Mary Canavan, Achilleas Floudas, Douglas J. Veale, Ursula Fearon
AbstractThe activation of antigen specific T cells during an immune response is
a tightly regulated process at the level of both costimulatory and coinhibitory
receptors. One such coinhibitory receptor or checkpoint inhibitor which has
received much attention in the field of oncology is the programmed cell death
protein 1 (PD-1). Blockade of PD-1 or its ligand PD-L1 has proven successful in
the tr... hiện toàn bộ
Adolfo Camargo Coronel, Francisco Javier Jiménez Balderas, H. Quiñones-Moya, Mario Raúl Hernández Zavala, Pedro Mandinabeitia Rodríguez, José Ramiro Hernández Vázquez, Sandy Zamora Zarco, Sergio De Jesús Aguilar Castillo
Abstract Background Dermatomyositis belongs to an infrequent group of diseases
predominantly found in patients older than 40 years old and is characterized by
dermal and muscular findings. This disease presents itself as proximal,
ascending and symmetric weakness and typical dermatosis with findings such as
elevated muscle enzymes, altered electromyography and typical changes in muscle
biopsy; as ... hiện toàn bộ
Frédéric Muench, Martin Krusche, Leif Erik Sander, Thomas Rose, Gerd‐Rüdiger Burmester, Udo Schneider
Abstract Background Adult-onset Still’s disease (AOSD) is an autoinflammatory
multi-systemic syndrome. Macrophage activation syndrome (MAS) is a potentially
life-threatening complication of AOSD with a mortality rate of 10–20%.
Especially viral infection is thought to be a common trigger for development of
MAS. On the other hand, the occurrence of MAS following vaccinations is
extremely rare and h... hiện toàn bộ