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Studies on cell division in mammalian cells: VI. A temperature-sensitive mutant blocked in both G1 and G2 phases of the cell cycle
Springer Science and Business Media LLC - Tập 8 - Trang 653-666 - 1982
David Jen-chi Chen, Richard J. Wang
A temperature-sensitive mammalian cell cycle mutant with blocks in G 1 and G2 phases of the cell cycle has been isolated in culture. When shifted from the permissive temperature of 33‡ C to the nonpermissive temperature of 39‡ C, the fraction of cells initiating DNA synthesis as well as the fraction of cells entering mitosis decreased rapidly. Combined cytophotometric and autoradiographic analysi...... hiện toàn bộ
Toward Expression Mapping of Albinism-Deafness Syndrome (ADFN) Locus on Chromosome Xq26
Springer Science and Business Media LLC - Tập 24 - Trang 135-140 - 1998
A.N.K. Jacob, Geeta Kandpal, N. Gill, Rajendra P. Kandpal
We have employed a direct cDNA selection methodology to isolate transcribed sequences encoded in the human chromosomal interval Xq26 that contains the gene for X-chromosome linked albinism deafness syndrome (ADFN). ADFN had been previously mapped to an 8 centi Morgan region on chromosome Xq26. We have constructed six cDNA libraries specific to six YACs mapping to a 1.5 mb span at ...... hiện toàn bộ
Genetic analysis of resistance to total bromodeoxyuridine substitution in mammalian cell hybrids
Springer Science and Business Media LLC - Tập 17 - Trang 567-572 - 1991
Elliot R. Kaufma
Somatic cell hybrids derived from the fusion of Chinese hamster ovary cells (CHO) and mutant Syrian hamster melanoma cells (2E) were tested for their ability to grow with all of the thymidine (dThd) in their DNA replaced with 5-bromo-2′-deoxyuridine (BrdU), a phenotypic capability of the 2E cells but not of the CHO cells. Under these conditions, the 2E cells survived and grew, all of the hybrid cl...... hiện toàn bộ
Three distinct loci on human chromosome 21 contribute to interferon-α/β responsiveness
Springer Science and Business Media LLC - Tập 21 - Trang 139-145 - 1995
Regina Raz, Kam Cheung, Leona Ling, David E. Levy
The species specificity of interferons (IFNs) depends on restricted recognition of these ligands by multisubunit cell surface receptors. Expression of the human receptor subunit IFNAR in mouse cells conferred sensitivity only to one subtype of human IFN, IFN-αB. Other genes on human chromosome 21 were required for responses to other subtypes of type I IFN. In contrast, IFNAR expression in hamster ...... hiện toàn bộ
Complementing mutant alleles define three loci involved in mannosylation of Man5-GlcNAc2-P-P-dolichol in Chinese hamster ovary cells
Springer Science and Business Media LLC - Tập 16 - Trang 539-548 - 1990
Pamela J. Beck, Mary-Jane Gething, Joseph Sambrook, Mark A. Lehrman
Dolichol-linked oligosaccharides consisting of twoN-acetylglucosamine, nine mannose, and three glucose residues (Glc3Man9GlcNAc2) are transferred to proteins that contain the consensus sequence Asn-X-Ser/Thr. This transfer occurs upon protein import into the lumen of the endoplasmic reticulum. An intermediate in the biosynthesis of the Glc3Man9GlcNAc2 lipid-linked oligosaccharide contains two GlcN...... hiện toàn bộ
New RNA species is produced by alternate polyadenylation following rearrangement associated withCAD gene amplification
Springer Science and Business Media LLC - Tập 12 - Trang 339-350 - 1986
Judy L. Meinkoth, Edith Legouy, Olivier Brison, Geoffrey M. Wahl
Mammalian cells selected to resist N-(phosphonacetyl)-L-aspartate (PALA) contain amplified copies of the CAD gene. While a single 7.9-kb mRNA species is detected in PALA-sensitive and most PALA-resistant cell lines, two RNA species (7.9 and 10.2 kb) are detected in two related drug-resistant mutants presumably derived from the same parental cell. In this report we show that the 10.2-kb RNA is prod...... hiện toàn bộ
Non-P-glycoprotein-mediated multidrug-resistant human KB cells selected in medium containing adriamycin, cepharanthine, and mezerein
Springer Science and Business Media LLC - Tập 20 - Trang 423-435 - 1994
Tomoyuki Sumizawa, Yutaka Chuman, Hidehiro Sakamoto, Kazuchiyo Iemura, Kurt C. Almquist, Roger G. Deeley, Susan P. C. Cole, Shin-ichi Akiyama
Human epidermoid KB cell lines resistant to high levels of adriamycin, C-A90, C-A120, C-A500, and C-A1000, were isolated in selection medium containing increasing concentrations of adriamycin, 1 μg/ml of cepharanthine, a multidrug-resistance (MDR) reversing agent, and 100 nM of mezerein, a protein kinase C activating agent. One of the adriamycin-resistant KB cell lines, C-A500, was cross-resistant...... hiện toàn bộ
The Human RNA Helicase A (DDX9) Gene Maps to the Prostate Cancer Susceptibility Locus at Chromosome Band 1q25 and Its Pseudogene (DDX9P) to 13q22, Respectively
Springer Science and Business Media LLC - - 1999
Chee-Gun Lee, Toshihiko Eki, Katsuhiko Okumura, Masahiro Nogami, Vera da Costa Soares, Yasufumi Murakami, Fumio Hanaoka, Jerard Hurwitz
Characterization and mapping of DNA sequence homologous to mouse U1a1 snRNA: Localization on chromosome 11 near theDlb-1 andRe loci
Springer Science and Business Media LLC - Tập 12 - Trang 215-223 - 1986
Simon K. Michael, Jo Hilgers, Christine Kozak, J. Barry Whitney, Eugene F. Howard
A phage clone which contained a functional U1a1snRNA gene was isolated from a mouse genomic library. A single copy fragment was isolated from the 3′ flanking region of the U1a1gene and used as a hybridization probe for Southern blotted DMAs from recombinant inbred strains of mice, mouse-hamster hybrid cells, and the offspring from backcrosses between BALB/c mice and mice which were heterozygous f...... hiện toàn bộ
Linkage mapping of microdissected clones from distal mouse chromosome 16
Springer Science and Business Media LLC - Tập 22 - Trang 227-232 - 1996
Jianjun Wei, Stephen R. Dlouhy, Yi Wang, Jianguo Zhu, Lillian Fitzpatrick, Bernardino Ghetti, M. E. Hodes
A total of 38 unique segments generated by microdissection of mouse chromosome 16 (MMU16), sequence independent amplification (SIA) and cloning were sequentially mapped on the distal portion of the chromosome with two mouse backross panels. Some reference markers from other sources were retyped in the panels and results integrated with those for our microdissected DNA segments. The clone map is mo...... hiện toàn bộ
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