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Intraosseous Versus Peripheral Intravenous Access During Out-of-Hospital Cardiac Arrest: a Comparison of 30-Day Survival and Neurological Outcome in the French National Registry
Springer Science and Business Media LLC - Tập 34 - Trang 189-197 - 2020
To compare intraosseous access with peripheral venous access on adults out-of-hospital cardiac arrest (OHCA) patients’ clinical outcomes. A national retrospective multicentre study was conducted based on the French National Cardiac Arrest Registry. Comparison of patients (intraosseous vs. peripheral venous access) was conducted before and after a matching using a propensity score. The propensity s...... hiện toàn bộ
Diuretic Downsides—But in Low Doses They Still Seem Among the Best Authenticated Antihypertensives
Springer Science and Business Media LLC - Tập 14 - Trang 407-409 - 2000
Diuretics in low doses have the greatest support among current available antihypertensives in that they have been shown to reduce total mortality, coronary mortality, stroke, and congestive heart failure in an important meta-analysis by Psaty. Recently, Messerli has linked long-term diuretic use to renal cell carcinoma in women. In some patients, diuretic use leads to increasing blood cholesterol ...... hiện toàn bộ
Treatment of hypercholesterolemia with the HMG CoA reductase inhibitor, simvastatin
Springer Science and Business Media LLC - Tập 3 - Trang 219-227 - 1989
We report the results of a two center study on the use of the HMG Co A reductase inhibitor, simvastatin, in 44 patients suffering from familial hypercholesterolemia or from primary hypercholesterolemia of unknown etiology. The study included two separate phases: Phase I was part of a multicenter, 4-week, placebo-controlled trial; phase II was a 6-month, open extension trial, the object of which wa...... hiện toàn bộ
Protection of Sacubitril/Valsartan against Pathological Cardiac Remodeling by Inhibiting the NLRP3 Inflammasome after Relief of Pressure Overload in Mice
Springer Science and Business Media LLC - Tập 34 - Trang 629-640 - 2020
The persistent existence of pathological cardiac remodeling, resulting from aortic stenosis, is related to poor clinical prognosis after successful transcatheter aortic valve replacement (TAVR). Sacubitril/valsartan (Sac/Val), comprising an angiotensin receptor blocker and a neprilysin inhibitor, has been demonstrated to have a beneficial effect against pathological cardiac remodeling, including c...... hiện toàn bộ
Myocardioprotective Effects of Felodipine in an Antihypertensive Dosage: An Experimental Study in Pigs
Springer Science and Business Media LLC - Tập 12 - Trang 37-45 - 1998
Altered responsiveness to endothelin-1 of myocardium from pacing-induced heart failure model in the dog
Springer Science and Business Media LLC - Tập 10 - Trang 107-112 - 1996
In congestive heart failure, in addition to a compensatory increase in neurohumoral activation, there is an increase in the endothelial-derived vasoconstrictive and positive inotropic substance, endothelin. Whether downregulation of the cardiac inotropic effects of this endothelial-derived substance occurs, as has been shown to occur with neurohumoral beta- and alpha-adrenergic agonists, remains u...... hiện toàn bộ
Interaction Between Genes and Environment in Inherited Lipid Disorders Determines Clinical Presentation
Springer Science and Business Media LLC - Tập 16 - Trang 271-272 - 2002
Levosimendan Use Reduces Matrix Metalloproteinase-2 in Patients with Decompensated Heart Failure
Springer Science and Business Media LLC - Tập 19 - Trang 399-402 - 2006
Background: Extracellular matrix metabolism (ECM) has an important role in left ventricular (LV) remodeling in chronic heart failure (CHF). Matrix metalloproteinases (MMPs) are involved in the regulation of extracellular matrix (ECM) metabolism. We investigated the effect of levosimendan, a novel calcium sensitizer, on serum levels of MMP-2. Methods: Our study population consisted of 60 consecutiv...... hiện toàn bộ
A Multisite Retrospective Review of Direct Oral Anticoagulants Compared to Warfarin in Adult Fontan Patients
Springer Science and Business Media LLC - - 2022
Direct oral anticoagulants (DOACs) are not recommended in adult Fontan patients (Level of Evidence C). We hypothesized that DOACs are comparable to warfarin and do not increase thrombotic and embolic complications (TEs) or clinically significant bleeds. We reviewed the medical records of adult Fontan patients on DOACs or warfarin at three major medical centers. We identified 130 patients: 48 on DO...... hiện toàn bộ
Alterations in sodium metabolism as an etiological model for hypertension
Springer Science and Business Media LLC - Tập 9 - Trang 377-399 - 1995
An adequate matching for race, sex, stage of the menstrual cycle, family history of hypertension, and the amount of sodium and other electrolytes in the diet should be a prerequisite for valid conclusions when interpreting the erythrocyte concentration and fluxes of sodium in essential hypertensive patients in comparison with normal subjects. Alterations in intracellular sodium concentration and t...... hiện toàn bộ
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