Human Macrophage- and Osteoclast-Based Constructs Do Not Induce Ectopic Bone FormationRegenerative Engineering and Translational Medicine - - Trang 1-12 - 2023
Johanna F. A. Husch, Laura Coquelin, Nathalie Chevallier, Natasja W. M. van Dijk, Sander C. G. Leeuwenburgh, Jeroen J. J. P. van den Beucken
An increasing body of evidence suggests that bone resorbing osteoclasts are important—but as yet underrated—cellular initiators of bone formation. Furthermore, macrophages also have shown stimulatory effects on the osteogenic differentiation of mesenchymal stromal cells (MSCs). Consequently, we here investigated whether human macrophage- and osteoclast-laden carrier materials can induce ectopic bo...... hiện toàn bộ
Differential Epigenetic Effects of BMI Inhibitor PTC-028 on Fusion-Positive Rhabdomyosarcoma Cell Lines from Distinct Metastatic SitesRegenerative Engineering and Translational Medicine - Tập 8 - Trang 446-455 - 2022
Cara E. Shields, Robert W. Schnepp, Karmella A. Haynes
This study aims to deepen our understanding of the novel potential therapeutic target BMI1 (B lymphoma Mo-MLV insert region 1 homolog) in the rare pediatric cancer fusion-positive rhabdomyosarcoma (FP-RMS) and identify gene expression changes that may underlie the loss of cell viability and proliferation that were induced by genetic and pharmacological inhibition of BMI1 in our previous study. FP-...... hiện toàn bộ
Stromal Vascular Fraction for Osteoarthritis of the Knee Regenerative EngineeringRegenerative Engineering and Translational Medicine - Tập 8 - Trang 210-224 - 2021
Chinedu C. Ude, Shiv Shah, Kenneth S. Ogueri, Lakshmi S. Nair, Cato T. Laurencin
The knee joint is prone to osteoarthritis (OA) due to its anatomical position, and several reports have implicated the imbalance between catabolic and anabolic processes within the joint as the main culprit, thus leading to investigations towards attenuation of these inflammatory signals for OA treatment. In this review, we have explored clinical evidence supporting the use of stromal vascular fra...... hiện toàn bộ
A 30% Volumetric Muscle Loss Does Not Result in Sustained Functional Deficits After a 90-Day Recovery in RatsRegenerative Engineering and Translational Medicine - Tập 6 - Trang 62-68 - 2019
Emmanuel E. Vega-Soto, Brittany L. Rodriguez, Rachel E. Armstrong, Lisa M. Larkin
Volumetric muscle loss (VML) is defined as the loss of skeletal muscle tissue which exceeds the body’s repair capabilities leading to sustained functional deficits over time. Some etiologies leading to VML include traumatic injuries, congenital diseases, and degenerative myopathies. Currently, the lack of standardized animal models prevents an appropriate estimation of the severity of injury capab...... hiện toàn bộ
In Vivo Colon Regeneration: from Decellularization to In Vivo Implantation in a Rat Model Using the Body as a Natural BioreactorRegenerative Engineering and Translational Medicine - Tập 8 - Trang 106-116 - 2021
Amir Hossein Zabolian, Minoo Rostami, Sahar Eftekharzadeh, Shabnam Sabetkish, Abdol-Mohammad Kajbafzadeh
Production of a tissue-engineered scaffold for replacement of colon would be a breakthrough affecting the clinical approach to several conditions, and it would alter the fate of patients who need total colectomy with ileoanal anastomosis. In the current study, we aimed to determine the histological aspects of a decellularized colon graft for further colon recellularization using omentum as a natur...... hiện toàn bộ