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Differential expression of miR-139, miR-486 and miR-21 in breast cancer patients sub-classified according to lymph node status
Springer Science and Business Media LLC - Tập 37 Số 3 - Trang 215-227 - 2014
Lene Rask, Eva Balslev, Rolf Søkilde, Estrid Høgdall, Henrik Flyger, Jens Eriksen, Thomas Litman
Correction: Targeting ARHGEF12 promotes neuroblastoma differentiation, MYCN degradation, and reduces tumorigenicity
Springer Science and Business Media LLC - Tập 46 Số 6 - Trang 1871-1872 - 2023
Yi Yang, Siqi Wang, Jiaoyang Cai, Liang Jiang, Yingwen Zhang, Yangyang Xie, Fei Luo, Jingjing Tang, Yijin Gao, Shuhong Shen, Haizhong Feng, Yanxin Li
Colorectal cancer organoid models uncover oxaliplatin-resistant mechanisms at single cell resolution
Springer Science and Business Media LLC - Tập 45 - Trang 1155-1167 - 2022
Guanglong Chen, Ting Gong, Zhe Wang, Zeyu Wang, Xiaolin Lin, Sunrui Chen, Chu Sun, Weijie Zhao, Ye Kong, Huihan Ai, Hang Yang, Yusheng Liu, Fangyan Wu, Jiawei Kang, Shasha Zhao, Xiuying Xiao, Jing Sun, Aina He, Zhi Li
Oxaliplatin-based chemotherapy is a standard treatment for advanced colorectal cancer (CRC) patients. However, chemoresistance-induced resistance is an essential cause for mortality. Therefore, it is necessary to study the mechanism of drug resistance in CRC. Here, we established two strains of patient-derived organoids (PDOs) selected from oxaliplatin-resistant and treatment-naïve CRC patients. T...... hiện toàn bộ
E4BP4 is a repressor of epigenetically regulated SOSTDC1 expression in breast cancer cells
Springer Science and Business Media LLC - - 2014
Akhilesh Rawat, Gopal Gopisetty, Thangarajan Rajkumar
Low SP1 SUMOylation-dependent SNHG17 upregulation promotes drug resistance of gastric cancer through impairing hsa-miR-23b-3p-induced Notch2 inhibition
Springer Science and Business Media LLC - Tập 45 - Trang 1329-1346 - 2022
Guoyu Huang, Guohao Cai, Dongwei Hu, Jinjie Li, Qigang Xu, Zongjing Chen, Bo Xu
Specificity protein 1 (SP1), a transcription factor mediated by SUMOylation modifiers, is upregulated in gastric cancer (GC) and shares negative correlation with patient prognosis. Here, we paid main attention to the role of SP1 SUMOylation in the drug resistance of GC cells and the possible long non-coding RNA (lncRNA) SNHG17/microRNA-23b-3p (miR-23b-3p)/Notch2 network engaged in this process. Tu...... hiện toàn bộ
Iron metabolism in colorectal cancer: a balancing act
Springer Science and Business Media LLC - - 2023
Diogo Estêvão, Miguel da Cruz-Ribeiro, Ana Patrícia Cardoso, Ângela M. Costa, Maria José Oliveira, Tiago Duarte, Tânia Cruz
Abstract Background Colorectal cancer (CRC) is the third most commonly diagnosed cancer and the second deadliest malignancy worldwide. Current dietary habits are associated with increased levels of iron and heme, both of which increase the risk of developing CRC. The harmful effects of iron overload...... hiện toàn bộ
The GNAS1 T393C single nucleotide polymorphism predicts the natural postoperative course of complete resected esophageal cancer
Springer Science and Business Media LLC - Tập 34 Số 4 - Trang 281-288 - 2011
Yogesh K. Vashist, Asad Kutup, Safije Musici, Emre F. Yekebas, Sormeh Mina, Guentac Uzunoglu, Oliver Zehler, Alexandra M. Koenig, Guellue Cataldegirmen, Maximillian Bockhorn, Katharina E. Effenberger, Viacheslav Kalinin, Klaus Pantel, Jakob R. Izbicki
Nestin involvement in tissue injury and cancer - a potential tumor marker?
Springer Science and Business Media LLC - Tập 37 - Trang 305-315 - 2014
Ekaterini Christina Tampaki, Lydia Nakopoulou, Athanasios Tampakis, Konstantinos Kontzoglou, Walter P. Weber, Gregory Kouraklis
In eukaryotic cells, the cytoskeleton contains three major filamentous components: actin microfilaments, microtubules and intermediate filaments. Nestin represents one of the class VI intermediate filament proteins. Clinical and molecular analyses have revealed substantial information regarding the presence of Nestin in cells with progenitor or stem cell properties. During tissue injury Nestin is ...... hiện toàn bộ
Chemotherapeutic agents in low noncytotoxic concentrations increase immunogenicity of human colon cancer cells
Springer Science and Business Media LLC - Tập 34 - Trang 97-106 - 2011
Ramon Kaneno, Galina V. Shurin, Felipe M. Kaneno, Hiam Naiditch, Jianhua Luo, Michael R. Shurin
We have recently reported that chemotherapeutic agents in ultra low noncytotoxic concentrations may block the ability of tumor cells to suppress functional activation of dendritic cells (DCs). HCT-116 human colon cancer cells were treated with 0.5 nM paclitaxel (PAC) or 2 nM doxorubicin (DOX) with the aim of defining the immunogenic changes induced by ultra low noncytotoxic concentrations of antin...... hiện toàn bộ
Dipyridamole enhances the anti-cancer ability of aspirin against colorectal cancer by inducing apoptosis in an unfolded protein response-dependent manner
Springer Science and Business Media LLC - Tập 46 - Trang 953-967 - 2023
Shan Huang, Nai-Qi Zhang, Chun-Jie Xu, Wu-Qing Huang, Dong-Xue Li, Jun Li, Lin-Li Yao, Kristina Sundquist, Jan Sundquist, Shu-Heng Jiang, Xin Xing, Li-Peng Hu, Zhi-Gang Zhang, Jianguang Ji, Xue-Li Zhang
Available evidence indicates that dipyridamole enhances the anti-thrombotic effects of aspirin for the prevention of secondary strokes. Aspirin is a well-known non-steroid anti-inflammatory drug. This anti-inflammatory property has turned aspirin into a potential drug for inflammation-related cancers such as colorectal cancer (CRC). Here, we aimed to explore whether the anti-cancer effect of aspir...... hiện toàn bộ
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