Reproductive Sciences

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Differential Gene Expression in Menstrual Endometrium From Women With Self-Reported Heavy Menstrual Bleeding
Reproductive Sciences - Tập 24 - Trang 28-46 - 2017
Jane E. Girling, Michelle G. Lockhart, Moshe Olshansky, Premila Paiva, Nicole Woodrow, Jennifer L. Marino, Martha Hickey, Peter A. W. Rogers
Heavy menstrual bleeding (HMB) is a significant social and public health issue for menstruating women. Development of targeted treatments has been limited by poor understanding of local mechanisms underlying HMB. We aimed to determine how gene expression differs in menstrual phase endometrium from women with HMB. Menstrual phase endometrial biopsies were collected from women with (n = 7) and witho...... hiện toàn bộ
Effect of a Low-Dose Contraceptive Patch on Efficacy, Bleeding Pattern, and Safety: A 1-Year, Multicenter, Open-Label, Uncontrolled Study
Reproductive Sciences - Tập 21 - Trang 1518-1525 - 2014
Inka Wiegratz, Susana Bassol, Edith Weisberg, Uwe Mellinger, Martin Merz
This Phase III, uncontrolled, open-label, multicenter study was conducted to investigate the contraceptive efficacy, bleeding pattern, and cycle control of a novel once-a-week contraceptive patch, delivering low-dose ethinyl estradiol (EE) and gestodene (GSD) at the same systemic exposure seen after oral administration of a combined oral contraceptive containing 0.02 mg EE/0.06 mg GSD. Participant...... hiện toàn bộ
Enhanced Expression of P2X4 and P2X7 Purinergic Receptors in the Myometrium of Pregnant Rats in Preterm Delivery Models
Reproductive Sciences - Tập 16 - Trang 1186-1192 - 2009
Satoshi Urabe, Hiroshi Miyoshi, Hisaya Fujiwara, Kaoru Yamaoka, Yoshiki Kudo
The expression levels of P2X purinergic receptors were determined in the myometrium of pregnant rats using the quantitative real-time reverse transcriptase polymerase chain reaction (RT-PCR). The messenger RNAs (mRNAs) of P2X4 and P2X7 were expressed most strongly. The expression levels of these receptors increased during the late stages of pregnancy; at the time of delivery, the mRNA levels of P2...... hiện toàn bộ
Intrauterine Morcellator Devices: The Icon of Hysteroscopic Future or Merely a Marketing Image? A Systematic Review Regarding Safety, Efficacy, Advantages, and Contraindications
Reproductive Sciences - Tập 22 - Trang 1289-1296 - 2015
Marco Noventa, Emanuele Ancona, Michela Quaranta, Amerigo Vitagliano, Erich Cosmi, Donato D’Antona, Salvatore Gizzo
The aim of this study was to analyze all available evidence regarding the use of intrauterine morcellator (IUM), for treatment of the most prevalent intrauterine benign lesions, compared to both traditional resectoscopy and conventional outpatient operative hysteroscopy in terms of safety, efficacy, contraindications, perioperative complications, operating time, and estimated learning curve. We re...... hiện toàn bộ
Programming of Endocrine Mechanisms of Cardiovascular Control and Growth
Reproductive Sciences - Tập 8 - Trang 57-68 - 2001
Lucy R. Green
Several epidemiologic studies have linked size at birth to health in adult life. One school of thought centers on the part that periconceptual or intrauterine events play in this relationship. The idea is that an event, or several events, during critical periods of development can program, or permanently alter, fetal physiology resulting in altered size at birth and subsequent adult disease, inclu...... hiện toàn bộ
In the Spotlight
Reproductive Sciences - Tập 23 - Trang 153-153 - 2016
Maria Rosa Maduro
Eutopic Endometrium From Women With Endometriosis Shows Altered Ultrastructure and Glycosylation Compared to That From Healthy Controls—A Pilot Observational Study
Reproductive Sciences - Tập 16 - Trang 559-572 - 2009
Carolyn J. P. Jones, Ibrahim M. Inuwa, Luciano G. Nardo, Pietro Litta, Asgerally T. Fazleabas
Endometrial curettings from a cohort of 24 women with endometriosis were compared with matched biopsies from 14 healthy, fertile women and examined for ultrastructural changes and the secretion of glycans bound by the lectin from Dolichos biflorus. Ultrastructural analysis of glandular endometrial tissue from women with stages I to III endometriosis showed heterogeneous responses to the disease, b...... hiện toàn bộ
Comments on “rhTNFR:Fc Suppresses the Development of Endometriosis in a Mouse Model by Downregulating Cell Proliferation and Invasiveness”
Reproductive Sciences - Tập 25 - Trang 983-984 - 2018
Antonio Simone Laganà, Francesca Maria Salmeri, Onofrio Triolo, Salvatore Giovanni Vitale, Roberta Granese, Vincenza Sofo
The Effect of Mild Hypothermia on Insulin-like Growth Factors After Severe Asphyxia in the Preterm Fetal Sheep
Reproductive Sciences - Tập 12 - Trang 232-237 - 2005
Vincent Roelfsema, Alistair Jan Gunn, Bernhard H. Breier, Josine S. Quaedackers, Laura Bennet
Persistent reductions in insulin-like growth factor I (IGF-I) levels in the preterm infant are strongly associated with increased risk of retinopathy and other complications, and may result from exposure to severe hypoxia. The effects of a potential new treatment for hypoxic-ischemic encephalopathy, cerebral hypothermia, on the responses of the IGF axis to hypoxia are unknown. The aim of this stud...... hiện toàn bộ
Feto-Maternal Interaction: A Mathematical Model Simulating Placental Response in Hypertensive Disorders of Pregnancy
Reproductive Sciences - Tập 17 - Trang 963-969 - 2010
Oded Luria, Jacob Bar, Michal Kovo, Abraham Golan, Ofer Barnea
Elevated maternal blood pressure (BP) is common in pregnancies complicated by hypertensive disorders. In response, increased production and accumulation of elastin occurs in the feto-placental blood vessels. This results in increased vascular wall stiffness that increases the resistance to flow. To study the interaction between the stiffness of the fetoplacental blood vessels, fetoplacental blood ...... hiện toàn bộ
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