Mary Canavan, Achilleas Floudas, Douglas J. Veale, Ursula Fearon
AbstractThe activation of antigen specific T cells during an immune response is a tightly regulated process at the level of both costimulatory and coinhibitory receptors. One such coinhibitory receptor or checkpoint inhibitor which has received much attention in the field of oncology is the programmed cell death protein 1 (PD-1). Blockade of PD-1 or its ligand PD-L...... hiện toàn bộ
Adolfo Camargo Coronel, Francisco Javier Jiménez Balderas, H. Quiñones-Moya, Mario Raúl Hernández Zavala, Pedro Mandinabeitia Rodríguez, José Ramiro Hernández Vázquez, Sandy Zamora Zarco, Sergio De Jesús Aguilar Castillo
AbstractBackgroundDermatomyositis belongs to an infrequent group of diseases predominantly found in patients older than 40 years old and is characterized by dermal and muscular findings. This disease presents itself as proximal, ascending and symmetric weakness and typical dermatosis with findings...... hiện toàn bộ
Frédéric Muench, Martin Krusche, Leif Erik Sander, Thomas Rose, Gerd‐Rüdiger Burmester, Udo Schneider
AbstractBackgroundAdult-onset Still’s disease (AOSD) is an autoinflammatory multi-systemic syndrome. Macrophage activation syndrome (MAS) is a potentially life-threatening complication of AOSD with a mortality rate of 10–20%. Especially viral infection is thought to be a common trigger for develop...... hiện toàn bộ