Springer Science and Business Media LLC
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Statins as a New Therapeutic Perspective in Myocarditis and Postmyocarditis Dilated Cardiomyopathy
Springer Science and Business Media LLC - Tập 27 - Trang 365-369 - 2013
Exercise tolerance in angina is improved by mivazerol?An alpha2-adrenoceptor agonist
Springer Science and Business Media LLC - Tập 7 Số 6 - Trang 929-934 - 1993
Alterations of vasomotor regulation in atherosclerosis
Springer Science and Business Media LLC - Tập 9 - Trang 55-63 - 1995
The vascular endothelium modulates vasomotor tone by the release of several vasoactive substances, predominantly nitric oxide or a closely related compound. This role of the endothelium is altered by several common disease states, as extensively studied in both animal models and humans with hypercholesterolemia and atherosclerosis. Although several mechanisms may underlie this pathophysiologic phe......
A First-in-Human Study of AMG 986, a Novel Apelin Receptor Agonist, in Healthy Subjects and Heart Failure Patients
Springer Science and Business Media LLC - Tập 37 - Trang 743-755 - 2022
AMG 986 is a novel apelin receptor (APJ) agonist that improves cardiac contractility in animal models without adversely impacting hemodynamics. This phase 1b study evaluated the safety/tolerability, pharmacokinetics, and pharmacodynamics of AMG 986 in healthy subjects and patients with heart failure (HF). Healthy adults (Parts A/B) and HF patients (Part C) aged 18–85 years were randomized 3:1 to s......
How to Mediate Cardioprotection in Ischemic Hearts—Accumulated Evidence of Basic Research Should Translate to Clinical Medicine
Springer Science and Business Media LLC - Tập 24 - Trang 217-223 - 2010
Ischemic heart failure is one of the leading causes of death in the western countries and it is a critical issue to overcome ischemic heart diseases for the human health care worldwide. There are several aspects of ischemic heart failure that we need to seriously consider for the conquest of cardiovascular death. First of all, we need to know either causes or pathophysiology of the onset of corona......
Enhanced NO Signaling in Patients with Takotsubo Cardiomyopathy: Short-Term Pain, Long-Term Gain?
Springer Science and Business Media LLC - Tập 27 - Trang 541-547 - 2013
Little information is available concerning the mechanism(s) underlying Takotsubo cardiomyopathy (TTC), other than evidence of associated catecholamine secretion. Given the known effects of catecholamines on endothelial function, we tested the hypothesis that TTC might also be associated with impairment of nitric oxide (NO) signaling. We now report an evaluation of NO signaling in TTC patients (vs.......
Editorial: Metabolic Supplementation with Orotic Acid and Magnesium Orotate
Springer Science and Business Media LLC - Tập 12 - Trang 147-152 - 1998
Orotic acid (OA), a naturally occurring substance, is a key intermediate in the biosynthetic pathway of pyrimidines. Previous investigations in the heart suggest that orotate can protect recently infarcted hearts against a further ischemic stress and may be beneficial in certain types of experimental cardiomyopathy. At the Hamburg symposium on magnesium orotate, a number of studies of this form of......
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