Reproductive Sciences

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Differential Gene Expression in Menstrual Endometrium From Women With Self-Reported Heavy Menstrual Bleeding
Reproductive Sciences - Tập 24 - Trang 28-46 - 2017
Jane E. Girling, Michelle G. Lockhart, Moshe Olshansky, Premila Paiva, Nicole Woodrow, Jennifer L. Marino, Martha Hickey, Peter A. W. Rogers
Heavy menstrual bleeding (HMB) is a significant social and public health issue for menstruating women. Development of targeted treatments has been limited by poor understanding of local mechanisms underlying HMB. We aimed to determine how gene expression differs in menstrual phase endometrium from women with HMB. Menstrual phase endometrial biopsies were collected from women with (n = 7) and witho...... hiện toàn bộ
Enhanced Expression of P2X4 and P2X7 Purinergic Receptors in the Myometrium of Pregnant Rats in Preterm Delivery Models
Reproductive Sciences - Tập 16 - Trang 1186-1192 - 2009
Satoshi Urabe, Hiroshi Miyoshi, Hisaya Fujiwara, Kaoru Yamaoka, Yoshiki Kudo
The expression levels of P2X purinergic receptors were determined in the myometrium of pregnant rats using the quantitative real-time reverse transcriptase polymerase chain reaction (RT-PCR). The messenger RNAs (mRNAs) of P2X4 and P2X7 were expressed most strongly. The expression levels of these receptors increased during the late stages of pregnancy; at the time of delivery, the mRNA levels of P2...... hiện toàn bộ
Comments on “rhTNFR:Fc Suppresses the Development of Endometriosis in a Mouse Model by Downregulating Cell Proliferation and Invasiveness”
Reproductive Sciences - Tập 25 - Trang 983-984 - 2018
Antonio Simone Laganà, Francesca Maria Salmeri, Onofrio Triolo, Salvatore Giovanni Vitale, Roberta Granese, Vincenza Sofo
The Effect of Mild Hypothermia on Insulin-like Growth Factors After Severe Asphyxia in the Preterm Fetal Sheep
Reproductive Sciences - Tập 12 - Trang 232-237 - 2005
Vincent Roelfsema, Alistair Jan Gunn, Bernhard H. Breier, Josine S. Quaedackers, Laura Bennet
Persistent reductions in insulin-like growth factor I (IGF-I) levels in the preterm infant are strongly associated with increased risk of retinopathy and other complications, and may result from exposure to severe hypoxia. The effects of a potential new treatment for hypoxic-ischemic encephalopathy, cerebral hypothermia, on the responses of the IGF axis to hypoxia are unknown. The aim of this stud...... hiện toàn bộ
Aberrant Splicing of the TSG101 Tumor Suppressor Gene in Human Breast and Ovarian Cancers
Reproductive Sciences - Tập 5 - Trang 281-285 - 1998
Michael E. Carney, G. Larry Maxwell, Johnathan M. Lancaster, Curtis Gumbs, Jeffrey Marks, Andrew Berchuck, P. Andrew Futreal
To determine whether large deletions or other alterations in the putative tumor suppressor gene TSG101 play a role in the molecular pathogenesis of breast and ovarian cancers. Expression of TSG101 transcripts was examined in breast and ovarian cancers using the reverse transcriptase-polymerase chain reaction (RT-PCR), and selected transcripts were sequenced. Southern blot analysis was performed to...... hiện toàn bộ
Constitutive Androstane Receptor Expression in the Rat Cervix During Gestation
Reproductive Sciences - Tập 7 - Trang 355-357 - 2000
Daniel F. Rychlik, Eric Bieber, Mark Phillippe
To investigate expression of the constitutive androstane receptor (CAR) in the pregnant rat cervix. Rat uterine tissue was obtained on gestational days 12, 16, 20, 21, and 22 (the day of parturition), and postpartum day 1. In addition, liver, lung, kidney, heart, and skeletal muscle tissue were obtained. Expression of the two known CAR isoforms was evaluated using reverse transcriptase-polymerase ...... hiện toàn bộ
Decreased Frequency of CD8+HLA-G+ T Cell in the Peripheral Blood of Primary Unexplained Infertile Females
Reproductive Sciences - Tập 28 - Trang 1939-1944 - 2021
Motahareh Ehsani, Mousa Mohammadnia-Afrouzi, Sedigheh Esmaeilzadeh, Zahra Tajalli, Mohammad Jafari, Mehdi Shahbazi
Most of the findings have focused on the importance of CD4+HLA-G+ and CD8+HLA-G+ regulatory T cells (Treg) during pregnancy. It has been demonstrated that these HLA-G+ T cell subsets could induce maternal immune tolerance against semi-allogenic conceptus during pregnancy. There are only a few experiments regarding the Treg cells in the context of unexplained infertility (UI). Thirty-five participa...... hiện toàn bộ
Potential Utility of Melatonin in Preeclampsia, Intrauterine Fetal Growth Retardation, and Perinatal Asphyxia
Reproductive Sciences - - 2016
Lucia Marseglia, Sara Manti, Russel J. Reíter, Eloisa Gitto
Molecular Background of Estrogen Receptor Gene Expression in Endometriotic Cells
Reproductive Sciences - Tập 23 - Trang 871-876 - 2016
Masao Izawa, Fuminori Taniguchi, Tasuku Harada
The molecular background of estrogen receptor (ER) expression is important to understand the pathophysiology of the high estrogen environment in endometriosis. However, the molecular details have not been fully understood. The objective of this study is to evaluate the molecular background of ERα and ERβ messenger RNA (mRNA) expression in endometriotic cells. The following summarizes our observati...... hiện toàn bộ
Current Perspectives in Uterine Research: Reviews From the Society for Gynecologic Investigation Myometrium and Parturition Satellite Symposia
Reproductive Sciences - Tập 20 - Trang 138-139 - 2013
Michael J. Taggart, R. Ann Word
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