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Methylated DNA/RNA in Body Fluids as Biomarkers for Lung Cancer
Springer Science and Business Media LLC - Tập 19 - Trang 1-9 - 2017
Yan Lu, Shulin/SL Li, Shiguo/SG Zhu, Yabin/YB Gong, Jun/J Shi, Ling/ L Xu
DNA/RNA methylation plays an important role in lung cancer initiation and progression. Liquid biopsy makes use of cells, nucleotides and proteins released from tumor cells into body fluids to help with cancer diagnosis and prognosis. Methylation of circulating tumor DNA (ctDNA) has gained increasing attention as biomarkers for lung cancer. Here we briefly introduce the biological basis and detecti...... hiện toàn bộ
Icariin: a Potential Compound for the Recovery of Tibial Dyschondroplasia Affected Chicken Via Up-Regulating BMP-2 Expression
Springer Science and Business Media LLC - Tập 20 - Trang 1-7 - 2018
Mujahid Iqbal, Hui Zhang, Khalid Mehmood, Aoyun Li, Xiong Jiang, Yaping Wang, Jialu Zhang, Muhammad Kashif Iqbal, Mujeeb Ur Rehman, Wangyuan Yao, Shijin Yang, Jiakui Li
Tibial dyschondroplasia (TD) is a skeletal disease of fast growing chicken and other avian species. It is characterized by an avascular and non-mineralized growth plate, which leads to a deformed tibial bone and lameness. Unfortunately, this disease is not only responsible for causing huge economic losses but also raises animal welfare concerns. Icariin is a flavonoid, which is isolated from Epime...... hiện toàn bộ
Targeting Mitochondrial Complex I Deficiency in MPP+/MPTP-induced Parkinson’s Disease Cell Culture and Mouse Models by Transducing Yeast NDI1 Gene
Springer Science and Business Media LLC -
Hongzhi Li, Jing Zhang, Yuqi Shi, Y. X. Ye, Quan Jiang, Lan Chen, Bohao Sun, Zhuo Chen, Luxi Shen, Hezhi Fang, Jun Yang, Haihua Gu
Abstract Background MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine), original found in synthetic heroin, causes Parkinson’s disease (PD) in human through its metabolite MPP+ by inhibiting complex I of mitochondrial respiratory chain in dopaminergic neurons. This study explor...... hiện toàn bộ
A semi-quantitative RT-PCR method to measure thein vivo effect of dietary conjugated linoleic acid on porcine muscle PPAR gene expression
Springer Science and Business Media LLC - - 2003
W. J. Meadus
Conjugated linoleic acid (CLA) can activate (in vitro) the nuclear transcription factors known as the peroxisome proliferators activated receptors (PPAR). CLA was fed at 11 g CLA/kg of feed for 45d to castrated male pigs (barrows) to better understand long term effects of PPAR activationin vivo. The barrows fed CLA had lean muscle increased by 3.5% and overall fat reduced by 9.2% but intramuscular...... hiện toàn bộ
A high-throughput screening system for SARS-CoV-2 entry inhibition, syncytia formation and cell toxicity
Springer Science and Business Media LLC - Tập 25 - Trang 1-15 - 2023
Shine Varghese Jancy, Santhik Subhasingh Lupitha, Aneesh Chandrasekharan, Shankara Narayanan Varadarajan, Shijulal Nelson-Sathi, Roshny Prasad, Sara Jones, Sreekumar Easwaran, Pramod Darvin, Aswathy Sivasailam, Thankayyan Retnabai Santhoshkumar
The entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into the host cell is mediated through the binding of the SARS-CoV-2 Spike protein via the receptor binding domain (RBD) to human angiotensin-converting enzyme 2 (hACE2). Identifying compounds that inhibit Spike-ACE2 binding would be a promising and safe antiviral approach against COVID-19. In this study, we used a BSL-2 com...... hiện toàn bộ
Ultra-Fast and Optimized Method for the Preparation of Rodent Testicular Cells for Flow Cytometric Analysis
Springer Science and Business Media LLC - Tập 11 - Trang 184-195 - 2009
Rosana Rodríguez-Casuriaga, Adriana Geisinger, Beatriz López-Carro, Valentina Porro, Rodolfo Wettstein, Gustavo A Folle
Homogeneity of cell populations is a prerequisite for the analysis of biochemical and molecular events during male gamete differentiation. Given the complex organization of the mammalian testicular tissue, various methods have been used to obtain enriched or purified cell populations, including flow cell sorting. Current protocols are usually time-consuming and may imply loss of short-lived RNAs, ...... hiện toàn bộ
An evaluation of the reliability of muscle fiber cross-sectional area and fiber number measurements in rat skeletal muscle
Springer Science and Business Media LLC - Tập 15 Số 1 - 2013
Lisa Ceglia, Sathit Niramitmahapanya, Lori Lyn Price, Susan S. Harris, Roger A. Fielding, Bess Dawson‐Hughes
Characterising protein/detergent complexes by triple-detection size-exclusion chromatography
Springer Science and Business Media LLC - Tập 18 - Trang 1-18 - 2016
Katharina Gimpl, Jessica Klement, Sandro Keller
In vitro investigations of membrane proteins usually depend on detergents for protein solubilisation and stabilisation. The amount of detergent bound to a membrane protein is relevant to successful experiment design and data analysis but is often unknown. Triple-detection size-exclusion chromatography enables simultaneous separation of protein/detergent complexes and protein-free detergent micelle...... hiện toàn bộ
Methods for direct determination of mitomycin C in aqueous solutions and in urine
Springer Science and Business Media LLC - - 1998
Dolores Pérez Marín, Pedro Emílio Zamorano Pérez, C. Teijeiro, Emil Paleček
Application of a colorimetric assay to identify putative ribofuranosylaminobenzene 5′-phosphate synthase genes expressed with activity inEscherichia coli
Springer Science and Business Media LLC - Tập 5 - Trang 69-77 - 2003
Matthew E. Bechard, Sonya Chhatwal, Rosemarie E. Garcia, Madeline E. Rasche
Tetrahydromethanopterin (H4MPT) is a tetrahydrofolate analog originally discovered in methanogenic archaea, but later found in other archaea and bacteria. The extent to which H4MPT occurs among living organisms is unknown. The key enzyme which distinguishes the biosynthetic pathways of H4MPT and tetrahydrofolate is ribofuranosylaminobenzene 5′-phosphate synthase (RFAP synthase). Given the importan...... hiện toàn bộ
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