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Surface antigens and potential virulence factors from parasites detected by comparative genomics of perfect amino acid repeats
Springer Science and Business Media LLC - Tập 5 - Trang 1-9 - 2007
Many parasitic organisms, eukaryotes as well as bacteria, possess surface
antigens with amino acid repeats. Making up the interface between host and
pathogen such repetitive proteins may be virulence factors involved in immune
evasion or cytoadherence. They find immunological applications in
serodiagnostics and vaccine development. Here we use proteins which contain
perfect repeats as a basis for ...
Fast subcellular localization by cascaded fusion of signal-based and homology-based methods
Springer Science and Business Media LLC - Tập 9 - Trang 1-12 - 2011
The functions of proteins are closely related to their subcellular locations. In
the post-genomics era, the amount of gene and protein data grows exponentially,
which necessitates the prediction of subcellular localization by computational
means. This paper proposes mitigating the computation burden of alignment-based
approaches to subcellular localization prediction by a cascaded fusion of
cleava...
Analysis of intracellular expressed proteins of Mycobacterium tuberculosis clinical isolates
Springer Science and Business Media LLC - Tập 10 Số 1 - 2012
Abstract Background Tuberculosis (TB) is the most threatening infectious disease
globally. Although progress has been made to reduce global incidence of TB,
emergence of multidrug resistant (MDR) TB threatens to undermine these advances.
To combat the disease, novel intervention strategies effective against drug
resistant and sensitive subpopulations of M. tuberculosis are urgently required
as add...
New insights in the composition of extracellular vesicles from pancreatic cancer cells: implications for biomarkers and functions
Springer Science and Business Media LLC - Tập 12 - Trang 1-18 - 2014
Pancreatic cancer development is associated with characteristic alterations like
desmoplastic reaction and immune escape which are mediated by the cell-cell
communication mechanism and by the microenvironment of the cells. The whole of
released components are important determinants in these processes. Especially
the extracellular vesicles released by pancreatic cancer cells play a role in
cell com...
Periostin identified as a potential biomarker of prostate cancer by iTRAQ-proteomics analysis of prostate biopsy
Springer Science and Business Media LLC - Tập 9 - Trang 1-11 - 2011
Proteomics may help us better understand the changes of multiple proteins
involved in oncogenesis and progression of prostate cancer(PCa) and identify
more diagnostic and prognostic biomarkers. The aim of this study was to screen
biomarkers of PCa by the proteomics analysis using isobaric tags for relative
and absolute quantification(iTRAQ). The patients undergoing prostate biopsies
were classifie...
Proteomic analysis of quail calcified eggshell matrix: a comparison to chicken and turkey eggshell proteomes
Springer Science and Business Media LLC - Tập 13 - Trang 1-19 - 2015
Eggshell mineralization in commercially important species such as chicken,
turkey or quail is of interest as a general model of calcium carbonate
biomineralization. Knowledge of proteins and molecular mechanisms in eggshell
assembly may also pave the way to manipulation of thickness of the calcified
layer or other features. Comparison of eggshell matrix proteomes of different
species may contribut...
Multi-Segment Direct Inject nano-ESI-LTQ-FT-ICR-MS/MS For Protein Identification
Springer Science and Business Media LLC - - 2011
Reversed phase high performance liquid chromatography (HPLC) interfaced to
electrospray tandem mass spectrometry (MS/MS) is commonly used for the
identification of peptides from proteolytically cleaved proteins embedded in a
polyacrylamide gel matrix as well as for metabolomics screening. HPLC
separations are time consuming (30-60 min average), costly (columns and mobile
phase reagents), and carry...
Prediction of heme binding residues from protein sequences with integrative sequence profiles
Springer Science and Business Media LLC - Tập 10 Số S1 - 2012
Abstract Background The heme-protein interactions are essential for various
biological processes such as electron transfer, catalysis, signal transduction
and the control of gene expression. The knowledge of heme binding residues can
provide crucial clues to understand these activities and aid in functional
annotation, however, insufficient work has been done on the research of heme
binding residu...
The Lottia gigantea shell matrix proteome: re-analysis including MaxQuant iBAQ quantitation and phosphoproteome analysis
Springer Science and Business Media LLC - - 2014
Proteomic analysis of Cucumis sativus cotyledons after glucohexaose treatment as a part of ROS accumulation related resistance mechanism
Springer Science and Business Media LLC - Tập 12 - Trang 1-10 - 2014
Glucohexaose is a safe farm chemical used for pathogen prevention, which can
induce systemic acquired resistance in cucumber. We found that glucohexaose
treatment of cucumber plant induced an accumulation of the reactive oxidative
species (ROS). Histochemistry showed sharp increases in O2- and H2O2 5 h after
glucohexaose treatment. After 5 h, the O2- content decreased to a normal level,
but the H2...
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