Springer Science and Business Media LLC

Công bố khoa học tiêu biểu

* Dữ liệu chỉ mang tính chất tham khảo

Sắp xếp:  
Primary Immunodeficiency in Iran: First Report of the National Registry of PID in Children and Adults
Springer Science and Business Media LLC - Tập 22 - Trang 375-380 - 2002
Asghar Aghamohammadi, Mosafa Moein, Abolhasan Farhoudi, Zahra Pourpak, Nima Rezaei, Kamran Abolmaali, Masoud Movahedi, Mohammad Gharagozlou, Bahram Mir Saeid Ghazi, Maryam Mahmoudi, Davoud Mansouri, Saba Arshi, Naser Javaher Trash, Hedayatallah Akbari, Roya Sherkat, Reza Farid Hosayni, Ahmad Hashemzadeh, Iraj Mohammadzadeh, Reza Amin, Sara Kashef, Abdalvahab Alborzi, Abdallah Karimi, Hosaynali Khazaei
Epidemiological studies have shown wide geographical and racial variation in the prevalence and patterns of immunodeficiency disorders. To determine the frequency of primary immunodeficiencies (PID) in Iran, the Iranian Primary Immunodeficiency Registry (IPIDR) was organized in 1999. We extracted the patient’s data, by using a uniform questionnaire from their hospital records. The diagnosis of pat...... hiện toàn bộ
Foxp3+ Regulatory T Cells, Th17 Effector Cells, and Cytokine Environment in Inflammatory Bowel Disease
Springer Science and Business Media LLC - Tập 30 - Trang 80-89 - 2009
Nicola Eastaff-Leung, Nicholas Mabarrack, Angela Barbour, Adrian Cummins, Simon Barry
Inflammatory bowel disease (IBD) is thought to result from an aberrant immune response. Inflammation in IBD may be caused by the loss of homeostasis between CD4+ CD25high Foxp3+ regulatory cells (T reg) and proinflammatory Th17 cells. The aim of this study was to investigate T reg and Th17 cells in the peripheral blood and intestinal mucosa of ...... hiện toàn bộ
An Immunological Axis Involving Interleukin 1β and Leucine-Rich-α2-Glycoprotein Reflects Therapeutic Response of Children with Kawasaki Disease: Implications from the KAWAKINRA Trial
Springer Science and Business Media LLC - Tập 42 - Trang 1330-1341 - 2022
Christoph Kessel, Isabelle Koné-Paut, Stéphanie Tellier, Alexandre Belot, Katja Masjosthusmann, Helmut Wittkowski, Sabrina Fuehner, Linda Rossi-Semerano, Perrine Dusser, Isabelle Marie, Nadja Boukhedouni, Helène Agostini, Céline Piedvache, Dirk Foell
A recent phase II open-label study of the interleukin 1 (IL-1) receptor antagonist (IL-1Ra) anakinra in treating IVIG-resistant Kawasaki disease (KD) patients reported promising results. Here, we aimed to characterize the immunological impact of IL-1 blockade in this unique study population. Patients’ and control sera and supernatants of cells (whole blood, neutrophils, coronary artery endothelial...... hiện toàn bộ
Lethal Influenza in Two Related Adults with Inherited GATA2 Deficiency
Springer Science and Business Media LLC - Tập 38 - Trang 513-526 - 2018
Ithaisa Sologuren, María Teresa Martínez-Saavedra, Jordi Solé-Violán, Edgar de Borges de Oliveira Jr, Eva Betancor, Inmaculada Casas, Carmen Oleaga-Quintas, Mónica Martínez-Gallo, Shen-Ying Zhang, Jose Pestano, Roger Colobran, Estefanía Herrera-Ramos, Carmen Pérez, Marta López-Rodríguez, José Juan Ruiz-Hernández, Nieves Franco, José María Ferrer, Cristina Bilbao, Miguel Andújar-Sánchez, Mercedes Álvarez Fernández, Michael J. Ciancanelli, Felipe Rodríguez de Castro, Jean-Laurent Casanova, Jacinta Bustamante, Carlos Rodríguez-Gallego
The pathogenesis of life-threatening influenza A virus (IAV) disease remains elusive, as infection is benign in most individuals. We studied two relatives who died from influenza. We Sanger sequenced GATA2 and evaluated the mutation by gene transfer, measured serum cytokine levels, and analyzed circulating T- and B-cells. Both patients (father and son, P1 and P2) died in 2011 of H1N1pdm IAV infect...... hiện toàn bộ
