Russian Journal of Bioorganic Chemistry

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Fluorescence Probe Based on Pyrimidine Applied for Rapid Identification of Different Amino Acids
Russian Journal of Bioorganic Chemistry - - 2023
Feng Jin, Linxian Zhao
Cloning, expression, isolation, and properties of thymidine kinase from herpes simplex virus type 1, strain L2
Russian Journal of Bioorganic Chemistry - - 2011
В. Н. Степаненко, Р. С. Есипов, А. И. Мирошников, В. Л. Андронова, Galegov Ga, M. V. Yas'ko, А. А. Гуськова, A. Yu. Skoblov, Yu. S. Skoblov
Evenly tritium labeled peptides in study of peptide in vivo and in vitro biodegradation
Russian Journal of Bioorganic Chemistry - Tập 32 - Trang 166-173 - 2006
Yu. A. Zolotarev, A. K. Dadayan, O. V. Dolotov, V. S. Kozik, N. V. Kost, O. Yu. Sokolov, E. M. Dorokhova, V. K. Meshavkin, L. S. Inozemtseva, M. V. Gabaeva, L. A. Andreeva, L. Yu. Alfeeva, T. S. Pavlov, K. E. Badmaeva, S. E. Badmaeva, Z. V. Bakaeva, G. N. Kopylova, G. E. Samonina, B. V. Vaskovsky, I. A. Grivennikov, A. A. Zozulya, N. F. Myasoedov
Biologically active peptides evenly labeled with tritium were used for studying the in vitro and in vivo biodegradation of the peptides. Tritium-labeled peptides with a specific radioactivity of 50–150 Ci/mmol were obtained by high temperature solid phase catalytic isotope exchange (HSCIE) with spillover tritium. The distribution of the isotope label among all amino acid residues of these peptides... hiện toàn bộ
Deletion Mutants of Human Granulocyte-Macrophage Colony-Stimulating Factor
Russian Journal of Bioorganic Chemistry - Tập 28 - Trang 397-403 - 2002
L. E. Petrovskaya, E. A. Kryukova, A. L. Kayushin, A. V. Rodina, E. Yu. Moskaleva, V. G. Korobko
To study the structure–function relationship of the human granulocyte-macrophage colony-stimulating factor (GM-CSF), genes were constructed that encode its three deletion mutants: D1, a mutant with the deletion of six amino acid residues (37–42) some of which are a part of a β-structural region; D2, a mutant with the deletion of the unstructured six-aa sequence of a loop (45–50); and D3, a mutant ... hiện toàn bộ
Synthesis and Biological Evaluation of Novel Fused [1,2,3]Triazolo[4',5':3,4] pyrrolo[2,1-f]purines as Potent Anti-Proliferative Agents
Russian Journal of Bioorganic Chemistry - Tập 47 - Trang 896-905 - 2021
E. Ramya Sucharitha, N. Satheesh Kumar, M. Ravinder, N. Vasudeva Reddy, Sirassu Narsimha
In search of the best anticancer agents, a series of novel fused [1,2,3]triazolo[4',5':3,4] pyrrolo[2,1-f]purine derivatives in one vessel was synthesized using 8-bromo-1,3-dimethyl-7-(prop-2-yn-1-yl)-1H-purine-2,6(3H,7H)-dione and various arylazides. The newly synthesized derivatives were evaluated for their in vitro anti-proliferative activity against four human cancer cell lines (MCF-7, HeLa, A... hiện toàn bộ
Modification of recombinant proteins by covalent polysialation illustrated with the example of human insulin
Russian Journal of Bioorganic Chemistry - - 2009
В. В. Безуглов, N. M. Greskaya, M. Yu. Bobrov, M. G. Akimov, E. V. Fomina-Ageeva, Г. Н. Зинченко, Д. И. Баирамашвили, А. И. Мирошников
Polymethylene Derivatives of Nucleic Bases with ω-Functional Groups: II. Adenine and Hypoxanthine Derivatives
Russian Journal of Bioorganic Chemistry - Tập 27 - Trang 167-172 - 2001
A. A. Makinsky, A. M. Kritzyn, E. A. Ul'yanova, O. D. Zakharova, D. V. Bugreev, G. A. Nevinsky
N 9-Polymethylene derivatives of adenine and hypoxanthine with various functional groups in the ω-position of the alkyl substituent were synthesized. Their physicochemical properties and effect on the HIV reverse transcriptase and DNA topoisomerase I were studied.
Synthesis, Characterization, and Antifungal Activity of Some New Thieno[2,3-b]pyridines Incorporating Quinazoline or Benzimidazole Moiety
Russian Journal of Bioorganic Chemistry - Tập 47 - Trang 918-928 - 2021
O. F. Ibrahim, E. A. Bakhite, S. A. M. Metwally, Y. A. El-Ossaily, H. H. M. Abdu-Allah, E. A. Al-Taifi, M. Kandel
Reaction of 4,6-dimethyl-3-cyanopyridine-2(1H)-thione (IIIa) or 4,5,6-trisubstituted-3-cyanopyridine-2(1H)-thiones (IIIb–d) with 2-chloromethylquinazoline-4(3H)-one (IVa) furnished the corresponding 3-amino-2-(4-oxo-3,4-dihydroquinazolin-2-yl)thieno[2,3-b]pyridines (VIa–d). Reaction of aminothieno-pyridines (VIa, b, d) were reacted with triethyl orthoformate, acetic anhydride or nitrous acid to fu... hiện toàn bộ
Convergent Synthesis of the Rat Galanin and Study of Its Biological Activity
Russian Journal of Bioorganic Chemistry - - 2020
M. V. Sidorova, M. E. Palkeeva, Д. В. Авдеев, А. С. Молокоедов, М. В. Овчинников, А. А. Азьмуко, L. I. Serebryakova, Oksana Veselova, И. М. Студнева, О. И. Писаренко
Synthesis, Characterization, and Study of Anticancer Activities of New Schiff Bases and 1,3-Oxazepine Containing Drug
Russian Journal of Bioorganic Chemistry - Tập 50 - Trang 28-33 - 2024
Rana Abid Ali, Luma S. Ahamed, Shaima Ibraheem Chyad AL-Khazraji
Objective: This study involved the synthesis of new Schiff bases and 1,3-oxazepine derivatives from the baclofen drug and study the anticancer activities. Methods: Baclofen was initially reacted with aromatic aldehydes to create Schiff base derivatives (Ia–Ib), which were then closed in the next step using anhydrous acids to form oxazepine derivatives (IIa–IId). Results: The title compounds were s... hiện toàn bộ
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