Impact of Tocilizumab Monotherapy on Clinical and Patient-Reported Quality-of-Life Outcomes in Patients with Rheumatoid ArthritisRheumatology and Therapy - Tập 4 - Trang 405-417 - 2017
Leslie R. Harrold, Ani John, George W. Reed, Tmirah Haselkorn, Chitra Karki, YouFu Li, Jennie Best, Steve Zlotnick, Joel M. Kremer, Jeffrey D. Greenberg
Tocilizumab (TCZ) monotherapy has been proven as an effective treatment for rheumatoid arthritis (RA) in clinical trials. However, there are limited data available regarding the effectiveness of TCZ monotherapy in real-world clinical settings in the United States. The objective of this study was to evaluate the impact of TCZ monotherapy on disease activity and patient-reported outcomes (PROs) in a...... hiện toàn bộ
Abatacept is Efficacious in the Treatment of Older Patients with csDMARD-Refractory Rheumatoid Arthritis: A Prospective, Multicenter, Observational StudyRheumatology and Therapy - Tập 8 - Trang 1585-1601 - 2021
Sei Muraoka, Zento Yamada, Mai Kawazoe, Wataru Hirose, Hajime Kono, Shinsuke Yasuda, Yukiko Komano, Hiroshi Kawano, Toshihiko Hidaka, Shusaku Nakashima, Tsuyoshi Kasama, Tamio Teramoto, Toshihiro Nanki
Abatacept efficacy in older patients with rheumatoid arthritis (RA) has been primarily demonstrated via retrospective comparisons with younger patients. The objective of this study was to compare efficacy of abatacept in older vs. younger patients with RA, and efficacy of abatacept with that of conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs) in both age groups. This prospe...... hiện toàn bộ
Long-Term Efficacy and Safety of Upadacitinib in Patients with Rheumatoid Arthritis: Final Results from the BALANCE-EXTEND Open-Label Extension StudyRheumatology and Therapy - Tập 10 - Trang 901-915 - 2023
Alan Kivitz, Alvin F. Wells, Juan I. Vargas, Herbert S. B. Baraf, Maureen Rischmueller, Justin Klaff, Nasser Khan, Yihan Li, Kyle Carter, Alan Friedman, Patrick Durez
Upadacitinib (UPA) is an oral, selective Janus kinase inhibitor that has demonstrated favorable efficacy with an acceptable safety profile across a global, phase 3 program in rheumatoid arthritis (RA). This phase 2 open-label extension investigated the efficacy and safety of UPA through 6 years of treatment. Patients from two phase 2b trials (BALANCE-1 and -2) enrolled in BALANCE-EXTEND (NCT020491...... hiện toàn bộ
Translating Improvements with Ixekizumab in Clinical Trial Outcomes into Clinical Practice: ASAS40, Pain, Fatigue, and Sleep in Ankylosing SpondylitisRheumatology and Therapy - Tập 6 Số 3 - Trang 435-450 - 2019
Philip J. Mease, Jessica A. Walsh, Xenofon Baraliakos, Robert D. Inman, Kurt de Vlam, James Cheng‐Chung Wei, Theresa Hunter, Gaia Gallo, David Sandoval, Fangyi Zhao, Yan Dong, Rebecca Bolce, Helena Marzo‐Ortega
Risk Factors for Progression from Subclinical to Clinical Phase of Psoriatic Arthritis: A Case–Control StudyRheumatology and Therapy - Tập 8 Số 1 - Trang 585-597 - 2021
Yiyi Wang, Li Ding, Jihui Chen, Lingyan Zhang, Min Yang, Zhibin Liu, Liangliang Cheng, Tianjiao Lan, Gaojie Li, Yuanxia Gu, Yi Liu, Wei Li
Practical Management of Respiratory Comorbidities in Patients with Rheumatoid ArthritisRheumatology and Therapy - Tập 4 - Trang 309-332 - 2017
James Bluett, Meghna Jani, Deborah P. M. Symmons
Lung disease is one of the most common causes of extra-articular morbidity and mortality in patients with rheumatoid arthritis (RA). Development of pulmonary manifestations may be due to the systemic disease itself; to serious respiratory adverse events such as pneumonitis and infections secondary to therapy; or to lifestyle habits such as smoking. Rheumatologists often need to make important trea...... hiện toàn bộ
Evaluation of Real-World Healthcare Resource Utilization and Associated Costs in Children with Juvenile Idiopathic Arthritis: A Canadian Retrospective Cohort StudyRheumatology and Therapy - - 2021
Luiza R Grazziotin, Gillian Currie, Marinka Twilt, Maarten J. IJzerman, Michelle M.A. Kip, Hendrik Koffijberg, Susanne M. Benseler, Joost F. Swart, Sebastiaan J. Vastert, Nico Wulffraat, Rae S. M. Yeung, Nicole Johnson, Nadia Luca, Päivi Miettunen, Heinrike Schmeling, Deborah Marshall, Ucan Cure consortia Ucan Can-Du