Russian Journal of Bioorganic Chemistry
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Novel 3-pyridinecarbonitriles incorporating sulfonamide moieties as anti-breast cancer agents
Russian Journal of Bioorganic Chemistry - Tập 42 - Trang 441-448 - 2016
A novel series of 3-pyridinecarbonitrile derivatives incorporating sulfonamide moieties and sulfonyl derivatives was synthesized using 2-chloro-6-methylnicotinonitrile as a strategic starting material. The structures of the synthesized compounds were elucidated on the basis of elemental analysis, IR, 1H NMR, 13C NMR, and mass spectral data. All the prepared compounds were evaluated for their in vi...... hiện toàn bộ
Anti-Influenza Activity of Extracts from Plants of the Lamiaceae Family
Russian Journal of Bioorganic Chemistry - Tập 48 - Trang 1534-1541 - 2022
We have demonstrated that the water and ethanol extracts of the Nepeta cataria, Nepeta sibirica, Scutellaria baicalensis, Hyssopus officinalis, and Betonica officinalis plants, water extracts of Dracocephalum moldavica, Glechoma hederacea, Mentha arvensis, Prunella vulgaris, and Melissa officinalis, and ethanol extracts of Mentha piperita, Mentha crispa, Origanum vulgare, Hyssopus officinalis, and...... hiện toàn bộ
Phytochemical Analysis of Extractive Substances Extracted by Different Methods from the Underground Part of Aconitum Septentrionale L., and the Development of Cream-Gels Based on Them
Russian Journal of Bioorganic Chemistry - Tập 49 - Trang 1754-1760 - 2023
The work is devoted to the study of the phytochemical composition of subcritical extracts of the underground part of aconite high (Aconitum septentrionale L.). The samples of roots and rhizomes of Aconitum septentrionale grown in the Altai Republic were studied. The quality characteristics of plant biomass were determined: moisture content, ash content, quantitative content of biologically active ...... hiện toàn bộ
A New Approach to Enhanced PCR Specificity
Russian Journal of Bioorganic Chemistry - Tập 29 - Trang 368-371 - 2003
A new approach to enhanced specificity and product yield of polymerase chain reaction is proposed. It is based on control of DNA polymerase activity during PCR by changing the magnesium ion concentration, which depends on the temperature of the reaction mixture. A slightly soluble magnesium salt, magnesium oxalate, whose solubility depends on temperature, was used as a source of magnesium ions. Du...... hiện toàn bộ
Enhancer activity of DNA fragments from the FXYD5-COX7A region of human chromosome 19
Russian Journal of Bioorganic Chemistry - Tập 37 - Trang 217-224 - 2011
The enhancer activity of four DNA fragments previously identified within a 1-Mb region of human chromosome 19 has been investigated. All the fragments have similar tissue-specific profiles: The greatest enhancer activity is observed in HEK293, and the least, in HeLa cells. The enhancers have clear specificity towards the cytomegalovirus promoter in comparison to the SV40 promoter. Functional disse...... hiện toàn bộ
An Analysis of Adaptive Reactions in Healthy Subjects Who Have Persistent and Prolonged Contact with Tuberculosis Patients
Russian Journal of Bioorganic Chemistry - Tập 45 - Trang 173-178 - 2019
Lasting contact of medical personnel in tuberculosis departments with the pathogen of Mycobacterium tuberculosis causes changes in their immune system, which is aimed at adapting the body to a constant antigenic load. Changes in the blood of medical staff indicate the participation of certain cells in the formation of protective immunity. Therefore, the observed changes are likely to be specific a...... hiện toàn bộ
Identification of proteins in blood nucleoprotein complexes
Russian Journal of Bioorganic Chemistry - Tập 41 Số 6 - Trang 617-625 - 2015
The Lipase/Lipoxygenase Bienzyme System in AOT Reversed Micelles in Octane
Russian Journal of Bioorganic Chemistry - Tập 28 - Trang 44-49 - 2002
In this work it is shown that the bienzyme lipase/lipoxygenase system can function in reversed micelles of bis(2-ethyl)hexyl sulfosuccinate (AOT) in octane. As a lipase substrate, a fish fat preparation (fat of sea mammals) with a high content of polyunsaturated fatty acids was used. It was demonstrated that the bienzyme reaction proceeded in a stationary mode and had a rate-limiting step catalyze...... hiện toàn bộ
Changes in the antigenic properties of proteins of laboratory mice during oxidative stress
Russian Journal of Bioorganic Chemistry - Tập 35 - Trang 469-473 - 2009
Changes in the level of oxidative damage to proteins in CD1 outbred mice γ irradiated with a dose of 3 Gy have been studied. The changes were estimated from the amount of carbonyl groups (CG) in the proteins. It was found that two hours after exposure to γ radiation, the amount of CG in the cytoplasmic and nuclear fractions of the liver, heart, brain, and spleen sharply increased. Two months after...... hiện toàn bộ
Elucidation of Structure of Lipid A from the Marine Gram-Negative Bacterium Pseudoalteromonas haloplanktis ATCC 14393T
Russian Journal of Bioorganic Chemistry - Tập 30 - Trang 367-373 - 2004
The chemical structure of lipid A, from the marine γ-proteobacterium Pseudoalteromonas
haloplanktis АТСС 14393Т, a main product of lipopolysaccharide hydrolysis (1% AcOH), was determined using chemical methods and NMR spectroscopy. The lipid A was shown to be β-1,6-glucosaminobiose 1,4′-diphosphate acylated with two (R)-3-hydroxyalkanoic acid residues at C3 and C3′ and amidated with one (R)-3-hydr...... hiện toàn bộ
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