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Methylated DNA/RNA in Body Fluids as Biomarkers for Lung Cancer
Springer Science and Business Media LLC - Tập 19 - Trang 1-9 - 2017
DNA/RNA methylation plays an important role in lung cancer initiation and
progression. Liquid biopsy makes use of cells, nucleotides and proteins released
from tumor cells into body fluids to help with cancer diagnosis and prognosis.
Methylation of circulating tumor DNA (ctDNA) has gained increasing attention as
biomarkers for lung cancer. Here we briefly introduce the biological basis and
detecti...
Icariin: a Potential Compound for the Recovery of Tibial Dyschondroplasia Affected Chicken Via Up-Regulating BMP-2 Expression
Springer Science and Business Media LLC - Tập 20 - Trang 1-7 - 2018
Tibial dyschondroplasia (TD) is a skeletal disease of fast growing chicken and
other avian species. It is characterized by an avascular and non-mineralized
growth plate, which leads to a deformed tibial bone and lameness. Unfortunately,
this disease is not only responsible for causing huge economic losses but also
raises animal welfare concerns. Icariin is a flavonoid, which is isolated from
Epime...
Blocking Abundant RNA Transcripts by High-Affinity Oligonucleotides during Transcriptome Library Preparation
Springer Science and Business Media LLC - Tập 25 - Trang 1-19 - 2023
RNA sequencing has become the gold standard for transcriptome analysis but has
an inherent limitation of challenging quantification of low-abundant
transcripts. In contrast to microarray technology, RNA sequencing reads are
proportionally divided in function of transcript abundance. Therefore,
low-abundant RNAs compete against highly abundant - and sometimes
non-informative - RNA species. We devel...
Targeting Mitochondrial Complex I Deficiency in MPP+/MPTP-induced Parkinson’s Disease Cell Culture and Mouse Models by Transducing Yeast NDI1 Gene
Springer Science and Business Media LLC -
Abstract Background MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine),
original found in synthetic heroin, causes Parkinson’s disease (PD) in human
through its metabolite MPP+ by inhibiting complex I of mitochondrial respiratory
chain in dopaminergic neurons. This study explored whether yeast internal
NADH-quinone oxidoreductase (NDI1) has therapeutic effects in MPTP- induced PD
models by functi...
A semi-quantitative RT-PCR method to measure thein vivo effect of dietary conjugated linoleic acid on porcine muscle PPAR gene expression
Springer Science and Business Media LLC - - 2003
Conjugated linoleic acid (CLA) can activate (in vitro) the nuclear transcription
factors known as the peroxisome proliferators activated receptors (PPAR). CLA
was fed at 11 g CLA/kg of feed for 45d to castrated male pigs (barrows) to
better understand long term effects of PPAR activationin vivo. The barrows fed
CLA had lean muscle increased by 3.5% and overall fat reduced by 9.2% but
intramuscular...
A high-throughput screening system for SARS-CoV-2 entry inhibition, syncytia formation and cell toxicity
Springer Science and Business Media LLC - Tập 25 - Trang 1-15 - 2023
The entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into
the host cell is mediated through the binding of the SARS-CoV-2 Spike protein
via the receptor binding domain (RBD) to human angiotensin-converting enzyme 2
(hACE2). Identifying compounds that inhibit Spike-ACE2 binding would be a
promising and safe antiviral approach against COVID-19. In this study, we used a
BSL-2 com...
Ultra-Fast and Optimized Method for the Preparation of Rodent Testicular Cells for Flow Cytometric Analysis
Springer Science and Business Media LLC - Tập 11 - Trang 184-195 - 2009
Homogeneity of cell populations is a prerequisite for the analysis of
biochemical and molecular events during male gamete differentiation. Given the
complex organization of the mammalian testicular tissue, various methods have
been used to obtain enriched or purified cell populations, including flow cell
sorting. Current protocols are usually time-consuming and may imply loss of
short-lived RNAs, ...
An evaluation of the reliability of muscle fiber cross-sectional area and fiber number measurements in rat skeletal muscle
Springer Science and Business Media LLC - Tập 15 Số 1 - 2013
Characterising protein/detergent complexes by triple-detection size-exclusion chromatography
Springer Science and Business Media LLC - Tập 18 - Trang 1-18 - 2016
In vitro investigations of membrane proteins usually depend on detergents for
protein solubilisation and stabilisation. The amount of detergent bound to a
membrane protein is relevant to successful experiment design and data analysis
but is often unknown. Triple-detection size-exclusion chromatography enables
simultaneous separation of protein/detergent complexes and protein-free
detergent micelle...
Methods for direct determination of mitomycin C in aqueous solutions and in urine
Springer Science and Business Media LLC - - 1998
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