S. Karger AG
1660-2110
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Các bài báo tiêu biểu
Selection Bias and Information Bias in Clinical ResearchThe internal validity of an epidemiological study can be affected by <i>random error</i> and <i>systematic error</i>. Random error reflects a problem of precision in assessing a given exposure-disease relationship and can be reduced by increasing the sample size. On the other hand, systematic error or bias reflects a problem of validity of the study and arises becau... ...
Tập 115 Số 2 - Trang c94-c99
Efficacy, Tolerability, and Safety of Lanthanum Carbonate in Hyperphosphatemia: A 6-Month, Randomized, Comparative Trial versus Calcium Carbonate<i>Background/Aims:</i> Hyperphosphatemia is an important clinical consequence of renal failure, and its multiple adverse systemic effects are associated with significantly increased risks of morbidity and mortality in dialysis patients. Existing oral phosphate binders have not permitted control of serum phosphate within currently accepted guidelines. This study compares lantha... ...
Tập 100 Số 1 - Trang c8-c19
Clinical Trial Endpoints in Acute Kidney InjuryThe development and use of consensus criteria for acute kidney injury (AKI) diagnosis and the inclusion of recently identified markers of renal parenchymal damage as endpoints in clinical trials have improved the ability of physicians to compare the incidence and severity of AKI across patient populations, provided targets for testing new treatments, and may increase insight into the mecha... ...
Tập 127 Số 1-4 - Trang 89-93
Accelerated Progression of Calcific Aortic Stenosis in Dialysis Patients<i>Background:</i> Abnormalities of the aortic valve occur with increased frequency in patients with renal failure and may contribute to the observed excess cardiovascular mortality. Little data exist on the rate at which aortic stenosis progresses in this patient group. <i>Methods:</i> A retrospective case-control study was designed to compare the rate of progressi... ...
Tập 94 Số 2 - Trang c40-c45
Long-Term Efficacy and Tolerability of Lanthanum Carbonate: Results from a 3-Year Study<i>Background:</i> Control of serum phosphate over the long term is essential in patients with end-stage renal disease. Six-month and 2-year extensions to a 6-month study evaluated the long-term safety, tolerability and efficacy of the new phosphate binder lanthanum carbonate. <i>Methods:</i> Patients who participated in a 6-month, randomized trial comparing lanthan... ...
Tập 102 Số 2 - Trang c61-c71
Deficient Counseling on Physical Activity among Nephrologists<i>Background:</i> An evaluation of exercise counseling practices among nephrologists in 2001 demonstrated few clinicians assessing patients’ levels of physical activity (PA) and counseling to increase activity. Recent Kidney Disease Outcomes Quality Initiative (KDOQI) cardiovascular guidelines recommended that nephrologists counsel patients to increase PA. Our objective was to... ...
Tập 116 Số 4 - Trang c330-c336
Acute and Transient Podocyte Loss and Proteinuria in PreeclampsiaGlomerular podocytes are known to regulate proteinuria and podocyturia correlated with proteinuria. Podocyturia, the urinary excretion of viable podocytes (glomerular epithelial cells), has been associated with proteinuria in preeclampsia. This study is the first to investigate the time course alterations of podocyturia in patients with preeclampsia (11 cases) and normotensive pregnant wom... ...
Tập 112 Số 2 - Trang c65-c70
Blood Pressure Control and Symptomatic Intradialytic Hypotension in Diabetic Haemodialysis Patients: A Cross-Sectional Survey<i>Background:</i>Cardiovascular disease remains the most common cause of mortality in end-stage kidney failure patients with diabetes. To improve blood pressure control, and reduce cardiovascular risk, in 2002 the UK Renal Association Standards’ Committee introduced pre- and post-dialysis target blood pressures of <140/90 and <130/80 mm Hg, respectively. <i>Methods... ...
Tập 109 Số 2 - Trang c65-c71
Vascular Calcification in Chronic Renal FailureThe prevalence and extent of vascular calcification (VC) increases rapidly with time on dialysis. There is increasing evidence that medial calcification of conduit arteries, without intimal disease, is associated with important abnormalities of vascular compliance and increased risk of cardiovascular death. Coronary artery calcification is also common in end-stage renal disease, but furthe... ...
Tập 93 Số 4 - Trang c124-c130