Synthesis, Characterization, and Antifungal Activity of Some New Thieno[2,3-b]pyridines Incorporating Quinazoline or Benzimidazole MoietyRussian Journal of Bioorganic Chemistry - Tập 47 - Trang 918-928 - 2021
O. F. Ibrahim, E. A. Bakhite, S. A. M. Metwally, Y. A. El-Ossaily, H. H. M. Abdu-Allah, E. A. Al-Taifi, M. Kandel
Reaction of 4,6-dimethyl-3-cyanopyridine-2(1H)-thione (IIIa) or 4,5,6-trisubstituted-3-cyanopyridine-2(1H)-thiones (IIIb–d) with 2-chloromethylquinazoline-4(3H)-one (IVa) furnished the corresponding 3-amino-2-(4-oxo-3,4-dihydroquinazolin-2-yl)thieno[2,3-b]pyridines (VIa–d). Reaction of aminothieno-pyridines (VIa, b, d) were reacted with triethyl orthoformate, acetic anhydride or nitrous acid to fu...... hiện toàn bộ
Virtual Screening of Orally Active Lead Compounds of Pearl Millet and Their Structural Activity Against Target Protein of COVID-19Russian Journal of Bioorganic Chemistry - Tập 49 - Trang S53-S70 - 2024
Adarsh Kumar Shukla, Ashwani Kumar
RNA-dependent RNA polymerase protein (target protein of COVID-19) caused the highly mutated coronavirus that was the reason for the global pandemic. Bioactive compounds of pearl millet were screened out several theoretical rules after that molecular docking and normal mode analysis were performed to check the most prominent inhibitor among the potentially orally active compounds against the therap...... hiện toàn bộ
Polyamidoamine dendrimers with different surface charge as carriers in anticancer drug deliveryRussian Journal of Bioorganic Chemistry - Tập 43 - Trang 155-162 - 2017
N. G. Yabbarov, E. D. Nikolskaya, O. A. Zhunina, I. G. Kondrasheva, I. A. Zamulaeva, E. S. Severin
Second-generation (G2) polyamidoamine (PAMAM) dendrimers are branched polymers containing 16 surface primary amine groups. Due to their structural properties, these polymers can be used as universal carriers in various drug delivery systems. Amine-terminated PAMAM dendrimers are characterized by a high positive surface charge, leading to effective but nonspecific interactions with negatively charg...... hiện toàn bộ
New syntheses of α-methyl- and α,α′-dimethylspermineRussian Journal of Bioorganic Chemistry - Tập 31 - Trang 183-188 - 2005
N. A. Grigorenko, J. Vepsalainen, A. Jarvinen, T. A. Keinanen, L. Alhonen, J. Janne, A. R. Khomutov
α-Methylspermine and α,α′-dimethylspermine were synthesized in high overall yields starting from N-(benzyloxycarbonyl)-3-aminobutanol in order to study polyamine biochemistry in vitro and in vivo.