S. Karger AG
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Structure-Function Relationships of C-Type Lectin-Related Proteins The structural and functional studies of the first identified C-type lectin-like protein (CLP), blood coagulation factor IX/factor X-binding protein (IX/X-bp), have been instrumental in defining how new functionally heterodimeric CLPs are generated from monomeric carbohydrate recognition domain in C-type lectins by three-dimensional domain swapping. The crystal structures of γ-carboxyglutamic acid domains of coagulation factors X and IX have recently been clarified in structural studies of complexes between the γ-carboxyglutamic acid domain of factors X and X-bp (a venom CLP) and between the γ-carboxyglutamic acid domain of factors IX and IX-bp (a venom CLP).
S. Karger AG - Tập 34 Số 4-5 - Trang 156-159 - 2005
The insulin resistance syndrome: implications for thrombosis and cardiovascular disease
S. Karger AG - Tập 32 Số 5-6 - Trang 269-273 - 2002
The Prothrombinase-Induced Clotting Test: A New Technique for the Monitoring of Anticoagulants
S. Karger AG - Tập 30 Số 2 - Trang 172-174 - 2000
Pathogenesis of the acute coronary syndromes and therapeutic implications
S. Karger AG - Tập 32 Số 5-6 - Trang 225-231 - 2002
Factor VIII Inhibitor-Bypassing Agents Act by Inducing Thrombin Generation and Can Be Monitored by a Thrombin Generation Assay Factor VIII (FVIII)-bypassing agents have complex modes of action but all control bleeding in inhibitor patients by triggering the generation of thrombin. No routine test is available for monitoring this therapy in patients with inhibitors against FVIII. We present an assay that records FEIBA- or FVIIa-mediated changes in thrombin generation (TG) in FVIII inhibitor plasma samples. In plasma samples spiked with FEIBA TG was normalized above 0.4 U/ml, while for recombinant FVIIa (rFVIIa) more than 12.5 µg/ml were required to induce TG in the absence of tissue factor (TF). Addition of TF increased the TG potential of rFVIIa in vitro. This assay seems suitable for monitoring the pharmacokinetics of inhibitor bypassing agents during treatment and possibly for predicting responses to treatment.
S. Karger AG - Tập 33 Số 1 - Trang 16-22 - 2003
Atrial Fibrillation and the Hypercoagulable State: From Basic Science to Clinical Practice
S. Karger AG - Tập 33 Số 5-6 - Trang 282-289 - 2003
Elevated Clotting Factor Levels and Venous Thrombosis
S. Karger AG - Tập 33 Số 5-6 - Trang 395-400 - 2003
Calibrated Automated Thrombin Generation Measurement in Clotting Plasma Calibrated automated thrombography displays the concentration of thrombin in clotting plasma with or without platelets (platelet-rich plasma/platelet-poor plasma, PRP/PPP) in up to 48 samples by monitoring the splitting of a fluorogenic substrate and comparing it to a constant known thrombin activity in a parallel, non-clotting sample. Thus, the non-linearity of the reaction rate with thrombin concentration is compensated for, and adding an excess of substrate can be avoided. Standard conditions were established at which acceptable experimental variation accompanies sensitivity to pathological changes. The coefficients of variation of the surface under the curve (endogenous thrombin potential) are: within experiment ∼3%; intra-individual: <5% in PPP, <8% in PRP; interindividual 15% in PPP and 19% in PRP. In PPP, calibrated automated thrombography shows all clotting factor deficiencies (except factor XIII) and the effect of all anticoagulants [AVK, heparin(-likes), direct inhibitors]. In PRP, it is diminished in von Willebrand’s disease, but it also shows the effect of platelet inhibitors (e.g. aspirin and abciximab). Addition of activated protein C (APC) or thrombomodulin inhibits thrombin generation and reflects disorders of the APC system (congenital and acquired resistance, deficiencies and lupus antibodies) independent of concomitant inhibition of the procoagulant pathway as for example by anticoagulants.
S. Karger AG - Tập 33 Số 1 - Trang 4-15 - 2003
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