Russian Journal of Bioorganic Chemistry

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Investigation of mechanical properties, morphology, and biodegradability of compositions based on polylactide and polysaccharides
Russian Journal of Bioorganic Chemistry - - 2017
S. Z. Rogovina, K. V. Aleksanyan, A. Ya. Gorenberg, Yu. I. Deryabina, E. P. Isakova, E. V. Prut, A. A. Berlin
The blends of polylactide with ethyl cellulose and chitosan are obtained in a Brabender mixer under conditions of high temperature shear deformation at different initial ratios of the reagents. The investigation of physicomechanical properties of the compositions has shown that the systems have high rigidity. Polyethylene glycol (PEG) and high-molecular-weight polyolefin polydecene have been added...... hiện toàn bộ
Past and present research on the kallikrein-kinin system (on the 90th anniversary of the discovery of the system)
Russian Journal of Bioorganic Chemistry - Tập 41 - Trang 245-259 - 2015
G. A. Yarovaya, A. E. Neshkova
The large number of components of the kallikrein-kinin system (KKS) and multifunctionality of the system as a whole and that of each of its components enable its participation in the processes of adaptation and organism defense, as well as in many other physiological and pathological states, and serve as the main reasons for unfailing interest in this system during nearly a century of research. Th...... hiện toàn bộ
Synthesis, Reactions, and Antimicrobial Activity of Novel Heterocyclic Compounds Containing Cyclopenta[d]thieno[2,3-b]pyridine Moiety and Related Fused Heterocycles
Russian Journal of Bioorganic Chemistry - Tập 46 - Trang 85-96 - 2020
Remon M. Zaki, Adel M. Kamal El-Dean, Shaban M. Radwan, Mahmoud A. Ammar
We describe a simple method to synthesize novel 4-cyano-1-morpholin-4-yl-6,7-dihydro-5H-cyclopenta[c]pyridine-3-thione by the reaction of 3-amino-1-thioxo-1,5,6,7-tetrahydrocyclopenta[c]thiopyran-4-carbonitrile with morpholine through Dimroth rearrangement. The 1-amino-5-morpholin-4-yl-7,8-dihydro-6H-cyclopenta[d]thieno[2,3-b]pyridine-2-carboxamide, which was synthesized by two methods, was used a...... hiện toàn bộ
Effect of the charge of the interface surface on the structure and activity of trypsin in reversed mycelles
Russian Journal of Bioorganic Chemistry - Tập 34 - Trang 359-363 - 2008
Yu. A. Valiullina, E. A. Stupishina, N. N. Vylegzhanina, B. Z. Idiyatullin, Yu. F. Zuev
The effect of the sign and value of the charge of the interface surface on the catalytic activity of trypsin in systems of reversed mycelles was investigated. n-Butanol was used for the modification of the phase interface in dispersions of reversed mycelles based on anionic sodium bis(2-ethylhexyl)sulfosuccinate (AOT) and cationic cetyltrimethylammonium bromide (CTAB). A direct correlation between...... hiện toàn bộ
Species and Tissue Distribution of Proteins Binding 16α,17α-Cycloalkanoprogesterone Derivatives
Russian Journal of Bioorganic Chemistry - Tập 28 - Trang 224-230 - 2002
A. N. Smirnov, E. V. Pokrovskaya, V. P. Shevchenko, I. Yu. Nagaev, N. F. Myasoedov, I. S. Levina, L. E. Kulikova, A. V. Kamernitsky
The binding of [3H]progesterone and [3H]16α,17α-cycloalkanoprogesterones to proteins from rat, rabbit, and human uteri and other organs was studied. We found that 16α,17α-cycloalkanoprogesterone derivatives display affinities for the uterine progesterone receptors comparable with that of the natural hormone and no substantial species differences in the affinity. Rabbit uterus was found to have no ...... hiện toàn bộ
Synthesis and Biological Activity of 3,4,-Tri-О-Acetyl-N-Acetylglucosamine and Tetraacetylglucopyranose Conjugated with Alkyl Phosphates
Russian Journal of Bioorganic Chemistry - Tập 45 - Trang 155-164 - 2019
R. R. Sharipova, B. F. Garifullin, A. S. Sapunova, A. D. Voloshina, M. A. Kravchenko, V. E. Kataev
Conjugates of 3,4,6-tri-О-acetyl-N-acetylglucosamine and tetraacetyl glucopyranose with alkyl phosphates were synthesized. The dependence of their antibacterial and antituberculosis activities on the length of the alkyl substituent at the phosphate group was found. The conjugates with a decyl substituent exhibited in vitro the highest antituberculosis activity against Mycobacterium tuberculosis H3...... hiện toàn bộ
A convenient synthesis and biological activity of novel thieno[2,3-c]pyrazole compounds as antimicrobial and anti-inflammatory agents
Russian Journal of Bioorganic Chemistry - Tập 41 - Trang 97-104 - 2015
Adel M. Kamal El-Dean, Remon M. Zaki, Abdullah Y. Abdulrazzaq
A new method for synthesizing 4-amino-3-methyl-1-phenyl-1H-5-substituted thieno[2,3-c]pyrazole was reported. The substituted groups at position 5 include carbonitrile, carboxamide, N-phenyl carboxamide, and benzoyl groups. The newly synthesized compounds and their derivatives were characterized by elemental analysis and spectroscopy (IR, 1H NMR, and mass spectra). Furthermore, some of these synthe...... hiện toàn bộ
Design of TiO2~DNA nanocomposites for penetration into cells
Russian Journal of Bioorganic Chemistry - Tập 39 - Trang 77-86 - 2013
A. S. Levina, Z. R. Ismagilov, M. N. Repkova, N. V. Shikina, S. I. Baiborodin, N. V. Shatskaya, S. N. Zagrebelnyi, V. F. Zarytova
Methods of noncovalent immobilization of DNA fragments on titanium dioxide nanoparticles (TiO2) were developed to design TiO2∼DNA nanocomposites, which were capable of penetrating through cell membranes. TiO2 nanoparticles of different forms (amorphous, anatase, brookite) with enhanced agglomeration stability were synthesized. The particles were characterized by X-ray diffraction, small-angle X-ra...... hiện toàn bộ
Formylation of porphyrin platinum complexes
Russian Journal of Bioorganic Chemistry - Tập 31 - Trang 94-98 - 2005
V. D. Rumyantseva, L. I. Konovalenko, E. A. Nagaeva, A. F. Mironov
The formylation reaction of platinum complexes of β-unsubstituted porphyrins was studied. The interaction of deuteroporphyrin IX derivatives with the Vilsmeyer reagent led to the selective formylation of their macrocycles in the β position. The resulting formyl derivatives of the porphyrins are of interest for fluorescent immunoassay.
Synthesis, Anti-Inflammatory Properties and Molecular Docking of 2-(5-Aryltetrazol-2-yl)-and 2-(1H-Tetrazol-5-ylsulphanyl)-N-Thiazol-2-ylacetamides
Russian Journal of Bioorganic Chemistry - Tập 47 - Trang 889-895 - 2021
T. I. Chaban, V. T. Foliush, V. V. Ogurtsov, V. S. Matiychuk
By the reaction of chloroacetamidothiazole with 5-aryltetrazoles and 5-mercaptotetrazoles 2-(5-aryltetrazol-2-yl)- and 2-(1H-tetrazol-5-ylsulfanyl)-N-thiazol-2-ylacetamides were prepared. The study of the anti-inflammatory properties of the synthesized compounds was carried out. Compounds have been identified, whose activity exceeds the reference drug ibuprofen. Molecular docking to cyclooxygenase...... hiện toàn bộ
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