2022
Proteome analysis of the Escherichia coli heat shock response under steady-state conditions
Springer Science and Business Media LLC - Tập 7 - Trang 1-15 - 2009
In this study a proteomic approach was used to investigate the steady-state response of Escherichia coli to temperature up-shifts in a cascade of two continuously operated bioreactors. The first reactor served as cell source with optimal settings for microbial growth, while in the second chemostat the cells were exposed to elevated temperatures. By using this reactor configuration, which has not b...... hiện toàn bộ
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