The Effect of Different Routes of Xenogeneic Mesenchymal Stem Cell Transplantation on the Regenerative Potential of Spinal Cord InjuryRegenerative Engineering and Translational Medicine - Tập 9 - Trang 407-415 - 2022
A. Suvarna, M. Hoque, A. C. Saxena, Vineet Kumar, Rajendra Singh, Sadhan Bag
Mesenchymal stem cell (MSC) transplantation has been touted as a possible treatment for spinal cord injury (SCI) patients’ locomotor and neurological rehabilitation. The intralesional injection of MSC is a typical delivery route for SCI, although this can result in further injury. We conducted the study with the aim of characterizing canine bone marrow–derived MSC (cBM-MSC) and evaluating the rela...... hiện toàn bộ
News and Views March 2020Regenerative Engineering and Translational Medicine - Tập 6 - Trang 111-113 - 2020
Ali Khademhosseini
Determinants of Hemodialysis Performance:Modeling Fluid and Solute Transport in Hollow-Fiber DialyzersRegenerative Engineering and Translational Medicine - Tập 7 - Trang 291-300 - 2019
Jian Yu, Vipul C. Chitalia, Olukemi O. Akintewe, Aurelie Edwards, Joyce Y. Wong
Hemodialysis constitutes the lifeline of patients with end stage renal disease, yet the parameters that affect hemodialyzer performance remain incompletely understood. We developed a computational model of mass transfer and solute transport in a hollow-fiber dialyzer to gain greater insight into the determinant factors. The model predicts fluid velocity, pressure, and solute concentration profiles...... hiện toàn bộ
Plant Recombinant Human Collagen Type I Hydrogels for Corneal RegenerationRegenerative Engineering and Translational Medicine - Tập 8 - Trang 269-283 - 2021
Michel Haagdorens, Elle Edin, Per Fagerholm, Marc Groleau, Zvi Shtein, Artūras Ulčinas, Amit Yaari, Ayan Samanta, Vytautas Cepla, Aneta Liszka, Marie-José Tassignon, Fiona Simpson, Oded Shoseyov, Ramūnas Valiokas, Isabel Pintelon, Monika Kozak Ljunggren, May Griffith
To determine feasibility of plant-derived recombinant human collagen type I (RHCI) for use in corneal regenerative implants RHCI was crosslinked with 1-ethyl-3-(3-dimethyl aminopropyl) carbodiimide (EDC) and N-hydroxysuccinimide (NHS) to form hydrogels. Application of shear force to liquid crystalline RHCI aligned the collagen fibrils. Both aligned and random hydrogels were evaluated for mechanica...... hiện toàn bộ
Human Macrophage- and Osteoclast-Based Constructs Do Not Induce Ectopic Bone FormationRegenerative Engineering and Translational Medicine - - Trang 1-12 - 2023
Johanna F. A. Husch, Laura Coquelin, Nathalie Chevallier, Natasja W. M. van Dijk, Sander C. G. Leeuwenburgh, Jeroen J. J. P. van den Beucken
An increasing body of evidence suggests that bone resorbing osteoclasts are important—but as yet underrated—cellular initiators of bone formation. Furthermore, macrophages also have shown stimulatory effects on the osteogenic differentiation of mesenchymal stromal cells (MSCs). Consequently, we here investigated whether human macrophage- and osteoclast-laden carrier materials can induce ectopic bo...... hiện toàn bộ
Differential Epigenetic Effects of BMI Inhibitor PTC-028 on Fusion-Positive Rhabdomyosarcoma Cell Lines from Distinct Metastatic SitesRegenerative Engineering and Translational Medicine - Tập 8 - Trang 446-455 - 2022
Cara E. Shields, Robert W. Schnepp, Karmella A. Haynes
This study aims to deepen our understanding of the novel potential therapeutic target BMI1 (B lymphoma Mo-MLV insert region 1 homolog) in the rare pediatric cancer fusion-positive rhabdomyosarcoma (FP-RMS) and identify gene expression changes that may underlie the loss of cell viability and proliferation that were induced by genetic and pharmacological inhibition of BMI1 in our previous study. FP-...... hiện toàn bộ
Three-Dimensional Porous Trabecular Scaffold Exhibits Osteoconductive Behaviors In VitroRegenerative Engineering and Translational Medicine - Tập 6 - Trang 241-250 - 2019
Brittany L Taylor, Isabel Perez, James Ciprano, Chinyere Onyekachi Utaegbulam Freeman, Aaron Goldstein, Joseph Freeman
In the USA, approximately 500,000 bone grafting procedures are performed annually to treat injured or diseased bone. Autografts and allografts are the most common treatment options but can lead to adverse outcomes such as donor site morbidity and mechanical failure within 10 years. Due to this, tissue engineered replacements have emerged as a promising alternative to the biological options. In thi...... hiện toàn bộ
Small Molecule–Mediated Enhanced Osteogenesis of Human Mesenchymal Stem Cells: a Probable Alternate for BMP-2Regenerative Engineering and Translational Medicine - Tập 6 - Trang 407-418 - 2020
Pearlin Hameed, Dwaipayan Sen, Geetha Manivasagam
The use of bone morphogenic protein-2 (BMP-2) to accelerate the healing of bone defects has resulted in side effects such as ectopic bone formation, soft tissue swelling, and cyst-like bone void formation. An equipotential and a cost-effective replacement for BMP-2 is therefore required. In this study, different combinations of small molecules like FK506 (F), an immunosuppressant; purmorphamine (P...... hiện toàn bộ