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Correction to: Colorectal cancer organoid models uncover oxaliplatin-resistant mechanisms at single cell resolution
Springer Science and Business Media LLC - - 2022
The PI3K/mTOR dual inhibitor GSK458 potently impedes ovarian cancer tumorigenesis and metastasis
Springer Science and Business Media LLC - Tập 43 - Trang 669-680 - 2020
The PI3K/AKT/mTOR pathway is one of the most highly activated cellular signaling pathways in advanced ovarian cancer. Although several PI3K/AKT/mTOR inhibitors have been developed to treat various types of cancer, the antitumor efficacy of many of these compounds against ovarian cancer has remained unclear. Here, we tested and compared a panel of 16 PI3K/AKT/mTOR inhibitors (XL765, Miltefosine, Ra...... hiện toàn bộ
Concomitant high expression of ERα36, GRP78 and GRP94 is associated with aggressive papillary thyroid cancer behavior
Springer Science and Business Media LLC - Tập 41 - Trang 269-282 - 2018
Papillary thyroid cancer (PTC) is more common in women than in men. It has been suggested that estrogen may be involved in its development, as has previously been shown for breast, endometrial and ovarian cancer. The purpose of this study was to assess correlations between the expression of the estrogen receptor alpha36 (ERα36) and the glucose regulated proteins GRP78 and GRP94 (chaperones involve...... hiện toàn bộ
Acetylation-stabilized chloride intracellular channel 1 exerts a tumor-promoting effect on cervical cancer cells by activating NF-κB
Springer Science and Business Media LLC - Tập 44 - Trang 557-568 - 2021
Cervical cancer remains a major cause of cancer-related death in women, especially in developing countries. Previously, we found that the acetylation levels of chloride intracellular channel 1 (CLIC1) at lysine 131 were increased in cervical cancer tissues using a label-free proteomics approach. The aim of this study was to further determine the role of CLIC1 expression and its acetylation in cerv...... hiện toàn bộ
Epigenetic modulation of ferroptosis in cancer: Identifying epigenetic targets for novel anticancer therapy
Springer Science and Business Media LLC - Tập 46 - Trang 1605-1623 - 2023
Ferroptosis is a newly recognized form of oxidative-regulated cell death resulting from iron-mediated lipid peroxidation accumulation. Radical-trapping antioxidant systems can eliminate these oxidized lipids and prevent disrupting the integrity of cell membranes. Epigenetic modifications can regulate ferroptosis by altering gene expression or cell phenotype without permanent sequence changes. Thes...... hiện toàn bộ
Tumor cell-expressed IL-15Rα drives antagonistic effects on the progression and immune control of gastric cancer and is epigenetically regulated in EBV-positive gastric cancer
Springer Science and Business Media LLC - Tập 43 - Trang 1085-1097 - 2020
Epstein-Barr virus associated gastric cancer (EBVaGC) often exhibits a favorable prognosis that correlates with highly methylated viral and host genes and significant immune cell infiltration compared to EBV-negative gastric cancers (GCs). Previously, it has been reported that expression of the IL-15 receptor α (IL-15Rα) is down-regulated in EBVaGC via promoter hypermethylation. In the present stu...... hiện toàn bộ
β-Catenin gene promoter hypermethylation by reactive oxygen species correlates with the migratory and invasive potentials of colon cancer cells
Springer Science and Business Media LLC - Tập 41 - Trang 569-580 - 2018
Over half of the colon cancer patients suffer from cancer-related events, mainly metastasis. Loss of β-catenin activity has previously been found to facilitate cancer cell dissociation and migration. Here, we aimed to investigate whether epigenetic silencing of β-catenin induces human colon cancer cell migration and/or invasion. HCT-116, Caco-2, HT-29 and SW620 cell migration and invasion capaciti...... hiện toàn bộ
Simultaneous determination of serum galectin-3 and -4 levels detects metastases in colorectal cancer patients
Springer Science and Business Media LLC - Tập 36 - Trang 9-13 - 2012
Development of effective ways to detect metastases is highly desirable for improving the therapeutic strategies and survival of cancer patients. Serum levels of galectin-3 and -4, two members of the galactoside-binding galectin family, have recently been reported to be markedly increased up to 31-fold in the bloodstream of colorectal cancer patients and in particular those with metastases. We foun...... hiện toàn bộ
Mitochondrial induction as a potential radio-sensitizer in lung cancer cells - a short report
Springer Science and Business Media LLC - Tập 38 - Trang 247-252 - 2015
Lung cancer is the leading cause of cancer death. Radiation therapy plays a key role in its treatment. Ionizing radiation induces cell death through chromosomal aberrations, which trigger mitotic catastrophe and apoptosis. However, many lung cancer patients show resistance to radiation. Dichloroacetate (DCA) is a small molecule that can promote mitochondrial activation by increasing the influx of ...... hiện toàn bộ
Emerging ways to treat breast cancer: will promises be met?
Springer Science and Business Media LLC - - 2018
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