H.C. Hemker, Peter Giesen, Raed Al Dieri, Véronique Regnault, Erik De Smedt, Rob Wagenvoord, Thomas Lecompte, Anne Lienhart
Calibrated automated thrombography displays the concentration of thrombin in
clotting plasma with or without platelets (platelet-rich plasma/platelet-poor
plasma, PRP/PPP) in up to 48 samples by monitoring the splitting of a
fluorogenic substrate and comparing it to a constant known thrombin activity in
a parallel, non-clotting sample. Thus, the non-linearity of the reaction rate
with thrombin con... hiện toàn bộ
P L Turecek, Katalin Váradi, B. Keil, Claude Négrier, Erik Berntorp, Jan Astermark, Jean‐Claude Bordet, Massimo Morfini, Silvia Linari, HP Schwarz
Factor VIII (FVIII)-bypassing agents have complex modes of action but all
control bleeding in inhibitor patients by triggering the generation of thrombin.
No routine test is available for monitoring this therapy in patients with
inhibitors against FVIII. We present an assay that records FEIBA- or
FVIIa-mediated changes in thrombin generation (TG) in FVIII inhibitor plasma
samples. In plasma sample... hiện toàn bộ
The structural and functional studies of the first identified C-type lectin-like
protein (CLP), blood coagulation factor IX/factor X-binding protein (IX/X-bp),
have been instrumental in defining how new functionally heterodimeric CLPs are
generated from monomeric carbohydrate recognition domain in C-type lectins by
three-dimensional domain swapping. The crystal structures of γ-carboxyglutamic
acid... hiện toàn bộ