S. Karger AG

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Factor VIII Inhibitor-Bypassing Agents Act by Inducing Thrombin Generation and Can Be Monitored by a Thrombin Generation Assay
S. Karger AG - Tập 33 Số 1 - Trang 16-22 - 2003
P L Turecek, Katalin Váradi, B. Keil, Claude Négrier, Erik Berntorp, Jan Astermark, Jean‐Claude Bordet, Massimo Morfini, Silvia Linari, HP Schwarz
Factor VIII (FVIII)-bypassing agents have complex modes of action but all control bleeding in inhibitor patients by triggering the generation of thrombin. No routine test is available for monitoring this therapy in patients with inhibitors against FVIII. We present an assay that records FEIBA- or FVIIa-mediated changes in thrombin generation (TG) in FVIII inhibitor plasma samples. In plasm...... hiện toàn bộ
Structure-Function Relationships of C-Type Lectin-Related Proteins
S. Karger AG - Tập 34 Số 4-5 - Trang 156-159 - 2005
Takashi Morita
The structural and functional studies of the first identified C-type lectin-like protein (CLP), blood coagulation factor IX/factor X-binding protein (IX/X-bp), have been instrumental in defining how new functionally heterodimeric CLPs are generated from monomeric carbohydrate recognition domain in C-type lectins by three-dimensional domain swapping. The crystal structures of γ-carboxygluta...... hiện toàn bộ
The insulin resistance syndrome: implications for thrombosis and cardiovascular disease
S. Karger AG - Tập 32 Số 5-6 - Trang 269-273 - 2002
I. Juhan‐Vague, Pierre‐Emmanuel Morange, Marie‐Christine Alessi
Atrial Fibrillation and the Hypercoagulable State: From Basic Science to Clinical Practice
S. Karger AG - Tập 33 Số 5-6 - Trang 282-289 - 2003
Anirban Choudhury, Gregory Y.H. Lip
Pathogenesis of the acute coronary syndromes and therapeutic implications
S. Karger AG - Tập 32 Số 5-6 - Trang 225-231 - 2002
Lina Badimón, Juan J. Badimón, Gemma Vilahur, E. Segalés, V. Llorente
Elevated Clotting Factor Levels and Venous Thrombosis
S. Karger AG - Tập 33 Số 5-6 - Trang 395-400 - 2003
R M Bertina
The Prothrombinase-Induced Clotting Test: A New Technique for the Monitoring of Anticoagulants
S. Karger AG - Tập 30 Số 2 - Trang 172-174 - 2000
A. Clatzis, M. Spannagl, P. Gempeler-Messina, Hans-Jürgen Kolde, W Schramm, Sylvia Haas
Calibrated Automated Thrombin Generation Measurement in Clotting Plasma
S. Karger AG - Tập 33 Số 1 - Trang 4-15 - 2003
H.C. Hemker, Peter Giesen, Raed Al Dieri, Véronique Regnault, Erik De Smedt, Rob Wagenvoord, Thomas Lecompte, Anne Lienhart
Calibrated automated thrombography displays the concentration of thrombin in clotting plasma with or without platelets (platelet-rich plasma/platelet-poor plasma, PRP/PPP) in up to 48 samples by monitoring the splitting of a fluorogenic substrate and comparing it to a constant known thrombin activity in a parallel, non-clotting sample. Thus, the non-linearity of the reaction rate with thro...... hiện toàn bộ
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