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Surface antigens and potential virulence factors from parasites detected by comparative genomics of perfect amino acid repeats
Springer Science and Business Media LLC - Tập 5 - Trang 1-9 - 2007
Niklaus Fankhauser, Tien-Minh Nguyen-Ha, Joël Adler, Pascal Mäser
Many parasitic organisms, eukaryotes as well as bacteria, possess surface antigens with amino acid repeats. Making up the interface between host and pathogen such repetitive proteins may be virulence factors involved in immune evasion or cytoadherence. They find immunological applications in serodiagnostics and vaccine development. Here we use proteins which contain perfect repeats as a basis for ...... hiện toàn bộ
Fast subcellular localization by cascaded fusion of signal-based and homology-based methods
Springer Science and Business Media LLC - Tập 9 - Trang 1-12 - 2011
Man-Wai Mak, Wei Wang, Sun-Yuan Kung
The functions of proteins are closely related to their subcellular locations. In the post-genomics era, the amount of gene and protein data grows exponentially, which necessitates the prediction of subcellular localization by computational means. This paper proposes mitigating the computation burden of alignment-based approaches to subcellular localization prediction by a cascaded fusion of cleava...... hiện toàn bộ
Analysis of intracellular expressed proteins of Mycobacterium tuberculosis clinical isolates
Springer Science and Business Media LLC - Tập 10 Số 1 - 2012
Neelja Singhal, Prashant Sharma, Manish Kumar, Beenu Joshi, Deepa Bisht
Abstract Background Tuberculosis (TB) is the most threatening infectious disease globally. Although progress has been made to reduce global incidence of TB, emergence of multidrug resistant (MDR) TB threatens to undermine these advances. To combat the disease, novel intervention strategies effect...... hiện toàn bộ
New insights in the composition of extracellular vesicles from pancreatic cancer cells: implications for biomarkers and functions
Springer Science and Business Media LLC - Tập 12 - Trang 1-18 - 2014
Susanne Klein-Scory, Mahnaz Moradian Tehrani, Christina Eilert-Micus, Kamila A Adamczyk, Nathalie Wojtalewicz, Martina Schnölzer, Stephan A Hahn, Wolff Schmiegel, Irmgard Schwarte-Waldhoff
Pancreatic cancer development is associated with characteristic alterations like desmoplastic reaction and immune escape which are mediated by the cell-cell communication mechanism and by the microenvironment of the cells. The whole of released components are important determinants in these processes. Especially the extracellular vesicles released by pancreatic cancer cells play a role in cell com...... hiện toàn bộ
Periostin identified as a potential biomarker of prostate cancer by iTRAQ-proteomics analysis of prostate biopsy
Springer Science and Business Media LLC - Tập 9 - Trang 1-11 - 2011
Chuanyu Sun, Chao Song, Zhicheng Ma, Ke Xu, Yang Zhang, Hong Jin, Shijun Tong, Weihong Ding, Guowei Xia, Qiang Ding
Proteomics may help us better understand the changes of multiple proteins involved in oncogenesis and progression of prostate cancer(PCa) and identify more diagnostic and prognostic biomarkers. The aim of this study was to screen biomarkers of PCa by the proteomics analysis using isobaric tags for relative and absolute quantification(iTRAQ). The patients undergoing prostate biopsies were classifie...... hiện toàn bộ
Proteomic analysis of quail calcified eggshell matrix: a comparison to chicken and turkey eggshell proteomes
Springer Science and Business Media LLC - Tập 13 - Trang 1-19 - 2015
Karlheinz Mann, Matthias Mann
Eggshell mineralization in commercially important species such as chicken, turkey or quail is of interest as a general model of calcium carbonate biomineralization. Knowledge of proteins and molecular mechanisms in eggshell assembly may also pave the way to manipulation of thickness of the calcified layer or other features. Comparison of eggshell matrix proteomes of different species may contribut...... hiện toàn bộ
Multi-Segment Direct Inject nano-ESI-LTQ-FT-ICR-MS/MS For Protein Identification
Springer Science and Business Media LLC - - 2011
Jing Chen, Lorena Canales, Rachel E Neal
Reversed phase high performance liquid chromatography (HPLC) interfaced to electrospray tandem mass spectrometry (MS/MS) is commonly used for the identification of peptides from proteolytically cleaved proteins embedded in a polyacrylamide gel matrix as well as for metabolomics screening. HPLC separations are time consuming (30-60 min average), costly (columns and mobile phase reagents), and carry...... hiện toàn bộ
Prediction of heme binding residues from protein sequences with integrative sequence profiles
Springer Science and Business Media LLC - Tập 10 Số S1 - 2012
Yi Xiong, Juan Liu, Wen Zhang, Tao Zeng
Abstract Background The heme-protein interactions are essential for various biological processes such as electron transfer, catalysis, signal transduction and the control of gene expression. The knowledge of heme binding residues can provide crucial clues to understand these activities and aid in...... hiện toàn bộ
The Lottia gigantea shell matrix proteome: re-analysis including MaxQuant iBAQ quantitation and phosphoproteome analysis
Springer Science and Business Media LLC - - 2014
Karlheinz Mann, Eric Edsinger
Proteomic analysis of Cucumis sativus cotyledons after glucohexaose treatment as a part of ROS accumulation related resistance mechanism
Springer Science and Business Media LLC - Tập 12 - Trang 1-10 - 2014
Yuhan Hao, Chunmei Lin, Haiyan Fan, Yang Yu, Ning Li, Shaoli Chen
Glucohexaose is a safe farm chemical used for pathogen prevention, which can induce systemic acquired resistance in cucumber. We found that glucohexaose treatment of cucumber plant induced an accumulation of the reactive oxidative species (ROS). Histochemistry showed sharp increases in O2- and H2O2 5 h after glucohexaose treatment. After 5 h, the O2- content decreased to a normal level, but the H2...... hiện toàn bộ
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