Purinergic Signalling
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The role of P2X7 receptors in tissue fibrosis: a brief review
Purinergic Signalling - Tập 11 Số 4 - Trang 435-440 - 2015
Many previous studies have demonstrated that P2X7 receptors (P2X7Rs) have a pleiotropic function in different pathological conditions and could represent a novel target for the treatment of a range of diseases. In particular, recent studies have explored the role of P2X7R in fibrosis, the pathological outcome of most chronic inflammatory diseases. The aim of this review is to discuss the biologica......
How Prof. Burnstock’s enthusiasm supported P2 receptor research in Germany
Purinergic Signalling - Tập 17 - Trang 139-140 - 2021
Purinergic signaling in the battlefield of viral infections
Purinergic Signalling - - Trang 1-16 - 2023
Purinergic signaling has been associated with immune defenses against pathogens such as bacteria, protozoa, fungi, and viruses, acting as a sentinel system that signals to the cells when a threat is present. This review focuses on the roles of purinergic signaling and its therapeutic potential for viral infections. In this context, the purinergic system may play potent antiviral roles by boosting ......
Purinergic mechanisms in the control of gastrointestinal motility
Purinergic Signalling - Tập 4 - Trang 197-212 - 2007
For many years, ATP and adenosine have been implicated in movement regulation of the gastrointestinal tract. They act through three major receptor subtypes: adenosine or P1 receptors, P2X receptors and P2Y receptors. Each of these major receptor types can be subdivided into several different classes and is widely distributed amongst various neurons, muscle types, glia and interstitial cells that r......
P2Y12 receptors in platelets and other hematopoietic and non-hematopoietic cells
Purinergic Signalling - Tập 8 - Trang 609-619 - 2012
The P2Y12 receptor is a Gi-coupled ADP receptor first described in blood platelets where it plays a central role in the complex processes of activation and aggregation. Platelet granules store important amounts of ADP which are released upon stimulation by interaction of platelets with the damaged vessel wall. Therefore, the P2Y12 receptor is a key player in primary hemostasis and in arterial thro......
Prenatal expression of purinergic receptor P2X3 in human dorsal root ganglion
Purinergic Signalling - Tập 8 - Trang 245-254 - 2011
The dorsal root ganglion (DRG) is consisted of neurons that relay multiple types of spinal sensory stimuli to the central nervous system. Several neuroactive molecules may be involved in sensory modulation especially pain processing at the DRG, including the purinergic receptor P2X3 and calcitonin-gene-related peptide (CGRP). P2X3 receptor has been considered a promising pharmaceutical target for ......
A novel definition and treatment of hyperinflammation in COVID-19 based on purinergic signalling
Purinergic Signalling - Tập 18 - Trang 13-59 - 2021
Hyperinflammation plays an important role in severe and critical COVID-19. Using inconsistent criteria, many researchers define hyperinflammation as a form of very severe inflammation with cytokine storm. Therefore, COVID-19 patients are treated with anti-inflammatory drugs. These drugs appear to be less efficacious than expected and are sometimes accompanied by serious adverse effects. SARS-CoV-2......
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