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Studies on cell division in mammalian cells: VI. A temperature-sensitive mutant blocked in both G1 and G2 phases of the cell cycle
Springer Science and Business Media LLC - Tập 8 - Trang 653-666 - 1982
David Jen-chi Chen, Richard J. Wang
A temperature-sensitive mammalian cell cycle mutant with blocks in G 1 and G2 phases of the cell cycle has been isolated in culture. When shifted from the permissive temperature of 33‡ C to the nonpermissive temperature of 39‡ C, the fraction of cells initiating DNA synthesis as well as the fraction of cells entering mitosis decreased rapidly. Combined cytophotometric and autoradiographic analysi...... hiện toàn bộ
Fast-twitch and slow-twitch/cardiac Ca2+ ATPase genes map to human chromosomes 16 and 12
Springer Science and Business Media LLC - Tập 14 - Trang 645-645 - 1988
David H. MacLennan, Christopher J. Brandi, Shashikant Champaneria, Paul C. Holland, Vicki E. Powers, Huntington F. Willard
Increased intracellular phosphoribosylpyrophosphate and accelerated orotic acid decarboxylation in a mouse cell line resistant to purine and pyrimidine ribonucleosides
Springer Science and Business Media LLC - Tập 3 - Trang 263-280 - 1977
S. Randolph May, Shahnaz Hashmi, Orlando J. Miller, Robert S. Krooth
A line of mouse fibroblasts (A9AU-1), originally selected for growth in the presence of 6-azauridine, has been found to be resistant to cytotoxic concentrations of adenosine, guanosine, and thymidine. A9AU-1 cells convert orotic acid to uridine 5′-monophosphate at twice the rate of the A9P line from which the A9AU-1 clone was selected. The resistant cells also excrete purines, synthesized de novo,...... hiện toàn bộ
Carcinoembryonic antigen (CEA) expression in somatic cell hybrids
Springer Science and Business Media LLC - Tập 8 - Trang 1-13 - 1982
Denise Sheer, Ruth M. Brown, Martin Bobrow
Five hybrids (LSB) were formed between LS174T, a human CEA-producing colonic tumor cell line, and BU25.CAPR, a HeLa derivative which does not produce CEA. All five hybrids produce CEA, but less per cell than LS174T. Approximately 10 % of the chromosomes have been lost from these hybrids. In an attempt to map the gene(s) coding for the protein moiety of CEA, 7 LSPG and 28 LSR hybrids were formed be...... hiện toàn bộ
Assignment of the structural genes for the ? subunit of hexosaminidase A, mannosephosphate isomerase, and pyruvate kinase to the region q22-qter of human chromosome 15
Springer Science and Business Media LLC - Tập 3 Số 6 - Trang 553-560 - 1977
Ching J. Chern, Roger H. Kennett, Eric Engel, William J. Mellman, Carlo M. Croce
Toward Expression Mapping of Albinism-Deafness Syndrome (ADFN) Locus on Chromosome Xq26
Springer Science and Business Media LLC - Tập 24 - Trang 135-140 - 1998
A.N.K. Jacob, Geeta Kandpal, N. Gill, Rajendra P. Kandpal
We have employed a direct cDNA selection methodology to isolate transcribed sequences encoded in the human chromosomal interval Xq26 that contains the gene for X-chromosome linked albinism deafness syndrome (ADFN). ADFN had been previously mapped to an 8 centi Morgan region on chromosome Xq26. We have constructed six cDNA libraries specific to six YACs mapping to a 1.5 mb span at ...... hiện toàn bộ
The Control of cell proliferation by preformed purines: A genetic study I. Isolation and preliminary characterization of Chinese hamster lines with single or multiple defects in purine “salvage” pathways
Springer Science and Business Media LLC - Tập 3 - Trang 497-511 - 1977
Michèlle Debatisse, Gérard Buttin
Sublines with single or multiple defects in purine “salvage” enzymes were isolated from the Chinese hamster fibroblastic line GMA32 through single or successive onestep selections for resistance to purine analogs. They were examined for their ability to incorporate purine bases and nucleosides into macromolecules, for their sensitivity to growth inhibitory purines, and for their rescue by exogeno...... hiện toàn bộ
Incorporation of isolated chromosomes and induction of hypoxanthine phosphoribosyltransferase in chinese hamster cells
Springer Science and Business Media LLC - Tập 1 - Trang 137-151 - 1975
G. J. Wullems, J. van der Horst, D. Bootsma
Evidence is presented for the uptake of radioactive-labeled isolated Chinese hamster chromosomes following incubation with Chinese hamster cells. Metaphases were found which contained radioactive labeled chromosomes in a very low frequency, and in some of the labeled chromosomes only one chromatid was labeled. Incubation of hypoxanthine phosphoribosyltransferase (HPRT)-deficient Chinese hamster c...... hiện toàn bộ
Modulation ofAPRT transcription by altering spacing betweenCis-regulatory elements
Springer Science and Business Media LLC - Tập 21 - Trang 43-50 - 1995
Bin-Ru She, Joel E. Schaley, Milton W. Taylor
Three regulatory regions on the promoter of CHO adenine phosphoribosyltransferase gene (APRT) were identified. Spacing constraints between these regions were analyzed. With normal spacing, region II (−33 to +19), which separates regions I (−101 to −53) and III (+56 to +85), is critical forAPRT transcription. However, when regions I and III are artificially placed in proximity to each other (region...... hiện toàn bộ
Structural gene encoding human factor XII is located at 5q33-qter
Springer Science and Business Media LLC - Tập 14 - Trang 217-221 - 1988
N. J. Royle, M. Nigli, D. Cool, R. T. MacGillivray, J. L. Hamerton
The gene encoding human factor XII (F12 ) or Hageman factor has been mapped to 5q33-qter. This has been achieved by analyzing the results obtained from hybridizing a cloned fragment from the factor XII gene to a panel of human-hamster somatic cell hybrid DNAs and also by in situ hybridization to normal human metaphase cells. The previously reported results localizingF12 to 6p23 are discussed.
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