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Replicative potentials of various fusion products between WI-38 and SV40 transformed WI-38 cells and their components
Springer Science and Business Media LLC - Tập 6 - Trang 689-698 - 1980
Audrey L. Muggleton-Harris, Douglas W. DeSimone
Hybrid cells derived from whole-cell fusions of replicating phase-II normal fibroblast cells (WI-38s) with SV40 transformed WI-38 fibroblast cells (CL-1s) demonstrated that the majority of the hybrid experimental cells still maintained a finite life-span. Approximately 2% demonstrated sustained and possibly indefinite replication. Experimental binucleate cells and subsequent hybrid synkaryons wer...... hiện toàn bộ
Genome regulation in mammalian cells
Springer Science and Business Media LLC - Tập 16 - Trang 257-265 - 1990
Theodore T. Puck, Alphonse Krystosek, Daniel C. Chan
A theory is presented proposing that genetic regulation in mammalian cells is at least a two-tiered effect; that one level of regulation involves the transition between gene exposure and sequestration; that normal differentiation requires a different spectrum of genes to be exposed in each separate state of differentiation; that the fiber systems of the cell cytoskeleton and the nuclear matrix tog...... hiện toàn bộ
Chromosomal Sublocalization of the Transcribed Human Telomere Repeat Binding Factor 2 Gene and Comparative Mapping in the Mouse
Springer Science and Business Media LLC - Tập 24 - Trang 157-163 - 1998
Alan Y. Sakaguchi, Susan S. Padalecki, Vicki Mattern, Angelica Rodriguez, Robin J. Leach, John R. McGill, Michelle Chavez, Troy A. Giambernardi
Telomere repeat binding factor 2 (TERF2) is one of two recently cloned mammalian telomere binding protein genes. TERF2 binds as a dimer with high affinity to the double-stranded TTAGGG telomeric repeat through an evolutionarily conserved myb-type DNA binding domain. TERF2 prevents telomere end-to-end fusion and may be important in maintaining genomic stability. We localized the transcribed TERF2 ...... hiện toàn bộ
Studies on cell division in mammalian cells: VI. A temperature-sensitive mutant blocked in both G1 and G2 phases of the cell cycle
Springer Science and Business Media LLC - Tập 8 - Trang 653-666 - 1982
David Jen-chi Chen, Richard J. Wang
A temperature-sensitive mammalian cell cycle mutant with blocks in G 1 and G2 phases of the cell cycle has been isolated in culture. When shifted from the permissive temperature of 33‡ C to the nonpermissive temperature of 39‡ C, the fraction of cells initiating DNA synthesis as well as the fraction of cells entering mitosis decreased rapidly. Combined cytophotometric and autoradiographic analysi...... hiện toàn bộ
Fast-twitch and slow-twitch/cardiac Ca2+ ATPase genes map to human chromosomes 16 and 12
Springer Science and Business Media LLC - Tập 14 - Trang 645-645 - 1988
David H. MacLennan, Christopher J. Brandi, Shashikant Champaneria, Paul C. Holland, Vicki E. Powers, Huntington F. Willard
Molecular cloning of a gene involved in methotrexate uptake by DNA-mediated gene transfer
Springer Science and Business Media LLC - Tập 18 - Trang 337-349 - 1992
T. Michael Underhill, Frederick M. R. Williams, Richard C. Murray, Wayne F. Flintoff
A methotrexate-resistant Chinese hamster ovary cell line deficient in methotrexate uptake has been complemented to methotrexate sensitivity by transfection with DNA isolated from a wild-type Chinese hamster ovary genomic cosmid library. Primary and secondary transfectants, which contain a limited number of cosmid sequences, have been shown to regain methotrexate sensitivity and to take up methotre...... hiện toàn bộ
Increased intracellular phosphoribosylpyrophosphate and accelerated orotic acid decarboxylation in a mouse cell line resistant to purine and pyrimidine ribonucleosides
Springer Science and Business Media LLC - Tập 3 - Trang 263-280 - 1977
S. Randolph May, Shahnaz Hashmi, Orlando J. Miller, Robert S. Krooth
A line of mouse fibroblasts (A9AU-1), originally selected for growth in the presence of 6-azauridine, has been found to be resistant to cytotoxic concentrations of adenosine, guanosine, and thymidine. A9AU-1 cells convert orotic acid to uridine 5′-monophosphate at twice the rate of the A9P line from which the A9AU-1 clone was selected. The resistant cells also excrete purines, synthesized de novo,...... hiện toàn bộ
Carcinoembryonic antigen (CEA) expression in somatic cell hybrids
Springer Science and Business Media LLC - Tập 8 - Trang 1-13 - 1982
Denise Sheer, Ruth M. Brown, Martin Bobrow
Five hybrids (LSB) were formed between LS174T, a human CEA-producing colonic tumor cell line, and BU25.CAPR, a HeLa derivative which does not produce CEA. All five hybrids produce CEA, but less per cell than LS174T. Approximately 10 % of the chromosomes have been lost from these hybrids. In an attempt to map the gene(s) coding for the protein moiety of CEA, 7 LSPG and 28 LSR hybrids were formed be...... hiện toàn bộ
Ouabain-resistant mutants of Chinese hamster ovary cells are not directly affected in Na+, K+-ATPase
Springer Science and Business Media LLC - Tập 12 - Trang 367-373 - 1986
Arvind Chopra, Radhey S. Gupta
The nature of biochemical lesions in a number of independent single-step ouabainresistant (OuaR) mutants of Chinese hamster ovary cells has been examined. The cellular uptake of86 Rb in the mutant cells was found to be resistant to inhibition by ouabain and correlated with the degree of resistance of the mutants to the drug. However, the plasma membrane Na+, K+-ATPase from all five of the OuaR mut...... hiện toàn bộ
Complementation analysis of Chediak-Higashi Syndrome: The same gene may be responsible for the defect in all patients and species
Springer Science and Business Media LLC - Tập 19 - Trang 459-468 - 1993
Charles M. Perou, Jerry Kaplan
Chediak-Higashi Syndrome is an autosomal recessive disorder, characterized by the presence of large intracellular granules, particularly lysosomes and melanosomes. While the Chediak-Higashi Syndrome is a rare disorder in humans, phenotypically similar syndromes are found in other species. Fusion of normal fibroblasts to Chediak fibroblasts complements the Chediak disorder, restoring normal lysosom...... hiện toàn bộ
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