Regenerative Engineering and Translational Medicine
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Small Molecule–Mediated Enhanced Osteogenesis of Human Mesenchymal Stem Cells: a Probable Alternate for BMP-2
Regenerative Engineering and Translational Medicine - Tập 6 - Trang 407-418 - 2020
The use of bone morphogenic protein-2 (BMP-2) to accelerate the healing of bone defects has resulted in side effects such as ectopic bone formation, soft tissue swelling, and cyst-like bone void formation. An equipotential and a cost-effective replacement for BMP-2 is therefore required. In this study, different combinations of small molecules like FK506 (F), an immunosuppressant; purmorphamine (P...... hiện toàn bộ
In Vitro Models of Ischemia-Reperfusion Injury
Regenerative Engineering and Translational Medicine - Tập 4 - Trang 142-153 - 2018
Timely reperfusion after a myocardial infarction is necessary to salvage the ischemic region; however, reperfusion itself is also a major contributor to the final tissue damage. Currently, there is no clinically relevant therapy available to reduce ischemia-reperfusion injury (IRI). While many drugs have shown promise in reducing IRI in preclinical studies, none of these drugs have demonstrated be...... hiện toàn bộ
A Single Administration of Synthetic Artificial Stem Cells (SASC) Attenuates Osteoarthritis Progression
Regenerative Engineering and Translational Medicine - Tập 10 Số 1 - Trang 78-92 - 2024
Effects of Surface Coating on Nanoparticle-Protein Adsorption Selectivity
Regenerative Engineering and Translational Medicine - Tập 4 - Trang 62-74 - 2018
Negatively charged, uni-sized naked gold (Au) and coated poly (acrylic acid) (PAA)—polyethyleneimine (PEI)-Au (PPAu) nanoparticles (NP)s were incubated with four proteins of different molecular weights: bovine serum albumin (BSA) ~ 67 kDa, cationic trypsin ~ 23.3 kDa, LL-37 peptide ~ 4.5 kDa, and PK(FK)5PK peptide ~ 1.9 kDa. Different interaction kinetics were observed and analyzed by cryogenic tr...... hiện toàn bộ
The Effect of Different Routes of Xenogeneic Mesenchymal Stem Cell Transplantation on the Regenerative Potential of Spinal Cord Injury
Regenerative Engineering and Translational Medicine - Tập 9 - Trang 407-415 - 2022
Mesenchymal stem cell (MSC) transplantation has been touted as a possible treatment for spinal cord injury (SCI) patients’ locomotor and neurological rehabilitation. The intralesional injection of MSC is a typical delivery route for SCI, although this can result in further injury. We conducted the study with the aim of characterizing canine bone marrow–derived MSC (cBM-MSC) and evaluating the rela...... hiện toàn bộ
Tissue-Engineered Endothelial Cells Induce Sustained Vascular Healing Through Early Induction of Vascular RepairAbstract
Background
Perivascular implantation of tissue-engineered endothelial cells (TEEC) after vascular injury profoundly inhibits neointimal hyperplasia. However, the time course and mechanism by which this effect occurs remain unknown. By developing genetically modified TEEC that express a “sui... ... hiện toàn bộ
Regenerative Engineering and Translational Medicine - - 2023
Stromal Vascular Fraction for Osteoarthritis of the Knee Regenerative Engineering
Regenerative Engineering and Translational Medicine - Tập 8 - Trang 210-224 - 2021
The knee joint is prone to osteoarthritis (OA) due to its anatomical position, and several reports have implicated the imbalance between catabolic and anabolic processes within the joint as the main culprit, thus leading to investigations towards attenuation of these inflammatory signals for OA treatment. In this review, we have explored clinical evidence supporting the use of stromal vascular fra...... hiện toàn bộ
News and Views March 2021
Regenerative Engineering and Translational Medicine - Tập 7 - Trang 115-117 - 2021
Multiscale Poly-(ϵ-caprolactone) Scaffold Mimicking Non-linearity in Tendon Tissue Mechanics
Regenerative Engineering and Translational Medicine - - 2016
Potency of Mesenchymal Stem Cell and Its Secretome in Treating COVID-19
Regenerative Engineering and Translational Medicine - Tập 8 - Trang 43-54 - 2021
The COVID-19 disease, which is caused by the novel coronavirus, SARS-CoV-2, has affected the world by increasing the mortality rate in 2020. Currently, there is no definite treatment for COVID-19 patients. Several clinical trials have been proposed to overcome this disease and many are still under investigation. In this review, we will be focusing on the potency of mesenchymal stem cells (MSCs) an...... hiện toàn bộ
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