S. Karger AG

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Acute and Transient Podocyte Loss and Proteinuria in Preeclampsia
S. Karger AG - Tập 112 Số 2 - Trang c65-c70
Kumi Aita, M. Etoh, Hiromi Hamada, Chie Yokoyama, Ayuko Takahashi, Taisei Suzuki, Masanori Hara, Michio Nagata
Glomerular podocytes are known to regulate proteinuria and podocyturia correlated with proteinuria. Podocyturia, the urinary excretion of viable podocytes (glomerular epithelial cells), has been associated with proteinuria in preeclampsia. This study is the first to investigate the time course alterations of podocyturia in patients with preeclampsia (11 cases) and normotensive pregnant women (45 c... hiện toàn bộ
Selection Bias and Information Bias in Clinical Research
S. Karger AG - Tập 115 Số 2 - Trang c94-c99
Giovanni Tripepi, Kitty J. Jager, Friedo W. Dekker, Carmine Zoccali
The internal validity of an epidemiological study can be affected by random error and systematic error. Random error reflects a problem of precision in assessing a given exposure-disease relationship and can be reduced by increasing the sample size. On the other hand, systematic error or bias reflects a problem of validity of the study and arises because of any error resulting from m... hiện toàn bộ
KDIGO Clinical Practice Guidelines for Acute Kidney Injury
S. Karger AG - Tập 120 Số 4 - Trang c179-c184
Arif Khwaja
Blood Pressure Control and Symptomatic Intradialytic Hypotension in Diabetic Haemodialysis Patients: A Cross-Sectional Survey
S. Karger AG - Tập 109 Số 2 - Trang c65-c71
Andrew Davenport, Claire Cox, Raj Thuraisingham
Background:Cardiovascular disease remains the most common cause of mortality in end-stage kidney failure patients with diabetes. To improve blood pressure control, and reduce cardiovascular risk, in 2002 the UK Renal Association Standards’ Committee introduced pre- and post-dialysis target blood pressures of <140/90 and <130/80 mm Hg, respectively. Methods: We audited blood pressure ... hiện toàn bộ
Comparison between 1α(OH)D<sub>3</sub> and 1,25(OH)<sub>2</sub>D<sub>3</sub> on the Suppression of Plasma PTH Levels in Uremic Patients, Evaluated by the ‘Whole’ and ‘Intact’ PTH Assays
S. Karger AG - Tập 99 Số 4 - Trang c128-c137
Lisbet Brandi, Martin Egfjord, Klaus Ølgaard
Background/Aims: The aim was to evaluate the acute effects of intravenous 1α(OH)D3 and 1,25(OH)2D3 on (1) plasma parathyroid hormone (PTH) and Ca2+ levels in chronic uremic patients and (2) circulating large C-terminal PTH fragments as measured by the ‘whole PTH’ assay compared to two different ‘intact PTH’ assays. Methods: 11 patients on c... hiện toàn bộ
Accelerated Progression of Calcific Aortic Stenosis in Dialysis Patients
S. Karger AG - Tập 94 Số 2 - Trang c40-c45
Vlado Perkovic, David Hunt, Siân Griffin, Moira du Plessis, Gavin J. Becker
Background: Abnormalities of the aortic valve occur with increased frequency in patients with renal failure and may contribute to the observed excess cardiovascular mortality. Little data exist on the rate at which aortic stenosis progresses in this patient group. Methods: A retrospective case-control study was designed to compare the rate of progression of aortic stenosis in dialysi... hiện toàn bộ
Vascular Calcification in Chronic Renal Failure
S. Karger AG - Tập 93 Số 4 - Trang c124-c130
Charles Tomson
The prevalence and extent of vascular calcification (VC) increases rapidly with time on dialysis. There is increasing evidence that medial calcification of conduit arteries, without intimal disease, is associated with important abnormalities of vascular compliance and increased risk of cardiovascular death. Coronary artery calcification is also common in end-stage renal disease, but further resear... hiện toàn bộ
Long-Term Efficacy and Tolerability of Lanthanum Carbonate: Results from a 3-Year Study
S. Karger AG - Tập 102 Số 2 - Trang c61-c71
Alastair J. Hutchison, Bart Maes, Johan Vanwalleghem, G. Asmus, Mohamed Elfatih, Roland E. Schmieder, Wolfgang Backs, R. Jamar, Andre Vosskühler
Background: Control of serum phosphate over the long term is essential in patients with end-stage renal disease. Six-month and 2-year extensions to a 6-month study evaluated the long-term safety, tolerability and efficacy of the new phosphate binder lanthanum carbonate. Methods: Patients who participated in a 6-month, randomized trial comparing lanthanum carbonate with calcium carbon... hiện toàn bộ
Efficacy, Tolerability, and Safety of Lanthanum Carbonate in Hyperphosphatemia: A 6-Month, Randomized, Comparative Trial versus Calcium Carbonate
S. Karger AG - Tập 100 Số 1 - Trang c8-c19
Alastair J. Hutchison, Bart Maes, Johan Vanwalleghem, G. Asmus, Essam Hassan Eldrehmy, R. E. Schmieder, Wolfgang Backs, R. Jamar, Andre Vosskühler
Background/Aims: Hyperphosphatemia is an important clinical consequence of renal failure, and its multiple adverse systemic effects are associated with significantly increased risks of morbidity and mortality in dialysis patients. Existing oral phosphate binders have not permitted control of serum phosphate within currently accepted guidelines. This study compares lanthanum carbonate with c... hiện toàn bộ
Deficient Counseling on Physical Activity among Nephrologists
S. Karger AG - Tập 116 Số 4 - Trang c330-c336
Cynthia Delgado, Kirsten L. Johansen
Background: An evaluation of exercise counseling practices among nephrologists in 2001 demonstrated few clinicians assessing patients’ levels of physical activity (PA) and counseling to increase activity. Recent Kidney Disease Outcomes Quality Initiative (KDOQI) cardiovascular guidelines recommended that nephrologists counsel patients to increase PA. Our objective was to ascertain whether n... hiện toàn bộ
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