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A unique syndrome of immunodeficiency and autoimmunity associated with absent T cell CD2 expression
Springer Science and Business Media LLC - Tập 14 - Trang 359-367 - 1994
Michael C. Sneller, Eli M. Eisenstein, Michael Baseler, H. Clifford Lane, Eileen T. Donoghue, Judith Falloon
CD2 is a glycoprotein expressed on the surface of human T cells that mediates adhesion between T cells and antigen presenting cells. CD2 also functions in concert with the T cell receptor to transduce signals that lead to T cell activation. The CD8 and CD4 molecules are transmembrane glycoproteins that are expressed on mutually exclusive populations of mature T cells and bind to determinants on ma...... hiện toàn bộ
Decreased Myocardial Expression of Dystrophin and Titin mRNA and Protein in Dilated Cardiomyopathy: Possibly an Adverse Effect of TNF-α
Springer Science and Business Media LLC - Tập 30 - Trang 520-530 - 2010
Shamim Ahmad, Taranjit Singh Rai, Madhu Khullar, Ajay Bahl, Uma Nahar Saikia, M. Thungapathra, Rohit Manoj Kumar, Rajiv Mahajan, Kewal K. Talwar
While the molecular basis of dilated cardiomyopathy (DCM) remains uncertain, concrete evidence is emerging that sarcomeric and cytoskeleton gene expression of myocardium isolated from failing versus non-failing patients differ dramatically. The central aim to this work was to find out the possible role of dystrophin and titin along with the TNF-α in the pathogenesis of cardiomyopathy. mRNA levels ...... hiện toàn bộ
Autoantibodies Neutralizing Type I Interferons in 20% of COVID-19 Deaths in a French Hospital
Springer Science and Business Media LLC - Tập 42 - Trang 459-470 - 2022
Angélique Chauvineau-Grenier, Paul Bastard, Antoine Servajean, Adrian Gervais, Jérémie Rosain, Emmanuelle Jouanguy, Aurélie Cobat, Jean-Laurent Casanova, Benjamin Rossi
Recent studies reported the presence of pre-existing autoantibodies (auto-Abs) neutralizing type I interferons (IFNs) in at least 15% of patients with critical COVID-19 pneumonia. In one study, these auto-Abs were found in almost 20% of deceased patients across all ages. We aimed to assess the prevalence and clinical impact of the auto-Abs to type I IFNs in the Seine-Saint-Denis district, which wa...... hiện toàn bộ
Primary Immunodeficiency in Iran: First Report of the National Registry of PID in Children and Adults
Springer Science and Business Media LLC - Tập 22 - Trang 375-380 - 2002
Asghar Aghamohammadi, Mosafa Moein, Abolhasan Farhoudi, Zahra Pourpak, Nima Rezaei, Kamran Abolmaali, Masoud Movahedi, Mohammad Gharagozlou, Bahram Mir Saeid Ghazi, Maryam Mahmoudi, Davoud Mansouri, Saba Arshi, Naser Javaher Trash, Hedayatallah Akbari, Roya Sherkat, Reza Farid Hosayni, Ahmad Hashemzadeh, Iraj Mohammadzadeh, Reza Amin, Sara Kashef, Abdalvahab Alborzi, Abdallah Karimi, Hosaynali Khazaei
Epidemiological studies have shown wide geographical and racial variation in the prevalence and patterns of immunodeficiency disorders. To determine the frequency of primary immunodeficiencies (PID) in Iran, the Iranian Primary Immunodeficiency Registry (IPIDR) was organized in 1999. We extracted the patient’s data, by using a uniform questionnaire from their hospital records. The diagnosis of pat...... hiện toàn bộ
Book reviews
Springer Science and Business Media LLC - Tập 2 Số 3 - Trang 246-248 - 1982
Elizabeth M. Smithwick, Sudhir Gupta
Serum antibodies to HIV-1 in recombinant vaccinia virus recipients boosted with purified recombinant gp160
Springer Science and Business Media LLC - Tập 12 - Trang 429-439 - 1992
David C. Montefiori, Barney S. Graham, Srisakul Kliks, Peter F. Wright
Serum antibody responses were studied in detail in four vaccinia-naive volunteers in a phase I trial evaluating primary vaccination with a recombinant vaccinia virus expressing the HIV-1 gp160 envelope glycoprotein (HIVAC-1e, Oncogen/Bristol-Myers Squibb), followed by booster immunization with baculovirus-derived rgp160 (VaxSyn, MicroGeneSys). Prior to boosting, low-titer Fc receptor (FcR)-mediate...... hiện toàn bộ
Disorders of Apoptosis: Mechanisms for Autoimmunity in Primary Immunodeficiency Diseases
Springer Science and Business Media LLC - - 2008
João Bosco Oliveira, Sudhir Gupta
Harnessing Type I IFN Immunity Against SARS-CoV-2 with Early Administration of IFN-β
Springer Science and Business Media LLC - Tập 41 - Trang 1425-1442 - 2021
Donald C. Vinh, Laurent Abel, Paul Bastard, Matthew P. Cheng, Antonio Condino-Neto, Peter K. Gregersen, Filomeen Haerynck, Maria-Pia Cicalese, David Hagin, Pere Soler-Palacín, Anna M. Planas, Aurora Pujol, Luigi D. Notarangelo, Qian Zhang, Helen C. Su, Jean-Laurent Casanova, Isabelle Meyts
Announcements
Springer Science and Business Media LLC - Tập 13 - Trang 371-372 - 1993
Functional characteristics of a modified immunoglobulin preparation for intravenous administration: Summary of studies of opsonic and protective activity against group B streptococci
Springer Science and Business Media LLC - Tập 2 - Trang 31S-35S - 1982
Gerald W. Fischer, Samuel R. Wilson, Kenneth W. Hunter
Group B streptococci (GBS) remains a major cause of morbidity and mortality in newborn babies, despite antibiotic therapy. Recent studies suggest that phagocytosis and killing of GBS is ineffective due to a deficiency in anti-GBS antibody. Using an opsonophagocytic bacterial assay and a suckling rat model of GBS sepsis, we analyzed a modified human immunoglobulin for opsonic and protective antibod...... hiện toàn bộ
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