Role of apoptosis in HIV disease pathogenesis
Springer Science and Business Media LLC - Tập 15 - Trang 217-231 - 1995
Naoki Oyaizu, Savita Pahwa
After approximately one and a half decades of intensive studies, the exact mechanisms to explain HIV-mediated cytopathicity are still enigmatic and need closer scrutiny. There has been a dichotomy between virological and immunological viewpoints in understanding HIV-mediated cytopathicity, the former emphasizing a killing of infected cells by HIV-1 and the latter emphasizing indirect mechanisms wh...... hiện toàn bộ
Novel STAT1 Alleles in a Patient with Impaired Resistance to Mycobacteria
Springer Science and Business Media LLC - Tập 31 - Trang 265-271 - 2010
Ines Ackerl Kristensen, Jens Erik Veirum, Bjarne Kuno Møller, Mette Christiansen
Partial defects in interferon (IFN)-γ signaling lead to susceptibility to infections with nontuberculous mycobacteria. The receptors for IFN-α and IFN-γ activate components of the Janus kinase-signal transducer and activator of transcription (STAT) signaling pathway. Some defects in STAT1 mainly affect IFN-γ signaling, thus resulting in mendelian susceptibility to mycobacterial disease (MSMD). MSM...... hiện toàn bộ
Droplet Digital PCR-Based Chimerism Analysis for Primary Immunodeficiency Diseases
Springer Science and Business Media LLC - Tập 38 Số 3 - Trang 300-306 - 2018
Toshio Okano, Yuki Tsujita, Hirokazu Kanegane, Kanako Mitsui-Sekinaka, Kay Tanita, Satoshi Miyamoto, Ta‐Sen Yeh, Motoi Yamashita, Naomi Terada, Yuichiro Ogura, Masatoshi Takagi, Kohsuke Imai, Shigeaki Nonoyama, Tomohiro Morio
Chemokines in the Inflammatory Bowel Diseases
Springer Science and Business Media LLC - Tập 19 - Trang 266-272 - 1999
Richard P. MacDermott
Ulcerative colitis and Crohn's disease are characterized by chronic intestinal inflammation. Intestinal bacteria initiate the activation of intestinal inflammatory processes, which are mediated by proinflammatory cytokines and chemokines. In inflammatory bowel disease, intestinal inflammation is not downregulated, in part due to defective or absent inhibitory processes. Studies to date have demons...... hiện toàn bộ
Lessons Learned from Phagocytic Function Studies in a Large Cohort of Patients with Recurrent Infections
Springer Science and Business Media LLC - Tập 32 - Trang 454-466 - 2011
Baruch Wolach, Ronit Gavrieli, Dirk Roos, Sivan Berger-Achituv
There is a paucity of data on the relationship between demographic characteristics, specific clinical manifestations, and neutrophil dysfunction, guiding physicians to decide which clinical signs and symptoms are a code for an underlying phagocytic disorder. The data over a 21-year period of all adult and pediatric patients referred to our Laboratory for Leukocyte Functions with recurrent pyogenic...... hiện toàn bộ
Malaria vaccines
Springer Science and Business Media LLC - Tập 16 - Trang 183-189 - 1996
Roberto Amador, Manuel E. Patarroyo
Significant progress has been made in the development of the malaria vaccine during the last 20 years. Ninety percent of the 300–500 million clinical cases of malaria per year worldwide occur in Africa. Thus, research must be directed toward the 1 million African children under 5 years of age who die every year of malaria. An asexual blood-stage vaccine, capable of reducing severe and complicated ...... hiện toàn bộ
Tổng số: 2,868   
  • 1
  • 2
  • 3
  • 4
  • 5
  • 6
  • 10